Compounds > dynorphin (1-17)
Page last updated: 2024-07-31 19:19:11

dynorphin (1-17)

Description

Cross-References

ID SourceID
PubMed CID10486131
PubMed CID3081578
PubMed CID16133805
CHEMBL ID217379
CHEMBL ID407832
MeSH IDM0006909

Synonyms (47)

Synonym
gtpl1621
dynorphin a-(1-8)
NCGC00163193-01
dynorphin(1-8)-oh
tyr-gly-gly-phe-leu-arg-arg-ile-oh
bdbm50128080
CHEMBL217379 ,
dynorphin a (1-8)
MS-31830
HY-P2159
CS-0109301
AKOS040744586
l-arginine, n2-(n-(n2-(n2-(n-(n-(n-(n-l-tyrosylglycyl)glycyl)-l-phenylalanyl)-l-leucyl)-l-arginyl)-l-arginyl)-l-isoleucyl)-
dynorphin a (1-9)
tyr-gly-gly-phe-leu-arg-arg-ile-arg-oh
bdbm50128088
CHEMBL407832 ,
(2s)-2-[[(2s,3s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[2-[[2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylidene
tyr-gly-gly-phe-leu-arg-arg-ile-arg
dynorphin a(1-9)
dynorphin a (swine)
dynorphin a1-17
dynorphin a porcine, >=95% (hplc)
NCGC00167144-01
dynorphin (1-17)
dynorphin a (1-17)
80448-90-4
unii-9m18t0td14
9m18t0td14 ,
Y-100015
dynorphin acetate
AKOS024457469
dynorphin a amide, porcine
mfcd00079857
JMNJYGMAUMANNW-FIXZTSJVSA-N
bdbm50096785
dynorphin a (porcine)
dyn-a17
porcine dynorphin a (1-17)
dynorphin a (human)
dynorphin a (rat)
dynorphin a (bos taurus)
dynorphin a (pig)
dynorphin [mi]
dyn a 1-17
dynorphin 17
F87314

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
glucocerebrosidaseHomo sapiens (human)Potency7.9433AID2101

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Delta-type opioid receptorMus musculus (house mouse)IC500.0397AID226081
Delta-type opioid receptorMus musculus (house mouse)Ki0.0092AID149069
Mu-type opioid receptorHomo sapiens (human)Ki0.0229AID150975; AID331199
Delta-type opioid receptorHomo sapiens (human)Ki0.0081AID149069; AID331200
Kappa-type opioid receptorHomo sapiens (human)Ki0.0024AID148006; AID331198

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Mu-type opioid receptorHomo sapiens (human)EC500.2138AID1229433
Delta-type opioid receptorHomo sapiens (human)EC500.0186AID1229436
Kappa-type opioid receptorHomo sapiens (human)EC500.0024AID1171840; AID1229439; AID331201; AID375524

Bioassays (45)

