| Assay ID | Title | Year | Journal | Article |
|---|
| AID466856 | Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as reduction in HbA1c at 100 mg/kg/day for 4 weeks | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID466668 | Inhibition of maltase by HPLC | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID466863 | Mean residence time in ZDE/Crl-leprfa rat at 3 mg/kg, iv | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID437998 | Inhibition of Bacillus stearothermophilus alpha glucosidase | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
| Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. |
| AID626356 | Inhibition of GCS activity in human A549 cells assessed as amount of GM1 on the cell membrane after 72 hrs by FL-CTB-based fluorescent microscopy | 2011 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 21, Issue:22
| Discovery of a new class of glucosylceramide synthase inhibitors. |
| AID466860 | AUC (infinity) in ZDE/Crl-leprfa rat at 3 mg/kg, iv | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID437999 | Inhibition of sweet almond beta glucosidase | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
| Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. |
| AID466853 | Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as reduction in blood insulin at 100 mg/kg/day for 4 weeks | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID437996 | Inhibition of rice alpha glucosidase | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
| Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. |
| AID699186 | Inhibition of GCS in C57/B6 mouse assessed as decrease in liver GM3 level at 25 mg/kg, po qd for 4 days measured 4 hrs post last dose by HPLC analysis | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Discovery and characterization of an inhibitor of glucosylceramide synthase. |
| AID466858 | Dose normalized Cmax in ZDE/Crl-leprfa rat at 3 mg/kg, iv | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID466868 | Antidiabetic activity in ZDF rat assessed as improvement in HbA1c levels at 20 to 100 mg/kg/day for 4 weeks | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID1596612 | Cytotoxicity against human CuFi1 cells assessed as reduction in cell viability incubated for 48 hrs by Muse cell analyser method | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease. |
| AID466666 | Inhibition of GCS by cell-based assay | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID1596606 | Inhibition of NLGase in human SH-SY5Y cells at 1 nM to 1 mM using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of AMP-DNM by fluorescence based assay relative to control | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease. |
| AID553253 | Inhibition of recombinant GBA1 preincubated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2
| Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID1596608 | Anti-inflammatory activity in human CuFi1 cells assessed as reduction in Pseudomonas aeruginosa PAO1-induced IL-8 mRNA expression level pretreated for 1 hr followed by Pseudomonas aeruginosa PAO1 challenge and measured after 4 hrs by RT-PCR analysis | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease. |
| AID466852 | Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as reduction in blood glucose at 100 mg/kg/day for 4 weeks | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID466870 | Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as blood glucose AUC at 100 mg/kg/day, po treated for 6 weeks administered 1 g/kg sucrose treatment at end of week 4 followed by 0.5 g/kg glucose treatment at end of week 6 measured | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID466869 | Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as blood glucose AUC at 100 mg/kg/day, po treated for 4 weeks followed by 1 g/kg sucrose treatment after last dose measured after 1 hr after sucrose challenge (Rvb=1325+/-210 mM.min | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID466670 | Inhibition of GBA1 by HPLC | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID437994 | Inhibition of human GBA2 | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
| Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. |
| AID437995 | Inhibition of human lysosomal alpha glucosidase | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
| Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. |
| AID553255 | Inhibition of sucrase in mouse intestinal input by glucose release assay | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2
| Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID466864 | Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as reduction in liver glycosphingolipids at 100 mg/kg/day for 4 weeks | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID466673 | Inhibition of glycogen glycogen de-branching enzyme by HPLC | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID466867 | Antidiabetic activity in ZDF rat assessed as improvement in blood glucose concentration at 20 to 100 mg/kg/day for 4 weeks | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID1596611 | Induction of apoptosis in human CuFi1 cells incubated for 48 hrs by Muse Annexin V based cell counter assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease. |
| AID466862 | Bioavailability in ZDE/Crl-leprfa rat at 3 mg/kg, iv | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID466674 | Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as reduction in plasma glycosphingolipids at 100 mg/kg/day for 4 weeks | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID466672 | Inhibition of lysosomal alpha-glucosidase by HPLC | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID1166039 | Inhibition of GBA2 (unknown origin) | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21
| Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors. |
| AID699187 | Inhibition of GCS in C57/B6 mouse assessed as decrease in liver lactosylceramide level at 25 mg/kg, po qd for 4 days measured 4 hrs post last dose by HPLC analysis | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Discovery and characterization of an inhibitor of glucosylceramide synthase. |
| AID466859 | Half life in ZDE/Crl-leprfa rat at 3 mg/kg, iv | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID553256 | Inhibition of lactase in mouse intestinal input by glucose release assay | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2
| Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID699189 | Inhibition of GCS in C57/B6 mouse assessed as decrease in liver ceramide level at 25 mg/kg, po qd for 4 days measured 4 hrs post last dose by HPLC analysis | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Discovery and characterization of an inhibitor of glucosylceramide synthase. |
| AID699203 | Inhibition of GCS assessed as amount of UDP glucose after 3 hrs by Fluorometry analysis | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Discovery and characterization of an inhibitor of glucosylceramide synthase. |
