An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of squalene synthase (EC 2.5.1.21).
ChEBI ID: 75174
| Member | Definition | Class |
|---|---|---|
| squalestatin 1 | A polyketide isolated from fungi that is a potent inhibitor of fungal and mammalian squalene synthase. | zaragozic acid A |
| zaragozic acid c | A polyketide isolated from fungi that is a potent inhibitor of fungal and mammalian squalene synthase. | zaragozic acid C |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 47 (41.96) | 18.2507 |
| 2000's | 32 (28.57) | 29.6817 |
| 2010's | 32 (28.57) | 24.3611 |
| 2020's | 1 (0.89) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 6 (5.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 114 (95.00%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | IC50 | 0.0004 | 1 | 2 |
| Protein farnesyltransferase subunit beta | Rattus norvegicus (Norway rat) | IC50 | 0.0120 | 1 | 1 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 0.0120 | 1 | 1 |
| Squalene synthase | Rattus norvegicus (Norway rat) | IC50 | 0.0043 | 2 | 3 |