Compounds > mk 0608
Page last updated: 2024-12-10

mk 0608

Description

7-deaza-2'-C-methyladenosine: an antiviral agent [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID3011893
CHEMBL ID236207
SCHEMBL ID733423
MeSH IDM0535762

Synonyms (40)

Synonym
AKOS015840274
7-deaza-2'-c-methyl-adenosine
(2r,3r,4r,5r)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol
7h-pyrrolo[2,3-d]pyrimidin-4-amine, 7-(2-c-methyl-b-d-ribofuranosyl)-
beta-2'-c-methyl-7-deaza-adenosine
CHEMBL236207
7-deaza-2'-c-methyladenosine
443642-29-3
(2r,3r,4r,5r)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol
A7035
(2r,3r,4r,5r)-2-(4-amino-7h-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol
(2r,3r,4r,5r)-2-(4-amino-7h-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol
7h-pyrrolo(2,3-d)pyrimidin-4-amine, 7-(2-c-methyl-beta-d-ribofuranosyl)-
mk 0608
mk-0608
unii-qrr62j6wef
qrr62j6wef ,
AKOS015901326
7h-pyrrolo(2,3-d)pyrimidin-4-amine, 7-(2-c-methyl-.beta.-d-ribofuranosyl)-
1001913-41-2
SCHEMBL733423
IRZRJANZDIOOIF-GAJNKVMBSA-N
4-amino-7-(2-c-methyl-beta-d-ribofuranosyl)-7h-pyrrolo[2,3-d]pyrimidine
4-amino-7-(2'-methyl-beta-d-ribofuranosyl)-7h-pyrrolo[2,3-d]pyrimidine
7-(2'-c-methyl-beta-d-ribofuranosyl)-4-amino-pyrrolo[2,3-d]pyrimidine
mk-608
mfcd14584964
BBL103031
STL556840
7-(2-c-methyl-beta-d-ribofuranosyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine
CS-0002510
(2r,3r,4r,5r)-2-(4-amino-7h-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyl tetrahydrofuran-3,4-diol
F12808
lamevudine
Q23309937
DTXSID60963208
HY-10244
h5v ,
AS-82894
7-deaza-2'-c-methyl-d-adenosine

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" 2'-C-Methyladenosine was found to be susceptible to enzymatic conversions by adenosine deaminase and purine nucleoside phosphorylase, and it displayed limited oral bioavailability in the rat."( Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication.
Ball, RG; Bennett, CF; Bera, S; Bhat, B; Bhat, N; Bosserman, M; Brooks, J; Burlein, C; Carroll, SS; Colwell, LF; Cook, PD; Dande, P; Eldrup, AB; Fay, JF; Flores, OA; Getty, K; LaFemina, RL; Leone, J; MacCoss, M; McMasters, DR; Olsen, DB; Prakash, TP; Prhavc, M; Song, Q; Tomassini, JE; Von Langen, D; Wolanski, B, 2004)		0.32
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (36)

Assay IDTitleYearJournalArticle
AID438027Antiviral activity against Dengue virus by cell based assay2009Journal of medicinal chemistry, Dec-24, Volume: 52, Issue:24
The medicinal chemistry of dengue fever.
AID662447Cytotoxicity against human HuH7 cells after 24 hrs by MTS assay2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors.
AID1156121Cytotoxicity against human HuH7 cells by MTT assay2014ACS medicinal chemistry letters, Jun-12, Volume: 5, Issue:6
Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents.
AID1542953Antiviral activity against Zika virus MR766 infected in African green monkey Vero E6 cells assessed as reduction in virus yield2019ACS medicinal chemistry letters, Apr-11, Volume: 10, Issue:4
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication.
AID740798Cytotoxicity against human HuH7 cells2013Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7
Synthesis and evaluation against hepatitis C virus of 7-deaza analogues of 2'-C-methyl-6-O-methyl guanosine nucleoside and L-Alanine ester phosphoramidates.
AID662448Inhibition of HCV genotype 1b NS5B after 90 mins2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors.
