Compounds > 8-hydroxy-2-(di-n-propylamino)tetralin, (r)-isomer
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8-hydroxy-2-(di-n-propylamino)tetralin, (r)-isomer

Description

(7R)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol : no description available [CHeBI]

Cross-References

ID SourceID
PubMed CID6603866
CHEMBL ID26998
SCHEMBL ID1682347
CHEBI ID103846
MeSH IDM0329201

Synonyms (39)

Synonym
BRD-K59765110-004-03-8
(r)-(+)-2-dipropylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide
lopac-h-140
tocris-1080
tocris-0529
NCGC00015493-02
lopac-h-8250
NCGC00024635-01
NCGC00015493-01
NCGC00024986-01 ,
PDSP1_001710
LOPAC0_000638
PDSP2_001693
CHEBI:103846
NCGC00024986-03
CHEMBL26998 ,
7-dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol ((r)-oh-dpat)
(r)-7-dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol
7-dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol
r-(+)-7-dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol
7-dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol(8-oh-dpat)
(8-hydroxyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-amine
((r)-8-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-ammonium
bdbm50016777
(7r)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
CCG-204725
AKOS015966329
NCGC00015493-03
80300-09-0
SCHEMBL1682347
DTXSID00424964
(r)-8-hydroxy-2-dipropylaminotetralin
r(+)-8-oh-dpat
Q27181018
(r)-8-hydroxy-2-(di-n-propyl-amino)tetralin
SDCCGSBI-0050618.P002
NCGC00024986-08
TQP0826
(r)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol

Drug Classes (1)

ClassDescription
tetralinsCompounds containing a tetralin skeleton.

Protein Targets (24)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
dopamine D1 receptorHomo sapiens (human)Potency7.3078AID624455
thioredoxin reductaseRattus norvegicus (Norway rat)Potency1.0000AID588453
USP1 protein, partialHomo sapiens (human)Potency56.2341AID504865
GLS proteinHomo sapiens (human)Potency11.2202AID624146
TDP1 proteinHomo sapiens (human)Potency27.3172AID686978
thyroid stimulating hormone receptorHomo sapiens (human)Potency15.8489AID926; AID938
arylsulfatase AHomo sapiens (human)Potency2.1331AID720538
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency15.8489AID504332
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency14.5891AID891
atrial natriuretic peptide receptor 1 precursorHomo sapiens (human)Potency3.0131AID1347049
chromobox protein homolog 1Homo sapiens (human)Potency0.0060AID488953
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency5.5303AID943; AID944
lethal factor (plasmid)Bacillus anthracis str. A2012Potency12.5893AID912
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency11.9048AID1457

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
5-hydroxytryptamine receptor 1AHomo sapiens (human)Ki0.0042AID1656651; AID3830
D(2) dopamine receptorHomo sapiens (human)Ki0.3537AID55449; AID63410; AID64155; AID64156
Translocator proteinRattus norvegicus (Norway rat)Ki0.0013AID3993
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)Ki0.0031AID1442392; AID3993; AID4103
5-hydroxytryptamine receptor 1DHomo sapiens (human)Ki0.4010AID4906; AID4942
5-hydroxytryptamine receptor 7 Rattus norvegicus (Norway rat)Ki0.0273AID6652; AID6666
5-hydroxytryptamine receptor 7Homo sapiens (human)Ki0.0480AID1656650
D(3) dopamine receptorHomo sapiens (human)Ki0.1790AID65787
D(2) dopamine receptorRattus norvegicus (Norway rat)Ki0.8260AID65725
5-hydroxytryptamine receptor 1AMus musculus (house mouse)Ki0.0005AID4474

Bioassays (138)

