Compounds > dipivefrin hydrochloride
Page last updated: 2024-09-23

dipivefrin hydrochloride

Description

dipivefrin hydrochloride : The hydrochloride salt of dipivefrin. It is used topically as eye drops to reduce intra-ocular pressure in the treatment of open-angle glaucoma or ocular hypertension. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID71486
CHEMBL ID1200833
CHEBI ID4647
SCHEMBL ID41350
MeSH IDM0312742

Synonyms (67)

Synonym
smr001233266
MLS002153922
dipivefrin hcl
(+-)-3,4-dihydroxy-alpha-((methylamino)methyl)benzyl alcohol 3,4-dipivalate hydrochloride
propanoic acid, 2,2-dimethyl-, 4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene ester, hydrochloride, (+-)-
dipivefrin hydrochloride
(1)-4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene dipivalate hydrochloride
akpro
einecs 264-609-5
dipivefrine hydrochloride
dipivalyl epinephrine hydrochloride
NCGC00016906-01
cas-64019-93-8
D01017
64019-93-8
dipivefrin hydrochloride (jan/usp)
propine (tn)
2-{3,4-bis[(2,2-dimethylpropanoyl)oxy]phenyl}-2-hydroxy-n-methylethanaminium chloride
1-(3',4'-dipivaloyloxyphenyl)-2-methylamino-1-ethanol hydrochloride
4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diyl bis(2,2-dimethylpropanoate) hydrochloride
dipivefrine hcl
CHEBI:4647 ,
CHEMBL1200833
HMS1569P06
(rs)-4-(1-hydroxy-2-(methylamino)ethyl)-o-phenylene dipivalate hydrochloride
tox21_110675
dtxsid2045494 ,
dtxcid0025494
dipivefrin hydrochloride [usp:jan]
5qth9uhv0k ,
unii-5qth9uhv0k
dipivefrin hydrochloride [usp monograph]
dipivefrin hydrochloride [vandf]
dipivefrine hydrochloride [ep monograph]
dipivefrine hydrochloride [jan]
dipivefrin hydrochloride [orange book]
propanoic acid, 2,2-dimethyl-, 4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene ester, (+/-)-, hydrochloride
dipivalylepinephrine hydrochloride
(+/-)-3,4-dihydroxy-.alpha.-((methylamino)methyl)benzyl alcohol 3,4-dipivalate hydrochloride
dipivefrin hydrochloride [mi]
dipivefrine hydrochloride [who-dd]
dipivefrin hydrochloride [jan]
dipivefrine hydrochloride [mart.]
CCG-220632
SCHEMBL41350
VKFAUCPBMAGVRG-UHFFFAOYSA-N
dipivefrin (hydrochloride)
SR-01000838856-2
sr-01000838856
2-[(2,2-dimethylpropanoyl)oxy]-4-[1-hydroxy-2-(methylamino)ethyl]phenyl 2,2-dimethylpropanoate hydrochloride
Q27106427
BCP13649
[2-(2,2-dimethylpropanoyloxy)-4-[1-hydroxy-2-(methylamino)ethyl]phenyl] 2,2-dimethylpropanoate;hydrochloride
dipivefrine (hydrochloride)
64019-93-8 (hcl)
MS-26426
HY-B1323
CS-0013083
AKOS037515482
dipivefrine for system suitability
dipivefrin hydrochloride (usp:jan)
alcon
(+/-)-3,4-dihydroxy-alpha-((methylamino)methyl)benzyl alcohol 3,4-dipivalate hydrochloride
propanoic acid, 2,2-dimethyl-, 4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene ester, hydrochloride,(+-)-
dipivefrin hydrochloride (usp monograph)
4-(1-hydroxy-2-(methylamino)ethyl)benzene-1,2-diyl bis(2,2-dimethylpropanoate) hydrochloride
2-(3,4-bis((2,2-dimethylpropanoyl)oxy)phenyl)-2-hydroxy-n-methylethanaminium chloride

Roles (3)

RoleDescription
adrenergic agonistAn agent that selectively binds to and activates adrenergic receptors.
