Compounds > kadsurin
Page last updated: 2024-12-08

kadsurin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

kadsurin: from the stems of Kadsura heteroclita; has anti-lipid peroxidative effect; cinnamate dimer similar to schisanhenol of Schisandra [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
KadsuragenusA plant genus of the family SCHISANDRACEAE used in folk medicine in a manner similar to SCHISANDRA. Members contain KADSURENONE and KADSURIN.[MeSH]SchisandraceaeA plant family of the order AUSTROBAILEYALES, class MAGNOLIOPSIDA.[MeSH]

Cross-References

ID SourceID
PubMed CID171064
CHEMBL ID559796
CHEBI ID67453
MeSH IDM0202512

Synonyms (17)

Synonym
kadsurin
[tetramethoxy(dimethyl)[?]yl] acetate
chebi:67453 ,
ananolignan a
CHEMBL559796
51670-40-7
benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-8-ol, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, acetate, stereoisomer (van)
kadsurin, (-)-
AC-31926
DTXSID80199608
Q15426250
[(9r,10r,11r)-3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-11-yl] acetate
3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-11-ol
MS-28385
XK178297
HY-121271
CS-0081345
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
tanninAny of a group of astringent polyphenolic vegetable principles or compounds, chiefly complex glucosides of catechol and pyrogallol.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (18)