Assay IDTitleYearJournalArticle
AID197609Half-minimal decrease in the accumulation of 5-HTP (5-Hydroxytryptophan) in non pretreated rat limbic brain at dose 0.25 umol/kg1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID180947Forepaw treading (FPT) behavior was studied in rats after subcutaneous administration of 1 uM/Kg of compound; 7/71995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
ISSN: 0022-2623		Derivatives of cis-2-amino-8-hydroxy-1-methyltetralin: mixed 5-HT1A-receptor agonists and dopamine D2-receptor antagonists.
AID174022post-synaptic activity was determined by locomotor activity (LMA) in Non pretreated rats1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID170410Effect of 5-HT accumulation in rat hippocampus at the dose of 0.32 umol/kg (p<0.01)1993Journal of medicinal chemistry, Dec-24, Volume: 36, Issue:26
ISSN: 0022-2623		Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors.
AID6672Agonistic activity against rat 5-HT7 adenyl cyclase expressed in HEK293 cells; Active2003Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
ISSN: 0022-2623		Characterization of the 5-HT(7) receptor. Determination of the pharmacophore for 5-HT(7) receptor agonism and CoMFA-based modeling of the agonist binding site.
AID177255Evaluated for receptor mediated feedback inhibition of 5-HTP formation in striatum tissue of rat brain when administered subcutaneously1988Journal of medicinal chemistry, Jan, Volume: 31, Issue:1
ISSN: 0022-2623		N,N-Dialkylated monophenolic trans-2-phenylcyclopropylamines: novel central 5-hydroxytryptamine receptor agonists.
AID174328Inhibition of Dopamine receptor accumulation in limbic part of rat brain after subcutaneous administration of compound before 60 min to death1981Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
ISSN: 0022-2623		8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist.
AID195533Half-minimal decrease in the accumulation of DOPA (3,4-dihydroxyphenylalanine) in rat striatal brain; partial response at 50 uM/Kg1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID6452Compound was tested for its effect on NSD 1015 induced accumulation of 5-HTP(ng/g) in rats in limbic system at a dosage of 0.10 umol/kg1989Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
ISSN: 0022-2623		Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain.
AID3830Binding affinity was measured on cloned Human 5-hydroxytryptamine 1A receptor which is labeled by [3H]8-OH-DPAT2000Journal of medicinal chemistry, Apr-06, Volume: 43, Issue:7
ISSN: 0022-2623		Derivatives of (R)-1,11-methyleneaporphine: synthesis, structure, and interactions with G-protein coupled receptors.
AID188183The effect on the accumulation of 5-HTP in rat brain(striatum), by subcutaneous administration at a dose of 0.32(umol/kg)1990Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
ISSN: 0022-2623		(S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: a putative 5-HT1A-receptor antagonist.
AID174329Inhibition of Dopamine receptor accumulation in striatum part of rat brain after subcutaneous administration of compound before 60 min to death1981Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
ISSN: 0022-2623		8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist.
AID173462DOPAC (3,4-dihydroxyphenylacetic acid) content of rat striatum reflecting DA metabolism and turnover1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
ISSN: 0022-2623		Derivatives of cis-2-amino-8-hydroxy-1-methyltetralin: mixed 5-HT1A-receptor agonists and dopamine D2-receptor antagonists.
AID196909Half-minimal decrease in the accumulation of DOPA (3,4-dihydroxyphenylalanine) in rat hemispheral brain; partial response at 50 uM/Kg1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID169705No of rats exhibiting 5-HT motor syndrome tested in reserpinized rats at a subcutaneous dose of a. 0.1 umol/kg; 0 rats out of 4 showed activity1989Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
ISSN: 0022-2623		Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain.
AID1734605-HT content of rat hippocampus reflecting 5-HT metabolism and turnover1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
ISSN: 0022-2623		Derivatives of cis-2-amino-8-hydroxy-1-methyltetralin: mixed 5-HT1A-receptor agonists and dopamine D2-receptor antagonists.
AID19541Plasma half life was determined in rats1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID177254Evaluated for receptor mediated feedback inhibition of 5-HTP formation in limbic tissue of rat brain when administered subcutaneously1988Journal of medicinal chemistry, Jan, Volume: 31, Issue:1
ISSN: 0022-2623		N,N-Dialkylated monophenolic trans-2-phenylcyclopropylamines: novel central 5-hydroxytryptamine receptor agonists.
AID177873Inhibition of 5-Hydroxy tryptamine accumulation in striatum part of rat brain after subcutaneous administration1981Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
ISSN: 0022-2623		8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist.
AID55449Binding affinity was measured on cloned Human D2A Receptor which is labeled by [3H]raclopride2000Journal of medicinal chemistry, Apr-06, Volume: 43, Issue:7
ISSN: 0022-2623		Derivatives of (R)-1,11-methyleneaporphine: synthesis, structure, and interactions with G-protein coupled receptors.
AID1442392Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor in Sprague-Dawley rat cortex membranes after 15 mins by liquid scintillation spectrometric method2017Journal of medicinal chemistry, 04-13, Volume: 60, Issue:7
ISSN: 1520-4804		The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.
AID195529Half-minimal decrease in the accumulation of 5-HTP (5-Hydroxytryptophan) in rat striatal brain1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID57535The effect on the accumulation of DOPA in rat brain(limbic), by subcutaneous administration at a dose of 0.32(umol/kg)1990Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
ISSN: 0022-2623		(S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: a putative 5-HT1A-receptor antagonist.
AID4179Effect on 5-hydroxytryptamine 1A receptor mediated inhibition of VIP-stimulated cAMP production at dose of 1 uM+ 3 uM 5-HT.1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
ISSN: 0022-2623		Derivatives of (R)- and (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: synthesis and interactions with 5-HT1A receptors.
