Compounds > helioxanthin
Page last updated: 2024-12-08

helioxanthin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

helioxanthin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

helioxanthin : A furonaphthodioxole that is furo[3',4':6,7]naphtho[1,2-d][1,3]dioxol-7(9H)-one substituted by a 1,3-benzodioxol-5-yl group at posiiton 10. It is a inhibitor of HBV, HCV and HSV-1 viruses. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID177023
CHEMBL ID436474
CHEBI ID191856
SCHEMBL ID2960321
MeSH IDM0492347

Synonyms (25)

Synonym
7,8-methylenedioxy-1-(3',4'-methylenedioxyphenyl)-2-hydroxymethylnaphthalene-3-carboxylic acid lactone
helioxanthin
zhu-ix-139-1
CHEMBL436474
10-(1,3-benzodioxol-5-yl)-9h-[2]benzofuro[6,5-g][1,3]benzodioxol-7-one
18920-47-3
he-145
CHEBI:191856
10-(1,3-benzodioxol-5-yl)furo[3',4':6,7]naphtho[1,2-d][1,3]dioxol-7(9h)-one
10-(2h-1,3-benzodioxol-5-yl)-2h-furo[3',4':6,7]naphtho[1,2-d][1,3]dioxol-7(9h)-one
JUBRYHUFFFYTGR-UHFFFAOYSA-N
10-benzo[1,3]dioxol-5-yl-9h-furo[3',4':6,7]naphtho[1,2-d][1,3]dioxol-7-one
HY-16678
CS-3196
SCHEMBL2960321
AC-35296
DTXSID90172321
J-690253
ach126447;helioxanthin
EX-A772
10-(1,3-benzodioxol-5-yl)furo[3',4':6,7]naphtho[1,2-d]-1,3-dioxol-7(9h)-one
FT-0700249
ach126447
10-(benzo[d][1,3]dioxol-5-yl)furo[3',4':6,7]naphtho[1,2-d][1,3]dioxol-7(9h)-one
furo[3',4':6,7]naphtho[1,2-d]-1,3-dioxol-7(9h)-one, 10-(1,3-benzodioxol-5-yl)-

Research Excerpts

Overview

Helioxanthin is a natural product that inhibits the replication of a number of viruses.

ExcerptReferenceRelevance
"Helioxanthin is a natural product that inhibits the replication of a number of viruses. "( Unique antiviral mechanism discovered in anti-hepatitis B virus research with a natural product analogue.
Cheng, YC; Leung, CH; Li, Y; Robek, MD; Ying, C, 2007)		1.78

Effects

ExcerptReferenceRelevance
"Helioxanthin and analogues have been demonstrated to suppress gene expression of human hepatitis B virus. "( Synthesis and biological evaluation of helioxanthin analogues.
Chen, TA; Hsieh, JY; Janmanchi, D; Jhuang, HJ; Lin, CH; Tseng, YP; Yeh, SF, 2013)		2.1
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
anti-HBV agentAn antiviral agent that destroys or inhibits the replication of the hepatitis B virus.
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
antineoplastic agentA substance that inhibits or prevents the proliferation of neoplasms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
benzodioxoles
furonaphthodioxole
lignanAny phenylpropanoid derived from phenylalanine via dimerization of substituted cinnamic alcohols, known as monolignols, to a dibenzylbutane skeleton. Note that while individual members of the class have names ending ...lignane, ...lignene, ...lignadiene, etc., the class names lignan, neolignan, etc., do not end with an "e".
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (36)

