Page last updated: 2024-08-05 15:43:23
EC 3.2.1.45 (glucosylceramidase) inhibitor
An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of glucosylceramidase (EC 3.2.1.45).
ChEBI ID: 67230
Members (1)
| Member | Definition | Class |
|---|---|---|
| n-nonyl-1-deoxynojirimycin | A hydroxypiperidine that is deoxynojirimycin (duvoglustat) in which the amino hydrogen is replaced by a nonyl group. | N-nonyldeoxynojirimycin |
Research
Studies (36)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.78) | 18.2507 |
| 2000's | 12 (33.33) | 29.6817 |
| 2010's | 22 (61.11) | 24.3611 |
| 2020's | 1 (2.78) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (2.70%) | 5.53% |
| Reviews | 4 (10.81%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 32 (86.49%) | 84.16% |
Protein Targets (17)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, Glucosylceramidase | Homo sapiens (human) | Potency | 0.0858 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 2.0575 | 1 | 1 |
| putative alpha-glucosidase | Oryza sativa Japonica Group (Japanese rice) | Potency | 0.0531 | 1 | 1 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alpha-galactosidase | Coffea arabica (coffee) | IC50 | 65.0000 | 2 | 2 |
| Beta-galactosidase | Bos taurus (cattle) | IC50 | 65.0000 | 2 | 2 |
| Beta-galactosidase | Mus musculus (house mouse) | IC50 | 200.0000 | 1 | 1 |
| Ceramide glucosyltransferase | Mus musculus (house mouse) | IC50 | 4.0000 | 1 | 1 |
| Cytochrome P450 2A6 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Galactocerebrosidase | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Lysosomal acid glucosylceramidase | Homo sapiens (human) | IC50 | 1.2639 | 15 | 15 |
| Lysosomal acid glucosylceramidase | Homo sapiens (human) | Ki | 0.4429 | 7 | 7 |
| Lysosomal alpha-glucosidase | Mus musculus (house mouse) | IC50 | 8.0000 | 1 | 1 |
| Non-lysosomal glucosylceramidase | Homo sapiens (human) | IC50 | 0.0050 | 2 | 2 |
| Oligo-1,6-glucosidase IMA1 | Saccharomyces cerevisiae S288C | IC50 | 100.0000 | 1 | 1 |
| Probable alpha-glucosidase Os06g0675700 | Oryza sativa Japonica Group (Japanese rice) | IC50 | 100.0000 | 1 | 1 |
| Protein-lysine 6-oxidase | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| Protein-lysine 6-oxidase | Homo sapiens (human) | Ki | 0.3000 | 1 | 1 |
| Sucrase-isomaltase | Mus musculus (house mouse) | IC50 | 0.4000 | 1 | 1 |