sympathomimetic agentA drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
antiglaucoma drugAny drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
hydrochlorideA salt formally resulting from the reaction of hydrochloric acid with an organic base.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (7)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Beta-lactamaseEscherichia coli K-12Potency2.81840.044717.8581100.0000AID485294
glp-1 receptor, partialHomo sapiens (human)Potency1.37770.01846.806014.1254AID624417; AID743262
TDP1 proteinHomo sapiens (human)Potency9.03490.000811.382244.6684AID686978; AID686979
beta-2 adrenergic receptorHomo sapiens (human)Potency0.76600.00586.026332.6427AID492947; AID588463; AID588790
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency1.99533.548119.542744.6684AID743266
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency10.96330.000323.4451159.6830AID743065; AID743067
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency89.12510.050127.073689.1251AID588590
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
beta-2 adrenergic receptorHomo sapiens (human)EC50 (µMol)7.13000.00161.87598.4400AID588763
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (18)

Assay IDTitleYearJournalArticle
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (11.11)29.6817
2010's6 (66.67)24.3611
2020's2 (22.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
brimonidine[no description available]low00imidazoles;
quinoxaline derivative;
secondary amine		adrenergic agonist;
alpha-adrenergic agonist;
antihypertensive agent
dipivefrin[no description available]low00ethanolamines;
pivalate ester		adrenergic agonist;
antiglaucoma drug;
ophthalmology drug;
prodrug;
sympathomimetic agent
acebutolol[no description available]low00aromatic amide;
ethanolamines;
ether;
monocarboxylic acid amide;
propanolamine;
secondary amino compound		anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
sympathomimetic agent
clenbuterol[no description available]low00amino alcohol;
dichlorobenzene;
ethanolamines;
primary arylamine;
secondary amino compound;
substituted aniline		beta-adrenergic agonist;
bronchodilator agent;
sympathomimetic agent
diazoxide[no description available]low00benzothiadiazine;
organochlorine compound;
sulfone		antihypertensive agent;
beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
diuretic;
K-ATP channel agonist;
sodium channel blocker;
sympathomimetic agent;
vasodilator agent
berotek[no description available]low00resorcinols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
sympathomimetic agent;
tocolytic agent
isoproterenol[no description available]low00catechols;
secondary alcohol;
secondary amino compound		beta-adrenergic agonist;
bronchodilator agent;
cardiotonic drug;
sympathomimetic agent
midodrine[no description available]low00amino acid amide;
aromatic ether;
secondary alcohol		alpha-adrenergic agonist;
prodrug;
sympathomimetic agent;
vasoconstrictor agent
oxymetazoline[no description available]low00carboxamidine;
imidazolines;
phenols		alpha-adrenergic agonist;
nasal decongestant;
sympathomimetic agent;
vasoconstrictor agent
phenmetrazine[no description available]low00morpholinesmetabolite;
sympathomimetic agent
phentermine[no description available]low00primary amineadrenergic agent;
appetite depressant;
central nervous system drug;
central nervous system stimulant;
dopaminergic agent;
sympathomimetic agent
terbutaline[no description available]low00phenylethanolamines;
resorcinols		anti-asthmatic drug;
beta-adrenergic agonist;
bronchodilator agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
hypoglycemic agent;
sympathomimetic agent;
tocolytic agent
tetrahydrozoline[no description available]low00carboxamidine;
imidazolines		nasal decongestant;
sympathomimetic agent
dextroamphetamine[no description available]low001-phenylpropan-2-amineadrenergic agent;
adrenergic uptake inhibitor;
dopamine uptake inhibitor;
dopaminergic agent;
neurotoxin;
sympathomimetic agent
metaraminol[no description available]low00phenylethanolaminesalpha-adrenergic agonist;
sympathomimetic agent;
vasoconstrictor agent
phenylephrine[no description available]low00phenols;
phenylethanolamines;
secondary amino compound		alpha-adrenergic agonist;
cardiotonic drug;
mydriatic agent;
nasal decongestant;
protective agent;
sympathomimetic agent;
vasoconstrictor agent
pseudoephedrine[no description available]low00phenylethanolamines;
secondary alcohol;
secondary amino compound		anti-asthmatic drug;
bronchodilator agent;
central nervous system drug;
nasal decongestant;
plant metabolite;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic
ephedrine[no description available]low00phenethylamine alkaloid;
phenylethanolamines		bacterial metabolite;
environmental contaminant;
nasal decongestant;
plant metabolite;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic
tetrahydrozoline hydrochloride[no description available]medium00hydrochloridenasal decongestant;
sympathomimetic agent;
vasoconstrictor agent
midodrine hydrochloride[no description available]medium00hydrochloridealpha-adrenergic agonist;
sympathomimetic agent;
vasoconstrictor agent
dobutamine[no description available]low00catecholamine;
secondary amine		beta-adrenergic agonist;
cardiotonic drug;
sympathomimetic agent
st 1059[no description available]low00aromatic ether;
primary amino compound;
secondary alcohol		alpha-adrenergic agonist;
sympathomimetic agent;
vasoconstrictor agent
bambuterol hydrochloride[no description available]medium00carbamate ester;
hydrochloride;
phenylethanolamines		anti-asthmatic drug;
beta-adrenergic agonist;
bronchodilator agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
prodrug;
sympathomimetic agent
bambuterol[no description available]low00carbamate ester;
phenylethanolamines		anti-asthmatic drug;
beta-adrenergic agonist;
bronchodilator agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
prodrug;
sympathomimetic agent;
tocolytic agent
dobutamine hydrochloride[no description available]medium00hydrochloridebeta-adrenergic agonist;
cardiotonic drug;
sympathomimetic agent
oxymetazoline hydrochloride[no description available]medium00hydrochloridealpha-adrenergic agonist;
nasal decongestant;
sympathomimetic agent;
vasoconstrictor agent
amezinium[no description available]low00aromatic ether;
primary arylamine;
pyridazinium ion		adrenergic uptake inhibitor;
antihypotensive agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
sympathomimetic agent
acebutolol hydrochloride[no description available]medium00hydrochlorideanti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
sympathomimetic agent
L-isoprenaline[no description available]low00catecholamine;
phenylethanolamines		beta-adrenergic agonist;
sympathomimetic agent
cocaine[no description available]low00benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid		adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic
benzphetamine[no description available]low00amphetamines;
tertiary amine		adrenergic uptake inhibitor;
appetite depressant;
dopamine uptake inhibitor;
sympathomimetic agent
fenoterol[no description available]low00hydrobromidebeta-adrenergic agonist;
bronchodilator agent;
sympathomimetic agent
nab-365[no description available]medium00hydrochloridebeta-adrenergic agonist;
bronchodilator agent;
sympathomimetic agent
apraclonidine[no description available]low00dichlorobenzene;
guanidines;
imidazolines		alpha-adrenergic agonist;
antiglaucoma drug;
beta-adrenergic agonist;
diagnostic agent;
ophthalmology drug
carteolol[no description available]low00quinolone;
secondary alcohol		anti-arrhythmia drug;
antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist;
sympatholytic agent
dichlorphenamide[no description available]low00dichlorobenzene;
sulfonamide		antiglaucoma drug;
EC 4.2.1.1 (carbonic anhydrase) inhibitor;
ophthalmology drug
ethoxzolamide[no description available]low00aromatic ether;
benzothiazoles;
sulfonamide		antiglaucoma drug;
diuretic;
EC 4.2.1.1 (carbonic anhydrase) inhibitor
pindolol[no description available]low00indoles;
secondary amine		antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist;
serotonergic antagonist;
vasodilator agent
pilocarpine[no description available]low00pilocarpineantiglaucoma drug
mannitol[no description available]low00mannitolallergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent
echothiophate iodide[no description available]low00iodide salt;
quaternary ammonium salt		antiglaucoma drug;
EC 3.1.1.8 (cholinesterase) inhibitor;
miotic
metipranolol[no description available]low00acetate ester;
aromatic ether;
propanolamine;
secondary amino compound		anti-arrhythmia drug;
antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist
timolol[no description available]low00timololanti-arrhythmia drug;
antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist
levobunolol[no description available]low00aromatic ether;
cyclic ketone;
propanolamine		antiglaucoma drug;
beta-adrenergic antagonist
carteolol hydrochloride[no description available]medium00hydrochlorideanti-arrhythmia drug;
antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist
alo 2145[no description available]medium00hydrochloridealpha-adrenergic agonist;
antiglaucoma drug
brinzolamide[no description available]low00sulfonamide;