Assay IDTitleYearJournalArticle
AID1175582Increase in transendothelial electrical resistance in RBEC at 5 uM after 2 hrs relative to control2014Journal of natural products, Dec-26, Volume: 77, Issue:12
Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain.
AID246342Effective concentration to inhibit 50% of epstein Barr virus replication in a cell culture model2005Journal of medicinal chemistry, Jan-27, Volume: 48, Issue:2
Synthesis and antiviral activity of helioxanthin analogues.
AID1175568Cytotoxicity against human A2058 cells at 1 to 10 uM after 8 hrs by EZ4U assay2014Journal of natural products, Dec-26, Volume: 77, Issue:12
Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain.
AID401841Insecticidal activity against yellow fever mosquito larvae1997Journal of natural products, Jan, Volume: 60, Issue:1
Bioactive compounds from Taiwania cryptomerioides.
AID401838Toxicity in Artemia salina1997Journal of natural products, Jan, Volume: 60, Issue:1
Bioactive compounds from Taiwania cryptomerioides.
AID1175583Increase in integrity of human CMEC/D3 cells at 2 uM after 2 hrs by ZO-1 staining method2014Journal of natural products, Dec-26, Volume: 77, Issue:12
Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain.
AID1175581Increase in integrity of RBEC at 5 uM after 2 hrs by ZO-1 staining method2014Journal of natural products, Dec-26, Volume: 77, Issue:12
Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain.
AID246413Effective concentration to inhibit 50% of herpes simplex virus type 2 replication in a cell culture model2005Journal of medicinal chemistry, Jan-27, Volume: 48, Issue:2
Synthesis and antiviral activity of helioxanthin analogues.
AID1175569Cytotoxicity against human CMEC/D3 cells at 1 to 10 uM after 8 hrs by EZ4U assay2014Journal of natural products, Dec-26, Volume: 77, Issue:12
Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain.
AID1175573Inhibition of migration of human A2058 cells assessed as filopodia at 5 uM using Alexa-488-labeled phalloidin by microscopy2014Journal of natural products, Dec-26, Volume: 77, Issue:12
Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain.
AID246412Effective concentration to inhibit 50% of herpes simplex virus type 1 replication in a cell culture model2005Journal of medicinal chemistry, Jan-27, Volume: 48, Issue:2
Synthesis and antiviral activity of helioxanthin analogues.
AID249056Cytotoxicity against CEM cell lines of human2005Journal of medicinal chemistry, Jan-27, Volume: 48, Issue:2
Synthesis and antiviral activity of helioxanthin analogues.
AID246416Effective concentration to inhibit 50% of human immunodeficiency virus replication in a cell culture model2005Journal of medicinal chemistry, Jan-27, Volume: 48, Issue:2
Synthesis and antiviral activity of helioxanthin analogues.
AID1444844Cytotoxicity against human HepG2(2.2.15) cells assessed as reduction in cell viability after 3 days by methylene blue assay2017Journal of medicinal chemistry, 08-10, Volume: 60, Issue:15
Past, Current, and Future Developments of Therapeutic Agents for Treatment of Chronic Hepatitis B Virus Infection.
AID1175578Inhibition of adhesion of human A2058 cells to endothelial cells at 10 uM pretreated for 3 hrs before adhesion and during adhesion2014Journal of natural products, Dec-26, Volume: 77, Issue:12
Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain.
AID1444845Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of viral DNA level after 6 days by Southern blot analysis2017Journal of medicinal chemistry, 08-10, Volume: 60, Issue:15
Past, Current, and Future Developments of Therapeutic Agents for Treatment of Chronic Hepatitis B Virus Infection.
AID1175584Inhibition of migration of human CMEC/D3 cells after 24 hrs by wound-healing assay2014Journal of natural products, Dec-26, Volume: 77, Issue:12
Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain.
AID1175580Inhibition of adhesion of human A2058 cells to endothelial cells at 2 uM pretreated to endothelial cells for 3 hrs before adhesion2014Journal of natural products, Dec-26, Volume: 77, Issue:12
Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain.
AID249057Cytotoxicity against MT-2 cell lines of human2005Journal of medicinal chemistry, Jan-27, Volume: 48, Issue:2
Synthesis and antiviral activity of helioxanthin analogues.
AID743634Antiviral activity against Hepatitis B virus infected in human 1.3ES2 cells assessed as inhibition of viral core promoter activity at 3 uM after 24 hrs by luciferase reporter gene assay2013Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
Synthesis and biological evaluation of helioxanthin analogues.
