Compounds > quadazocine

Page last updated: 2024-09-03

quadazocine and u-50488

quadazocine has been researched along with u-50488 in 14 studies

Compound Research Comparison

Studies (quadazocine)	Trials (quadazocine)	Recent Studies (post-2010) (quadazocine)	Studies (u-50488)	Trials (u-50488)	Recent Studies (post-2010) (u-50488)
81	0	0	1,664	3	209

Protein Interaction Comparison

Protein	Taxonomy	quadazocine (IC50)	u-50488 (IC50)
Delta-type opioid receptor	Rattus norvegicus (Norway rat)		2.15
Kappa-type opioid receptor	Mus musculus (house mouse)		0.0027
Mu-type opioid receptor	Rattus norvegicus (Norway rat)		2.15
Kappa-type opioid receptor	Rattus norvegicus (Norway rat)		0.7171
Kappa-type opioid receptor	Cavia porcellus (domestic guinea pig)		0.0958
Kappa-type opioid receptor	Homo sapiens (human)		0.0537

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (50.00)	18.7374
1990's	6 (42.86)	18.2507
2000's	1 (7.14)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A	1
Frank, C; Proietti, ML; Sagratella, S; Scotti de Carolis, A; Zeng, YC	1
Hernández, A; Paeile, C; Pelissier, T; Pérez, H; Soto-Moyano, R	1
Patel, VA; Pohorecky, LA; Roberts, P	1
Patel, V; Pohorecky, LA; Roberts, P	1
Clow, DW; Jhamandas, K	1
Dykstra, LA; Massie, CA	1
Adler, MW; Geller, EB; Tiseo, PJ	1
Portoghese, PS; Takemori, AE	1
Dykstra, LA; Gmerek, DE; Winger, G; Woods, JH	1
Brusa, L; D'Amore, A; Lorenzini, P; Massotti, M	1
Butelman, ER; Ko, MC; Woods, JH	1
Bian, JS; Wang, HX; Wong, TM; Wu, S; Yu, XC; Zhang, WM	1
Johnson, MD; Ko, MC; Tuchman, JE; Wiesenauer, K; Woods, JH	1

Other Studies

14 other study(ies) available for quadazocine and u-50488

Article	Year
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications. NIDA research monograph, 1998, Volume: 178 Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders	1998
In vitro depressant effects of U-54494A, an anticonvulsant related to kappa opioids, in the hippocampus. Neuropharmacology, 1991, Volume: 30, Issue:6 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Anticonvulsants; Azocines; Calcium; Cell Membrane; Depression, Chemical; Electric Stimulation; Female; Hippocampus; In Vitro Techniques; Membrane Potentials; Naltrexone; Narcotic Antagonists; Neurons; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Synapses; Synaptic Transmission	1991
Kappa opioid receptor-mediated depression of activity evoked in convergent dorsal horn cells by thermal and non-thermal noxious stimulation. European journal of pharmacology, 1990, Sep-21, Volume: 186, Issue:2-3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Anterior Horn Cells; Azocines; Hot Temperature; Narcotic Antagonists; Nociceptors; Physical Stimulation; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Synaptic Transmission	1990
Effects of ethanol on plasma corticosterone and rectal temperature modification by U50488H and WIN 44441-3. Life sciences, 1989, Volume: 44, Issue:22 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Body Temperature; Chromatography, Gas; Corticosterone; Ethanol; Male; Pyrrolidines; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Time Factors	1989
Effects of ethanol in an open field apparatus: modification by U50488H and WIN 44441-3. Physiology & behavior, 1989, Volume: 45, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Male; Motor Activity; Narcotic Antagonists; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa	1989
Effects of a kappa-receptor agonist, U-50,488H, on the release of endogenous brain dopamine. Canadian journal of physiology and pharmacology, 1988, Volume: 66, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Azocines; Brain; Dopamine; In Vitro Techniques; Male; Narcotic Antagonists; Potassium; Putamen; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Synaptosomes	1988
Antagonism of the analgesic effects of mu and kappa opioid agonists in the squirrel monkey. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Azocines; Benzomorphans; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Male; Methadone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Saimiri	1988
Antinociceptive action of intracerebroventricularly administered dynorphin and other opioid peptides in the rat. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Azocines; Cold Temperature; Drug Interactions; Dynorphins; Enkephalins; Injections, Intraventricular; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid	1988
TENA, a selective kappa opioid receptor antagonist. Life sciences, 1985, Feb-25, Volume: 36, Issue:8 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens	1985
Kappa opioids in rhesus monkeys. II. Analysis of the antagonistic actions of quadazocine and beta-funaltrexamine. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Diuresis; Endorphins; Ethylketocyclazocine; Female; Hot Temperature; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Reaction Time; Tail	1987
Area tempestas modulates the behavioural responses to nociceptive stimuli in rats. Annali dell'Istituto superiore di sanita, 1993, Volume: 29, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Azocines; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Foot; Hot Temperature; Male; Morphine; Naltrexone; Narcotic Antagonists; Olfactory Pathways; Pain; Phenazocine; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Seizures; Tail	1993
Activation of peripheral kappa opioid receptors inhibits capsaicin-induced thermal nociception in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Azocines; Benzomorphans; Capsaicin; Dynorphins; Female; Hot Temperature; Ligands; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Pain Measurement; Peptide Fragments; Receptors, Opioid, kappa	1999
Effects of U50488 and bremazocine on [Ca2+]i and cAMP in naive and tolerant rat ventricular myocytes: evidence of kappa opioid receptor multiplicity in the heart. Journal of molecular and cellular cardiology, 1999, Volume: 31, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Drug Resistance; Electric Stimulation; Heart; Heart Ventricles; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa	1999
Local administration of mu or kappa opioid agonists attenuates capsaicin-induced thermal hyperalgesia via peripheral opioid receptors in rats. Psychopharmacology, 2000, Volume: 148, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Local; Animals; Azocines; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Fentanyl; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Male; Narcotic Antagonists; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu	2000