| AID466855 | Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as insulin resistance at 100 mg/kg/day for 4 weeks by HOMA-IR analysis | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID553254 | Inhibition of recombinant GBA2 preincubated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assay | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2
| Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID466667 | Inhibition of sucrase by HPLC | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID1596603 | Inhibition of GCase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of conduritol B epoxide by fluorescence based assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease. |
| AID626355 | Inhibition of GCS assessed as amount of UDP-glucose consumed during enzyme-catalyzed reaction | 2011 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 21, Issue:22
| Discovery of a new class of glucosylceramide synthase inhibitors. |
| AID1596605 | Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of AMP-DNM by fluorescence based assay | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease. |
| AID700849 | Activation of Beta-glucocerebrosidase G202R mutant in cell based assay | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
| The many faces of the adamantyl group in drug design. |
| AID1166041 | Inhibition of intestinal lactase (unknown origin) | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21
| Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors. |
| AID699188 | Inhibition of GCS in C57/B6 mouse assessed as decrease in liver glucosylceramide level at 25 mg/kg, po qd for 4 days measured 4 hrs post last dose by HPLC analysis | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Discovery and characterization of an inhibitor of glucosylceramide synthase. |
| AID652572 | Inhibition of recombinant glucosylceramidase 1 using 4-methylumbelliferyl-B-glucoside as substrate by fluorimetric analysis | 2011 | ACS medicinal chemistry letters, Jul-14, Volume: 2, Issue:7
| Assessment of partially deoxygenated deoxynojirimycin derivatives as glucosylceramide synthase inhibitors. |
| AID1166037 | Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramide | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21
| Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors. |
| AID466865 | Antidiabetic activity in ZDF rat assessed as reduction in plasma glycosphingolipids at 20 to 100 mg/kg/day for 4 weeks | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID553258 | Selectivity index, ratio of IC50 for recombinant GBA1 to IC50 for glucosylceramide synthase in mouse RAW cells | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2
| Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID699202 | Inhibition of GCS in human A549 cells assessed as decrease in GM1 synthesis after 72 hrs by Fluorescence assay | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Discovery and characterization of an inhibitor of glucosylceramide synthase. |
| AID1166042 | Inhibition of intestinal maltase (unknown origin) | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21
| Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors. |
| AID1596604 | Inhibition of GCase in human SH-SY5Y cells at 1 nM to 1 mM using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs in presence of conduritol B epoxide by fluorescence based assay relative to | 2019 | European journal of medicinal chemistry, Aug-01, Volume: 175 | Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease. |
| AID466857 | Cmax in ZDE/Crl-leprfa rat at 3 mg/kg, iv | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID466669 | Inhibition of lactase by HPLC | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID1166040 | Inhibition of intestinal sucrase (unknown origin) | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21
| Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors. |
| AID466866 | Antidiabetic activity in ZDF rat assessed as reduction in liver glycosphingolipids at 20 to 100 mg/kg/day for 4 weeks | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID437993 | Inhibition of human GBA1 | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
| Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. |
| AID437997 | Inhibition of Saccharomyces cerevisiae alpha glucosidase | 2009 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23
| Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. |
| AID700851 | Inhibition of non-lysosomal glucosylceramidase in cultured melanoma cells | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
| The many faces of the adamantyl group in drug design. |
| AID700850 | Activation of Beta-glucocerebrosidase N370S mutant in cell based assay | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
| The many faces of the adamantyl group in drug design. |
| AID466854 | Antidiabetic activity in obese, insulin resistant C57BL/6J mouse assessed as increase in glucose tolerance at 100 mg/kg/day for 4 weeks by OGTT | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID700852 | Inhibition of non-lysosomal glucosylceramidase | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
| The many faces of the adamantyl group in drug design. |
| AID1166038 | Inhibition of GBA1 (unknown origin) using beta-D-[1-14C]glucocerebroside assessed as 4-methylumbelliferrone by fluorimetry | 2014 | Journal of medicinal chemistry, Nov-13, Volume: 57, Issue:21
| Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors. |
| AID553257 | Inhibition of maltase in mouse intestinal input by glucose release assay | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2
| Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID553252 | Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assay | 2011 | ACS medicinal chemistry letters, Feb-10, Volume: 2, Issue:2
| Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. |
| AID652571 | Inhibition of glucosylceramide synthase in mouse RAW cells preincubated for 15 mins followed by substrate addition and measured after 1 hr by fluorescence scanner | 2011 | ACS medicinal chemistry letters, Jul-14, Volume: 2, Issue:7
| Assessment of partially deoxygenated deoxynojirimycin derivatives as glucosylceramide synthase inhibitors. |
| AID466861 | Dose normalized AUC (infinity) in ZDE/Crl-leprfa rat at 3 mg/kg, iv | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID466671 | Inhibition of GBA2 by HPLC | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. |
| AID652573 | Inhibition of glucosylceramidase 2 from spleen of patient with gaucher's disease by fluorimetric analysis | 2011 | ACS medicinal chemistry letters, Jul-14, Volume: 2, Issue:7
| Assessment of partially deoxygenated deoxynojirimycin derivatives as glucosylceramide synthase inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |