Page last updated: 2024-09-03

quadazocine and naltrexone

quadazocine has been researched along with naltrexone in 23 studies

Compound Research Comparison

Studies
(quadazocine)
Trials
(quadazocine)
Recent Studies (post-2010)
(quadazocine)
Studies
(naltrexone)
Trials
(naltrexone)
Recent Studies (post-2010) (naltrexone)
81008,7451,2282,642

Protein Interaction Comparison

ProteinTaxonomyquadazocine (IC50)naltrexone (IC50)
Cytochrome P450 2D6Homo sapiens (human)1
Delta-type opioid receptorMus musculus (house mouse)0.0051
Delta-type opioid receptorRattus norvegicus (Norway rat)0.0063
Kappa-type opioid receptorMus musculus (house mouse)0.006
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0005
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.0005
Mu-type opioid receptorHomo sapiens (human)0.006
Delta-type opioid receptorHomo sapiens (human)0.0319
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.0093
Kappa-type opioid receptorHomo sapiens (human)0.0377
Mu-type opioid receptorMus musculus (house mouse)0.0076
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.0004

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19907 (30.43)18.7374
1990's12 (52.17)18.2507
2000's4 (17.39)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A1
Frank, C; Proietti, ML; Sagratella, S; Scotti de Carolis, A; Zeng, YC1
France, CP; Morse, WH1
Portoghese, PS; Takemori, AE1
Dykstra, LA; Gmerek, DE; Winger, G; Woods, JH1
Gmerek, DE; Woods, JH1
France, CP; Woods, JH1
Billington, CJ; Gosnell, BA; Levine, AS; Morley, JE1
Amir, S1
Butelman, ER; DeCosta, BR; Walker, EA; Woods, JH1
Dykstra, LA; Pitts, RC1
Brusa, L; D'Amore, A; Lorenzini, P; Massotti, M1
Al, Y; Butelman, ER; Negus, SS; Woods, JH1
Butelman, ER; Ko, MC; Woods, JH2
Bian, JS; Wang, HX; Wong, TM; Wu, S; Yu, XC; Zhang, WM1
Pakarinen, ED; Williams, KL; Woods, JH1
Brandt, MR; Furness, MS; Mello, NK; Negus, SS; Rice, KC; Zhang, X1
Butelman, ER; Harris, TJ; Kreek, MJ1
David Clark, J; Demirci, H; Gharagozlou, P; Lameh, J1
Brandt, MR; Gatch, MB; Mello, NK; Negus, SS1
Clithero, AD; Leitermann, RJ; MacDougall, RS; Terashvili, M; Tseng, LF; Wu, HE1
Kolar, F; Krylatov, AV; Lishmanov, YB; Maslov, LN; Naryzhnaya, NV; Ovchinnikov, MV; Stakheev, DL1

Other Studies

23 other study(ies) available for quadazocine and naltrexone

ArticleYear
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
    NIDA research monograph, 1998, Volume: 178

    Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders

1998
In vitro depressant effects of U-54494A, an anticonvulsant related to kappa opioids, in the hippocampus.
    Neuropharmacology, 1991, Volume: 30, Issue:6

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Anticonvulsants; Azocines; Calcium; Cell Membrane; Depression, Chemical; Electric Stimulation; Female; Hippocampus; In Vitro Techniques; Membrane Potentials; Naltrexone; Narcotic Antagonists; Neurons; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Synapses; Synaptic Transmission

1991
Pharmacological characterization of supersensitivity to naltrexone in squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:3

    Topics: Animals; Azocines; Behavior, Animal; Benzomorphans; Diprenorphine; Drug Administration Schedule; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Saimiri

1989
TENA, a selective kappa opioid receptor antagonist.
    Life sciences, 1985, Feb-25, Volume: 36, Issue:8

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens

1985
Kappa opioids in rhesus monkeys. II. Analysis of the antagonistic actions of quadazocine and beta-funaltrexamine.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 242, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Diuresis; Endorphins; Ethylketocyclazocine; Female; Hot Temperature; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Reaction Time; Tail

1987
Effects of beta-funaltrexamine in normal and morphine-dependent rhesus monkeys: observational studies.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Animals; Azocines; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Subcutaneous; Macaca mulatta; Morphine; Muscle Relaxation; Naloxone; Naltrexone; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors

1985
Antagonistic and rate-suppressing effects of opioid antagonists in the pigeon.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Animals; Azocines; Benzomorphans; Buprenorphine; Columbidae; Conditioning, Operant; Diprenorphine; Dose-Response Relationship, Drug; Morphine; Naloxone; Naltrexone; Narcotic Antagonists

1985
Which opioid receptor mechanism modulates feeding?
    Appetite, 1984, Volume: 5, Issue:1

    Topics: Animals; Azocines; Diprenorphine; Dynorphins; Endorphins; Feeding Behavior; Humans; Mice; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma

1984
Morphine exacerbates anaphylactic shock in mice by stimulating central opiate receptors.
    Neuroscience letters, 1983, Sep-30, Volume: 40, Issue:2

    Topics: Anaphylaxis; Animals; Azocines; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Receptors, Opioid

1983
Opioid thermal antinociception in rhesus monkeys: receptor mechanisms and temperature dependency.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1