Assay IDTitleYearJournalArticle
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
ISSN: 1091-6490		Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
ISSN: 2211-1247		A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1346329Human kappa receptor (Opioid receptors)1998NIDA research monograph, Mar, Volume: 178ISSN: 1046-9516Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
AID1346329Human kappa receptor (Opioid receptors)1990Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
ISSN: 0022-2623		Synthesis and structure-activity relationships of dynorphin A-(1-8) amide analogues.
AID1346361Human delta receptor (Opioid receptors)1998NIDA research monograph, Mar, Volume: 178ISSN: 1046-9516Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
AID1346329Human kappa receptor (Opioid receptors)1995Proceedings of the National Academy of Sciences of the United States of America, Jul-18, Volume: 92, Issue:15
ISSN: 0027-8424		kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system.
AID1346364Human mu receptor (Opioid receptors)1998NIDA research monograph, Mar, Volume: 178ISSN: 1046-9516Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
AID1346341Mouse kappa receptor (Opioid receptors)1993Proceedings of the National Academy of Sciences of the United States of America, Jul-15, Volume: 90, Issue:14
ISSN: 0027-8424		Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.
AID150975In vitro binding affinity to human Opioid receptor mu 1 on CHO cell membranes using [3H]diprenorphine displacement.2003Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
ISSN: 0022-2623		Structure-activity relationships of dynorphin a analogues modified in the address sequence.
AID149069In vitro binding affinity to human Opioid receptor delta 1 on CHO cell membranes using [3H]diprenorphine displacement.2003Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
ISSN: 0022-2623		Structure-activity relationships of dynorphin a analogues modified in the address sequence.
AID228157Binding affinity towards human kappa,mu,delta receptors was calculated as the ratio; 1/7.7/1.82003Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
ISSN: 0022-2623		Structure-activity relationships of dynorphin a analogues modified in the address sequence.
AID148006In vitro binding affinity towards human Opioid receptor kappa 1 on CHO cell membranes using [3H]diprenorphine displacement.2003Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
ISSN: 0022-2623		Structure-activity relationships of dynorphin a analogues modified in the address sequence.
AID228160Binding affinity towards human kappa,mu,delta receptors was calculated as the ratio; 1/9.5/3.92003Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
ISSN: 0022-2623		Structure-activity relationships of dynorphin a analogues modified in the address sequence.
AID152408Opioid receptors antagonist activity in smooth-muscle tissue of guinea pig ileum (GPI)1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
ISSN: 0022-2623		Design and synthesis of highly potent and selective cyclic dynorphin A analogues.
AID761674Displacement of [131I]-[D-Ala2,4'-I-Phe8]alpha-Neoendorphin from opioid receptor in CD-1 mouse brain after 90 mins by competitive binding assay2013Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15
ISSN: 1464-3405		Sandmeyer reaction repurposed for the site-selective, non-oxidizing radioiodination of fully-deprotected peptides: studies on the endogenous opioid peptide α-neoendorphin.
AID150232Opioid receptors antagonist activity in smooth-muscle tissue of guinea pig ileum (GPI) in presence of NLX1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
ISSN: 0022-2623		Design and synthesis of highly potent and selective cyclic dynorphin A analogues.
AID149732Binding affinity against Opioid receptor mu 1 in guinea pig brain homogenate using [3H]- PL-17 as radioligand1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
ISSN: 0022-2623		Design and synthesis of highly potent and selective cyclic dynorphin A analogues.
AID152409Opioid receptors antagonist activity in smooth-muscle tissue of guinea pig ileum (GPI) in presence of CTAP1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
ISSN: 0022-2623		Design and synthesis of highly potent and selective cyclic dynorphin A analogues.
