1,3,7,12-tetrahydroxycholanoic acid is a more specific name for **cholic acid**, a primary bile acid synthesized by the liver.
Here's why it's important for research:
**1. Bile Acid Metabolism and Function:**
* **Digestion and Absorption:** Cholic acid is essential for the digestion and absorption of fats. It acts as a detergent, breaking down large fat globules into smaller droplets that can be more easily digested by enzymes.
* **Regulation of Cholesterol Levels:** Cholic acid helps regulate cholesterol levels by promoting its excretion in bile.
* **Gut Microbiome:** Cholic acid interacts with gut bacteria, influencing their composition and function.
**2. Medical Applications:**
* **Gallstone Treatment:** Cholic acid is used in some medications to dissolve gallstones.
* **Liver Disease Research:** Studying cholic acid metabolism can help understand liver disease progression and find new therapeutic targets.
* **Cholesterol Management:** Cholic acid derivatives are being investigated for potential use in lowering cholesterol levels.
* **Drug Delivery:** Cholic acid derivatives are used in drug delivery systems, as they can help increase drug absorption and bioavailability.
**3. Research into its Properties:**
* **Chemical Structure and Activity:** Researchers are investigating the precise molecular interactions of cholic acid with enzymes, receptors, and other molecules.
* **Pharmacology:** Understanding the pharmacology of cholic acid can help develop better treatments for diseases related to bile acid metabolism.
* **Biochemistry:** Cholic acid is a valuable tool for studying various biochemical processes, including lipid metabolism, cholesterol synthesis, and membrane transport.
**Overall, 1,3,7,12-tetrahydroxycholanoic acid (cholic acid) is a crucial molecule for various research areas, particularly related to digestion, metabolism, liver function, and potential therapeutic applications.** Its complex interactions with the body highlight the importance of further research into this fascinating compound.
| ID Source | ID |
|---|---|
| PubMed CID | 194158 |
| SCHEMBL ID | 1492131 |
| MeSH ID | M0109774 |
| Synonym |
|---|
| 1,3,7,12-tetrahydroxycholan-24-oic acid |
| 63266-89-7 |
| cholan-24-oic acid, 1,3,7,12-tetrahydroxy- |
| 1,3,7,12-thca |
| ca-1beta-ol |
| 1,3,7,12-tetrahydroxycholanoic acid |
| SCHEMBL1492131 |
| 1,3,7,12-tetrahydroxy-cholan-24-oic acid |
| 1,3,7,12-tetrahydroxy-cholan-24-oate |
| 1,3,7,12-tetrahydroxycholanoate |
| 1,3,7,12-tetrahydroxycholan-24-oate |
| 1beta-hydroxycholate |
| (4r)-4-((8s,9s,10s,13r,14s,17r)-1,3,7,12-tetrahydroxy-10,13-dimethylhexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoic acid |
| (4r)-4-((8s,9s,10s,13r,14s,17r)-1,3,7,12-tetrahydroxy-10,13-dimethylhexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoicacid |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.09) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||