4,5,6,7-tetrachlorophthalide profile

4,5,6,7-tetrachlorophthalide: a fungicide [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

4,5,6,7-tetrachloro-2-benzofuran-1(3H)-one : A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one in which all or the hydrogens attached to the benzene ring are replaced by chlorines. A fungicide used for the control of rice blast, it is not approved for use within the European Union. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	33791
CHEMBL ID	357452
CHEBI ID	47617
SCHEMBL ID	27454
MeSH ID	M0524372

Synonyms (30)

Synonym
phthalide, 4,5,6,7-tetrachloro-
bayer 96610
brn 0182477
4,5,6,7-tetrachlorophthalidefthalide
4,5,6,7-tetrachlorophthalide
4,5,6,7-tetrachloro-1(3h)-isobenzofuranone
fthalide
rabcide
kf-32
4,5,6,7-tetrachloro-phthalide
4,5,6,7-tetrachloro-3h-isobenzofuran-1-one
DB03302
CHEMBL357452
chebi:47617 ,
4,5,6,7-tetrachloro-3h-2-benzofuran-1-one
AKOS004907316
27355-22-2
C18611
unii-44ihe2m2t4
1(3h)-isobenzofuranone, 4,5,6,7-tetrachloro-
44ihe2m2t4 ,
4-17-00-04950 (beilstein handbook reference)
tetrachlorophthalide
FT-0630532
SCHEMBL27454
DTXSID2058045
4,5,6,7-tetrachloro-2-benzofuran-1(3h)-one
4,5,6,7-tetrachloroisobenzofuran-1(3h)-one
Q27094229
PD007105

Roles (2)

Role	Description
melanin synthesis inhibitor	A depigmentation agent which inhibits the synthesis of melanin.
antifungal agrochemical	Any substance used in acriculture, horticulture, forestry, etc. for its fungicidal properties.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (4)

Class	Description
propan-1-ol	The parent member of the class of propan-1-ols that is propane in which a hydrogen of one of the methyl groups is replaced by a hydroxy group.
gamma-lactone	A lactone having a five-membered lactone ring.
tetrachlorobenzene	Any member of the class of chlorobenzenes carrying four chloro groups at unspecified positions.
organic heterobicyclic compound
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay ID	Title	Year	Journal	Article
AID214624	Compound was evaluated for its inhibition constant against Trihydroxynaphthalene reductase [3H]-NR)	2000	Bioorganic & medicinal chemistry letters, Mar-06, Volume: 10, Issue:5	Selection of a potent inhibitor of trihydroxynaphthalene reductase by sorting disease control data.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (80.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.87 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.66 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.87)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
hydrogen Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.	2.47	2	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite
tricyclazole tricyclazole: RN given refers to parent cpd. tricyclazole : A triazolobenzothiazole that is [1,2,4]triazolo[3,4-b][1,3]benzothiazole which is substituted at position 5 by a methyl group. A fungicide used for the control of rice blast, it is not approved for use within the European Union.	2	1	triazolobenzothiazole	antifungal agrochemical; melanin synthesis inhibitor
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	2.97	4

4,5,6,7-tetrachlorophthalide

Description