AID1229436Agonist activity at human recombinant delta opioid receptor expressed in CHO cells co-expressing Galphaq66Di5 assessed as stimulation of calcium release by Fluo-4 AM dye-based fluorescence assay2015ACS medicinal chemistry letters, May-14, Volume: 6, Issue:5
ISSN: 1948-5875		Synthesis of mixed opioid affinity cyclic endomorphin-2 analogues with fluorinated phenylalanines.
AID331203Displacement of [3H]diprenorphine from human kappa/mu opioid chimera 4 receptor2008Bioorganic & medicinal chemistry letters, Jun-15, Volume: 18, Issue:12
ISSN: 1464-3405		Use of receptor chimeras to identify small molecules with high affinity for the dynorphin A binding domain of the kappa opioid receptor.
AID331199Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO-K1 cells2008Bioorganic & medicinal chemistry letters, Jun-15, Volume: 18, Issue:12
ISSN: 1464-3405		Use of receptor chimeras to identify small molecules with high affinity for the dynorphin A binding domain of the kappa opioid receptor.
AID149847Selectivity for kappa and mu opioid receptors of guinea pig brain and ileum respectively1993Journal of medicinal chemistry, Mar-19, Volume: 36, Issue:6
ISSN: 0022-2623		Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs.
AID149619Binding affinity against Opioid receptor delta 1 in guinea pig brain homogenate using [3H]- DPDPE as radioligand1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
ISSN: 0022-2623		Design and synthesis of highly potent and selective cyclic dynorphin A analogues.
AID331202Displacement of [3H]diprenorphine from human kappa/mu opioid chimera 3 receptor2008Bioorganic & medicinal chemistry letters, Jun-15, Volume: 18, Issue:12
ISSN: 1464-3405		Use of receptor chimeras to identify small molecules with high affinity for the dynorphin A binding domain of the kappa opioid receptor.
AID1229438Intrinsic activity at human recombinant delta opioid receptor expressed in CHO cells co-expressing Galphaq66Di5 assessed as efficacy ratio by measuring stimulation of calcium release by Fluo-4 AM dye-based fluorescence assay relative to DPDPE2015ACS medicinal chemistry letters, May-14, Volume: 6, Issue:5
ISSN: 1948-5875		Synthesis of mixed opioid affinity cyclic endomorphin-2 analogues with fluorinated phenylalanines.
AID150250Opioid receptors antagonist activity in smooth-muscle tissue mouse vas deferens (MVD) in presence of NLX1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
ISSN: 0022-2623		Design and synthesis of highly potent and selective cyclic dynorphin A analogues.
AID226072Inhibition of [3H]PL-17 binding to mu opioid receptor of guinea pig brain homogenate1993Journal of medicinal chemistry, Mar-19, Volume: 36, Issue:6
ISSN: 0022-2623		Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs.
AID331198Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO-K1 cells2008Bioorganic & medicinal chemistry letters, Jun-15, Volume: 18, Issue:12
ISSN: 1464-3405		Use of receptor chimeras to identify small molecules with high affinity for the dynorphin A binding domain of the kappa opioid receptor.
AID1229439Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells co-expressing C-terminally modified Galphaqi5 assessed as stimulation of calcium release by Fluo-4 AM dye-based fluorescence assay2015ACS medicinal chemistry letters, May-14, Volume: 6, Issue:5
ISSN: 1948-5875		Synthesis of mixed opioid affinity cyclic endomorphin-2 analogues with fluorinated phenylalanines.
AID226071Inhibition of [3H]DPDPE binding to delta opioid receptor of guinea pig brain homogenate1993Journal of medicinal chemistry, Mar-19, Volume: 36, Issue:6
ISSN: 0022-2623		Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs.
AID331201Agonist activity at human kappa opioid receptor transfected in CHO cells by [35S]GTP-gamma-S binding assay2008Bioorganic & medicinal chemistry letters, Jun-15, Volume: 18, Issue:12
ISSN: 1464-3405		Use of receptor chimeras to identify small molecules with high affinity for the dynorphin A binding domain of the kappa opioid receptor.
AID375531Antagonist activity at human recombinant kappa opioid receptor expressed in CHO cells coexpressing alphaqi5 assessed as inhibition of dynorphin A-induced intracellular calcium mobilization at up to 10 uM2009Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13
ISSN: 1520-4804		Further studies at neuropeptide s position 5: discovery of novel neuropeptide S receptor antagonists.