AID173463HVA (Homovanillic acid)content of rat striatum reflecting DA metabolism and turnover1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
ISSN: 0022-2623		Derivatives of cis-2-amino-8-hydroxy-1-methyltetralin: mixed 5-HT1A-receptor agonists and dopamine D2-receptor antagonists.
AID4169Effect against 5-hydroxytryptamine 1A receptor mediated inhibition of VIP-stimulated cAMP production at 0.1 uM dose1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
ISSN: 0022-2623		Derivatives of (R)- and (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: synthesis and interactions with 5-HT1A receptors.
AID57537The effect on the accumulation of DOPA in rat brain(striatum), by subcutaneous administration at a dose of 0.32(umol/kg)1990Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
ISSN: 0022-2623		(S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: a putative 5-HT1A-receptor antagonist.
AID6451Compound was tested for its effect on NSD 1015 induced accumulation of 5-HTP(ng/g) in rats in limbic system at a dosage of 0.032 umol/kg1989Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
ISSN: 0022-2623		Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain.
AID177298Effect of compound on 5-Hydroxy transaminase accumulation upon subcutaneous administration in the limbic system of rat brain1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
ISSN: 0022-2623		Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties.
AID4942In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]-5-HT as radioligand1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID4474In vitro binding affinity towards 5-hydroxytryptamine 1A receptor by using [3H]-8-OH-DPAT as radioligand1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID197623Half-minimal decrease in the accumulation of DOPA (3,4-dihydroxyphenylalanine) in rat limbic brain; partial response at 50 uM/Kg1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID6874Approximate dose levels for a half maximal reduction of 5-HTP levels1989Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
ISSN: 0022-2623		Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain.
AID49575Maximum decrease in sympathetic nerve discharge(SND) observed at 1 mg/kg dose in cat1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
ISSN: 0022-2623		Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants.
AID190309Change in body temperature of rats upon administration after 30 minutes (p<0.01)1993Journal of medicinal chemistry, Dec-24, Volume: 36, Issue:26
ISSN: 0022-2623		Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors.
AID6442Compound was tested for its effect on NSD 1015 induced accumulation of 5-HTP in rats in corpus striatum at a dosage of 0.32 umol/kg1989Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
ISSN: 0022-2623		Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain.
AID65787In vitro binding affinity towards Dopamine receptor D3 by using [3H]spiperone as radioligand1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID172342Induction of clear-cut 5-HT motor syndrome in normal rats at the dose of 10 micro mol/kg1993Journal of medicinal chemistry, Dec-24, Volume: 36, Issue:26
ISSN: 0022-2623		Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors.
AID177326In vivo evaluation for DOPA accumulation in the corpus striatum in male rats at highest test dose of 50 uM/Kg (sc); inactive1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
ISSN: 0022-2623		(S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists.
AID4103In vitro binding affinity against 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT (agonist) as radioligand (sc)1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
ISSN: 0022-2623		(S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists.
AID174323Inhibition of 5-HTP accumulation in hemisphere of rat brain after subcutaneous administration of compound before 60 min to death1981Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
ISSN: 0022-2623		8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist.
AID188770behavioral syndrome(flat body posture and forepaw treading) at 0.25 mg/Kg1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID174324Inhibition of 5-HTP accumulation in limbic part of rat brain after subcutaneous administration of compound before 60 min to death1981Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
ISSN: 0022-2623		8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist.
AID172593Change in body temperature was studied in rats upon subcutaneous administration of 1 uM/Kg of compound1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
ISSN: 0022-2623		Derivatives of cis-2-amino-8-hydroxy-1-methyltetralin: mixed 5-HT1A-receptor agonists and dopamine D2-receptor antagonists.
AID124449Maximum obtainable hypothermic effect up to 30 mg/kg dose in mice expressed as temperature decrease in degree Centigrade1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
ISSN: 0022-2623		Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants.
AID4430Concentration of compound required to inhibit cortical 5-hydroxytryptamine 1A receptor binding sites in rat brain was evaluated1989Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
ISSN: 0022-2623		Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain.
AID6440Compound was tested for its effect on NSD 1015 induced accumulation of 5-HTP in rats corpus striatum at a dosage of 0.10 umol/kg1989Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
ISSN: 0022-2623		Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain.
AID177486Effect on Dopa accumulation upon subcutaneous administration in the limbic system of rat brain; I - inactive at highest dose (50 umol/kg)1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
ISSN: 0022-2623		Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties.
AID196906Half-minimal decrease in the accumulation of 5-HTP (5-Hydroxytryptophan) in rat hemispheral brain1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID1656650Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method2020Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3
ISSN: 1464-3391		Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HT
AID6666Binding affinity at rat 5-hydroxytryptamine 7 receptor.2003Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25
ISSN: 0022-2623		Characterization of the 5-HT(7) receptor. Determination of the pharmacophore for 5-HT(7) receptor agonism and CoMFA-based modeling of the agonist binding site.