AID1175577Inhibition of adhesion of human A2058 cells to endothelial cells at 2 uM pretreated for 3 hrs before adhesion and during adhesion2014Journal of natural products, Dec-26, Volume: 77, Issue:12
Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain.
AID246329Effective concentration to inhibit 50% of hepatitis C virus replication in a cell culture model2005Journal of medicinal chemistry, Jan-27, Volume: 48, Issue:2
Synthesis and antiviral activity of helioxanthin analogues.
AID1072531Antiviral activity against Hepatitis B virus2014European journal of medicinal chemistry, Mar-21, Volume: 75A review of non-nucleoside anti-hepatitis B virus agents.
AID246328Effective concentration to inhibit 50% of hepatitis B virus replication in a cell culture model2005Journal of medicinal chemistry, Jan-27, Volume: 48, Issue:2
Synthesis and antiviral activity of helioxanthin analogues.
AID1175579Inhibition of adhesion of human A2058 cells to endothelial cells at 5 uM pretreated for 3 hrs before adhesion2014Journal of natural products, Dec-26, Volume: 77, Issue:12
Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain.
AID458521Antiviral activity against Hepatitis B virus in human HepA2 cells assessed as reduction of HBsAg secretion after 48 hrs by enzyme immunoassay2010Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
Synthesis and the biological evaluation of arylnaphthalene lignans as anti-hepatitis B virus agents.
AID1175572Inhibition of migration of human A2058 cells assessed as elongated shape with actin-rich protrusion at 5 uM using Alexa-488-labeled phalloidin by microscopy2014Journal of natural products, Dec-26, Volume: 77, Issue:12
Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain.
AID251782Percent inhibition against Hepatitis C virus replication in a cell culture model2005Journal of medicinal chemistry, Jan-27, Volume: 48, Issue:2
Synthesis and antiviral activity of helioxanthin analogues.
AID1175570Cytotoxicity against RBEC at 1 to 10 uM after 8 hrs by EZ4U assay2014Journal of natural products, Dec-26, Volume: 77, Issue:12
Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain.
AID1175571Inhibition of migration of human A2058 cells assessed as elongated shape and longer protrusion at 5 uM by phase contrast microscopy2014Journal of natural products, Dec-26, Volume: 77, Issue:12
Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain.
AID743641Cytotoxicity against human HepA2 cells after 2 days by MTT assay2013Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
Synthesis and biological evaluation of helioxanthin analogues.
AID246364Effective concentration to inhibit 50% of cytomegalovirus (CMV) replication in a cell culture model2005Journal of medicinal chemistry, Jan-27, Volume: 48, Issue:2
Synthesis and antiviral activity of helioxanthin analogues.
AID743640Antiviral activity against Hepatitis B virus infected in human HepA2 cells assessed as inhibition of viral surface antigen production after 2 days by enzyme immunoassay2013Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
Synthesis and biological evaluation of helioxanthin analogues.
AID1175574Inhibition of migration of human A2058 cells assessed as cells with stress fibers at 5 uM using Alexa-488-labeled phalloidin by microscopy2014Journal of natural products, Dec-26, Volume: 77, Issue:12
Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain.
AID458522Cytotoxicity against human HepA2 cells after 48 hrs by MTT assay2010Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3
Synthesis and the biological evaluation of arylnaphthalene lignans as anti-hepatitis B virus agents.
AID1175585Inhibition of migration of human CMEC/D3 cells at 10 uM after 24 hrs by wound-healing assay2014Journal of natural products, Dec-26, Volume: 77, Issue:12
Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (4.17)18.2507
2000's7 (29.17)29.6817
2010's14 (58.33)24.3611
2020's2 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.56 (24.57)
Research Supply Index3.22 (2.92)
Research Growth Index5.60 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other21 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
arecoline
Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.. arecoline : A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.		7.1310enoate ester;
methyl ester;
pyridine alkaloid;
tetrahydropyridine		metabolite;
muscarinic agonist
avapro
Irbesartan: A spiro compound, biphenyl and tetrazole derivative that acts as an angiotensin II type 1 receptor antagonist. It is used in the management of HYPERTENSION, and in the treatment of kidney disease.. irbesartan : A biphenylyltetrazole that is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.		3.2510azaspiro compound;
