L-histidine transport

Definition

Target type: biologicalprocess

The directed movement of a L-histidine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:kmv, GOC:TermGenie, PMID:22822152]

L-histidine transport is a crucial process that enables cells to take up the essential amino acid L-histidine from the extracellular environment. This process is facilitated by specialized transmembrane proteins known as histidine transporters, which are responsible for the selective and efficient movement of L-histidine across the cell membrane. The transport mechanism can be either passive or active, depending on the specific transporter involved and the concentration gradient of L-histidine. In passive transport, L-histidine moves down its concentration gradient, from an area of high concentration to an area of low concentration, without requiring energy expenditure. This type of transport is typically mediated by facilitated diffusion, where L-histidine binds to the transporter and is then released on the other side of the membrane. In contrast, active transport requires energy to move L-histidine against its concentration gradient, from an area of low concentration to an area of high concentration. This energy is typically derived from ATP hydrolysis or the electrochemical gradient of other ions. Active transport systems are often coupled to other transport processes, such as the movement of sodium ions, to drive the uptake of L-histidine. The specific mechanisms of L-histidine transport vary depending on the organism and the type of transporter involved. However, in general, the process can be divided into several key steps: 1. Binding of L-histidine to the transporter protein on the extracellular side of the cell membrane. 2. Conformational change in the transporter protein, allowing L-histidine to move through the membrane. 3. Release of L-histidine into the intracellular space. 4. Return of the transporter protein to its original conformation, ready to bind another L-histidine molecule. The transport of L-histidine is essential for various cellular processes, including protein synthesis, DNA replication, and the production of enzymes and hormones. L-histidine is also a precursor for histamine, a key molecule in the immune response and inflammation. Disruptions in L-histidine transport can lead to various health problems, including neurological disorders, immune deficiencies, and developmental abnormalities. Therefore, understanding the mechanisms of L-histidine transport is crucial for developing strategies to treat these conditions and maintain overall health.'
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Proteins (1)

Compounds (19)