Page last updated: 2024-09-27

Double Aortic Arch

Congenital vascular malformation in which the AORTA arch and its branches encircle the TRACHEA and ESOPHAGUS. Signs and symptoms include DYSPNEA; RESPIRATORY SOUNDS, especially with eating, DYSPHAGIA, persistent cough, and GASTROESOPHAGEAL REFLUX or may be asymptomatic. Two most common types are double aortic arch and right aortic arch. It may be associated with other anomalies (e.g., DIGEORGE SYNDROME).

Synonyms(4)

Synonym
Vascular Ring
Double Aortic Arch
Right Aortic Arch with Left Ligamentum Arteriosum
Right Aortic Arch Syndrome

Research Excerpts

Research

Studies (7)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's1 (14.29)28.8240
2020's6 (85.71)9.53
DrugIndicatedRelationship StrengthStudiesTrials
4-aminopyridine0low10
glyburide0low10
indomethacin0low10
metformin0low10
prednisone0low10
adenosine monophosphate0low10
dideoxyadenosine0low10
zithromax0low10
pulmicort0medium11
fluticasone0medium11
empagliflozin0low10

Protein Targets (371)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, Cruzipain3003
thioredoxin reductase2002
RAR-related orphan receptor gamma6006
USP1 protein, partial2002
Microtubule-associated protein tau3003
aldehyde dehydrogenase 1 family, member A14004
thyroid stimulating hormone receptor4004
estrogen receptor 2 (ER beta)4004
cytochrome P450 family 3 subfamily A polypeptide 45005
glucocorticoid receptor [Homo sapiens]6006
cytochrome P450 2D63003
glucocerebrosidase3003
IDH13003
euchromatic histone-lysine N-methyltransferase 25005
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
cytochrome P450 2D6 isoform 13003
chromobox protein homolog 15005
transcriptional regulator ERG isoform 31001
thyroid hormone receptor beta isoform 25005
mitogen-activated protein kinase 11001
geminin5005
peripheral myelin protein 222002
survival motor neuron protein isoform d2002
lethal factor (plasmid)1001
lamin isoform A-delta105005
Potassium channel subfamily K member 20022
Rap guanine nucleotide exchange factor 31001
Cellular tumor antigen p534004
Potassium voltage-gated channel subfamily A member 30011
Acetylcholinesterase0101
Pteridine reductase 10101
Potassium voltage-gated channel subfamily A member 10101
Potassium voltage-gated channel subfamily H member 20303
ATP-dependent phosphofructokinase4004
Chain A, Glycogen Phosphorylase B0011
Chain B, Glycogen Phosphorylase B0011
Chain A, ADP-dependent glucokinase0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, phosphodiesterase-nucleotide pyrophosphatase0101
Chain A, GLYCOGEN PHOSPHORYLASE B0011
Chain B, GLYCOGEN PHOSPHORYLASE B0011
Chain A, GLYCOGEN PHOSPHORYLASE B0011
AR protein7007
regulator of G-protein signaling 42002
estrogen-related nuclear receptor alpha6006
v-jun sarcoma virus 17 oncogene homolog (avian)3003
2'-deoxynucleoside 5'-phosphate N-hydrolase 10101
Mitogen-activated protein kinase kinase kinase 70011
2'-deoxynucleoside 5'-phosphate N-hydrolase 10101
5'-AMP-activated protein kinase subunit beta-20011
Transient receptor potential cation channel subfamily M member 20101
Alcohol dehydrogenase E chain0101
Alcohol dehydrogenase S chain0101
L-lactate dehydrogenase A chain0112
Adenylate kinase isoenzyme 10001
Fructose-1,6-bisphosphatase 10101
Alkaline phosphatase, tissue-nonspecific isozyme0001
Fructose-1,6-bisphosphatase 10101
2-dehydropantoate 2-reductase0112
Inosine-5'-monophosphate dehydrogenase0101
Cytochrome P450 2C9 0202
Proto-oncogene tyrosine-protein kinase Src0101
Amine oxidase [flavin-containing] B0101
5'-nucleotidase0001
Choline O-acetyltransferase0101
Adenylate kinase 2, mitochondrial0102
GTP:AMP phosphotransferase AK3, mitochondrial0001
Adenosine receptor A10011
Adenylate kinase isoenzyme 1 0102
P2Y purinoceptor 20011
P2Y purinoceptor 10011
P2Y purinoceptor 10011
5'-AMP-activated protein kinase subunit gamma-10022
5'-AMP-activated protein kinase catalytic subunit alpha-20011
Adenylate kinase 2, mitochondrial0001
Glycine--tRNA ligase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10022
