Page last updated: 2024-10-24

myo-inositol:sodium symporter activity

Definition

Target type: molecularfunction

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in). [TC:2.A.21.4.-]

Myo-inositol:sodium symporter activity describes the facilitated movement of myo-inositol across the cell membrane, coupled with the movement of sodium ions. This transport process is driven by the electrochemical gradient of sodium ions, which are typically higher in concentration outside the cell. As sodium ions move down their concentration gradient into the cell, they provide the energy to drive the uptake of myo-inositol, which is typically present in lower concentrations inside the cell. This symporter activity is crucial for cellular processes that rely on myo-inositol, including phosphoinositide signaling, osmotic regulation, and the synthesis of inositol phosphates, which serve as second messengers in various signaling pathways. The symporter protein itself is embedded in the cell membrane and exhibits high specificity for both myo-inositol and sodium ions, ensuring that the correct molecules are transported. Its activity can be modulated by factors such as pH, temperature, and the presence of specific inhibitors or activators, providing a mechanism for regulating cellular myo-inositol levels. '
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Proteins (1)

ProteinDefinitionTaxonomy
Sodium/glucose cotransporter 1A sodium/glucose cotransporter 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P13866]Homo sapiens (human)

Compounds (15)

CompoundDefinitionClassesRoles
phloretindihydrochalconesantineoplastic agent;
plant metabolite
phlorhizinaryl beta-D-glucoside;
dihydrochalcones;
monosaccharide derivative
antioxidant;
plant metabolite
vexibinolsophoraflavanone G : A tetrahydroxyflavanone having a structure of naringenin bearing an additional hydroxyl substituent at position 2' as well as a (2R)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl (lavandulyl) substituent at position 8'.

vexibinol: flavanol from Sophora; structure in first source; RN given refers to (S-(R*,S*))-isomer
(2S)-flavan-4-one;
4'-hydroxyflavanones;
tetrahydroxyflavanone
antimalarial;
antimicrobial agent;
antioxidant;
plant metabolite
2',4',6'-Trihydroxydihydrochalconechalcones
2',4',6'-trihydroxychalconepinocembrin chalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 2', 4' and 6' respectively.

pinocembrin chalcone: isolated from Helichrysum trilineatum; structure in first source
chalconesantifungal agent;
plant metabolite
sergliflozin etabonatesergliflozin: a hypoglycemic agent that inhibits SGLT2 sodium-glucose transporter; structure in first sourceglycoside
remogliflozin etabonateremogliflozin etabonate: orally administered hypoglycemic agent; structure in first sourceglycoside
dapagliflozinaromatic ether;
C-glycosyl compound;
monochlorobenzenes
hypoglycemic agent;
sodium-glucose transport protein subtype 2 inhibitor
ipragliflozinglycoside
empagliflozinaromatic ether;
C-glycosyl compound;
monochlorobenzenes;
tetrahydrofuryl ether
hypoglycemic agent;
sodium-glucose transport protein subtype 2 inhibitor
1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitoldiarylmethane
nothofaginnothofagin: a dihydrochalcone
canagliflozincanagliflozin hydrate : A hydrate that is the hemihydrate form of canagliflozin. Used for treatment of type II diabetes via inhibition of sodium-glucose transport protein subtype 2.C-glycosyl compound;
organofluorine compound;
thiophenes
hypoglycemic agent;
sodium-glucose transport protein subtype 2 inhibitor
pf 04971729ertugliflozin: structure in first sourcediarylmethane
deberza2-benzofurans