Page last updated: 2024-09-03

quadazocine and naloxone

quadazocine has been researched along with naloxone in 27 studies

Compound Research Comparison

Studies
(quadazocine)
Trials
(quadazocine)
Recent Studies (post-2010)
(quadazocine)
Studies
(naloxone)
Trials
(naloxone)
Recent Studies (post-2010) (naloxone)
810020,1341,2573,321

Protein Interaction Comparison

ProteinTaxonomyquadazocine (IC50)naloxone (IC50)
Cytochrome P450 2D6Homo sapiens (human)2
Delta-type opioid receptorMus musculus (house mouse)0.043
Delta-type opioid receptorRattus norvegicus (Norway rat)0.0219
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0019
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.0019
Mu-type opioid receptorHomo sapiens (human)0.0397
Delta-type opioid receptorHomo sapiens (human)0.1896
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.05
Kappa-type opioid receptorHomo sapiens (human)0.0795
Mu-type opioid receptorMus musculus (house mouse)0.0154
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.0089
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0055

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-199023 (85.19)18.7374
1990's4 (14.81)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Adapa, ID; Auh, JS; Berzetei-Gurske, IP; Brandt, SR; Craymer, K; Farrington, L; Haggart, D; Kennedy, JM; O'Brien, A; Polgar, WE; Rodriguez, L; Schwartz, RW; Toll, L; White, A1
Flitstein, A; Oppenheimer, E; Sarne, Y1
Cagampang, FR; Maeda, K1
Hahn, EF; Howard, DH; Levison, JA; Pasternak, GW; Paul, D; Pick, CG1
France, CP; Morse, WH1
Condon, RE; Szurszewski, JH; Telford, GL1
Skarphedinsson, JO; Thorén, P1
Dodson, BA; Miller, KW1
Bradford, HF; Crowder, JM; White, EJ1
Adler, MW; Geller, EB; Tiseo, PJ1
George, R; Pechnick, R; Poland, RE1
Portoghese, PS; Takemori, AE1
Carter, R; Cooper, SJ; Jackson, A; Morgan, R1
Barber, DJ; Barbour-McMullen, J; Cooper, SJ1
Chandra, A; Diliberto, EJ; Dixon, WR; Holaday, JW; Lewis, JW; Long, JB; Tortella, FC; Unsworth, CD; Viveros, OH; Way, EL1
Faden, AI1
DeFelice, AF; Lape, HE; Michne, WF; Norton, JD1
Gmerek, DE; Woods, JH1
France, CP; Woods, JH1
Huidobro-Toro, JP; Parada, S1
Huidobro-Toro, JP; Way, EL; Yoshimura, K1
Billington, CJ; Gosnell, BA; Levine, AS; Morley, JE1
Curtis, MT; Lefer, AM1
Hynes, MD; Leander, JD1
Amir, S1
Michne, WF; Pierson, AK; Ward, SJ1
Bermudez-Rattoni, F; Cruz-Morales, S; Reid, LD1

Other Studies

27 other study(ies) available for quadazocine and naloxone

ArticleYear
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
    NIDA research monograph, 1998, Volume: 178

    Topics: Animals; Aorta, Thoracic; Cocaine; Cyclic AMP; Electric Stimulation; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Opioid-Related Disorders; Rats; Receptors, Dopamine; Receptors, Opioid; Receptors, Serotonin; Substance-Related Disorders

1998
Anti-arrhythmic activities of opioid agonists and antagonists and their stereoisomers.
    British journal of pharmacology, 1991, Volume: 102, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Azocines; Levorphanol; Male; Morphine; Naloxone; Narcotic Antagonists; Rats; Stereoisomerism

1991
Effects of intracerebroventricular administration of opiate receptor antagonists on the suppressed pulsatile LH release during acute fasting in ovariectomized estradiol-treated rats.
    Life sciences, 1991, Volume: 49, Issue:24

    Topics: Animals; Azocines; Enkephalin, Leucine; Estradiol; Fasting; Female; Injections, Intraventricular; Luteinizing Hormone; Naloxone; Narcotic Antagonists; Ovariectomy; Periodicity; Rats; Rats, Inbred Strains; Receptors, Opioid

1991
Naloxone benzoylhydrazone (NalBzoH) analgesia.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:2

    Topics: Analgesia; Analgesics; Animals; Azocines; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

1990
Pharmacological characterization of supersensitivity to naltrexone in squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 1989, Volume: 250, Issue:3