AID1656652Selectivity ratio of Ki for displacement of [3H]-5-carboxamidotryptamine from human 5-HT1A receptor expressed in HEK293T cell membranes to Ki for displacement of [3H]-5-carboxamidotryptamine from human 5-HT7 receptor expressed in HEK293 cell membranes2020Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3
ISSN: 1464-3391		Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HT
AID6652Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT2000Journal of medicinal chemistry, Apr-06, Volume: 43, Issue:7
ISSN: 0022-2623		Derivatives of (R)-1,11-methyleneaporphine: synthesis, structure, and interactions with G-protein coupled receptors.
AID178700Subcutaneous dose giving half-maximal decrease of Dopa formation in the rat brain (limbic)1984Journal of medicinal chemistry, Jan, Volume: 27, Issue:1
ISSN: 0022-2623		8-Hydroxy-2-(alkylamino)tetralins and related compounds as central 5-hydroxytryptamine receptor agonists.
AID113319Dose required to obtain hypothermic effect in mice following subcutaneous administration1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
ISSN: 0022-2623		Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants.
AID177897Inhibition of dopamine accumulation in limbic part of rat brain after subcutaneous administration; I= Inactive1981Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
ISSN: 0022-2623		8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist.
AID177315In vivo evaluation for 5-HTP accumulation in the corpus striatum in male rats (sc)1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
ISSN: 0022-2623		(S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists.
AID230547Ratio of serotonin turnover (5HIAA to 5-HT) in rat brain hippocampus compared to control1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
ISSN: 0022-2623		Derivatives of cis-2-amino-8-hydroxy-1-methyltetralin: mixed 5-HT1A-receptor agonists and dopamine D2-receptor antagonists.
AID4175Effect on 5-hydroxytryptamine 1A receptor mediated inhibition of VIP-stimulated cAMP production at dose of 1 uM1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
ISSN: 0022-2623		Derivatives of (R)- and (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: synthesis and interactions with 5-HT1A receptors.
AID177484Effect on Dopa accumulation upon subcutaneous administration in the hemispheres of rat brain; I - inactive at highest dose (50 umol/kg)1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
ISSN: 0022-2623		Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties.
AID64155In vitro binding affinity towards Dopamine receptor D2 by using [3H]U-86170 as radioligand1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID178697Subcutaneous dose giving half-maximal decrease of 5-HTP formation in the rat brain hemispheres (cortex)1984Journal of medicinal chemistry, Jan, Volume: 27, Issue:1
ISSN: 0022-2623		8-Hydroxy-2-(alkylamino)tetralins and related compounds as central 5-hydroxytryptamine receptor agonists.
AID173461DA (dopamine) content of rat striatum reflecting DA metabolism and turnover1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
ISSN: 0022-2623		Derivatives of cis-2-amino-8-hydroxy-1-methyltetralin: mixed 5-HT1A-receptor agonists and dopamine D2-receptor antagonists.
AID6453Compound was tested for its effect on NSD 1015 induced accumulation of 5-HTP(ng/g) in rats in limbic system at a dosage of 0.32 umol/kg1989Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
ISSN: 0022-2623		Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain.
AID174327Inhibition of Dopamine receptor accumulation in hemisphere of rat brain after subcutaneous administration of compound before 60 min to death1981Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
ISSN: 0022-2623		8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist.
AID230548Ratio of turnover (DOPAC to DA) in rat brain striatum compared to control.1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
ISSN: 0022-2623		Derivatives of cis-2-amino-8-hydroxy-1-methyltetralin: mixed 5-HT1A-receptor agonists and dopamine D2-receptor antagonists.
AID188765uM/kg1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID4906In vitro binding affinity towards 5-hydroxytryptamine 1D receptor alpha by using [3H]5-HT as radioligand1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID172481Induction of clear-cut 5-HT motor syndrome in reserpine (5 mg/kg, sc) pretreated rats at the dose of 1.0 micro mol/kg1993Journal of medicinal chemistry, Dec-24, Volume: 36, Issue:26
ISSN: 0022-2623		Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors.
AID177333In vivo evaluation for DOPA accumulation in the hemispheres in male rats at highest test dose of 50 uM/Kg (sc); inactive1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
ISSN: 0022-2623		(S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists.
AID170411Effect of 5-HT accumulation in rat hippocampus at the dose of 1.0 umol/kg (p<0.01)1993Journal of medicinal chemistry, Dec-24, Volume: 36, Issue:26
ISSN: 0022-2623		Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors.
AID4023Binding affinity against rat hippocampal 5-hydroxytryptamine 1A (5-HT1A) receptor determined using [3H]8-OH-DPAT as radioligand1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
ISSN: 0022-2623		Derivatives of (R)- and (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: synthesis and interactions with 5-HT1A receptors.
AID170421Effect of accumulation of DOPA in rat striatum at the dose of 1.0 umol/kg1993Journal of medicinal chemistry, Dec-24, Volume: 36, Issue:26
ISSN: 0022-2623		Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors.
AID63410Displacement of [3H]U-86170 from human D2-dopamine receptor expressed in CHO K1 cells1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
ISSN: 0022-2623		Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants.
AID170414Effect of DOPA accumulation in rat striatum at the dose of 0.32 umol/kg (p<0.01)1993Journal of medicinal chemistry, Dec-24, Volume: 36, Issue:26
ISSN: 0022-2623		Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors.
AID177319In vivo evaluation for 5-HTP accumulation in the hemispheres in male rats (sc)1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
ISSN: 0022-2623		(S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists.