Assay IDTitleYearJournalArticle
AID655287Neuroprotective activity against amyloid beta(25-35)-induced cell death in rat PC12 cells assessed as cell viability at 1 uM incubated for 2 hrs prior to amyloid beta(25-35)-challenge measured after 24 hrs by MTT assay (Rvb = 34.8 +/- 0.8%)2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Dibenzocyclooctadiene lignans from Kadsura polysperma and their antineurodegenerative activities.
AID335889Cytotoxicity against human Raji cells at 1000 mol ratio by trypan blue staining method2002Journal of natural products, Sep, Volume: 65, Issue:9
Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation.
AID335888Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 10 mol ratio relative to TPA2002Journal of natural products, Sep, Volume: 65, Issue:9
Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation.
AID335887Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 100 mol ratio relative to TPA2002Journal of natural products, Sep, Volume: 65, Issue:9
Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation.
AID655291Neuroprotective activity against H2O2-induced cell death in rat PC12 cells assessed as cell viability at 1 uM incubated for 2 hrs prior to H2O2-challenge measured after 24 hrs by MTT assay (Rvb = 53.1 +/- 1.1%)2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Dibenzocyclooctadiene lignans from Kadsura polysperma and their antineurodegenerative activities.
AID655292Neuroprotective activity against H2O2-induced cell death in rat PC12 cells assessed as cell viability at 10 uM incubated for 2 hrs prior to H2O2-challenge measured after 24 hrs by MTT assay (Rvb = 53.7 +/- 1.7%)2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Dibenzocyclooctadiene lignans from Kadsura polysperma and their antineurodegenerative activities.
AID655288Neuroprotective activity against amyloid beta(25-35)-induced cell death in rat PC12 cells assessed as cell viability at 10 uM incubated for 2 hrs prior to amyloid beta(25-35)-challenge measured after 24 hrs by MTT assay (Rvb = 38.8 +/- 1%)2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Dibenzocyclooctadiene lignans from Kadsura polysperma and their antineurodegenerative activities.
AID429824Cytotoxicity against human C8166 cells by MTT assay2009Journal of natural products, Jun, Volume: 72, Issue:6
Lignans with anti-HIV activity from Schisandra propinqua var. sinensis.
AID429826Selectivity index, ratio of CC50 for human C8166 cells to EC50 for HIV1 3B2009Journal of natural products, Jun, Volume: 72, Issue:6
Lignans with anti-HIV activity from Schisandra propinqua var. sinensis.
AID335885Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 1000 mol ratio relative to TPA2002Journal of natural products, Sep, Volume: 65, Issue:9
Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation.
AID600565Neuroprotective activity against H2O2-induced neurotoxicity in human SH-SY5Y cells assessed as cell survival at 10 uM incubated for 2 hrs before H2O2 challenge measured after 24 hrs by MTT assay2011Journal of natural products, May-27, Volume: 74, Issue:5
Dibenzocyclooctadiene lignans with antineurodegenerative potential from Kadsura ananosma.
AID600566Neuroprotective activity against H2O2-induced neurotoxicity in human SH-SY5Y cells assessed as cell survival at 1 uM incubated for 2 hrs before H2O2 challenge measured after 24 hrs by MTT assay2011Journal of natural products, May-27, Volume: 74, Issue:5
Dibenzocyclooctadiene lignans with antineurodegenerative potential from Kadsura ananosma.
AID429825Antiviral activity against HIV1 3B in human C8166 cells assessed as inhibition of virus-induced cytopathogenicity2009Journal of natural products, Jun, Volume: 72, Issue:6
Lignans with anti-HIV activity from Schisandra propinqua var. sinensis.
AID655289Neuroprotective activity against amyloid beta(25-35)-induced cell death in rat PC12 cells assessed as cell viability at 10 uM incubated for 2 hrs prior to amyloid beta(25-35)-challenge measured after 24 hrs by MTT assay (Rvb = 34.8 +/- 0.8%)2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Dibenzocyclooctadiene lignans from Kadsura polysperma and their antineurodegenerative activities.
AID655286Neuroprotective activity against amyloid beta(25-35)-induced cell death in rat PC12 cells assessed as cell viability at 1 uM incubated for 2 hrs prior to amyloid beta(25-35)-challenge measured after 24 hrs by MTT assay (Rvb = 38.8 +/- 1%)2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Dibenzocyclooctadiene lignans from Kadsura polysperma and their antineurodegenerative activities.
AID655293Neuroprotective activity against H2O2-induced cell death in rat PC12 cells assessed as cell viability at 10 uM incubated for 2 hrs prior to H2O2-challenge measured after 24 hrs by MTT assay (Rvb = 53.1 +/- 1.1%)2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Dibenzocyclooctadiene lignans from Kadsura polysperma and their antineurodegenerative activities.
AID655290Neuroprotective activity against H2O2-induced cell death in rat PC12 cells assessed as cell viability at 1 uM incubated for 2 hrs prior to H2O2-challenge measured after 24 hrs by MTT assay (Rvb = 53.7 +/- 1.7%)2012Journal of natural products, Feb-24, Volume: 75, Issue:2
Dibenzocyclooctadiene lignans from Kadsura polysperma and their antineurodegenerative activities.
AID335886Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 500 mol ratio relative to TPA2002Journal of natural products, Sep, Volume: 65, Issue:9
Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's3 (42.86)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbon tetrachloride
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.		1.9810chlorocarbon;
chloromethanes		hepatotoxic agent;
refrigerant
zidovudine
Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.		2.0510azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
schizandrol b
schizandrol B: from Schizandra chinensis, plant used as tonic in traditional Chinese medicine		2.0510tannin
galgravin
galgravin: an anti-PAF constituent from the stems of Piper futokadsura, the Chinese drug haifengteng; structures of the isomers galgravin, galbelgin (10569-12-7) and veraguensin (19950-55-1) given in first source; RN given refers to galgravin, the (2alpha,3beta,4beta,5alpha)-isomer. galgravin : A member of the class of aryltetrahydrofurans carrying two 3,4-dimethoxyphenyl substituents at positions 2 and 5 as well as two methyl groups at positions 3 and 4.		2.0510aryltetrahydrofuran;
dimethoxybenzene;
lignan;
ring assembly		bone density conservation agent;
neuroprotective agent;
plant metabolite;
platelet aggregation inhibitor
schizandrin b
schizandrin B: a phytogenic antineoplastic agent with anti-inflammatory activity; isolated from Schisandra plant		2.0510
1-hexadecyl-2-acetyl-glycero-3-phosphocholine
Platelet Activating Factor: A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.. 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine : A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has hexadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.		3.11102-acetyl-1-alkyl-sn-glycero-3-phosphocholineantihypertensive agent;
beta-adrenergic antagonist;
bronchoconstrictor agent;
hematologic agent;
vasodilator agent
schisantherin a
[no description available]		2.0110tannin
schizandrin a
schizandrin A: the major lignan, 2-9%, of Schisandra plant; has hepatoprotective, antioxidant, and antineoplastic activities		2.0510
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		3.830
schizandrin c
schizandrin C: from Schizandra chinensis Baill & Fructus schisandrae; protects liver from carbon tetrachloride injury;		2.0110tannin
meso-dihydroguaiaretic acid
meso-dihydroguaiaretic acid : A lignan that is 2,3-dimethylbutane substituted by 2-methoxyphenol groups at positions 1 and 4 respectively. It has been isolated from the bark of Machilus robusta.		2.0510guaiacols;
lignan		plant metabolite
terameprocol
[no description available]		2.0510lignan
gomisin-g
[no description available]		2.0110
interiotherin b
interiotherin B: isolated from kadsura interior; structure given in first source. interiotherin B : A lignan with a dibenzocyclooctadiene skeleton attached to a fatty acid ester side chain. It is isolated from Kadsura interior and has been shown to exhibit anti-HIV activity.		2.0110aromatic ether;
fatty acid ester;
lignan;
organic heteropentacyclic compound;
oxacycle		anti-HIV agent;
metabolite
ConditionIndicatedRelationship StrengthStudiesTrials