skeletal muscle tissue growth

Definition

Target type: biologicalprocess

The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size. [GOC:lm, PMID:15726494, PMID:15907921]

Skeletal muscle tissue growth, also known as myogenesis, is a complex biological process that involves the proliferation, differentiation, and fusion of myoblasts, which are precursor cells for muscle fibers. This process is tightly regulated by a variety of signaling pathways and transcription factors, and it is essential for the development and maintenance of skeletal muscle.

The process begins with the commitment of mesenchymal stem cells to the myogenic lineage, which is driven by transcription factors such as MyoD, Myf5, and MRF4. Once committed, myoblasts undergo a series of proliferative divisions, increasing their numbers. As myoblasts proliferate, they also express a variety of genes that are required for muscle differentiation, including genes encoding muscle-specific proteins such as myosin, actin, and troponin.

Muscle differentiation is characterized by the withdrawal of myoblasts from the cell cycle and the initiation of a program of gene expression that leads to the formation of mature muscle fibers. During differentiation, myoblasts fuse together to form multinucleated myotubes. Myotubes then mature into muscle fibers, which are highly specialized cells that are capable of generating force and movement.

The growth of muscle fibers is driven by the synthesis of new muscle proteins, such as myosin and actin. This protein synthesis is regulated by a variety of factors, including growth hormones, insulin-like growth factors, and testosterone. Muscle growth also requires the removal of old or damaged muscle fibers, a process known as muscle regeneration.

Muscle regeneration occurs through a process called satellite cell activation. Satellite cells are quiescent stem cells that are located beneath the basal lamina of muscle fibers. When muscle tissue is injured or damaged, satellite cells are activated and differentiate into myoblasts, which then fuse to repair the damaged muscle fibers.

The growth of skeletal muscle tissue is influenced by a variety of factors, including genetics, nutrition, exercise, and hormones. Regular exercise is particularly important for stimulating muscle growth. Exercise leads to an increase in the production of growth hormones, which promote muscle protein synthesis. Exercise also causes muscle damage, which stimulates satellite cell activation and muscle regeneration.'
"

Proteins (2)

Compounds (18)