AID178702Subcutaneous dose giving half-maximal decrease of Dopa formation in the rat brain (striatum)1984Journal of medicinal chemistry, Jan, Volume: 27, Issue:1
ISSN: 0022-2623		8-Hydroxy-2-(alkylamino)tetralins and related compounds as central 5-hydroxytryptamine receptor agonists.
AID177294Effect of compound on 5-Hydroxy transaminase accumulation upon subcutaneous administration in the corpus striatum of rat brain1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
ISSN: 0022-2623		Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties.
AID4071Binding affinity for 5-hydroxytryptamine 1A receptor in rat brain tissue using [3H]8-OH-DPAT as radioligand1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
ISSN: 0022-2623		Derivatives of cis-2-amino-8-hydroxy-1-methyltetralin: mixed 5-HT1A-receptor agonists and dopamine D2-receptor antagonists.
AID1656651Displacement of [3H]-5-carboxamidotryptamine from human 5-HT1A receptor expressed in HEK293T cell membranes incubated for 90 mins by scintillation counting method2020Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3
ISSN: 1464-3391		Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HT
AID188763Number of rats displaying the 5-HT syndrome or leaving the cage out of the number of rats tested1993Journal of medicinal chemistry, Dec-24, Volume: 36, Issue:26
ISSN: 0022-2623		Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors.
AID177253Evaluated for receptor mediated feedback inhibition of 5-HTP formation in hemisphere of rat brain when administered subcutaneously1988Journal of medicinal chemistry, Jan, Volume: 31, Issue:1
ISSN: 0022-2623		N,N-Dialkylated monophenolic trans-2-phenylcyclopropylamines: novel central 5-hydroxytryptamine receptor agonists.
AID188181The effect on the accumulation of 5-HTP in rat brain(limbic), by subcutaneous administration at a dose of 0.32(umol/kg)1990Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
ISSN: 0022-2623		(S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: a putative 5-HT1A-receptor antagonist.
AID4171Effect on 5-hydroxytryptamine 1A receptor mediated inhibition of VIP-stimulated cAMP production at dose of 0.1 uM + 1 uM 5-HT.1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
ISSN: 0022-2623		Derivatives of (R)- and (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: synthesis and interactions with 5-HT1A receptors.
AID6445Compound was tested for its effect on NSD 1015 induced accumulation of 5-HTP(ng/g) in rats in corpus striatum at a dosage of 0.032 umol/kg1989Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
ISSN: 0022-2623		Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain.
AID177871Inhibition of 5-Hydroxy tryptamine accumulation in limbic part of rat brain after subcutaneous administration1981Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
ISSN: 0022-2623		8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist.
AID3168Dose to reduce neuronal firing against 5-HT cells in rats (iv)1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
ISSN: 0022-2623		Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants.
AID178695Subcutaneous dose giving half-maximal decrease of 5-HTP formation in the rat brain (striatum)1984Journal of medicinal chemistry, Jan, Volume: 27, Issue:1
ISSN: 0022-2623		8-Hydroxy-2-(alkylamino)tetralins and related compounds as central 5-hydroxytryptamine receptor agonists.
AID177869Inhibition of 5-Hydroxy tryptamine accumulation in hemispheres of rat brain after subcutaneous administration1981Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
ISSN: 0022-2623		8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist.
AID3457Binding affinity at 5-hydroxytryptamine 1A receptor in bovine hippocampal preparation using [3H]8-OH-DPAT1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
ISSN: 0022-2623		Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants.
AID1897955-HT (serotonin) turnover in rat hippocampus (p<0.01)1993Journal of medicinal chemistry, Dec-24, Volume: 36, Issue:26
ISSN: 0022-2623		Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors.
AID195387Half-minimal decrease in the accumulation of 5-HTP (5-Hydroxytryptophan) in non pretreated rat striatal brain at dose 0.25 umol/kg1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID17943Oral bioavailability in rat1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID177899Inhibition of dopamine accumulation in striatum part of rat brain after subcutaneous administration; I= Inactive1981Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
ISSN: 0022-2623		8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist.
AID65725Displacement of [3H]spiperone from dopamine receptor D21993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
ISSN: 0022-2623		(S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists.
AID169561No of rats exhibiting 5-HT motor syndrome tested in reserpinized rats at a subcutaneous dose of 0.32 umol/kg; 4 rats out of 4 showed activity1989Journal of medicinal chemistry, Apr, Volume: 32, Issue:4
ISSN: 0022-2623		Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain.
AID1734595-HIAA (5-Hydroxyindoleacetic acid) content of rat hippocampus reflecting 5-HT metabolism and turnover1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
ISSN: 0022-2623		Derivatives of cis-2-amino-8-hydroxy-1-methyltetralin: mixed 5-HT1A-receptor agonists and dopamine D2-receptor antagonists.
AID180770Flat body posture behavior was studied in rats after subcutaneous administration of 1 uM/Kg of compound; 7/71995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
ISSN: 0022-2623		Derivatives of cis-2-amino-8-hydroxy-1-methyltetralin: mixed 5-HT1A-receptor agonists and dopamine D2-receptor antagonists.
AID55589Dose to reduce neuronal firing against DA cells (antagonist) in rats (iv)1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
ISSN: 0022-2623		Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants.
AID3993Binding affinity of 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand.1993Journal of medicinal chemistry, Dec-24, Volume: 36, Issue:26
ISSN: 0022-2623		Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors.
AID177296Effect of compound on 5-Hydroxy transaminase accumulation upon subcutaneous administration in the hemisphere of rat brain1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
ISSN: 0022-2623		Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties.
