scavenger receptor binding

Definition

Target type: molecularfunction

Binding to scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles. [GOC:ceb]

Scavenger receptors are a diverse family of cell surface receptors that bind and internalize a wide range of ligands, including modified lipoproteins, polysaccharides, and pathogens. These receptors play crucial roles in cellular processes such as lipid metabolism, immune surveillance, and inflammation. The molecular function of scavenger receptor binding involves the recognition and interaction of the receptor with its specific ligands through non-covalent interactions, such as electrostatic forces, hydrogen bonds, and hydrophobic interactions. This binding event triggers a series of downstream signaling events that ultimately lead to the internalization of the ligand via endocytosis. Once internalized, the ligand can be degraded, recycled, or presented to other cellular components for further processing. The specific molecular mechanisms underlying scavenger receptor binding vary depending on the receptor and ligand involved. For example, some scavenger receptors utilize a specific binding site for a particular ligand, while others may exhibit broader specificity. In addition, the affinity of the interaction between the receptor and ligand can also vary depending on the specific molecules involved. Despite these variations, the overall molecular function of scavenger receptor binding is to facilitate the uptake and processing of a diverse range of molecules that are essential for maintaining cellular homeostasis.'
"

Proteins (3)

Compounds (48)