AID1636906Inhibition of DOT1L (unknown origin) at 200 uM using chicken nucleosome as substrate in presence of [3H]SAM incubated for 1 hr by TopCount method2016Bioorganic & medicinal chemistry letters, 09-15, Volume: 26, Issue:18
New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms.
AID1206545Antiviral activity in HCV 2a JFH1 infected in HUH 7-lunet cells after 3 days by Dual-Glo luciferase assay2015Journal of medicinal chemistry, May-14, Volume: 58, Issue:9
Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action.
AID662521Prodrug activation in Golden Syrian hamster liver assessed as compound triphosphate form at 20 mg/kg, po after 4 to 24 hrs2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors.
AID1542955Selectivity index, ratio of CC50 for African green monkey Vero B cells to EC50 for Dengue virus type 2 NGC infected in African green monkey Vero B cells2019ACS medicinal chemistry letters, Apr-11, Volume: 10, Issue:4
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication.
AID1638600Antiviral activity against West Nile virus2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection.
AID1156120Antiviral activity against Hepatitis C virus assessed as inhibition of subgenomic replicon RNA replication2014ACS medicinal chemistry letters, Jun-12, Volume: 5, Issue:6
Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents.
AID672003Antiviral activity against Hepatitis C virus genotype 1b infected in human HBI10A cells assessed as inhibition of viral replication in presence of 10% FBS2012Bioorganic & medicinal chemistry, Aug-01, Volume: 20, Issue:15
Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase.
AID1542950Antiviral activity against Zika virus2019ACS medicinal chemistry letters, Apr-11, Volume: 10, Issue:4
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication.
AID1206546Cytotoxicity against human HeLa cells2015Journal of medicinal chemistry, May-14, Volume: 58, Issue:9
Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action.
AID1206542Anticoxsackie activity in CVB3 strain Nancy infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 4 hrs by XTT assay2015Journal of medicinal chemistry, May-14, Volume: 58, Issue:9
Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action.
AID299923Antiviral activity against HCV genotype 1b in Huh7 cells assessed as inhibition of viral RNA replication after 72 hrs by ribonuclease protection assay2007Bioorganic & medicinal chemistry, Aug-01, Volume: 15, Issue:15
Synthesis and HCV inhibitory properties of 9-deaza- and 7,9-dideaza-7-oxa-2'-C-methyladenosine.
AID1206544Antiviral activity in HCV 1b infected in HUH 7-lunet cells after 3 days by Dual-Glo luciferase assay2015Journal of medicinal chemistry, May-14, Volume: 58, Issue:9
Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action.
AID740799Antiviral activity against Hepatitis C virus assessed as inhibition of viral replication2013Bioorganic & medicinal chemistry letters, Apr-01, Volume: 23, Issue:7
Synthesis and evaluation against hepatitis C virus of 7-deaza analogues of 2'-C-methyl-6-O-methyl guanosine nucleoside and L-Alanine ester phosphoramidates.
AID245909Cytotoxicity against HB-1 cells in an MTS-based assay2004Journal of medicinal chemistry, Oct-07, Volume: 47, Issue:21
Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication.
AID246173Inhibition of HCV RNA replication in a subgenomic bicistronic replicon assay in HB-1 cells2004Journal of medicinal chemistry, Oct-07, Volume: 47, Issue:21
Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication.
AID299922Antiviral activity against HCV genotype 1b in Huh7 cells assessed as inhibition of viral RNA replication after 24 hrs by ribonuclease protection assay2007Bioorganic & medicinal chemistry, Aug-01, Volume: 15, Issue:15
Synthesis and HCV inhibitory properties of 9-deaza- and 7,9-dideaza-7-oxa-2'-C-methyladenosine.
AID1542949Antiviral activity against Dengue virus2019ACS medicinal chemistry letters, Apr-11, Volume: 10, Issue:4
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication.
AID1156129Inhibition of N-terminal His6-tagged Hepatitis C virus genotype 1b isolate Con1 NS5B RNA-dependent RNA polymerase activity by plate reader analysis2014ACS medicinal chemistry letters, Jun-12, Volume: 5, Issue:6
Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents.
AID1542952Cytotoxicity in African green monkey Vero B cells assessed as reduction in cell viability by MTS assay2019ACS medicinal chemistry letters, Apr-11, Volume: 10, Issue:4
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication.