AID174325Inhibition of 5-HTP accumulation in striatum part of rat brain after subcutaneous administration of compound before 60 min to death1981Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
ISSN: 0022-2623		8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist.
AID197613Half-minimal decrease in the accumulation of DOPA (3,4-dihydroxyphenylalanine) in non pretreated rat limbic brain at dose 0.25 umol/kg1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID4173Effect on 5-hydroxytryptamine 1A receptor mediated inhibition of VIP-stimulated cAMP production at dose of 10 uM1996Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
ISSN: 0022-2623		Derivatives of (R)- and (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: synthesis and interactions with 5-HT1A receptors.
AID170419Effect of accumulation of DOPA in rat striatum at the dose of 0.32 umol/kg1993Journal of medicinal chemistry, Dec-24, Volume: 36, Issue:26
ISSN: 0022-2623		Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors.
AID189797Dopamine (DA) turnover in rat corpus striatum1993Journal of medicinal chemistry, Dec-24, Volume: 36, Issue:26
ISSN: 0022-2623		Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors.
AID64156In vitro binding affinity towards Dopamine receptor D2 by using [3H]spiperone as radioligand1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID177321In vivo evaluation for 5-HTP accumulation in the limbic system in male rats (sc)1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
ISSN: 0022-2623		(S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists.
AID188911behavioral syndrome(flat body posture and forepaw treading) at 0.25 ug/Kg1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID172487Compound was tested for 5-HT behavioral response in reserpine pretreated rats; +5HT syndrome1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
ISSN: 0022-2623		(S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists.
AID177337In vivo evaluation for DOPA accumulation in the limbic system in male rats at highest test dose of 50 uM/Kg (sc); inactive1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
ISSN: 0022-2623		(S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists.
AID177481Effect on Dopa accumulation upon subcutaneous administration in the carpus striatum of rat brain; I - inactive at highest dose (50 umol/kg)1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
ISSN: 0022-2623		Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties.
AID197625In vitro binding affinity towards 5-hydroxytryptamine 1D receptor beta by using [3H]5-HT as radioligand1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID47963Dose required to reduce sympathetic nerve discharge in mice following intravenous administration1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
ISSN: 0022-2623		Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants.
AID178693Subcutaneous dose giving half-maximal decrease of 5-HTP formation in the rat brain (limbic)1984Journal of medicinal chemistry, Jan, Volume: 27, Issue:1
ISSN: 0022-2623		8-Hydroxy-2-(alkylamino)tetralins and related compounds as central 5-hydroxytryptamine receptor agonists.
AID170415Effect of DOPA accumulation in rat striatum at the dose of 1.0 umol/kg (p<0.01)1993Journal of medicinal chemistry, Dec-24, Volume: 36, Issue:26
ISSN: 0022-2623		Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors.
AID171514Cage leaving response was studied in rats after subcutaneous administration of 1 uM/Kg of compound; 0/71995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
ISSN: 0022-2623		Derivatives of cis-2-amino-8-hydroxy-1-methyltetralin: mixed 5-HT1A-receptor agonists and dopamine D2-receptor antagonists.
AID195520Half-minimal decrease in the accumulation of DOPA (3,4-dihydroxyphenylalanine) in non pretreated rat striatal brain at dose 0.25 umol/kg1995Journal of medicinal chemistry, Apr-14, Volume: 38, Issue:8
ISSN: 0022-2623		Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
ISSN: 1091-6490		Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
ISSN: 2211-1247		A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID504836Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation2002The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16
ISSN: 0021-9258		Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
AID1347058CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation2019PloS one, , Volume: 14, Issue:7
ISSN: 1932-6203		Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.
AID1347059CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation2019PloS one, , Volume: 14, Issue:7
ISSN: 1932-6203		Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1347049Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen2019Science translational medicine, 07-10, Volume: 11, Issue:500
ISSN: 1946-6242		Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
AID588349qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173ISSN: 1872-9096A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347057CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation2019PloS one, , Volume: 14, Issue:7
ISSN: 1932-6203		Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173ISSN: 1872-9096A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1347045Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line2019Science translational medicine, 07-10, Volume: 11, Issue:500
ISSN: 1946-6242		Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173ISSN: 1872-9096A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347410qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library2019Cellular signalling, 08, Volume: 60ISSN: 1873-3913A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening.
AID1347151Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
ISSN: 1091-6490		Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347405qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection2020ACS chemical biology, 07-17, Volume: 15, Issue:7
ISSN: 1554-8937		High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347050Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay2019Science translational medicine, 07-10, Volume: 11, Issue:500
ISSN: 1946-6242		Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
AID588378qHTS for Inhibitors of ATXN expression: Validation2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
ISSN: 1552-454X		A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.