AID232185Ratio of guinea pig brain Vs peripheral guinea pig ileum selectivies at kappa and mu opioid receptor1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
ISSN: 0022-2623		Design and synthesis of highly potent and selective cyclic dynorphin A analogues.
AID150249Opioid receptors antagonist activity in smooth-muscle tissue mouse vas deferens (MVD) in presence of ICI1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
ISSN: 0022-2623		Design and synthesis of highly potent and selective cyclic dynorphin A analogues.
AID1171840Agonist activity at human KOR expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by luminescence assay2014Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
ISSN: 1520-4804		Synthesis and κ-opioid receptor activity of furan-substituted salvinorin A analogues.
AID331200Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO-K1 cells2008Bioorganic & medicinal chemistry letters, Jun-15, Volume: 18, Issue:12
ISSN: 1464-3405		Use of receptor chimeras to identify small molecules with high affinity for the dynorphin A binding domain of the kappa opioid receptor.
AID1229435Intrinsic activity at human recombinant mu opioid receptor expressed in CHO cells co-expressing C-terminally modified Galphaqi5 assessed as efficacy ratio by measuring stimulation of calcium release by Fluo-4 AM dye-based fluorescence assay relative to EM2015ACS medicinal chemistry letters, May-14, Volume: 6, Issue:5
ISSN: 1948-5875		Synthesis of mixed opioid affinity cyclic endomorphin-2 analogues with fluorinated phenylalanines.
AID1229433Agonist activity at human recombinant mu opioid receptor expressed in CHO cells co-expressing C-terminally modified GGalphaqi5 assessed as stimulation of calcium release by Fluo-4 AM dye-based fluorescence assay2015ACS medicinal chemistry letters, May-14, Volume: 6, Issue:5
ISSN: 1948-5875		Synthesis of mixed opioid affinity cyclic endomorphin-2 analogues with fluorinated phenylalanines.
AID150248Opioid receptors antagonist activity in smooth-muscle tissue mouse vas deferens (MVD) in presence of CTAP1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
ISSN: 0022-2623		Design and synthesis of highly potent and selective cyclic dynorphin A analogues.
AID147934Relative affinity for delta and kappa opioid receptors of guinea pig brain homogenate1993Journal of medicinal chemistry, Mar-19, Volume: 36, Issue:6
ISSN: 0022-2623		Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs.
AID226076Inhibition of mu-selective antagonist binding to opioid receptor of guinea pig ileum1993Journal of medicinal chemistry, Mar-19, Volume: 36, Issue:6
ISSN: 0022-2623		Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs.
AID226081Inhibition of delta-selective antagonist binding to opioid receptor of mouse vas dferens1993Journal of medicinal chemistry, Mar-19, Volume: 36, Issue:6
ISSN: 0022-2623		Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs.
AID141519Relative affinity for mu and kappa opioid receptors of guinea pig brain homogenate1993Journal of medicinal chemistry, Mar-19, Volume: 36, Issue:6
ISSN: 0022-2623		Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs.
AID148554Binding affinity against Opioid receptor kappa 1 in guinea pig brain homogenate using [3H]- U-69593 as radioligand1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
ISSN: 0022-2623		Design and synthesis of highly potent and selective cyclic dynorphin A analogues.
AID375524Antagonist activity at human recombinant kappa opioid receptor expressed in CHO cells coexpressing alphaqi5 assessed as inhibition of dynorphin A-induced intracellular calcium mobilization2009Journal of medicinal chemistry, Jul-09, Volume: 52, Issue:13
ISSN: 1520-4804		Further studies at neuropeptide s position 5: discovery of novel neuropeptide S receptor antagonists.
AID150247Opioid receptors antagonist activity in smooth-muscle tissue mouse vas deferens (MVD)1990Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
ISSN: 0022-2623		Design and synthesis of highly potent and selective cyclic dynorphin A analogues.
AID226073Inhibition of [3H]U-69593 binding to kappa opioid receptor of guinea pig brain homogenate1993Journal of medicinal chemistry, Mar-19, Volume: 36, Issue:6
ISSN: 0022-2623		Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs.