Adenosine deaminase-like protein0001
Protease 0112
P2Y purinoceptor 110011
Histamine H3 receptor0101
5'-AMP-activated protein kinase subunit gamma-30011
5'-AMP-activated protein kinase subunit gamma-20011
5'-AMP-activated protein kinase subunit beta-10022
ATAD5 protein, partial1001
TDP1 protein6006
retinoid X nuclear receptor alpha5005
pregnane X nuclear receptor4004
estrogen nuclear receptor alpha7007
nuclear factor erythroid 2-related factor 2 isoform 16006
DNA polymerase iota isoform a (long)2002
Voltage-dependent calcium channel gamma-2 subunit3003
Glutamate receptor 23003
Deoxycytidine kinase0001
Adenosine deaminase 0102
TAR DNA-binding protein 432002
Reverse transcriptase/RNaseH 0001
Sodium/glucose cotransporter 10011
Sodium/glucose cotransporter 20112
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Luciferase2002
SMAD family member 23003
GLS protein2002
SMAD family member 33003
GLI family zinc finger 34004
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
nuclear receptor subfamily 1, group I, member 32002
progesterone receptor4004
nonstructural protein 11001
G3003
Parkin2002
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma3003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
Bloom syndrome protein isoform 11001
peripheral myelin protein 22 isoform 12002
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
nuclear receptor ROR-gamma isoform 14004
cytochrome P450 3A4 isoform 13003
muscarinic acetylcholine receptor M11001
Gamma-aminobutyric acid receptor subunit pi3003
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Solute carrier family 22 member 60202
ATP-binding cassette sub-family C member 90101
Bile salt export pump0202
Solute carrier organic anion transporter family member 2B1 0203
Bile salt export pump0707
Chymotrypsinogen A0101
Beta-lactamase0101
ATP synthase subunit beta, mitochondrial0101
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 3003
ATP synthase subunit delta, mitochondrial0101
ATP synthase subunit gamma, mitochondrial0101
ATP synthase subunit epsilon, mitochondrial0101
Cystic fibrosis transmembrane conductance regulator0101
Gamma-aminobutyric acid receptor subunit beta-13003
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
5-hydroxytryptamine receptor 1A0101
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Cholesteryl ester transfer protein0101
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Peroxisome proliferator-activated receptor gamma0112
Malate dehydrogenase, cytoplasmic0101
Histamine H2 receptor2002
Solute carrier family 15 member 10101
Gamma-aminobutyric acid receptor subunit alpha-13104
Gamma-aminobutyric acid receptor subunit beta-33003
Guanine nucleotide-binding protein G2002
Gamma-aminobutyric acid receptor subunit beta-23003
Inositol monophosphatase 12002
ATP-binding cassette sub-family C member 80101
ATP-sensitive inward rectifier potassium channel 110101
Solute carrier family 22 member 70102
Solute carrier family 15 member 20101
NACHT, LRR and PYD domains-containing protein 3 0101
GABA theta subunit3003
Inositol hexakisphosphate kinase 13003
NACHT, LRR and PYD domains-containing protein 3 0101
Gamma-aminobutyric acid receptor subunit epsilon3003
CDGSH iron-sulfur domain-containing protein 10202
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Solute carrier organic anion transporter family member 1B10303
cytochrome P450 2C9, partial3003
Chain A, membrane-associated prostaglandin E synthase-20101
Chain A, 2-oxoglutarate Oxygenase1001
interleukin 82002
hypoxia-inducible factor 1 alpha subunit1001
EWS/FLI fusion protein3003
farnesoid X nuclear receptor1001
67.9K protein1001
bromodomain adjacent to zinc finger domain 2B1001
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
aryl hydrocarbon receptor2002
vitamin D3 receptor isoform VDRA2002
thyroid hormone receptor beta isoform a1001
heat shock protein beta-11001
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
DNA polymerase kappa isoform 11001
M-phase phosphoprotein 81001
neuropeptide S receptor isoform A1001