Research

Studies (27)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (18.52)18.7374
1990's7 (25.93)18.2507
2000's3 (11.11)29.6817
2010's6 (22.22)24.3611
2020's6 (22.22)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other27 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
7-hydroxy-2-n,n-dipropylaminotetralin
0
tetralins00low000000
8-hydroxy-2-(di-n-propylamino)tetralin
0
phenols;
tertiary amino compound;
tetralins		serotonergic antagonist00low000000
2-(n-phenethyl-n-propyl)amino-5-hydroxytetralin
0
tetralins00low000000
am 580
0
amidobenzoic acid;
tetralins		antineoplastic agent;
retinoic acid receptor alpha/beta agonist		00low000000
liranaftate
0
tetralins00low000000
nadolol
0
tetralins00low000000
tramazoline
0
tetralins00low000000
tetralin
0
ortho-fused bicyclic hydrocarbon;
tetralins		00low000000
6-Methoxy-1-tetralone
0
tetralins00low000000
2-aminotetralin
0
tetralins00low000000
be 2254
0
tetralins00low000000
5,6-dihydroxy-2-dimethylaminotetralin
0
tetralins00low000000
n 0437, (-)-isomer
0
tetralins00low000000
mibefradil
0
tetralinsT-type calcium channel blocker00low000000
5,6,7,8-tetrahydro-1-naphthol
0
tetralins00low000000
sertraline
0
dichlorobenzene;
secondary amino compound;
tetralins		antidepressant;
serotonin uptake inhibitor		00low000000
acetyl methyl tetramethyl tetralin
0
tetralins00low000000
tamibarotene
0
dicarboxylic acid monoamide;
retinoid;
tetralins		antineoplastic agent;
retinoic acid receptor alpha/beta agonist		00low000000
aj 76
0
secondary amino compound;
tetralins		dopaminergic antagonist00low000000
oxoline
0
aromatic ketone;
tetralins		geroprotector00low000000
lasofoxifene
0
aromatic ether;
N-alkylpyrrolidine;
naphthols;
tetralins		antineoplastic agent;
bone density conservation agent;
cardioprotective agent;
estrogen receptor agonist;
estrogen receptor antagonist		00low000000
isoshinanolone
0
tetralins00low000000
3-(4-chlorophenyl)-2-methyl-3,3a,4,5-tetrahydrobenzo[g]indazole
0
tetralins00low000000
N1-(5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)acetamide
0
tetralins00low000000
eptazocine
0
tetralins00low000000
1-(1H-imidazol-5-ylsulfonyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-piperidinecarboxamide
0
tetralins00low000000
4-oxo-4-[5-(1,2,3,4-tetrahydronaphthalen-1-ylsulfamoyl)-2,3-dihydroindol-1-yl]butanoic acid
0
tetralins00low000000
2-phenoxy-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]acetamide
0
tetralins00low000000
1-(phenylmethyl)-3-(1,2,3,4-tetrahydronaphthalen-1-yl)thiourea
0
tetralins00low000000
4-phenyl-2-propionamidotetraline
0
tetralins00low000000
a 61603
0
tetralins00low000000
N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]cyclohexanecarboxamide
0
tetralins00low000000
2-chloro-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide
0
tetralins00low000000
2-(4-chlorophenoxy)-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]acetamide
0
tetralins00low000000
2,6-difluoro-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide
0
tetralins00low000000
2,4-dichloro-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide
0
tetralins00low000000
8-methoxy-2-propionamidotetralin
0
tetralins00low000000
sr 59230a
0
tetralins00low000000
7-hydroxy-2-(n-n-propyl-n-(3-iodo-2'-propenyl)-amino)tetralin
0
organoiodine compound;
phenols;
tertiary amino compound;
tetralins		dopamine agonist00low000000
pseudopteroxazole
0
tetralinsmetabolite00low000000
uh 232
0
tetralins00low000000
4-[(2,1,3-benzothiadiazol-4-ylsulfonylamino)methyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-cyclohexanecarboxamide
0
tetralins00low000000
nepicastat
0
1,3-dihydroimidazole-2-thiones;
organofluorine compound;
primary amino compound;
tetralins		EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor00low000000
NNC 55-0396 (free base)
0
benzimidazoles;
cyclopropanecarboxylate ester;
organofluorine compound;
tertiary amino compound;
tetralins		angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
neuroprotective agent;
potassium channel blocker;
T-type calcium channel blocker		00low000000
(S)-Isosclerone
0
tetralins00low000000
PB28
0
aromatic ether;
piperazines;
tetralins		anticoronaviral agent;
antineoplastic agent;
apoptosis inducer;
sigma-2 receptor agonist		00low000000
(+)-lyoniresinol-3-alpha-O-beta-D-glucopyranoside
0
beta-D-glucoside;
dimethoxybenzene;
lignan;
monosaccharide derivative;
polyphenol;
primary alcohol;
tetralins		antibacterial agent;
antifungal agent;
metabolite		00low000000
eptazocine hydrobromide
0
tetralins00low000000
lyoniresinol
0
dimethoxybenzene;
lignan;
polyphenol;
primary alcohol;
tetralins		antineoplastic agent;
metabolite		00low000000
N-[2-methyl-5-(2-thiazolo[5,4-b]pyridinyl)phenyl]-5,6,7,8-tetrahydronaphthalene-2-sulfonamide
0
tetralins00low000000
N-methyl-N-(3-pyridinylmethyl)-5-(5,6,7,8-tetrahydronaphthalen-2-yloxymethyl)-3-isoxazolecarboxamide
0
tetralins00low000000
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
phenethylamine
1
alkaloid;
aralkylamine;
phenylethylamine		Escherichia coli metabolite;
human metabolite;
mouse metabolite		201720177.0low000010
tryptamine
1
aminoalkylindole;
aralkylamino compound;
indole alkaloid;
tryptamines		human metabolite;
mouse metabolite;
plant metabolite		201720177.0low000010
7-hydroxy-2-n,n-dipropylaminotetralin
1
tetralins1981198143.0low010000
8-hydroxy-2-(di-n-propylamino)tetralin
6
phenols;
tertiary amino compound;
tetralins		serotonergic antagonist1981201731.7low032010
4-iodo-2,5-dimethoxyphenylisopropylamine
1
amphetamines;
dimethoxybenzene;
organoiodine compound		201720177.0low000010