AID1070548Selectivity ratio of EC50 for HCV harboring NS5B RNA dependent RNA polymerase S282T mutant to EC50 for wild-type HCV2014Journal of medicinal chemistry, Mar-13, Volume: 57, Issue:5
Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients.
AID1542956Selectivity index, ratio of CC50 for African green monkey Vero E6 cells to EC50 for Zika virus MR766 infected in African green monkey Vero E6 cells2019ACS medicinal chemistry letters, Apr-11, Volume: 10, Issue:4
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication.
AID299924Cytotoxicity against Huh7 cells after 24 hrs by MTS assay2007Bioorganic & medicinal chemistry, Aug-01, Volume: 15, Issue:15
Synthesis and HCV inhibitory properties of 9-deaza- and 7,9-dideaza-7-oxa-2'-C-methyladenosine.
AID662523Prodrug activation in Sprague-Dawley rat liver assessed as compound triphosphate form at 2 mg/kg, po after 4 to 24 hrs2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors.
AID1156119Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH7 cells assessed as inhibition of subgenomic replicon RNA replication after 72 hrs by luciferase reporter assay2014ACS medicinal chemistry letters, Jun-12, Volume: 5, Issue:6
Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents.
AID1206543Antirhinovirus activity in HRVM infected in H1-HeLa cells assessed as inhibition of virus-induced cytopathic effect after 3 days by Cell-Titer Glo viability assay2015Journal of medicinal chemistry, May-14, Volume: 58, Issue:9
Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action.
AID1156128Inhibition of Hepatitis C virus NS5B RNA-dependent RNA polymerase activity2014ACS medicinal chemistry letters, Jun-12, Volume: 5, Issue:6
Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents.
AID662449Stability of the compound assessed as compound remaining at 10 uM after 60 mins in presence of bovine adenosine deaminase2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors.
AID1542951Antiviral activity against Dengue virus type 2 NGC infected in African green monkey Vero B cells assessed as reduction in virus yield2019ACS medicinal chemistry letters, Apr-11, Volume: 10, Issue:4
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication.
AID1542954Cytotoxicity in African green monkey Vero E6 cells assessed as reduction in cell viability by MTS assay2019ACS medicinal chemistry letters, Apr-11, Volume: 10, Issue:4
Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication.
AID662446Antiviral activity against HCV genotype 1b infected in human HuH7 cells assessed as cytoprotection after 24 hrs2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (22)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (22.73)29.6817
2010's16 (72.73)24.3611
2020's1 (4.55)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.03

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.03 (24.57)
Research Supply Index3.14 (2.92)
Research Growth Index4.98 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.03)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.55%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other21 (95.45%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pleconaril
WIN 63843: structure given in first source		2.110
aurintricarboxylic acid
Aurintricarboxylic Acid: A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.. aurintricarboxylic acid : A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'.		3.1410monohydroxybenzoic acid;
quinomethanes;
tricarboxylic acid		fluorochrome;
histological dye;
insulin-like growth factor receptor 1 antagonist
suramin
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.. suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.		3.1410naphthalenesulfonic acid;
phenylureas;
secondary carboxamide		angiogenesis inhibitor;
antinematodal drug;
antineoplastic agent;
apoptosis inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
GABA antagonist;
GABA-gated chloride channel antagonist;
purinergic receptor P2 antagonist;
ryanodine receptor agonist;
trypanocidal drug
azauridine
Azauridine: A triazine nucleoside used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.		3.1410N-glycosyl-1,2,4-triazineantimetabolite;
antineoplastic agent;
drug metabolite
leucine
Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.		2.0610amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
phenylalanine
Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.		2.110amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
cytidine
[no description available]		2.5420cytidinesEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
tubercidin
