Short transient receptor potential channel 6

A short transient receptor potential channel 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y210]

TrpC6;
Transient receptor protein 6;
TRP-6

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
clemizole	Homo sapiens (human)	IC50	11.3000	1	1

This protein enables 6 target(s):

Target	Category	Definition
monoatomic cation channel activity	molecular function	Enables the energy-independent passage of monoatomic cations across a lipid bilayer down a concentration gradient. [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]
calcium channel activity	molecular function	Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]
inositol 1,4,5 trisphosphate binding	molecular function	Binding to inositol 1,4,5 trisphosphate. [GOC:BHF, GOC:mah]
store-operated calcium channel activity	molecular function	A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. [GOC:dph, GOC:tb, PMID:15788710]

This protein is located in 4 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
slit diaphragm	cellular component	A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration. [GOC:mtg_kidney_jan10, GOC:rph, PMID:12386277, PMID:15994232, PMID:18971929, PMID:19478094]

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is part of 1 target(s):

Target	Category	Definition
cation channel complex	cellular component	An ion channel complex through which cations pass. [GOC:mah]

This protein is involved in 5 target(s):

Target	Category	Definition
monoatomic cation transport	biological process	The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. [GOC:ai]
positive regulation of cytosolic calcium ion concentration	biological process	Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
calcium ion transmembrane transport	biological process	A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
regulation of cytosolic calcium ion concentration	biological process	Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. [GOC:ai, GOC:mah, GOC:rph]
single fertilization	biological process	The union of male and female gametes to form a zygote. [GOC:ems, GOC:mtg_sensu]