    Topics: Animals; Azocines; Behavior, Animal; Benzomorphans; Diprenorphine; Drug Administration Schedule; Morphine; Naloxone; Naltrexone; Receptors, Opioid; Saimiri

1989
Opioid receptors and the initiation of migrating myoelectric complexes in dogs.
    The American journal of physiology, 1989, Volume: 256, Issue:1 Pt 1

    Topics: Animals; Azocines; Bethanechol; Bethanechol Compounds; Digestive System; Digestive System Physiological Phenomena; Dogs; Duodenum; Electrophysiology; Food; Gastrointestinal Motility; Ileum; Morphine; Motilin; Naloxone; Narcotic Antagonists; Receptors, Opioid; Stereoisomerism; Stomach

1989
Endorphin mechanisms are responsible for the beneficial effects of opioid antagonists on cerebral function during relative cerebral ischaemia in rats.
    Acta physiologica Scandinavica, 1988, Volume: 132, Issue:3

    Topics: Animals; Azocines; Bicuculline; Brain; Brain Ischemia; Evoked Potentials, Somatosensory; Hemodynamics; Male; Naloxone; Rats; Rats, Inbred SHR; Receptors, Opioid; Thyrotropin-Releasing Hormone

1988
Evidence for a dual mechanism in the anesthetic action of an opioid peptide.
    Anesthesiology, 1985, Volume: 62, Issue:5

    Topics: 1-Octanol; Analgesics, Opioid; Anesthetics; Animals; Atmospheric Pressure; Azocines; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Lipids; Naloxone; Narcotic Antagonists; Octanols; Postural Balance; Rana pipiens; Receptors, Opioid; Reflex; Solubility; Time Factors

1985
Inhibitory actions of opioid compounds on calcium fluxes and neurotransmitter release from mammalian cerebral cortical slices.
    British journal of pharmacology, 1986, Volume: 88, Issue:1

    Topics: Amino Acids; Animals; Azocines; Calcium; Calcium Radioisotopes; Cerebral Cortex; Endorphins; In Vitro Techniques; Naloxone; Narcotic Antagonists; Nerve Tissue Proteins; Neurotransmitter Agents; Potassium; Rats; Stereoisomerism

1986
Antinociceptive action of intracerebroventricularly administered dynorphin and other opioid peptides in the rat.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Azocines; Cold Temperature; Drug Interactions; Dynorphins; Enkephalins; Injections, Intraventricular; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid

1988
Identification of multiple opiate receptors through neuroendocrine responses. II. Antagonism of mu, kappa and sigma agonists by naloxone and WIN 44,441-3.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 232, Issue:1

    Topics: Animals; Azocines; Corticosterone; Cyclazocine; Drug Interactions; Ethylketocyclazocine; Growth Hormone; Luteinizing Hormone; Male; Morphine; Naloxone; Narcotic Antagonists; Phenazocine; Pituitary Hormones, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid

1985
TENA, a selective kappa opioid receptor antagonist.
    Life sciences, 1985, Feb-25, Volume: 36, Issue:8

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Azocines; Benzomorphans; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Guinea Pigs; Ileum; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens

1985
Evidence for opiate receptor involvement in the consumption of a high palatability diet in nondeprived rats.
    Neuropeptides, 1985, Volume: 5, Issue:4-6

    Topics: Animals; Appetite Depressants; Azocines; Diet; Feeding Behavior; Female; Male; Naloxone; Obesity; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Sex Factors

1985
Selective attenuation of sweetened milk consumption by opiate receptor antagonists in male and female rats of the Roman strains.
    Neuropeptides, 1985, Volume: 5, Issue:4-6

    Topics: Animals; Appetite Depressants; Azocines; Benzomorphans; Diprenorphine; Enkephalin, Leucine; Feeding Behavior; Female; Male; Naloxone; Narcotic Antagonists; Rats; Receptors, Opioid; Sex Factors; Species Specificity

1985
Multiple opiate receptors: functional implications.
    Federation proceedings, 1985, Volume: 44, Issue:13

    Topics: Adrenal Medulla; Adrenalectomy; Animals; Azocines; Behavior, Animal; Binding Sites; Blood Pressure; Clonidine; Corticosterone; Enkephalins; Naloxone; Receptors, Opioid; Stress, Physiological; Sympathetic Nervous System

