Page last updated: 2024-12-08

1,3,7,12-tetrahydroxycholanoic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1,3,7,12-tetrahydroxycholanoic acid is a more specific name for **cholic acid**, a primary bile acid synthesized by the liver.

Here's why it's important for research:

**1. Bile Acid Metabolism and Function:**

* **Digestion and Absorption:** Cholic acid is essential for the digestion and absorption of fats. It acts as a detergent, breaking down large fat globules into smaller droplets that can be more easily digested by enzymes.
* **Regulation of Cholesterol Levels:** Cholic acid helps regulate cholesterol levels by promoting its excretion in bile.
* **Gut Microbiome:** Cholic acid interacts with gut bacteria, influencing their composition and function.

**2. Medical Applications:**

* **Gallstone Treatment:** Cholic acid is used in some medications to dissolve gallstones.
* **Liver Disease Research:** Studying cholic acid metabolism can help understand liver disease progression and find new therapeutic targets.
* **Cholesterol Management:** Cholic acid derivatives are being investigated for potential use in lowering cholesterol levels.
* **Drug Delivery:** Cholic acid derivatives are used in drug delivery systems, as they can help increase drug absorption and bioavailability.

**3. Research into its Properties:**

* **Chemical Structure and Activity:** Researchers are investigating the precise molecular interactions of cholic acid with enzymes, receptors, and other molecules.
* **Pharmacology:** Understanding the pharmacology of cholic acid can help develop better treatments for diseases related to bile acid metabolism.
* **Biochemistry:** Cholic acid is a valuable tool for studying various biochemical processes, including lipid metabolism, cholesterol synthesis, and membrane transport.

**Overall, 1,3,7,12-tetrahydroxycholanoic acid (cholic acid) is a crucial molecule for various research areas, particularly related to digestion, metabolism, liver function, and potential therapeutic applications.** Its complex interactions with the body highlight the importance of further research into this fascinating compound.

Cross-References

ID SourceID
PubMed CID194158
SCHEMBL ID1492131
MeSH IDM0109774

Synonyms (14)

Synonym
1,3,7,12-tetrahydroxycholan-24-oic acid
63266-89-7
cholan-24-oic acid, 1,3,7,12-tetrahydroxy-
1,3,7,12-thca
ca-1beta-ol
1,3,7,12-tetrahydroxycholanoic acid
SCHEMBL1492131
1,3,7,12-tetrahydroxy-cholan-24-oic acid
1,3,7,12-tetrahydroxy-cholan-24-oate
1,3,7,12-tetrahydroxycholanoate
1,3,7,12-tetrahydroxycholan-24-oate
1beta-hydroxycholate
(4r)-4-((8s,9s,10s,13r,14s,17r)-1,3,7,12-tetrahydroxy-10,13-dimethylhexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoic acid
(4r)-4-((8s,9s,10s,13r,14s,17r)-1,3,7,12-tetrahydroxy-10,13-dimethylhexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoicacid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's4 (80.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.09

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.09 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.88 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.09)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]