thienothiazine		antiglaucoma drug;
EC 4.2.1.1 (carbonic anhydrase) inhibitor
timolol maleate[no description available]low00maleate saltanti-arrhythmia drug;
antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist
uf 021[no description available]low00isopropyl ester;
ketone;
prostaglandins Falpha		antiglaucoma drug;
antihypertensive agent;
prodrug
travoprost[no description available]low00(trifluoromethyl)benzenes;
isopropyl ester;
prostaglandins Falpha		antiglaucoma drug;
antihypertensive agent;
ophthalmology drug;
prodrug;
prostaglandin receptor agonist
levobunolol hydrochloride[no description available]medium00hydrochlorideantiglaucoma drug;
beta-adrenergic antagonist
dorzolamide[no description available]low00sulfonamide;
thiophenes		antiglaucoma drug;
antihypertensive agent;
EC 4.2.1.1 (carbonic anhydrase) inhibitor
bimatoprost[no description available]low00monocarboxylic acid amideantiglaucoma drug;
antihypertensive agent
fluprostenol[no description available]low00(trifluoromethyl)benzenes;
hydroxy monocarboxylic acid;
prostaglandins Falpha		abortifacient;
antiglaucoma drug;
antihypertensive agent;
female contraceptive drug;
prostaglandin receptor agonist
latanoprost[no description available]low00isopropyl ester;
prostaglandins Falpha;
triol		antiglaucoma drug;
antihypertensive agent;
EC 4.2.1.1 (carbonic anhydrase) inhibitor;
prodrug
phxa 85[no description available]low00hydroxy monocarboxylic acid;
prostaglandins Falpha		antiglaucoma drug;
antihypertensive agent;
EC 4.2.1.1 (carbonic anhydrase) inhibitor
l 671152[no description available]medium00hydrochloride;
organoammonium salt		antiglaucoma drug;
antihypertensive agent;
EC 4.2.1.1 (carbonic anhydrase) inhibitor
meperidine hydrochloride[no description available]low00hydrochlorideantispasmodic drug;
kappa-opioid receptor agonist;
mu-opioid receptor agonist;
opioid analgesic
promazine hydrochloride[no description available]low00hydrochloride
pilocarpine hydrochloride[no description available]low00hydrochloride
mechlorethamine hydrochloride[no description available]low00hydrochlorideantineoplastic agent
promethazine hydrochloride[no description available]low00hydrochlorideanti-allergic agent;
anticoronaviral agent;
antiemetic;
antipruritic drug;
geroprotector;
H1-receptor antagonist;
local anaesthetic;
sedative
pyridoxine hydrochloride[no description available]low00hydrochloride;
vitamin B6
thiamine hydrochloride[no description available]low00hydrochloride;
vitamin B1		insect repellent
chlorpromazine hydrochloride[no description available]low00hydrochloride;
phenothiazines		anticoronaviral agent;
phenothiazine antipsychotic drug
lidocaine hydrochloride[no description available]low00hydrochlorideanti-arrhythmia drug;
local anaesthetic
imipramine hydrochloride[no description available]low00hydrochlorideantidepressant
methapyrilene hydrochloride[no description available]low00hydrochlorideanti-allergic agent;
carcinogenic agent;
H1-receptor antagonist;
sedative
phenazopyridine hydrochloride[no description available]low00hydrochloridecarcinogenic agent;
local anaesthetic;
non-narcotic analgesic
diphenhydramine hydrochloride[no description available]low00hydrochloride;
organoammonium salt		anti-allergic agent;
antiemetic;
antiparkinson drug;
antipruritic drug;
H1-receptor antagonist;
local anaesthetic;
muscarinic antagonist;
sedative
cycloguanil hydrochloride[no description available]low00hydrochloride;
organic molecular entity
hydralazine hydrochloride[no description available]low00hydrochlorideantihypertensive agent;
vasodilator agent
orphenadrine hydrochloride[no description available]low00hydrochlorideantiparkinson drug;
H1-receptor antagonist;
muscarinic antagonist;
muscle relaxant;
NMDA receptor antagonist;
parasympatholytic
pseudoephedrine hydrochloride[no description available]low00hydrochlorideplant metabolite
procarbazine hydrochloride[no description available]low00hydrochlorideantineoplastic agent
pyridoxamine dihydrochloride[no description available]low00hydrochloride;
vitamin B6		Escherichia coli metabolite;
human metabolite;
iron chelator;
mouse metabolite;
nephroprotective agent;
plant metabolite;
Saccharomyces cerevisiae metabolite
neutral red[no description available]low00hydrochlorideacid-base indicator;
dye;
two-colour indicator
cyproheptadine hydrochloride (anhydrous)[no description available]low00hydrochloride
ethambutol hydrochloride[no description available]low00hydrochlorideantitubercular agent
metformin hydrochloride[no description available]low00hydrochlorideenvironmental contaminant;
hypoglycemic agent;
xenobiotic
n-(1-naphthyl)ethylenediamine dihydrochloride[no description available]low00hydrochloride