1985
New pharmacologic approaches to spinal cord injury: opiate antagonists and thyrotropin-releasing hormone.
    Central nervous system trauma : journal of the American Paralysis Association, 1985,Spring, Volume: 2, Issue:1

    Topics: Animals; Azocines; Cats; Endorphins; Enkephalin, Leucine; Humans; Naloxone; Narcotic Antagonists; Rabbits; Receptors, Opioid; Spinal Cord Injuries; Thiazolidines; Thyrotropin-Releasing Hormone

1985
Effect of Win 44441-3 and naloxone on endotoxin-induced hypotensive shock in anesthetized hypertensive rats.
    Neuropeptides, 1985, Volume: 5, Issue:4-6

    Topics: Animals; Azocines; Disease Models, Animal; Escherichia coli; Lipopolysaccharides; Male; Naloxone; Rats; Rats, Inbred SHR; Shock, Septic

1985
Effects of beta-funaltrexamine in normal and morphine-dependent rhesus monkeys: observational studies.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Animals; Azocines; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Subcutaneous; Macaca mulatta; Morphine; Muscle Relaxation; Naloxone; Naltrexone; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors

1985
Antagonistic and rate-suppressing effects of opioid antagonists in the pigeon.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Animals; Azocines; Benzomorphans; Buprenorphine; Columbidae; Conditioning, Operant; Diprenorphine; Dose-Response Relationship, Drug; Morphine; Naloxone; Naltrexone; Narcotic Antagonists

1985
Kappa-opiates and urination: pharmacological evidence for an endogenous role of the kappa-opiate receptor in fluid and electrolyte balance.
    European journal of pharmacology, 1984, Dec-15, Volume: 107, Issue:1

    Topics: Animals; Azocines; Benzomorphans; Cyclazocine; Diuresis; Ethylketocyclazocine; Female; Injections, Intraperitoneal; Morphinans; Morphine; Naloxone; Potassium; Rats; Rats, Inbred Strains; Receptors, Opioid; Sodium; Water-Electrolyte Balance

1984
Potency of three opiate antagonists to reverse the inhibitory activity of dynorphin, enkephalins and opioid-like alkaloids on the guinea pig ileum.
    European journal of pharmacology, 1982, Oct-15, Volume: 84, Issue:1-2

    Topics: Animals; Azocines; Benzomorphans; Cyclazocine; Dynorphins; Endorphins; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine Derivatives; Muscle, Smooth; Naloxone; Narcotic Antagonists

1982
Which opioid receptor mechanism modulates feeding?
    Appetite, 1984, Volume: 5, Issue:1

    Topics: Animals; Azocines; Diprenorphine; Dynorphins; Endorphins; Feeding Behavior; Humans; Mice; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma

1984
Beneficial action of a new opiate antagonist (Win 44,441-3) in hemorrhagic shock.
    European journal of pharmacology, 1982, Mar-12, Volume: 78, Issue:3

    Topics: Animals; Azocines; Benzomorphans; Blood Pressure; Cathepsin D; Cathepsins; Cats; Liver; Male; Morphinans; Myocardial Depressant Factor; Naloxone; Narcotic Antagonists; Receptors, Opioid; Shock, Hemorrhagic; Time Factors

1982
Opioid antagonists and drinking: evidence of kappa-receptor involvement.
    European journal of pharmacology, 1983, Mar-04, Volume: 87, Issue:4

    Topics: Animals; Azocines; Benzomorphans; Drinking; Male; Naloxone; Narcotic Antagonists; Rats; Receptors, Opioid

1983
Morphine exacerbates anaphylactic shock in mice by stimulating central opiate receptors.
    Neuroscience letters, 1983, Sep-30, Volume: 40, Issue:2

    Topics: Anaphylaxis; Animals; Azocines; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Naltrexone; Receptors, Opioid

1983
Multiple opioid receptor profile in vitro and activity in vivo of the potent opioid antagonist Win 44,441-3.
    Life sciences, 1983, Volume: 33 Suppl 1

    Topics: Animals; Azocines; Guinea Pigs; Ileum; Male; Mice; Morphine; Muscle Contraction; Naloxone; Narcotic Antagonists; Phenazocine; Receptors, Opioid; Vas Deferens

1983
Addictive agents and intracranial stimulation (ICS): novel antagonists and agonists of morphine and pressing for ICS.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 18, Issue:5

    Topics: Animals; Azocines; Brain; Electric Stimulation; Hypothalamic Area, Lateral; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Self Stimulation

1983