biphenylyltetrazole		angiotensin receptor antagonist;
antihypertensive agent;
environmental contaminant;
xenobiotic
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.		2.0510mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
protocatechualdehyde
protocatechualdehyde: found in wheat grains, wheat seedlings, & other plants; RN given refers to parent cpd; see also rancinamycins; structure		3.1910dihydroxybenzaldehyde
aloe emodin
aloe emodin: structure distinct from emodin; this does not mean emodin from aloe. Aloe emodin : A dihydroxyanthraquinone that is chrysazin carrying a hydroxymethyl group at position 3. It has been isolated from plant species of the genus Aloe.		3.1910aromatic primary alcohol;
dihydroxyanthraquinone		antineoplastic agent;
plant metabolite
chrysophanic acid
chrysophanic acid: RN given refers to parent cpd; structure in Merck, 9th ed, #2260. chrysophanol : A trihydroxyanthraquinone that is chrysazin with a methyl substituent at C-3. It has been isolated from Aloe vera and exhibits antiviral and anti-inflammatory activity.		3.1910dihydroxyanthraquinoneanti-inflammatory agent;
antiviral agent;
plant metabolite
physcione
physcione: structure. physcion : A dihydroxyanthraquinone that is 9,10-anthraquinone bearing hydroxy substituents at positions 1 and 8, a methoxy group at position 3, and a methyl group at position 6. It has been widely isolated and characterised from both terrestrial and marine sources.		3.1910dihydroxyanthraquinoneanti-inflammatory agent;
antibacterial agent;
antifungal agent;
antineoplastic agent;
apoptosis inducer;
hepatoprotective agent;
metabolite
zalcitabine
Zalcitabine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.. zalcitabine : A pyrimidine 2',3'-dideoxyribonucleoside compound having cytosine as the nucleobase.		2.0210pyrimidine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
tricalcium phosphate
tricalcium phosphate: a form of tricalcium phosphate used as bioceramic bone replacement material; see also records for alpha-tricalcium phosphate, beta-tricalcium phosphate, calcium phosphate; apatitic tricalcium phosphate Ca9(HPO4)(PO4)5(OH) is the calcium orthophosphate leading to beta tricalcium phosphate Ca3(PO4)2 (b-TCP). calcium phosphate : A calcium salt composed of calcium and phosphate/diphosphate ions; present in milk and used for the mineralisation of calcified tissues.		2.0810calcium phosphate
nitazoxanide
nitazoxanide: a 5-nitrothiazolyl derivative used for a broad range of intestinal parasitic infections including CRYPTOSPORIDIUM and GIARDIA; it is a redox-active nitrothiazolyl-salicylamide prodrug		4.1320benzamides;
carboxylic ester
lamivudine
[no description available]		4.2450monothioacetal;
nucleoside analogue;
oxacycle;
primary alcohol		allergen;
anti-HBV agent;
antiviral drug;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor;
HIV-1 reverse transcriptase inhibitor;
prodrug
epigallocatechin gallate
epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.		3.2510flavans;
gallate ester;
polyphenol		antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite
diphyllin
diphyllin: extract of Cleistanthus collinus (Roxb), a highly poisonous plant; do not confuse with diphyllin or diphylline which is the main heading AMINOPHYLLINE; do not confuse with the theophylline derivative DYPHYLLINE		2.0510lignan
justicidin a
justicidins: from Justica procumbens		2.1110lignan
tizoxanide
tizoxanide: major metabolite of nitazoxanide; structure in first source		3.2510salicylamides
ferruginol
ferruginol: structure in first source. ferruginol : An abietane diterpenoid that is abieta-8,11,13-triene substituted by a hydroxy group at positions 12.		1.9910abietane diterpenoid;
carbotricyclic compound;
meroterpenoid;
phenols		antibacterial agent;
antineoplastic agent;
plant metabolite;
protective agent
chrysophanol 8-o-glucoside
chrysophanol 8-O-glucoside: has anti-hepatitis B virus activity; also has antiplatelet and anticoagulant activities; isolated from Rheum palmatum. chrysophanol 8-O-beta-D-glucoside : A beta-D-glucoside in which the aglycone species is chrysophanol, the glycosidic linkage being to the hydroxy group at C-8.		3.1910beta-D-glucoside;
monohydroxyanthraquinone
lignans
Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)		5.52200
retrojusticidin b
retrojusticidin B: isolated from Phyllanthus myrtifolius; structure in first source		7.1110
dihydrochelerythrine
