| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
phencyclidine
Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.. phencyclidine : A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects. | 2.03 | 1 | 0 | benzenes;
piperidines | anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug |
deoxynivalenol
deoxynivalenol : A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination. | 2.02 | 1 | 0 | cyclic ketone;
enone;
primary alcohol;
secondary alpha-hydroxy ketone;
trichothecene;
triol | mycotoxin |
acetyldeoxynivalenol
[no description available] | 2.02 | 1 | 0 | trichothecene | |
satratoxin g
[no description available] | 2.69 | 3 | 0 | | |
nsc 141537
diacetoxyscirpenol: mycotoxin belonging to 12,13-epoxytrichothecene group; RN given refers to (3alpha,4beta)-isomer; structure | 2.67 | 3 | 0 | trichothecene | |
15-acetoxyscirpen-3,4-diol
15-acetoxyscirpen-3,4-diol: hydrolysis product of anguidine | 1.96 | 1 | 0 | trichothecene | |
mevalonic acid
Mevalonic Acid: A dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions.. mevalonic acid : A racemate composed of equimolar amounts of (R)- and (S)-mevalonic acid.. (R)-mevalonic acid : The (R)-enantiomer of mevalonic acid. | 2.35 | 2 | 0 | 3,5-dihydroxy-3-methylpentanoic acid | |
nivalenol
nivalenol: RN given refers to 3alpha,4beta,7alpha-isomer | 2.02 | 1 | 0 | trichothecene | |
sesquiterpenes
[no description available] | 3.35 | 7 | 0 | | |
sterigmatocystin
[no description available] | 2.03 | 1 | 0 | sterigmatocystins | metabolite |
zearalenone
Zearalenone: (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione. One of a group of compounds known under the general designation of resorcylic acid lactones. Cis, trans, dextro and levo forms have been isolated from the fungus Gibberella zeae (formerly Fusarium graminearum). They have estrogenic activity, cause toxicity in livestock as feed contaminant, and have been used as anabolic or estrogen substitutes.. zearalenone : A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species. | 2.02 | 1 | 0 | macrolide;
resorcinols | fungal metabolite;
mycoestrogen |
scirpentriol
scirpentriol: T-2 toxin metabolite in Curtobacterium; structure given in first source | 1.96 | 1 | 0 | | |
roridin e
roridin E: RN given refers to (2'E,7'R(R))-isomer; see also roridin J: 74042-83-6 | 1.96 | 1 | 0 | | |
satratoxin h
satratoxin H: toxic metabolite of Stachybotrys atra; see also record for satratoxin G; structure | 2.69 | 3 | 0 | trichothecene | |
t-2 toxin
T-2 Toxin: A potent mycotoxin produced in feedstuffs by several species of the genus FUSARIUM. It elicits a severe inflammatory reaction in animals and has teratogenic effects.. T-2 toxin : A trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals. | 2.67 | 3 | 0 | | |
trichodermin
Trichodermin: Antifungal metabolite from several fungi, mainly Trichoderma viride; inhibits protein synthesis by binding to ribosomes; proposed as antifungal and antineoplastic; used as tool in cellular biochemistry.. trichodermin : A tetracyclic spiroepoxide which acts as an antifungal and protein synthesis inhibitor. | 2.03 | 1 | 0 | | |
ht-2 toxin
HT-2 toxin : A trichothecene mycotoxin that is T-2 toxin in which the acetyloxy group at position 4S has been hydrolysed to the corresponding hydroxy group. It is the major metabolite of T-2 toxin. | 2.67 | 3 | 0 | | |
fusarenon-x
fusarenon-X: mycotoxin isolated from Fusarium nivale; belongs to 12,13-epoxytrichothecene group; structure | 2.02 | 1 | 0 | | |