Research

Studies (27)

TimeframeStudies, This Drug (%)All Drugs %
pre-19908 (29.63)18.7374
1990's10 (37.04)18.2507
2000's4 (14.81)29.6817
2010's3 (11.11)24.3611
2020's2 (7.41)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (3.33%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other29 (96.67%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
fentanyl
1
anilide;
monocarboxylic acid amide;
piperidines		adjuvant;
anaesthesia adjuvant;
anaesthetic;
intravenous anaesthetic;
mu-opioid receptor agonist;
opioid analgesic		1998199826.0low001000
ici 204448
1
monocarboxylic acid1993199331.0low001000
enkephalin, leucine
1
peptide1998199826.0high001000
etonitazene
1
1998199826.0low001000
levomethadone
1
6-(dimethylamino)-4,4-diphenylheptan-3-oneantitussive;
mu-opioid receptor agonist;
NMDA receptor antagonist;
opioid analgesic		1998199826.0high001000
spiradoline
1
1993199331.0low001000
enkephalin, d-penicillamine (2,5)-
1
heterodetic cyclic peptidedelta-opioid receptor agonist1998199826.0low001000
u 69593
3
monocarboxylic acid amide;
N-alkylpyrrolidine;
organic heterobicyclic compound;
oxaspiro compound		anti-inflammatory agent;
diuretic;
kappa-opioid receptor agonist		1993199828.7low003000
enkephalin, ser(2), leu(5), thr(6)-
1
oligopeptide1998199826.0low001000
quadazocine
1
1998199826.0low001000
morphiceptin, n-me-phe(3)-
1
1998199826.0low001000
enkephalin-leu, arg(6)-
1
2003200321.0low000100
beta-neo-endorphin
1
1995199529.0low001000
ethylketocyclazocine
1
1993199331.0low001000
pentazocine
1
benzazocine1998199826.0low001000
enkephalin, methionine
1
pentapeptide;
peptide zwitterion		analgesic;
antineoplastic agent;
delta-opioid receptor agonist;
human metabolite;
mu-opioid receptor agonist		1993199331.0low001000
diprenorphine
1
morphinane alkaloid1998199826.0low001000
enkephalin, leucine
1
pentapeptide;
peptide zwitterion		analgesic;
delta-opioid receptor agonist;
human metabolite;
mu-opioid receptor agonist;
neurotransmitter;
rat metabolite		2003200321.0low000100
buprenorphine
1
morphinane alkaloiddelta-opioid receptor antagonist;
kappa-opioid receptor antagonist;
mu-opioid receptor agonist;
opioid analgesic		1998199826.0low001000
u-50488
3
dichlorobenzene;
monocarboxylic acid amide;
N-alkylpyrrolidine		analgesic;
antitussive;
calcium channel blocker;
diuretic;
kappa-opioid receptor agonist		1993199828.7low003000
dynorphin (1-17)
1
2003200321.0low000100
dynorphin (1-11)
1
1998199826.0medium001000
codeine
1
morphinane alkaloid;
organic heteropentacyclic compound		antitussive;
drug allergen;
environmental contaminant;
opioid analgesic;
opioid receptor agonist;
prodrug;
xenobiotic		1998199826.0low001000
nalmefene
1
morphinane alkaloid1998199826.0low001000
nalorphine
1
morphinane alkaloid1998199826.0low001000
naloxone
4
morphinane alkaloid;
organic heteropentacyclic compound;
tertiary alcohol		antidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist		1993200326.8low003100
morphine
2
morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic		1990199830.0low002000
alpha-neoendorphin
2
1993199530.0low002000
beta-funaltrexamine
1
morphinane alkaloid1998199826.0low001000
nalbuphine
1
organic heteropentacyclic compoundmu-opioid receptor antagonist;
opioid analgesic		1993199331.0low001000
dihydromorphine
1
morphinane alkaloid1998199826.0low001000
naltrexone
3
cyclopropanes;
morphinane-like compound;
organic heteropentacyclic compound		antidote to opioid poisoning;
central nervous system depressant;
environmental contaminant;
mu-opioid receptor antagonist;
xenobiotic		1993199828.7low003000
enkephalin, ala(2)-mephe(4)-gly(5)-
1
peptide1998199826.0low001000
normorphine
1
morphinane alkaloid1998199826.0low001000
norbinaltorphimine
4
isoquinolines1993200326.8low003100
naltrindole benzofuran
1
morphinane alkaloid1998199826.0low001000
naltrindole
2
isoquinolines1993199828.5low002000
naloxone benzoylhydrazone
1
1998199826.0low001000
7-benzylidenenaltrexone
1
1998199826.0medium001000
enkephalin, leucine-2-alanine
1
1998199826.0low001000
dynorphin a (1-11)-amide
1
2003200321.0low000100
deltorphin ii, ala(2)-
1
1998199826.0medium001000
beta-endorphin
3
1993199828.7low003000
rimorphin
3
1993199828.7low003000
dynorphins
1
1998199826.0low001000
enkephalin-leu, arg(6)-
1
2003200321.0low000100
enkephalin, leucine
1
pentapeptide;
peptide zwitterion		analgesic;
delta-opioid receptor agonist;
human metabolite;
mu-opioid receptor agonist;
neurotransmitter;
rat metabolite		2003200321.0low000100
naloxone
1
morphinane alkaloid;
organic heteropentacyclic compound;