    Topics: Alfentanil; Analgesics; Animals; Azocines; Benzimidazoles; Benzomorphans; Dose-Response Relationship, Drug; Female; Hot Temperature; Macaca mulatta; Male; Nalbuphine; Naltrexone; Nociceptors; Pyrrolidines; Receptors, Opioid; Tail

1993
Antinociceptive and response rate-altering effects of kappa opioid agonists, spiradoline, enadoline and U69,593, alone and in combination with opioid antagonists in squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:3

    Topics: Analgesics; Animals; Azocines; Benzeneacetamides; Benzofurans; Dose-Response Relationship, Drug; Male; Morphine; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid, kappa; Saimiri

1994
Area tempestas modulates the behavioural responses to nociceptive stimuli in rats.
    Annali dell'Istituto superiore di sanita, 1993, Volume: 29, Issue:3

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Azocines; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Foot; Hot Temperature; Male; Morphine; Naltrexone; Narcotic Antagonists; Olfactory Pathways; Pain; Phenazocine; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Seizures; Tail

1993
Prostaglandin E2-induced thermal hyperalgesia and its reversal by morphine in the warm-water tail-withdrawal procedure in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:3

    Topics: Animals; Azocines; Data Interpretation, Statistical; Dinoprostone; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Sodium Chloride; Temperature

1993
The role of peripheral mu opioid receptors in the modulation of capsaicin-induced thermal nociception in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:1

    Topics: Animals; Azocines; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Hot Temperature; Macaca mulatta; Male; Naltrexone; Pain; Receptors, Opioid, mu

1998
Activation of peripheral kappa opioid receptors inhibits capsaicin-induced thermal nociception in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Azocines; Benzomorphans; Capsaicin; Dynorphins; Female; Hot Temperature; Ligands; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Pain Measurement; Peptide Fragments; Receptors, Opioid, kappa

1999
Effects of U50488 and bremazocine on [Ca2+]i and cAMP in naive and tolerant rat ventricular myocytes: evidence of kappa opioid receptor multiplicity in the heart.
    Journal of molecular and cellular cardiology, 1999, Volume: 31, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Drug Resistance; Electric Stimulation; Heart; Heart Ventricles; Male; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa

1999
Quadazocine decreases responding reinforced by ethanol, sucrose, and phencyclidine fluid deliveries in rhesus monkeys: comparison to naltrexone's effects.
    Psychopharmacology, 1999, Volume: 144, Issue:4

    Topics: Alcohol Drinking; Animals; Azocines; Central Nervous System Depressants; Drinking Behavior; Ethanol; Excitatory Amino Acid Antagonists; Female; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Phencyclidine; Receptors, Opioid; Reinforcement, Psychology; Self Administration; Sucrose

1999
Discriminative stimulus effects of the nonpeptidic delta-opioid agonist SNC80 in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:3

    Topics: Analgesics, Opioid; Animals; Azocines; Benzamides; Discrimination Learning; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Naltrexone; Narcotic Antagonists; Piperazines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism

1999
Effects of E-2078, a stable dynorphin A(1-8) analog, on sedation and serum prolactin levels in rhesus monkeys.
    Psychopharmacology, 1999, Volume: 147, Issue:1

    Topics: Animals; Azocines; Dose-Response Relationship, Drug; Dynorphins; Female; Hypnotics and Sedatives; Injections, Subcutaneous; Macaca mulatta; Male; Motor Activity; Muscle Relaxation; Naltrexone; Narcotic Antagonists; Peptide Fragments; Prolactin; Pyrrolidines; Receptors, Opioid, kappa; Time Factors

1999
Activity of opioid ligands in cells expressing cloned mu opioid receptors.
    BMC pharmacology, 2003, Jan-04, Volume: 3

    Topics: Azocines; beta-Endorphin; Binding, Competitive; Butorphanol; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Etorphine; Fentanyl; Humans; Hydromorphone; Ligands; Morphine; Naltrexone; Phenazocine; Radioligand Assay; Receptors, Opioid, mu; Tritium

2003
Effects of heroin and its metabolites on schedule-controlled responding and thermal nociception in rhesus monkeys: sensitivity to antagonism by quadazocine, naltrindole and beta-funaltrexamine.
    Drug and alcohol dependence, 2003, May-01, Volume: 70, Issue:1

    Topics: Animals; Azocines; Behavior, Animal; Dose-Response Relationship, Drug; Food; Heroin; Hot Temperature; Macaca mulatta; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Pain Measurement

2003
Opposite conditioned place preference responses to endomorphin-1 and endomorphin-2 in the mouse.
    Neuroscience letters, 2004, Jul-29, Volume: 365, Issue:3

    Topics: Animals; Azocines; Conditioning, Operant; Injections, Intraventricular; Ligands; Male; Mice; Naltrexone; Oligopeptides; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2004
Myocardial resistance to ischemic and reperfusion injuries under conditions of chronic administration of opioid receptor agonists and antagonists.
    Bulletin of experimental biology and medicine, 2008, Volume: 145, Issue:6

    Topics: Animals; Azocines; Enkephalin, Leucine-2-Alanine; Heart; Male; Myocardial Reperfusion Injury; Naltrexone; Narcotic Antagonists; Piperazines; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2008