low-affinity glucose:sodium symporter activity

Definition

Target type: molecularfunction

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. [TC:2.A.21.3.-]

Low-affinity glucose:sodium symporter activity refers to the transport of glucose across a cell membrane, coupled with the movement of sodium ions down their electrochemical gradient. This type of transport is known as secondary active transport, as it indirectly utilizes energy from the sodium gradient established by the sodium-potassium pump. The symporter protein binds both glucose and sodium ions simultaneously, facilitating their co-transport into the cell. The driving force for glucose uptake is the electrochemical gradient of sodium ions, which are typically more concentrated outside the cell. As sodium ions move into the cell down their concentration gradient, they provide the energy needed for the symporter to move glucose against its concentration gradient. Low-affinity glucose:sodium symporter activity is characterized by a lower affinity for glucose compared to high-affinity transporters, meaning they require a higher concentration of glucose to achieve the same transport rate. This characteristic allows these transporters to function efficiently in environments with lower glucose concentrations. These symporters play a crucial role in glucose absorption from the intestinal lumen and reabsorption from the renal tubules, contributing to maintaining glucose homeostasis in the body.'
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Proteins (1)

Compounds (15)