sk&f 10047
1
201720177.0medium000010
1-(1-naphthyl)piperazine
1
N-arylpiperazine2003200321.0low000100
1-(2-methoxyphenyl)piperazine
1
piperazines2003200321.0low000100
monomethylpropion
1
aromatic ketone;
secondary amino compound		201720177.0low000010
3,4-methylenedioxyamphetamine
1
benzodioxoles201720177.0low000010
n-methyl-3,4-methylenedioxyamphetamine
1
amphetamines;
benzodioxoles		neurotoxin201720177.0low000010
5-carboxamidotryptamine
2
tryptamines2000200322.5low001100
methylbufotenin
1
aromatic ether;
tertiary amino compound;
tryptamine alkaloid		hallucinogen;
plant metabolite		2003200321.0low000100
5-methoxytryptamine
1
aromatic ether;
primary amino compound;
tryptamines		5-hydroxytryptamine 2A receptor agonist;
5-hydroxytryptamine 2B receptor agonist;
5-hydroxytryptamine 2C receptor agonist;
antioxidant;
cardioprotective agent;
human metabolite;
mouse metabolite;
neuroprotective agent;
radiation protective agent;
serotonergic agonist		2003200321.0low000100
buspirone
4
azaspiro compound;
N-alkylpiperazine;
N-arylpiperazine;
organic heteropolycyclic compound;
piperidones;
pyrimidines		anxiolytic drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
sedative;
serotonergic agonist		1993202017.5low002020
amphetamine
1
primary amine201720177.0low000010
diazepam
1
1,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic		201720177.0low000010
fenfluramine
1
(trifluoromethyl)benzenes;
secondary amino compound		appetite depressant;
serotonergic agonist;
serotonin uptake inhibitor		201720177.0low000010
p-hydroxyamphetamine
1
amphetamines201720177.0low000010
ketanserin
1
aromatic ketone;
organofluorine compound;
piperidines;
quinazolines		alpha-adrenergic antagonist;
antihypertensive agent;
cardiovascular drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
serotonergic antagonist		201720177.0low000010
octopamine
1
phenylethanolamines;
tyramines		neurotransmitter201720177.0low000010
tyramine
1
monoamine molecular messenger;
primary amino compound;
tyramines		EC 3.1.1.8 (cholinesterase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter		201720177.0low000010
lysergic acid diethylamide
2
ergoline alkaloid;
monocarboxylic acid amide;
organic heterotetracyclic compound		dopamine agonist;
hallucinogen;
serotonergic agonist		1984200330.5low010100
dextroamphetamine
1
1-phenylpropan-2-amineadrenergic agent;
adrenergic uptake inhibitor;
dopamine uptake inhibitor;
dopaminergic agent;
neurotoxin;
sympathomimetic agent		201720177.0low000010
apomorphine
1
aporphine alkaloidalpha-adrenergic drug;
antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
emetic;
serotonergic drug		2000200024.0low001000
etryptamine
1
indoles201720177.0low000010
indopan
1
tryptamines201720177.0low000010
ephedrine
1
phenethylamine alkaloid;
phenylethanolamines		bacterial metabolite;
environmental contaminant;
nasal decongestant;
plant metabolite;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic		201720177.0low000010
bufotenin
1
tertiary amine;
tryptamine alkaloid		coral metabolite;
hallucinogen		2003200321.0low000100
methamphetamine
1
amphetamines;
secondary amine		central nervous system stimulant;
environmental contaminant;
neurotoxin;
psychotropic drug;
xenobiotic		201720177.0low000010
2,4,5-trimethoxyphenylisopropylamine
1
201720177.0low000010
2,5-dimethoxy-4-bromoamphetamine
1
201720177.0low000010
cathinone
1
2-aminopropiophenone;
monoamine alkaloid		central nervous system stimulant;
psychotropic drug		201720177.0low000010
2,5-dimethoxyamphetamine
1
201720177.0low000010
2-(2,5-dimethoxyphenyl)ethanamine
1
dimethoxybenzene201720177.0medium000010
2,5-dimethoxy-4-methylamphetamine
1
201720177.0low000010
n,n-dipropyl-2-aminotetralin
1
1993199331.0medium001000
4-methoxymethamphetamine
1
201720177.0low000010
uh 301
4
1990200029.2medium004000
3-methoxyamphetamine
1
201720177.0medium000010
n-desmethylmethoxyphenamine
1
201720177.0low000010
5-hydroxy-2-n,n-dipropylaminotetralin
1
1981198143.0low010000
8-(di-n-propylamino)-6,7,8,9-tetrahydro-3h-benz(e)indole-1-carbaldehyde
1
1993199331.0high001000
8-methoxy-2-(di-n-propylamino)tetralin
1
201720177.0medium000010
norpseudoephedrine
1
amphetamines;
phenethylamine alkaloid		central nervous system stimulant;
plant metabolite;
psychotropic drug		201720177.0low000010
dironyl
1
organic molecular entity1989198935.0low010000
cocaine
1
benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid		adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic		201720177.0low000010
sk&f 10047
1
201720177.0high000010
7-hydroxy-2-n,n-dipropylaminotetralin, (r)-isomer
2
1981198939.0medium020000
ms-245
1
201720177.0low000010
4-iodo-2,5-dimethoxyphenylisopropylamine, (r)-isomer
1
201720177.0low000010
u 92016a
1
1993199331.0medium001000
2,5-dimethoxy-4-bromoamphetamine, (r)-isomer
1
201720177.0medium000010
mephedrone
1
amphetamines;
aromatic ketone;
secondary amino compound		environmental contaminant;
xenobiotic		201720177.0low000010
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Anemia, Fanconi0
1
201620168.0medium000010
Congenital Zika Syndrome0
1
202020204.0medium000010
Contact Dermatitis0
1
201920195.0medium000010
Dermatitis, Contact0
1
201920195.0medium000010
Disease Models, Animal0
2
201920204.5medium000020
Fanconi Anemia0
1
201620168.0medium000010
Itching0
1
201920195.0medium000010
Pruritus0
1
201920195.0medium000010
Zika Virus Infection0
1
202020204.0medium000010

Bioavailability (1)

ArticleYear
Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.
Journal of medicinal chemistry, , Apr-14, Volume: 38, Issue:8		1995