amiloride hydrochloride, anhydrous[no description available]low00hydrochloridediuretic;
sodium channel blocker
benzophenoneidum[no description available]low00hydrochloridefluorochrome;
histological dye
quinacrine mustard[no description available]low00hydrochlorideintercalator
mexiletine hydrochloride[no description available]low00hydrochlorideanti-arrhythmia drug
cyclobenzaprine hydrochloride[no description available]low00hydrochlorideantidepressant;
muscle relaxant
nsc-145,668[no description available]low00hydrochlorideantimetabolite;
antineoplastic agent
selegiline hydrochloride, (r)-isomer[no description available]low00hydrochloride;
terminal acetylenic compound		antiparkinson drug;
dopaminergic agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor
benserazide hydrochloride[no description available]low00hydrochlorideantiparkinson drug;
dopaminergic agent;
EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor
minaprine dihydrochloride[no description available]low00hydrochloride
lofepramine hydrochloride[no description available]low00hydrochlorideantidepressant
moricizine hydrochloride[no description available]low00hydrochlorideanti-arrhythmia drug
buspirone hydrochloride[no description available]low00hydrochlorideanxiolytic drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
sedative;
serotonergic agonist
propafenone hydrochloride[no description available]low00hydrochlorideanti-arrhythmia drug
midazolam hydrochloride[no description available]low00hydrochloride;
imidazobenzodiazepine		anticonvulsant;
antineoplastic agent;
anxiolytic drug;
apoptosis inducer;
central nervous system depressant;
GABAA receptor agonist;
general anaesthetic;
muscle relaxant;
sedative
cerm-1978[no description available]low00hydrochloride
mitoxantrone hydrochloride[no description available]low00hydrochlorideantineoplastic agent
azelastine hydrochloride[no description available]low00hydrochlorideanti-allergic agent;
anti-asthmatic drug;
bronchodilator agent;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
H1-receptor antagonist;
platelet aggregation inhibitor
atomoxetine hydrochloride[no description available]low00hydrochlorideadrenergic uptake inhibitor;
antidepressant
ci 906[no description available]low00hydrochlorideantihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
raloxifene hydrochloride[no description available]low00hydrochloridebone density conservation agent;
estrogen antagonist;
estrogen receptor modulator
nefazodone hydrochloride[no description available]low00hydrochloride
mk 458[no description available]low00hydrochlorideanticonvulsant;
antiparkinson drug;
dopamine agonist
gemcitabine hydrochloride[no description available]low00hydrochloride;
organofluorine compound		anticoronaviral agent;
antimetabolite;
antineoplastic agent;
antiviral drug;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
immunosuppressive agent;
radiosensitizing agent
alosetron hydrochloride[no description available]low00hydrochlorideantiemetic;
serotonergic antagonist
ziprasidone hydrochloride[no description available]low00hydrate;
hydrochloride
naratriptan hydrochloride[no description available]low00hydrochloride
tirofiban hydrochloride[no description available]low00hydrochloride
phenylhydrazine hydrochloride[no description available]low00hydrochloride
fluoxetine hydrochloride[no description available]low00hydrochloride;
N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
paroxetine hydrochloride[no description available]low00hydrochlorideantidepressant;
anxiolytic drug;
hepatotoxic agent;
P450 inhibitor;
serotonin uptake inhibitor
propranolol hydrochloride[no description available]low00hydrochloride
diltiazem hydrochloride[no description available]low00hydrochlorideantihypertensive agent;
calcium channel blocker;
vasodilator agent
venlafaxine hydrochloride[no description available]low00hydrochloride
trazodone hydrochloride[no description available]low00hydrochlorideadrenergic antagonist;
antidepressant;
H1-receptor antagonist;
sedative;
serotonin uptake inhibitor
ciprofloxacin hydrochloride anhydrous[no description available]low00hydrochlorideantibacterial drug;
antiinfective agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
topoisomerase IV inhibitor
sertraline hydrochloride[no description available]low00hydrochlorideantidepressant;
serotonin uptake inhibitor
tramadol hydrochloride[no description available]low00hydrochlorideadrenergic uptake inhibitor;
antitussive;
capsaicin receptor antagonist;
delta-opioid receptor agonist;
kappa-opioid receptor agonist;
mu-opioid receptor agonist;
muscarinic antagonist;
nicotinic antagonist;
NMDA receptor antagonist;
