regulation of striated muscle tissue development
Definition
Target type: biologicalprocess
Any process that modulates the frequency, rate or extent of striated muscle development. [GOC:go_curators]
Striated muscle tissue development is a complex process involving a coordinated interplay of genetic, epigenetic, and environmental factors. It begins with the commitment of mesodermal precursor cells to the myogenic lineage. This commitment is driven by the expression of specific transcription factors, such as Myf5 and MyoD, which activate the myogenic program. Myogenic progenitor cells then undergo a series of proliferative and differentiative stages. During proliferation, cells divide rapidly, expanding the pool of myoblasts. These cells then differentiate into myocytes, fusing together to form multinucleated myotubes. Myotube formation is accompanied by the synthesis and assembly of muscle-specific proteins, including myosin, actin, and titin. These proteins are organized into sarcomeres, the basic contractile units of muscle. The sarcomeres are then aligned in parallel within the myofibrils, which are bundled together to form muscle fibers. The development of striated muscle is tightly regulated by a complex network of signaling pathways. These pathways are influenced by a variety of factors, including growth factors, hormones, and mechanical stimuli. For instance, the Wnt signaling pathway plays a crucial role in the proliferation and differentiation of myoblasts, while the Hedgehog signaling pathway regulates myoblast migration and fusion. As muscle fibers mature, they undergo hypertrophy, increasing in size and strength. This process involves the addition of new sarcomeres and the production of new myofibrils. Regulation of striated muscle development is also influenced by the surrounding environment. For example, the availability of nutrients and oxygen is critical for muscle growth and differentiation. Overall, the development of striated muscle is a highly orchestrated process that involves the precise regulation of cell proliferation, differentiation, and growth. This complex process is essential for the formation of functional muscle tissue, which is critical for movement, locomotion, and overall bodily function.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Protein-lysine 6-oxidase | A protein-lysine 6-oxidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P28300] | Homo sapiens (human) |
Compounds (10)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| pyrithione | pyrithione : A pyridinethione that is pyridine-2(1H)-thione in which the hydrogen attached to the nitrogen is replaced by a hydroxy group. It is a Zn(2+) ionophore; the zinc salt is used as an antifungal and antibacterial agent. pyrithione: split from cephalosporin molecule; some metal complexes of this have fumarate reductase inhibitory activity and may be useful against trypanosomes; RN given refers to parent cpd; structure | monohydroxypyridine; pyridinethione | ionophore |
| aminopropionitrile | Aminopropionitrile: Reagent used as an intermediate in the manufacture of beta-alanine and pantothenic acid. | aminopropionitrile | antineoplastic agent; antirheumatic drug; collagen cross-linking inhibitor; plant metabolite |
| disulfiram | organic disulfide; organosulfur acaricide | angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor; EC 3.1.1.1 (carboxylesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 5.99.1.2 (DNA topoisomerase) inhibitor; ferroptosis inducer; fungicide; NF-kappaB inhibitor | |
| thiram | thiram : An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment. Thiram: A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations. | organic disulfide | antibacterial drug; antifungal agrochemical; antiseptic drug |
| 1-deoxynojirimycin | 1-deoxy-nojirimycin: structure in first source duvoglustat : An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration. | 2-(hydroxymethyl)piperidine-3,4,5-triol; piperidine alkaloid | anti-HIV agent; anti-obesity agent; bacterial metabolite; EC 3.2.1.20 (alpha-glucosidase) inhibitor; hepatoprotective agent; hypoglycemic agent; plant metabolite |
| miglustat | miglustat : A hydroxypiperidine that is deoxynojirimycin in which the amino hydrogen is replaced by a butyl group. miglustat: a glucosylceramide synthase inhibitor | piperidines; tertiary amino compound | anti-HIV agent; EC 2.4.1.80 (ceramide glucosyltransferase) inhibitor |
| mor-14 | N-methyldeoxynojirimycin: glucosidase inhibitor | hydroxypiperidine; piperidine alkaloid; tertiary amino compound | anti-HIV agent; cardioprotective agent; EC 3.2.1.20 (alpha-glucosidase) inhibitor; plant metabolite |
| homonojirimycin | homonojirimycin: inhibits alpha-glucosidase; RN given for (2R-(2alpha,3alpha,4beta,5alpha,6beta))-isomer; structure in first source | ||
| n-nonyl-1-deoxynojirimycin | N-nonyldeoxynojirimycin : A hydroxypiperidine that is deoxynojirimycin (duvoglustat) in which the amino hydrogen is replaced by a nonyl group. | hydroxypiperidine; tertiary amino compound | antiviral agent; EC 3.2.1.20 (alpha-glucosidase) inhibitor; EC 3.2.1.45 (glucosylceramidase) inhibitor |
| somatostatin | heterodetic cyclic peptide; peptide hormone |