Prostaglandin-H2 D-isomerase0101
Prostaglandin E synthase0101
Prostaglandin G/H synthase 1 0102
Prostaglandin G/H synthase 2 0203
3',5'-cyclic-AMP phosphodiesterase 0101
Cytochrome c oxidase subunit 20202
Epidermal growth factor receptor0101
Phospholipase A2, major isoenzyme0101
Albumin0112
Prostaglandin G/H synthase 10304
Procathepsin L0101
ATP-dependent translocase ABCB10101
Neuronal acetylcholine receptor subunit alpha-40101
Interleukin-80101
Androgen receptor0011
Neuronal acetylcholine receptor subunit beta-20101
Polyunsaturated fatty acid 5-lipoxygenase0102
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10202
Prostaglandin G/H synthase 10202
Sodium-dependent dopamine transporter0101
Sodium- and chloride-dependent GABA transporter 10101
Thromboxane-A synthase 0101
Adenosine receptor A10101
Serum paraoxonase/arylesterase 10101
Indoleamine 2,3-dioxygenase 10101
Caspase-10001
Nitric oxide synthase, inducible0101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin E2 receptor EP3 subtype0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0101
Bifunctional epoxide hydrolase 20202
Prostaglandin G/H synthase 20314
Prostaglandin G/H synthase 2 0202
Prostaglandin E2 receptor EP1 subtype0101
Aldo-keto reductase family 1 member C30202
Sodium- and chloride-dependent betaine transporter0101
C-X-C chemokine receptor type 30202
Nuclear receptor ROR-gamma3003
Aldo-keto reductase family 1 member C2 0101
Spike glycoprotein2002
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30101
Prostaglandin G/H synthase 20303
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Prostaglandin G/H synthase 20203
Uracil nucleotide/cysteinyl leukotriene receptor0101
Solute carrier family 22 member 60101
Sigma intracellular receptor 20101
Prostaglandin E2 receptor EP2 subtype0101
Rho-associated protein kinase 20101
Prostaglandin G/H synthase 1 0202
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 80101
Canalicular multispecific organic anion transporter 10505
Multidrug and toxin extrusion protein 10202
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Solute carrier organic anion transporter family member 1B30202
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Chain A, Ferritin light chain1001
histone acetyltransferase KAT2A isoform 11001
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0101
Dihydrofolate reductase0101
Dipeptidyl peptidase 40101
Solute carrier family 22 member 10001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
pregnane X receptor1001
thioredoxin glutathione reductase1001
retinoic acid nuclear receptor alpha variant 13003
nuclear factor erythroid 2-related factor 2 isoform 21001
Glucocorticoid receptor0426
Glycine receptor subunit alpha-10404
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Chain A, Beta-lactamase1001
glp-1 receptor, partial2002
NFKB1 protein, partial1001
Thrombopoietin1001
activating transcription factor 61001
nuclear receptor subfamily 1, group I, member 22002
Estrogen receptor0101
Interleukin-50101
Interleukin-50101
Progesterone receptor0101
Glucocorticoid receptor0101
Mineralocorticoid receptor 0112
Matrix metalloproteinase-90101
Androgen receptor0202
Interleukin-5 receptor subunit alpha0101
Sodium-dependent serotonin transporter0101
Estrogen receptor beta0101
ATPase family AAA domain-containing protein 51001
Ataxin-21001
inositol monophosphatase 11001
Prostaglandin G/H synthase 20101
Cytochrome c oxidase subunit 10101
Seed linoleate 13S-lipoxygenase-10101
Polyunsaturated fatty acid 5-lipoxygenase0101
Calpain-2 catalytic subunit0101
Mu-type opioid receptor0101
Transporter0101
Sodium-dependent serotonin transporter0101
PPM1D protein1001
thyroid stimulating hormone receptor1001
streptokinase A precursor0011
twin arginine protein translocation system - TatA protein0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Cytochrome P450 3A40101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Protein-arginine deiminase type-40101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]