opioid analgesic;
serotonergic antagonist;
serotonin uptake inhibitor
amantadine hydrochloride[no description available]low00hydrochlorideantiviral agent;
dopamine agonist;
NMDA receptor antagonist
amodiaquine hydrochloride[no description available]low00hydrochlorideanticoronaviral agent
doxapram hydrochloride[no description available]low00hydrochloridecentral nervous system stimulant
bupivacaine hydrochloride[no description available]low00hydrochloride;
racemate		adrenergic antagonist;
amphiphile;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor;
local anaesthetic
spectinomycin dihydrochloride[no description available]low00hydrochlorideantibacterial drug;
antimicrobial agent
desipramine hydrochloride[no description available]low00hydrochloridedrug allergen
mefloquine hydrochloride[no description available]low00hydrochloride
ticlopidine hydrochloride[no description available]low00hydrochloride
thioridazine hydrochloride[no description available]low00hydrochloridefirst generation antipsychotic;
geroprotector
diphenylpyraline hydrochloride[no description available]low00hydrochloridecholinergic antagonist;
H1-receptor antagonist
trifluoperazine hydrochloride[no description available]low00hydrochloride
procainamide hydrochloride[no description available]low00hydrochlorideanti-arrhythmia drug
siquil[no description available]low00hydrochlorideanticoronaviral agent
mepivacaine hydrochloride[no description available]low00hydrochloride;
piperidinecarboxamide		local anaesthetic
sotalol hydrochloride[no description available]low00hydrochlorideanti-arrhythmia drug;
beta-adrenergic antagonist
ay-20694[no description available]low00hydrochloride
alprenolol hydrochloride[no description available]low00hydrochloride
dyclonine hydrochloride[no description available]low00hydrochloridetopical anaesthetic
clomipramine hydrochloride[no description available]low00hydrochlorideanticoronaviral agent;
antidepressant;
serotonergic antagonist;
serotonergic drug
prazosin hydrochloride[no description available]low00hydrochloride
mianserin hydrochloride[no description available]low00hydrochloridegeroprotector
medetomidine hydrochloride[no description available]low00hydrochloride
lomefloxacin hydrochloride[no description available]low00hydrochlorideantimicrobial agent;
antitubercular agent;
photosensitizing agent
methixene hydrochloride[no description available]low00hydrate;
hydrochloride
pirenzepine dihydrochloride[no description available]low00hydrochloride
loperamide hydrochloride[no description available]low00hydrochlorideanticoronaviral agent;
antidiarrhoeal drug;
mu-opioid receptor agonist
talampicillin hydrochloride[no description available]low00hydrochloride
uroxatral[no description available]low00hydrochloride
1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride[no description available]low00hydrochlorideEC 2.7.11.13 (protein kinase C) inhibitor
amperozide hydrochloride[no description available]low00hydrochlorideanxiolytic drug;
dopamine uptake inhibitor;
geroprotector;
second generation antipsychotic;
serotonergic antagonist
eprazinone hydrochloride[no description available]low00hydrochloridemucolytic
irinotecan hydrochloride[no description available]low00hydrochlorideantineoplastic agent;
apoptosis inducer;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
prodrug
tiagabine hydrochloride[no description available]low00hydrochlorideanticonvulsant;
GABA reuptake inhibitor
diethylpropion hydrochloride[no description available]low00hydrochlorideappetite depressant
oxybutynin hydrochloride[no description available]low00hydrochloride
nimustine[no description available]low00hydrochlorideantineoplastic agent
cordium[no description available]low00hydrate;
hydrochloride
biperiden hydrochloride[no description available]low00hydrochloride;
piperidines;
tertiary alcohol		antiparkinson drug;
muscarinic antagonist;
parasympatholytic
prilocaine hydrochloride[no description available]low00hydrochloridelocal anaesthetic
moxifloxacin hydrochloride[no description available]low00hydrochlorideantibacterial drug
asl 8052[no description available]low00hydrochlorideanti-arrhythmia drug;
beta-adrenergic antagonist
vanoxerine[no description available]low00hydrochloridedopamine uptake inhibitor
methoctramine[no description available]low00hydrochloridemuscarinic antagonist
betaxolol hydrochloride[no description available]low00hydrochlorideantihypertensive agent;
beta-adrenergic antagonist
fingolimod hydrochloride[no description available]low00hydrochlorideimmunosuppressive agent;
prodrug;
sphingosine-1-phosphate receptor agonist
pivmecillinam hydrochloride[no description available]low00hydrochloride