Tubercidin: An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids.. tubercidin : An N-glycosylpyrrolopyrimidine that is adenosine in which the in the 5-membered ring that is not attached to the ribose moiety is replaced by a carbon. Tubercidin is produced in the culture broth of Streptomyces tubericidus.		3.89110antibiotic antifungal agent;
N-glycosylpyrrolopyrimidine;
ribonucleoside		antimetabolite;
antineoplastic agent;
bacterial metabolite
valine
Valine: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.. valine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isopropyl group.. L-valine : The L-enantiomer of valine.		2.110L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid;
valine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
isoxazoles
Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.		2.110isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		2.1101,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
toyocamycin
Toyocamycin: 4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an analog of adenosine, blocks RNA synthesis and ribosome function, and is used mainly as a tool in biochemistry.. toyocamycin : An N-glycosylpyrrolopyrimidine that is tubercidin in which the hydrogen at position 5 of the pyrrolopyrimidine moiety has been replaced by a cyano group.		2.1310antibiotic antifungal agent;
N-glycosylpyrrolopyrimidine;
nitrile;
ribonucleoside		antimetabolite;
antineoplastic agent;
apoptosis inducer;
bacterial metabolite
nsc 65346
sangivamycin: RN given refers to parent cpd. sangivamycin : A nucleoside analogue that is adenosine in which the nitrogen at position 7 is replaced by a carbamoyl-substituted carbon. It is a potent inhibitor of protein kinase C.		2.1310nucleoside analogueprotein kinase inhibitor
3-deazaadenosine
3-deazaadenosine: RN given refers to parent cpd.		2.1310
1-deoxynojirimycin
1-deoxy-nojirimycin: structure in first source. duvoglustat : An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.		2.03102-(hydroxymethyl)piperidine-3,4,5-triol;
piperidine alkaloid		anti-HIV agent;
anti-obesity agent;
bacterial metabolite;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
hepatoprotective agent;
hypoglycemic agent;
plant metabolite
ribavirin
Rebetron: Rebetron is tradename		4.1401-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
castanospermine
castanospermine: indolizidine alkaloid from seeds of Australian legume, Castanospermum australe. castanospermine : A tetrahydroxyindolizidine alkaloid that consists of octahydroindolizine having four hydroxy substituents located at positions 1, 6, 7 and 8 (the 1S,6S,7R,8R,8aR-diastereomer).		3.1410indolizidine alkaloidanti-HIV-1 agent;
anti-inflammatory agent;
EC 3.2.1.* (glycosidase) inhibitor;
metabolite
celgosivir
celgosivir: inhibits glycoprotein processing & the growth of HIVs		2.0310
adenosine
quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit		3.0740adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
triciribine
[no description available]		2.1310nucleoside analogueEC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
pirodavir
pirodavir: antipicornavirus agent; structure given in first source		2.110
5-iodotubercidin
7-iodotubercidin: inhibits Toxoplasma gondii adenosine kinase		2.1310organoiodine compound
antibiotic g 418
antibiotic G 418: from Micromonospora rhodorangea		3.1410
win 56291
Win 56291: anti-rhinoviral drug; structure given in first source		2.110
proline
Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.		2.0610amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid		algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
vx 497
N-3-(3-(3-methoxy-4-oxazol-5-ylphenyl)ureido)benzylcarbamic acid tetrahydrofuran-3-yl ester: structure in first source		3.1410
s-adenosylhomocysteine
S-Adenosylhomocysteine: 5'-S-(3-Amino-3-carboxypropyl)-5'-thioadenosine. Formed from S-adenosylmethionine after transmethylation reactions.. S-adenosyl-L-homocysteine : An organic sulfide that is the S-adenosyl derivative of L-homocysteine.		2.1310adenosines;
amino acid zwitterion;
homocysteine derivative;
homocysteines;
organic sulfide		cofactor;
EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor;
EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor;
epitope;
fundamental metabolite
mycophenolic acid
Mycophenolic Acid: Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.. mycophenolate : A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of mycophenolic acid.. mycophenolic acid : A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.		3.14102-benzofurans;
gamma-lactone;
monocarboxylic acid;
phenols		anticoronaviral agent;
