scirpentriol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

scirpentriol: T-2 toxin metabolite in Curtobacterium; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	15571716
MeSH ID	M0116730

Synonyms (2)

Synonym
scirpentriol
(1s,2r,9r,10r,11s,12r)-2-(hydroxymethyl)-1,5-dimethylspiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-10,11-diol

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
" Of the eight toxins, 4,15-DAS was the most toxic in the three assays, 3-MAS was the least toxic in brine shrimp and dermal assays, and 3,4-DAS was the least toxic in the chick assay."	( Comparative toxicity of scirpentriol and its acetylated derivatives. Hamilton, PB; Richardson, KE, 1990)	0.28
" Several acute and chronic toxic effects were observed in humans after consumption of contaminated food."	( Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture. Gekle, M; Humpf, HU; Königs, M; Mulac, D; Schwerdt, G, 2009)	0.35

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (18)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (22.22)	18.7374
1990's	7 (38.89)	18.2507
2000's	4 (22.22)	29.6817
2010's	3 (16.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (5.26%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	18 (94.74%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
ethyl acetate ethyl acetate : The acetate ester formed between acetic acid and ethanol.	1.97	1	acetate ester; ethyl ester; volatile organic compound	EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor; metabolite; polar aprotic solvent; Saccharomyces cerevisiae metabolite
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	1.97	1	benzenes; phenyl acetates
deoxynivalenol deoxynivalenol : A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.	2.42	2	cyclic ketone; enone; primary alcohol; secondary alpha-hydroxy ketone; trichothecene; triol	mycotoxin
t-2 tetraol T-2 tetraol: RN given refers to (3alpha,4beta,8alpha)-isomer	2.94	4
verrucarol [no description available]	1.96	1
nsc 141537 diacetoxyscirpenol: mycotoxin belonging to 12,13-epoxytrichothecene group; RN given refers to (3alpha,4beta)-isomer; structure	2.91	4	trichothecene
15-acetoxyscirpen-3,4-diol 15-acetoxyscirpen-3,4-diol: hydrolysis product of anguidine	2.9	4	trichothecene
nivalenol nivalenol: RN given refers to 3alpha,4beta,7alpha-isomer	2.07	1	trichothecene
sesquiterpenes [no description available]	3.06	5
3-acetyldeoxynivalenol 3-acetyldeoxynivalenol : A trichothecene mycotoxin that is deoxynivalenol acetylated on the oxygen at C-3. A skin and eye irritant, along with its 15-acetyl regioisomer and its parent deoxynivalenol it is considered among the most commonly and widely distributed cereal contaminants.	2.07	1	trichothecene	epitope; mycotoxin
15-acetyldeoxynivalenol 15-acetyldeoxynivalenol : A trichothecene mycotoxin that is deoxynivalenol acetylated on the oxygen at C-15. A skin and eye irritant, along with its 3-acetyl regioisomer and its parent deoxynivalenol it is considered among the most commonly and widely distributed cereal contaminants.	2.07	1	trichothecene	epitope; mycotoxin
neosolaniol neosolaniol: RN given refers to (3 alpha,4 beta,8 alpha)-isomer	2.93	4
t-2 toxin T-2 Toxin: A potent mycotoxin produced in feedstuffs by several species of the genus FUSARIUM. It elicits a severe inflammatory reaction in animals and has teratogenic effects.. T-2 toxin : A trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals.	5.34	18
ht-2 toxin HT-2 toxin : A trichothecene mycotoxin that is T-2 toxin in which the acetyloxy group at position 4S has been hydrolysed to the corresponding hydroxy group. It is the major metabolite of T-2 toxin.	3.38	7
fusarenon-x fusarenon-X: mycotoxin isolated from Fusarium nivale; belongs to 12,13-epoxytrichothecene group; structure	2.07	1

Condition	Relationship Strength	Studies
Sick Building Syndrome A group of symptoms that are two- to three-fold more common in those who work in large, energy-efficient buildings, associated with an increased frequency of headaches, lethargy, and dry skin. Clinical manifestations include hypersensitivity pneumonitis (ALVEOLITIS, EXTRINSIC ALLERGIC); allergic rhinitis (RHINITIS, ALLERGIC, PERENNIAL); ASTHMA; infections, skin eruptions, and mucous membrane irritation syndromes. Current usage tends to be less restrictive with regard to the type of building and delineation of complaints. (From Segen, Dictionary of Modern Medicine, 1992)	2.95	1
Poultry Diseases Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.	2.38	2
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	1.97	1
Mouth Diseases Diseases involving the MOUTH.	1.97	1
Fungus Poisoning [description not available]	1.97	1
Weight Gain Increase in BODY WEIGHT over existing weight.	1.97	1

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