profenamine hydrochloride[no description available]low00hydrochlorideadrenergic antagonist;
antiparkinson drug;
histamine antagonist;
muscarinic antagonist
aminolevulinic acid hydrochloride[no description available]low00hydrochlorideantineoplastic agent;
dermatologic drug;
photosensitizing agent;
prodrug
1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride[no description available]low00hydrochlorideanxiolytic drug;
serotonergic agonist
ng-nitroarginine methyl ester[no description available]low00hydrochlorideEC 1.14.13.39 (nitric oxide synthase) inhibitor
cinacalcet hydrochloride[no description available]low00hydrochloridecalcimimetic;
P450 inhibitor
epinastine hydrochloride[no description available]low00hydrochloride
methyl 5-aminolevulinate hydrochloride[no description available]low00hydrochlorideantineoplastic agent;
dermatologic drug;
photosensitizing agent;
prodrug
fasudil hydrochloride[no description available]low00hydrochlorideantihypertensive agent;
calcium channel blocker;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
neuroprotective agent;
nootropic agent;
vasodilator agent
ropivacaine[no description available]low00hydrochloridelocal anaesthetic
erlotinib hydrochloride[no description available]low00hydrochloride;
terminal acetylenic compound		antineoplastic agent;
protein kinase inhibitor
memantine hydrochloride[no description available]low00hydrochlorideantidepressant;
antiparkinson drug;
dopaminergic agent;
neuroprotective agent;
NMDA receptor antagonist
procyclidine hydrochloride[no description available]low00hydrochloride
l 778,123[no description available]low00hydrochlorideantineoplastic agent;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor;
EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor;
radiosensitizing agent
dicyclomine hydrochloride[no description available]low00hydrochlorideantispasmodic drug;
muscarinic antagonist
flavoxate hydrochloride[no description available]low00hydrochlorideantispasmodic drug;
muscarinic antagonist;
parasympatholytic
eflornithine hydrochloride[no description available]low00hydrate;
hydrochloride
bacampicillin hydrochloride[no description available]low00hydrochloride
cocaine hydrochloride[no description available]low00hydrochloridecentral nervous system stimulant;
local anaesthetic
(1R,2S)-tranylcypromine hydrochloride[no description available]low00hydrochloride
ranitidine hydrochloride[no description available]low00hydrochloridedrug allergen
corlanor[no description available]low00hydrochloridecardiotonic drug
emetine dihydrochloride[no description available]low00hydrochlorideanticoronaviral agent;
antimalarial;
antineoplastic agent;
antiprotozoal drug;
antiviral agent;
autophagy inhibitor;
emetic;
protein synthesis inhibitor
naftifine hydrochloride[no description available]low00allylamine antifungal drug;
hydrochloride
pibutidine hydrochloride[no description available]low00hydrochlorideanti-ulcer drug;
H2-receptor antagonist
terbinafine hydrochloride[no description available]low00allylamine antifungal drug;
hydrochloride		EC 1.14.13.132 (squalene monooxygenase) inhibitor;
P450 inhibitor
cis-flupenthixol dihydrochloride[no description available]low00hydrochloridegeroprotector
phenylephrine hydrochloride[no description available]low00hydrochloride
nalbuphine hydrochloride[no description available]low00hydrochloride
lotensin[no description available]low00hydrochlorideEC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
tamsulosin hydrochloride[no description available]low00hydrochloridealpha-adrenergic antagonist;
antineoplastic agent
naloxone hydrochloride[no description available]low00hydrochlorideantidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist
morphine chloride[no description available]low00hydrochloride
naltrexone hydrochloride[no description available]low00hydrochlorideantidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist
triprolidine hydrochloride anhydrous[no description available]low00hydrochlorideH1-receptor antagonist
bromhexine hydrochloride[no description available]low00hydrochloridemucolytic
cyclizine hydrochloride[no description available]low00hydrochlorideantiemetic;
central nervous system depressant;
cholinergic antagonist;
H1-receptor antagonist
benoxinate hydrochloride[no description available]low00hydrochloridelocal anaesthetic
diphenoxylate hydrochloride[no description available]low00hydrochlorideantidiarrhoeal drug
protriptyline hydrochloride[no description available]low00hydrochlorideantidepressant
rs 25259-197[no description available]low00hydrochlorideantiemetic;
serotonergic antagonist
vilazodone hydrochloride[no description available]low00hydrochlorideantidepressant;
