interiotherin b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

interiotherin B: isolated from kadsura interior; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

interiotherin B : A lignan with a dibenzocyclooctadiene skeleton attached to a fatty acid ester side chain. It is isolated from Kadsura interior and has been shown to exhibit anti-HIV activity. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Flora	Rank	Flora Definition	Family	Family Definition
Kadsura	genus	A plant genus of the family SCHISANDRACEAE used in folk medicine in a manner similar to SCHISANDRA. Members contain KADSURENONE and KADSURIN.[MeSH]	Schisandraceae	A plant family of the order AUSTROBAILEYALES, class MAGNOLIOPSIDA.[MeSH]
Kadsura interior	species	[no description available]	Schisandraceae	A plant family of the order AUSTROBAILEYALES, class MAGNOLIOPSIDA.[MeSH]

Cross-References

ID Source	ID
PubMed CID	20839677
CHEMBL ID	490161
CHEBI ID	66083
MeSH ID	M0270489

Synonyms (6)

Synonym
interiotherin b
chebi:66083 ,
CHEMBL490161
2-butenoic acid, 2-methyl-, (5s,6s,7s,13as)-5,6,7,8-tetrahydro-6-hydroxy-13,14-dimethoxy-6,7-dimethylcycloocta(1,2-f:3,4-f')bis(1,3)benzodioxol-5-yl ester, (2z)-
Q27134596
[(11s,12s,13s)-12-hydroxy-3,22-dimethoxy-12,13-dimethyl-5,7,18,20-tetraoxapentacyclo[13.7.0.02,10.04,8.017,21]docosa-1(22),2,4(8),9,15,17(21)-hexaen-11-yl] (z)-2-methylbut-2-enoate

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

Role	Description
metabolite	Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
anti-HIV agent	An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

Class	Description
aromatic ether	Any ether in which the oxygen is attached to at least one aryl substituent.
lignan	Any phenylpropanoid derived from phenylalanine via dimerization of substituted cinnamic alcohols, known as monolignols, to a dibenzylbutane skeleton. Note that while individual members of the class have names ending ...lignane, ...lignene, ...lignadiene, etc., the class names lignan, neolignan, etc., do not end with an "e".
fatty acid ester	A carboxylic ester in which the carboxylic acid component can be any fatty acid.
organic heteropentacyclic compound
oxacycle	Any organic heterocyclic compound containing at least one ring oxygen atom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (12)

Assay ID	Title	Year	Journal	Article
AID335886	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 500 mol ratio relative to TPA	2002	Journal of natural products, Sep, Volume: 65, Issue:9	Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation.
AID569566	Antiviral activity against HIV1-3B infected in human C1866 cells assessed as inhibition of virus-induced cytopathic effect	2011	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3	Compounds from Kadsura angustifolia with anti-HIV activity.
AID335885	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 1000 mol ratio relative to TPA	2002	Journal of natural products, Sep, Volume: 65, Issue:9	Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation.
AID569567	Therapeutic index, ratio of CC50 for human C1866 cells to EC50 for HIV1-3B	2011	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3	Compounds from Kadsura angustifolia with anti-HIV activity.
AID354616	Therapeutic index, ratio of IC50 for mock-infected human H9 cells to EC50 for HIV1 3B	1996	Journal of natural products, Nov, Volume: 59, Issue:11	Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior.
AID724310	Inhibition of NF-kappaB (unknown origin) expressed in TNFalpha-stimulated rat HSC-T6 cells assessed as reduction of HSC activation at 50 ug/ml treated 30 mins before TNFalpha stimulation measured after 6 hrs by bioluminescence based luciferase reporter ge	2013	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 23, Issue:3	Anti-liver fibrotic lignans from the fruits of Schisandra arisanensis and Schisandra sphenanthera.
AID354615	Cytotoxicity against mock-infected human H9 cells after 4 days	1996	Journal of natural products, Nov, Volume: 59, Issue:11	Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior.
AID335889	Cytotoxicity against human Raji cells at 1000 mol ratio by trypan blue staining method	2002	Journal of natural products, Sep, Volume: 65, Issue:9	Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation.
AID335888	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 10 mol ratio relative to TPA	2002	Journal of natural products, Sep, Volume: 65, Issue:9	Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation.
AID569565	Cytotoxicity against human C1866 cells	2011	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3	Compounds from Kadsura angustifolia with anti-HIV activity.
AID354614	Antiviral activity against HIV1 3B in human H9 cells assessed as inhibition of p24 antigen production after 4 days by ELISA	1996	Journal of natural products, Nov, Volume: 59, Issue:11	Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior.
AID335887	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 100 mol ratio relative to TPA	2002	Journal of natural products, Sep, Volume: 65, Issue:9	Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
zidovudine Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.	2.42	2	azide; pyrimidine 2',3'-dideoxyribonucleoside	antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor
schisantherin a [no description available]	2.44	2	tannin
schisantherin d schisantherin D: a lignan from the fruits of Schisandra sphenanthera	2.72	3
kadsurin kadsurin: from the stems of Kadsura heteroclita; has anti-lipid peroxidative effect; cinnamate dimer similar to schisanhenol of Schisandra	2.01	1	tannin	metabolite
lignans Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	2.42	2
schizandrin c schizandrin C: from Schizandra chinensis Baill & Fructus schisandrae; protects liver from carbon tetrachloride injury;	2.01	1	tannin
schizandrin [no description available]	2.06	1
gomisin j gomisin J: a lignan from Schizandra fruits	2.08	1
schisantherin b schisantherin B: lignan isolated from fruit of Schisandra sphenanthera; RN given refers to schisanterin B and gomisin B	2.06	1	tannin
nigranoic acid nigranoic acid: from stem of Schisandra sphaerandra; structure in first source. nigranoic acid : A tetracyclic triterpenoid that is 3,4-secocycloarta-4(28),24-(Z)-diene substituted by carboxy groups at positions 3 and 26. Isolated from Schisandra henryi and Schisandra propinqua, it exhibits cytotoxic and anti-HIV activities.	2.06	1	dicarboxylic acid; tetracyclic triterpenoid	antineoplastic agent; HIV-1 reverse transcriptase inhibitor; metabolite
gomisin-g [no description available]	2.01	1
pinoresinol pinoresinol: in plants; a furo[3,4-c]furan created from dimer of coniferyl alcohol. pinoresinol : A lignan that is tetrahydro-1H,3H-furo[3,4-c]furan substituted at positions 1 and 4 by 4-hydroxy-3-methoxyphenyl groups.	2.08	1

Condition	Relationship Strength	Studies
HIV Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.	2.06	1
Cirrhosis, Liver [description not available]	2.08	1
Liver Cirrhosis Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.	2.08	1

chemdatabank.com