tertiary alcohol		antidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist		2003200321.0low000100
norbinaltorphimine
1
isoquinolines2003200321.0low000100
dynorphin (1-17)
1
2003200321.0medium000100
dynorphin a (1-11)-amide
1
2003200321.0low000100
substance p
1
peptideneurokinin-1 receptor agonist;
neurotransmitter;
vasodilator agent		2009200915.0low000100
u 69593
1
monocarboxylic acid amide;
N-alkylpyrrolidine;
organic heterobicyclic compound;
oxaspiro compound		anti-inflammatory agent;
diuretic;
kappa-opioid receptor agonist		2014201410.0low000010
salvinorin a
1
organic heterotricyclic compound;
organooxygen compound		metabolite;
oneirogen		2014201410.0low000010
bradykinin
1
oligopeptidehuman blood serum metabolite;
vasodilator agent		2009200915.0low000100
u-50488
1
dichlorobenzene;
monocarboxylic acid amide;
N-alkylpyrrolidine		analgesic;
antitussive;
calcium channel blocker;
diuretic;
kappa-opioid receptor agonist		2013201311.0low000010
ici 199441
1
acetamides2008200816.0low000100
dynorphin (1-11)
1
1993199331.0medium001000
alpha-neoendorphin
1
2013201311.0low000010
endomorphin 2
1
201520159.0low000010
enkephalin, ala(2)-mephe(4)-gly(5)-
1
peptide2013201311.0low000010
dermorphin
1
oligopeptide2009200915.0low000100
dynorphin a (1-11)-amide
1
1990199034.0low001000
sha 68
1
2009200915.0medium000100
nociceptin
1
organic molecular entity;
polypeptide		human metabolite;
rat metabolite		2009200915.0low000100
rimorphin
1
2013201311.0low000010
dynorphins
1
1993199331.0low001000
urotensin ii
1
2009200915.0high000100
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
2-amino-5-phosphonovalerate
1
non-proteinogenic alpha-amino acidNMDA receptor antagonist1997199727.0low001000
fentanyl
1
anilide;
monocarboxylic acid amide;
piperidines		adjuvant;
anaesthesia adjuvant;
anaesthetic;
intravenous anaesthetic;
mu-opioid receptor agonist;
opioid analgesic		2001200123.0low000100
leucine
2
amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite		1985198937.0low020000
enkephalin, methionine
2
1985198738.0low020000
captopril
1
alkanethiol;
L-proline derivative;
N-acylpyrrolidine;
pyrrolidinemonocarboxylic acid		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor		1989198935.0low010000
f 7302
1
piperidines2001200123.0low000100
ubenimex
1
1989198935.0low010000
enkephalinamide-met, ala(2)-
1
1987198737.0low010000
u 69593
1
monocarboxylic acid amide;
N-alkylpyrrolidine;
organic heterobicyclic compound;
oxaspiro compound		anti-inflammatory agent;
diuretic;
kappa-opioid receptor agonist		1989198935.0low010000
n,n-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine
1
1985198539.0low010000
bremazocine
2
1985198937.0low020000
dynorphin (1-8)
1
1985198539.0low010000
diprenorphine
1
morphinane alkaloid1989198935.0low010000
enkephalin, leucine
2
pentapeptide;
peptide zwitterion		analgesic;
delta-opioid receptor agonist;
human metabolite;
mu-opioid receptor agonist;
neurotransmitter;
rat metabolite		1985198738.0low020000
mr 2266
1
1985198539.0low010000
glycodeoxycholic acid
1
bile acid glycine conjugatehuman metabolite1987198737.0low010000
u-50488
1
dichlorobenzene;
monocarboxylic acid amide;
N-alkylpyrrolidine		analgesic;
antitussive;
calcium channel blocker;
diuretic;
kappa-opioid receptor agonist		2001200123.0low000100
naloxone
2
morphinane alkaloid;
organic heteropentacyclic compound;
tertiary alcohol		antidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist		1987199234.5low011000
enkephalin, ala(2)-mephe(4)-gly(5)-
1
1987198737.0low010000
cgp 39653
1
1997199727.0low001000
dynorphins
13
1983200134.2medium184100
beta-endorphin
1
1995199529.0low101000
dynorphins
1
1987198737.0low010000
cyclic gmp
1
3',5'-cyclic purine nucleotide;
guanyl ribonucleotide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite		1995199529.0low001000
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Burns0
1
1995199529.0low001000
Injuries, Spinal Cord0
1
1985198539.0low010000
Muscle Contraction0
1
2003200321.0low000100
Polycystic Ovarian Syndrome0
1
1995199529.0low101000
Polycystic Ovary Syndrome0
1
1995199529.0low101000
Spinal Cord Injuries0
1
1985198539.0low010000
Addiction, Opioid0
1
1998199826.0low001000
Chemical Dependence0
1
1998199826.0low001000
Congenital Zika Syndrome0
1
202020204.0low000010
Disease Models, Animal0
1
202020204.0low000010
Muscle Contraction0
1
2003200321.0low000100
Opioid-Related Disorders0
1
1998199826.0low001000
Substance-Related Disorders0
1
1998199826.0low001000
Zika Virus Infection0
1
202020204.0low000010
Muscle Contraction0
2
1990199332.5medium002000