Page last updated: 2024-10-24

galactose:sodium symporter activity

Definition

Target type: molecularfunction

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in). [TC:2.A.21.3.-]

Galactose:sodium symporter activity is a membrane transport process that simultaneously moves galactose and sodium ions across the cell membrane. This process is driven by the electrochemical gradient of sodium ions, which is maintained by the sodium-potassium pump. Galactose:sodium symporters are typically found in the small intestine and kidney, where they play a crucial role in the absorption of galactose from the diet. This activity involves the binding of both galactose and sodium ions to the transporter protein, triggering a conformational change that allows both molecules to move across the membrane. The symporter has a high affinity for both galactose and sodium, ensuring efficient transport even at low concentrations of these molecules. This process is essential for the uptake of galactose, a monosaccharide, and for maintaining sodium homeostasis in the body.'
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Proteins (1)

ProteinDefinitionTaxonomy
Sodium/glucose cotransporter 1A sodium/glucose cotransporter 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P13866]Homo sapiens (human)

Compounds (15)

CompoundDefinitionClassesRoles
phloretindihydrochalconesantineoplastic agent;
plant metabolite
phlorhizinaryl beta-D-glucoside;
dihydrochalcones;
monosaccharide derivative
antioxidant;
plant metabolite
vexibinolsophoraflavanone G : A tetrahydroxyflavanone having a structure of naringenin bearing an additional hydroxyl substituent at position 2' as well as a (2R)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl (lavandulyl) substituent at position 8'.

vexibinol: flavanol from Sophora; structure in first source; RN given refers to (S-(R*,S*))-isomer
(2S)-flavan-4-one;
4'-hydroxyflavanones;
tetrahydroxyflavanone
antimalarial;
antimicrobial agent;
antioxidant;
plant metabolite
2',4',6'-Trihydroxydihydrochalconechalcones
2',4',6'-trihydroxychalconepinocembrin chalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 2', 4' and 6' respectively.

pinocembrin chalcone: isolated from Helichrysum trilineatum; structure in first source
chalconesantifungal agent;
plant metabolite
sergliflozin etabonatesergliflozin: a hypoglycemic agent that inhibits SGLT2 sodium-glucose transporter; structure in first sourceglycoside
remogliflozin etabonateremogliflozin etabonate: orally administered hypoglycemic agent; structure in first sourceglycoside
dapagliflozinaromatic ether;
C-glycosyl compound;
monochlorobenzenes
hypoglycemic agent;
sodium-glucose transport protein subtype 2 inhibitor
ipragliflozinglycoside
empagliflozinaromatic ether;
C-glycosyl compound;
monochlorobenzenes;
tetrahydrofuryl ether
hypoglycemic agent;
sodium-glucose transport protein subtype 2 inhibitor
1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitoldiarylmethane
nothofaginnothofagin: a dihydrochalcone
canagliflozincanagliflozin hydrate : A hydrate that is the hemihydrate form of canagliflozin. Used for treatment of type II diabetes via inhibition of sodium-glucose transport protein subtype 2.C-glycosyl compound;
organofluorine compound;
thiophenes
hypoglycemic agent;
sodium-glucose transport protein subtype 2 inhibitor
pf 04971729ertugliflozin: structure in first sourcediarylmethane
deberza2-benzofurans