| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
tocopheroxy radical
tocopheroxy radical: RN given refers to radical ion (1+), (2R-(2R*(4R*,8R*)))-isomer; RN for cpd without isomeric designation not available 12/90 | 3.21 | 1 | 0 | tocopherol | |
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives. | 3.21 | 1 | 0 | C-nitro compound;
carboxamide;
diol;
organochlorine compound | antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor |
mansonone c
mansonone C: structure in first source | 3.21 | 1 | 0 | 1,2-naphthoquinones;
sesquiterpenoid | |
betulinic acid
[no description available] | 2.49 | 2 | 0 | hydroxy monocarboxylic acid;
pentacyclic triterpenoid | anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite |
epicatechin
(-)-epicatechin : A catechin with (2R,3R)-configuration. | 3.21 | 1 | 0 | catechin;
polyphenol | antioxidant |
Tormentic acid
tormentic acid: aglycone of Rosamultin | 2.15 | 1 | 0 | triterpenoid | metabolite |
maslinic acid
(2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid: from Luehea divaricata and Agrimonia eupatoria | 2.15 | 1 | 0 | dihydroxy monocarboxylic acid;
pentacyclic triterpenoid | anti-inflammatory agent;
antineoplastic agent;
antioxidant;
plant metabolite |
procyanidin b2
procyanidin B2 : A proanthocyanidin consisting of two molecules of (-)-epicatechin joined by a bond between positions 4 and 8' in a beta-configuration. Procyanidin B2 can be found in Cinchona pubescens (Chinchona, in the rind, bark and cortex), in Cinnamomum verum (Ceylon cinnamon, in the rind, bark and cortex), in Crataegus monogyna (Common hawthorn, in the flower and blossom), in Uncaria guianensis (Cat's claw, in the root), in Vitis vinifera (Common grape vine, in the leaf), in Litchi chinensis (litchi, in the pericarp), in the apple, in Ecdysanthera utilis and in red wine. | 3.21 | 1 | 0 | biflavonoid;
hydroxyflavan;
polyphenol;
proanthocyanidin | antioxidant;
metabolite |
procyanidin b5
procyanidin B5 : A proanthocyanidin consisting of two molecules of (-)-epicatechin joined by a bond between positions 4 and 6' in beta-configuration. It can be found in grape seeds, in Hibiscus cannabinus (kenaf) root and bark, in apple and in cacao. | 3.21 | 1 | 0 | biflavonoid;
hydroxyflavan;
polyphenol;
proanthocyanidin | metabolite |
omega-n-methylarginine
omega-N-Methylarginine: A competitive inhibitor of nitric oxide synthetase.. N(omega)-methyl-L-arginine : A L-arginine derivative with a N(omega)-methyl substituent. | 2.15 | 1 | 0 | amino acid zwitterion;
arginine derivative;
guanidines;
L-arginine derivative;
non-proteinogenic L-alpha-amino acid | |
procyanidin C1
procyanidin trimer C1: a flavonoid found in multiple plant sources including grape, apple, and cacao, which has antioxidant and anti-inflammatory properties. procyanidin C1 : A proanthocyanidin consisting of three (-)-epicatechin units joined by two successive (4beta->8)-linkages. | 3.21 | 1 | 0 | hydroxyflavan;
polyphenol;
proanthocyanidin | anti-inflammatory agent;
antioxidant;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
lipoxygenase inhibitor;
metabolite |
pomolic acid
pomolic acid: from Rosa woodsii & Hyptis capitata; structure in first source | 2.05 | 1 | 0 | triterpenoid | metabolite |
gamma-sitosterol
clionasterol : A member of the class of phytosterols that is poriferast-5-ene carrying a beta-hydroxy substituent at position 3. | 2.06 | 1 | 0 | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols | marine metabolite;
plant metabolite |
mansonone g
[no description available] | 3.21 | 1 | 0 | | |
methyl caffeate
methyl caffeate: from plant Gaillardia pulchella. methyl caffeate : An alkyl caffeate ester formed by the formal condensation of caffeic acid with methyl alcohol. | 2.07 | 1 | 0 | alkyl caffeate ester;
methyl ester | |
cytellin
cytellin: a phytosterol preparation of mainly B-sitosterol, that was marketed by Eli Lilly to lower cholesterol 1957 to 1982 | 2.06 | 1 | 0 | | |
poliothrysoside
poliothrysoside: isolated from Laxocalyx urticifolius; structure in first source | 2.07 | 1 | 0 | | |
cucurbitacin b
[no description available] | 2.06 | 1 | 0 | cucurbitacin;
secondary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone | |
cucurbitacin d
cucurbitacin D: toxic constituent in edible gourd; see also records for cucurbitacins & specific cucurbitacins. cucurbitacin D : A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23. | 3.59 | 2 | 0 | cucurbitacin;
secondary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone | |
shogaol
shogaol: from ginger, ZINGIBER OFFICINALE; less mutagenic than GINGEROL; structure given in first source | 2.15 | 1 | 0 | enone;
monomethoxybenzene;
phenols | |
corosolic acid
[no description available] | 2.15 | 1 | 0 | triterpenoid | metabolite |
betulin-3-caffeate
betulin-3-caffeate: has antineoplastic activity; isolated from Hibiscus syriacus; structure in first source | 2.15 | 1 | 0 | | |
2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid
alphitolic acid: from the aerial parts of Gouania longipetala; structure in first source. 2alpha,3beta-dihydroxy-20(29)-lupen-28-oic acid : A pentacyclic triterpenoid that is betulinic acid carrying an additional alpha-hydroxy group at position 2. It has been isolated from Breynia fruticosa. | 2.15 | 1 | 0 | dihydroxy monocarboxylic acid;
pentacyclic triterpenoid | plant metabolite |
cinnamtannin a2
cinnamtannin A2: a tetrameric proanthcyanidin; isolated from cacao products; structure in first source. cinnamtannin A2 : A proanthocyanidin isolated from Cinnamomum cassia. | 3.21 | 1 | 0 | proanthocyanidin | plant metabolite |
epi-maslinic acid
epi-maslinic acid : A pentacyclic triterpenoid that is 3alpha-hydroxy epimer of maslinic acid. Isolated from Prunella vulgaris and Isodon japonicus, it exhibits anti-inflammatory activity. | 2.49 | 2 | 0 | dihydroxy monocarboxylic acid;
pentacyclic triterpenoid | anti-inflammatory agent;
metabolite |