ziyuglycoside I: isolated from the leaves of Hex pupurea; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 71609288 |
| CHEMBL ID | 4060751 |
| MeSH ID | M0465571 |
| Synonym |
|---|
| S9160 |
| kudinoside h |
| ziyuglycoside i |
| 35286-58-9 |
| AC-34127 |
| ziyuglycoside-i |
| AKOS032948462 |
| 3-o-alpha-l-arabinopyranosylpomolic acid beta-d-glucopyranosyl ester |
| gouguside 7 |
| ziyu-glycoside i |
| zigu-glucoside i |
| CHEMBL4060751 |
| CCG-270452 |
| MS-31380 |
| [(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1r,2r,4as,6ar,6as,6br,8ar,10s,12ar,14bs)-1-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-10-[(2s,3r,4s,5s)-3,4,5-trihydroxyoxan-2-yl]oxy-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-ca |
| ziyuglycosidei |
| EX-A8002N |
Ziyuglycoside I (ZGS1) is a promising drug candidate for the treatment of leucopenia.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Ziyuglycoside I (ZGS1) is a promising drug candidate for the treatment of leucopenia. " | ( A Sample and Sensitive HPLC-MS/MS Method for Simultaneous Determination of Ziyuglycoside I and Its Metabolite Ziyuglycoside II in Rat Pharmacokinetics. Feng, YL; Li, ZF; Luo, YY; Ouyang, H; Pan, LL; Tan, T; Wang, Q; Yang, SL; Zhong, CC; Zhou, MY, 2018) | 2.15 |
The method was then successfully applied to the preclinical pharmacokinetic studies of ziyuglycoside I and ziyUGlyCoside II.
| Excerpt | Reference | Relevance |
|---|---|---|
| " This method was then successfully applied to the preclinical pharmacokinetic studies of ziyuglycoside I and ziyuglycoside II." | ( Development and validation of a quantification method for ziyuglycoside I and II in rat plasma: Application to their pharmacokinetic studies. Fu, H; Kang, D; Liang, Y; Rao, T; Shao, Y; Wang, G; Wang, Q; Xiao, J; Xie, L; Ye, W; Zhou, L, 2015) | 0.88 |
| "To study the effects of sanguisorba tannins and saponins compatibility at different proportions [tannins-saponins (1∶1) and tannins-saponins(8∶1)] after intragastric administration (50 mg•kg⁻¹) on pharmacokinetic parameters of catechin, epicatechin and ziyuglycoside Ⅰ in rats by using pharmacokinetic techniques and methods." | ( [Effects of sanguisorba tannins and saponins compatibility on pharmacokinetic parameters of catechin, epicatechin and ziyuglycoside Ⅰ in rats]. Xiong, YA; Yang, M, 2016) | 0.43 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " However, oral ZgI therapy has been deterred by poor bioavailability because of its low aqueous solubility and permeability." | ( Development and In Vivo Evaluation of Ziyuglycoside I-Loaded Self-Microemulsifying Formulation for Activity of Increasing Leukocyte. Chen, L; Wang, S; Xiong, Y; Xu, Y; Zou, Y, 2019) | 0.78 |
| " The bioavailability of 29 was significantly improved in comparison with its aglycon." | ( Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid. Chen, C; Cheng, K; Dai, L; Hu, K; Li, H; Liu, L; Sun, H; Wen, X; Xu, Q; Yuan, H, 2021) | 0.62 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1436763 | Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway preincubated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometer | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4 | Anticomplement triterpenoids from the roots of Ilex asprella. |
| AID1728066 | Activation of AMPK in human Huh-7 cells assessed as increase in AMPK phosphorylation at Thr172 residue at 10 uM measured after 12 hrs by Western blot analysis | 2021 | European journal of medicinal chemistry, Jan-01, Volume: 209 | Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid. |
| AID1436764 | Anticomplement activity in New Zealand White rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway preincubated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 min | 2017 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4 | Anticomplement triterpenoids from the roots of Ilex asprella. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 11 (57.89) | 24.3611 |
| 2020's | 6 (31.58) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.26) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 2 (10.53%) | 5.53% |
| Reviews | 1 (5.26%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 16 (84.21%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||