serotonergic agonist;
serotonin uptake inhibitor
2-methyl-6-(phenylethynyl)pyridine hydrochloride[no description available]low00hydrochlorideanxiolytic drug;
metabotropic glutamate receptor antagonist
(R)-fluoxetine hydrochloride[no description available]low00hydrochlorideantidepressant;
serotonin uptake inhibitor
(S)-fluoxetine hydrochloride[no description available]low00hydrochlorideantidepressant;
serotonin uptake inhibitor
5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride[no description available]low00hydrochloride;
iminium salt		antineoplastic agent;
EC 2.4.2.4 (thymidine phosphorylase) inhibitor
hmr 1275[no description available]low00hydrochlorideantineoplastic agent;
antirheumatic drug;
apoptosis inducer;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
jte 607[no description available]low00hydrochlorideanti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
cardioprotective agent;
CPSF3 inhibitor;
prodrug
a 77636[no description available]low00hydrochlorideantiparkinson drug;
dopamine agonist
n,n-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride[no description available]low00aromatic ether;
hydrochloride;
methoxybenzenes;
tertiary amino compound		antipsychotic agent;
receptor modulator
u 18666a[no description available]low00hydrochlorideantiviral agent;
EC 1.3.1.72 (Delta(24)-sterol reductase) inhibitor;
Hedgehog signaling pathway inhibitor;
nicotinic antagonist;
sterol biosynthesis inhibitor
lurasidone hydrochloride[no description available]low00hydrochlorideadrenergic antagonist;
dopaminergic antagonist;
second generation antipsychotic;
serotonergic antagonist
zm 252868[no description available]low00hydrochlorideEC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
epidermal growth factor receptor antagonist
GR 127935 hydrochloride[no description available]low00hydrochlorideserotonergic antagonist
nebivolol hydrochloride[no description available]low00hydrochloride
n,n'-dibenzhydrylethane-1,2-diamine dihydrochloride[no description available]low00hydrochloridegeroprotector;
metabotropic glutamate receptor agonist;
neuroprotective agent
pipamperone dihydrochloride[no description available]low00hydrochloridedopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
brl 15572[no description available]low00hydrochlorideprodrug;
serotonergic antagonist
(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzodioxan hydrochloride[no description available]low00hydrochloridealpha-adrenergic antagonist
(2R,3S)-EHNA hydrochloride[no description available]low00hydrochlorideEC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
EC 3.5.4.4 (adenosine deaminase) inhibitor
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride[no description available]low00hydrochloridedopamine uptake inhibitor
1-(2-(4-(4-fluoro-benzoyl)-piperidin-1-yl)-ethyl)-3,3-dimethyl-1,2-dihydro-indol-2-one[no description available]low00hydrochloridereceptor modulator;
serotonergic antagonist
glycinexylidide monohydrochloride[no description available]low00hydrochloride
new fuchsin[no description available]low00hydrochloridefluorochrome;
histological dye
3,6-diamino-10-methylacridinium chloride hydrochloride[no description available]low00hydrochlorideantibacterial agent;
antiseptic drug;
carcinogenic agent;
intercalator
GS4012[no description available]low00hydrochloride;
pyridinium salt		VEGF activator
nsc 23766[no description available]low00hydrochlorideantiviral agent;
apoptosis inducer;
EC 3.6.5.2 (small monomeric GTPase) inhibitor;
muscarinic antagonist
rs 39604[no description available]low00hydrochlorideserotonergic antagonist
nnc 55-0396[no description available]low00hydrochlorideangiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
neuroprotective agent;
potassium channel blocker;
T-type calcium channel blocker
acridine yellow[no description available]low00aminoacridines;
hydrochloride		fluorochrome
pf-670462[no description available]low00hydrochlorideEC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
sapropterin dihydrochloride[no description available]low00hydrochloridecoenzyme;
diagnostic agent
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio0low10
Epidemic Acute Poliomyelitis0low10
Infantile Paralysis0low10
Inflammation0low10
Innate Inflammatory Response0low10
Polio0low10
Polio Encephalitis0low10
Poliomyelitis0low10
Poliomyelitis Infection0low10
Poliomyelitis, Acute0low10
Poliomyelitis, Nonpoliovirus0low10
Poliomyelitis, Preparalytic0low10

Research Highlights

Bioavailability (1)

ArticleYear
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology, Volume: 96, Issue: 5		2019
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]