antimicrobial agent;
antineoplastic agent;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
environmental contaminant;
immunosuppressive agent;
mycotoxin;
Penicillium metabolite;
xenobiotic
2'-c-methyladenosine
2'-C-methyladenosine: antiviral		3.4870
2'-c-methylcytidine
2'-C-methylcytidine: structure in first source		2.830
2'-c-methyluridine
2'-C-methyluridine: structure in first source		2.0710
n-nonyl-1-deoxynojirimycin
N-nonyldeoxynojirimycin : A hydroxypiperidine that is deoxynojirimycin (duvoglustat) in which the amino hydrogen is replaced by a nonyl group.		2.0310hydroxypiperidine;
tertiary amino compound		antiviral agent;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
EC 3.2.1.45 (glucosylceramidase) inhibitor
telaprevir
[no description available]		2.0610cyclopentapyrrole;
cyclopropanes;
oligopeptide;
pyrazines		antiviral drug;
hepatitis C protease inhibitor;
peptidomimetic
zosteric acid
zosteric acid: has antifouling activity; isolated from eelgrass; structure in first source. 4-(sulfooxy)-cinnamic acid : An aryl sulfate that is (2E)-3-phenylprop-2-enoic acid which is substituted by a sulfooxy group at position 4. It is produced by the seagrass Zostera marina and has very promising antifouling potential against several micro- and macrofouling organisms.		3.1410aryl sulfate;
cinnamic acids		antifouling biocide;
plant metabolite
rupintrivir
rupintrivir: a rhinovirus 3C protease inhibitor		2.110
valopicitabine
valopicitabine: prodrug of 2'-C-methylcytidine; an anti-hepatitis C virus agent; structure in first source		2.0310
oxadiazoles
Oxadiazoles: Compounds containing five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom which exist in various regioisomeric forms.		2.110
mk-7009
vaniprevir: inhibits hepatitis C virus NS3/4a protease. vaniprevir : An azamacrocyclic compound that is a hepatitis C virus (HCV) NS3/4A protease inhibitor which is approved for the treatment of hepatitis C virus infections in Japan.		2.0610azamacrocycle;
carbamate ester;
cyclopropanes;
N-sulfonylcarboxamide;
pyrrolidinecarboxamide		antiviral drug;
hepatitis C protease inhibitor
piperidines
Piperidines: A family of hexahydropyridines.		2.110
bms-986094
BMS-986094: a prodrug of 2'-C-methylguanosine and antiviral agent		2.0810
epz004777
[no description available]		2.1310N-glycosyl compound
guanosine monophosphate
Guanosine Monophosphate: A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.. guanosine 5'-monophosphate : A purine ribonucleoside 5'-monophosphate having guanine as the nucleobase.		2.1310guanosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		biomarker;
Escherichia coli metabolite;
metabolite;
mouse metabolite
idx184
IDX184: prodrug to enhance formation in the liver of the active triphosphate of 2'-methylguanosine, a potent and specific polymerase inhibitor of the hepatitis C virus; structure in first source		2.1310
ConditionIndicatedRelationship StrengthStudiesTrials
Break-Bone Fever
[description not available]		03.3620
Dengue
An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.		03.3620
Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted
[description not available]		02.7830
Hepatitis C
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.		02.7830
Encephalitis, West Nile Fever
[description not available]		02.2110
West Nile Fever
A mosquito-borne viral illness caused by the WEST NILE VIRUS, a FLAVIVIRUS and endemic to regions of Africa, Asia, and Europe. Common clinical features include HEADACHE; FEVER; maculopapular rash; gastrointestinal symptoms; and lymphadenopathy. MENINGITIS; ENCEPHALITIS; and MYELITIS may also occur. The disease may occasionally be fatal or leave survivors with residual neurologic deficits. (From Joynt, Clinical Neurology, 1996, Ch26, p13; Lancet 1998 Sep 5;352(9130):767-71)		02.2110
Congenital Zika Syndrome
[description not available]		02.8530
Zika Virus Infection
A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.		02.8530
Catarrh
Inflammation of a mucous membrane with increased flow of mucous in humans or animals. Catarrh is used mostly in a historical context.		02.110
Common Cold
A catarrhal disorder of the upper respiratory tract, which may be viral or a mixed infection. It generally involves a runny nose, nasal congestion, and sneezing.		02.110
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.7630
Chronic Hepatitis C
[description not available]		02.4720
Hepatitis C, Chronic
INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.		02.4720
Viremia
The presence of viruses in the blood.		02.0310
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