Page last updated: 2024-08-05 15:43:23

EC 3.2.1.45 (glucosylceramidase) inhibitor

An EC 3.2.1.* (glycosidase) inhibitor that interferes with the action of glucosylceramidase (EC 3.2.1.45).

ChEBI ID: 67230

Members (1)

MemberDefinitionClass
n-nonyl-1-deoxynojirimycinA hydroxypiperidine that is deoxynojirimycin (duvoglustat) in which the amino hydrogen is replaced by a nonyl group.N-nonyldeoxynojirimycin

Research

Studies (36)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (2.78)18.2507
2000's12 (33.33)29.6817
2010's22 (61.11)24.3611
2020's1 (2.78)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials1 (2.70%)5.53%
Reviews4 (10.81%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other32 (86.49%)84.16%

Protein Targets (17)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain A, GlucosylceramidaseHomo sapiens (human)Potency0.085811
glucocerebrosidaseHomo sapiens (human)Potency2.057511
putative alpha-glucosidaseOryza sativa Japonica Group (Japanese rice)Potency0.053111

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Alpha-galactosidaseCoffea arabica (coffee)IC5065.000022
Beta-galactosidaseBos taurus (cattle)IC5065.000022
Beta-galactosidaseMus musculus (house mouse)IC50200.000011
Ceramide glucosyltransferaseMus musculus (house mouse)IC504.000011
Cytochrome P450 2A6Homo sapiens (human)IC5030.000011
Cytochrome P450 2C9 Homo sapiens (human)IC5030.000011
GalactocerebrosidaseHomo sapiens (human)IC5030.000011
Lysosomal acid glucosylceramidaseHomo sapiens (human)IC501.26391515
Lysosomal acid glucosylceramidaseHomo sapiens (human)Ki0.442977
Lysosomal alpha-glucosidaseMus musculus (house mouse)IC508.000011
Non-lysosomal glucosylceramidaseHomo sapiens (human)IC500.005022
Oligo-1,6-glucosidase IMA1Saccharomyces cerevisiae S288CIC50100.000011
Probable alpha-glucosidase Os06g0675700Oryza sativa Japonica Group (Japanese rice)IC50100.000011
Protein-lysine 6-oxidaseHomo sapiens (human)IC501.500011
Protein-lysine 6-oxidaseHomo sapiens (human)Ki0.300011
Sucrase-isomaltase Mus musculus (house mouse)IC500.400011