dihydrochelerythrine: trypanocidal and antileishmanial dihydrochelerythrine derivative from Garcinia lucida; structure in first source		3.1910benzophenanthridine alkaloid
bay 41-4109
BAY 41-4109: structure in first source		4.1320
hbf 0259
[no description available]		3.1910
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.1310prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
robustaflavone
robustaflavone: bis-apigenin coupled at 6 and 3' positions; a potential non-nucleoside anti-hepatitis B agent;. robustaflavone : A biflavonoid that is obtained by oxidative coupling of two molecules of apigenin resulting in a bond between positions C-3 of the hydroxyphenyl ring and C-6 of the chromene ring. Isolated from Thuja orientalis and Rhus succedanea it exhibits antioxidant, cytotoxic and anti-hepatitis B activity.		3.2510biflavonoid;
hydroxyflavone;
ring assembly		anti-HBV agent;
antineoplastic agent;
antioxidant;
metabolite
wogonin
wogonin: structure in first source. wogonin : A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8.		3.1910dihydroxyflavone;
monomethoxyflavone		angiogenesis inhibitor;
antineoplastic agent;
cyclooxygenase 2 inhibitor;
plant metabolite
cyclosporine
ramihyphin A: one of the metabolites produced by Fusarium sp. S-435; RN given refers to cpd with unknown MF		3.2510homodetic cyclic peptideanti-asthmatic drug;
anticoronaviral agent;
antifungal agent;
antirheumatic drug;
carcinogenic agent;
dermatologic drug;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
geroprotector;
immunosuppressive agent;
metabolite
icariin
[no description available]		2.0510flavonols;
glycosyloxyflavone		antioxidant;
bone density conservation agent;
EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor;
phytoestrogen
helioxanthin 8-1
helioxanthin 8-1: an antiviral agent; structure in first source		4.5940
artesunate
artesunic acid: RN given for (3R-(3alpha,5abeta,6beta,8abeta,9alpha,10alpha,12beta,(2aR*))-isomer; succinic ester of artemether		3.1910artemisinin derivative;
cyclic acetal;
dicarboxylic acid monoester;
hemisuccinate;
semisynthetic derivative;
sesquiterpenoid		antimalarial;
antineoplastic agent;
ferroptosis inducer
leucamide a
leucamide A: a cytotoxic heptapeptide from the Australian sponge Leucetta microraphis; structure in first source		3.1910
alpha-cadinol
alpha-cadinol : A cadinane sesquiterpenoid that is cadin-4-ene carrying a hydroxy substituent at position 10.		1.9910cadinane sesquiterpenoid;
carbobicyclic compound;
octahydronaphthalenes;
tertiary alcohol		fungicide;
plant metabolite;
volatile oil component
astragaloside IV
[no description available]		3.1910pentacyclic triterpenoid;
triterpenoid saponin		anti-inflammatory agent;
antioxidant;
EC 4.2.1.1 (carbonic anhydrase) inhibitor;
neuroprotective agent;
plant metabolite;
pro-angiogenic agent
rosamultin
rosamultin: isolated from roots of Rosa multiflora; RN not in Chemline 3/87; RN from Chem Abstracts Index Guide 1985		3.1910
caudatin
caudatin: antineoplastic from Cynanchum; structure in first source		3.2510
2-hydroxybenzoyl-n-(5-chlorothiazol-2-yl)amide
2-hydroxybenzoyl-N-(5-chlorothiazol-2-yl)amide: an antiviral agent effective against hepatitis B virus; structure in first source		3.1910
transforming growth factor beta
Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.		2.0310
alisol f
[no description available]		3.1910
alisol a 24-acetate
alisol A 24-acetate: isolated from Alismatis Rhizoma; structure in first source		3.1910
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		2.02102-aminopurines;
oxopurine		antimetabolite;
antiviral drug
ConditionIndicatedRelationship StrengthStudiesTrials
Cytomegalovirus
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.		02.0210
HIV
Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.		02.0210
Hepatitis B Virus Infection
[description not available]		04.3740
Hepatitis B
INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.		04.3740
Chronic Hepatitis B
[description not available]		03.0610
Hepatitis B, Chronic
INFLAMMATION of the LIVER in humans caused by HEPATITIS B VIRUS lasting six months or more. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.		03.0610
Carcinoma, Epidermoid
[description not available]		02.1310
Cancer of Mouth
[description not available]		02.1310
Carcinoma, Squamous Cell
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)		02.1310
Mouth Neoplasms
Tumors or cancer of the MOUTH.		02.1310
Linear Skull Fracture
[description not available]		02.0510
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)		02.0510
Infections, Hepadnaviridae
[description not available]		02.0510
Hepadnaviridae Infections
Virus diseases caused by the HEPADNAVIRIDAE.		02.0510