| Assay ID | Title | Year | Journal | Article |
|---|
| AID677316 | Immunostimulatory activity in C57BL/6 mouse splenocytes assessed as IFN-gamma release at 100 ng/ml after 72 hrs by ELISA relative to OCH | 2012 | Bioorganic & medicinal chemistry, May-01, Volume: 20, Issue:9
| Synthesis and biological evaluation of truncated α-galactosylceramide derivatives focusing on cytokine induction profile. |
| AID425892 | Stimulation of human iNKT cell proliferation | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH. |
| AID295919 | Induction of IFN gamma secretion in C57BL/6 mouse spleen cells at 100 ng/ml after 72 hrs relative to OCH | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10
| Minimum structure requirement of immunomodulatory glycolipids for predominant Th2 cytokine induction and the discovery of non-linear phytosphingosine analogs. |
| AID1593616 | Induction of serum IFNgamma production in C57BL/6 mouse at 100 ug/kg, ip and measured for 48 hrs by AUC method relative to KRN7000 | 2019 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11
| Design, synthesis, and evaluation of α-galactopyranosylceramide mimics promoting Th2 cytokines production. |
| AID387827 | Induction of IL13 production in C57BL/6 mouse natural killer T cells after 48 hrs by cytometric bead array | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| RCAI-17, 22, 24-26, 29, 31, 34-36, 38-40, and 88, the analogs of KRN7000 with a sulfonamide linkage: their synthesis and bioactivity for mouse natural killer T cells to produce Th2-biased cytokines. |
| AID1593615 | Induction of serum IL-4 production in C57BL/6 mouse assessed as serum IL-4 level at 100 ug/kg, ip and measured for 48 hrs by AUC method | 2019 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11
| Design, synthesis, and evaluation of α-galactopyranosylceramide mimics promoting Th2 cytokines production. |
| AID1593617 | Induction of serum IL-4 production in C57BL/6 mouse at 100 ug/kg, ip and measured for 48 hrs by AUC method relative to KRN7000 | 2019 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11
| Design, synthesis, and evaluation of α-galactopyranosylceramide mimics promoting Th2 cytokines production. |
| AID387826 | Induction of IL4 production in C57BL/6 mouse natural killer T cells after 48 hrs by cytometric bead array | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| RCAI-17, 22, 24-26, 29, 31, 34-36, 38-40, and 88, the analogs of KRN7000 with a sulfonamide linkage: their synthesis and bioactivity for mouse natural killer T cells to produce Th2-biased cytokines. |
| AID1593619 | Induction of serum IL-4 production in C57BL/6 mouse assessed as serum IL-4 level at 100 ug/kg, ip and measured for 48 hrs by peak value method | 2019 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11
| Design, synthesis, and evaluation of α-galactopyranosylceramide mimics promoting Th2 cytokines production. |
| AID1593614 | Induction of serum IFNgamma production in C57BL/6 mouse assessed as serum IFNgamma level at 100 ug/kg, ip and measured for 48 hrs by AUC method | 2019 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11
| Design, synthesis, and evaluation of α-galactopyranosylceramide mimics promoting Th2 cytokines production. |
| AID1593623 | Ratio of induction activity for IL-4 production in C57BL/6 mouse at 100 ug/kg, ip after 48 hrs by peak value method to induction activity for IFN-gamma production in C57BL/6 mouse at 100 ug/kg, ip after 48 hrs by peak value method | 2019 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11
| Design, synthesis, and evaluation of α-galactopyranosylceramide mimics promoting Th2 cytokines production. |
| AID677319 | Immunostimulatory activity iv dosed in C57BL/6 mouse assessed as IL-4 secretion | 2012 | Bioorganic & medicinal chemistry, May-01, Volume: 20, Issue:9
| Synthesis and biological evaluation of truncated α-galactosylceramide derivatives focusing on cytokine induction profile. |
| AID1593622 | Induction of serum IFNgamma production in C57BL/6 mouse assessed as serum IFNgamma level at 100 ug/kg, ip and measured for 48 hrs by peak value method relative to KRN7000 | 2019 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11
| Design, synthesis, and evaluation of α-galactopyranosylceramide mimics promoting Th2 cytokines production. |
| AID677315 | Immunostimulatory activity in C57BL/6 mouse splenocytes assessed as IL-4 release at 100 ng/ml after 72 hrs by ELISA relative to OCH | 2012 | Bioorganic & medicinal chemistry, May-01, Volume: 20, Issue:9
| Synthesis and biological evaluation of truncated α-galactosylceramide derivatives focusing on cytokine induction profile. |
| AID1593621 | Induction of serum IFNgamma production in C57BL/6 mouse assessed as serum IFNgamma level at 100 ug/kg, ip and measured for 48 hrs by peak value method | 2019 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11
| Design, synthesis, and evaluation of α-galactopyranosylceramide mimics promoting Th2 cytokines production. |
| AID677322 | Immunostimulatory activity iv dosed in C57BL/6 mouse assessed as IFN-gamma secretion | 2012 | Bioorganic & medicinal chemistry, May-01, Volume: 20, Issue:9
| Synthesis and biological evaluation of truncated α-galactosylceramide derivatives focusing on cytokine induction profile. |
| AID575776 | Antibacterial activity against Sphingomonas capsulata ATCC 14666 infected in C57BL/6 mouse assessed as reduction in lung bacterial load at 100 ug/kg, ip administered 2 hrs post infection measured 24 hrs post infection | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| In vivo protection provided by a synthetic new alpha-galactosyl ceramide analog against bacterial and viral infections in murine models. |
| AID1593620 | Induction of serum IL-4 production in C57BL/6 mouse assessed as serum IL-4 level at 100 ug/kg, ip and measured for 48 hrs by peak value method relative to KRN7000 | 2019 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11
| Design, synthesis, and evaluation of α-galactopyranosylceramide mimics promoting Th2 cytokines production. |
| AID425889 | Stimulation of mouse splenocyte proliferation by [3H]thymidine after 48 hrs by incorporation assay | 2009 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
| Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH. |
| AID295918 | Induction of IL4 secretion in C57BL/6 mouse spleen cells at 100 ng/ml after 72 hrs relative to OCH | 2007 | Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10
| Minimum structure requirement of immunomodulatory glycolipids for predominant Th2 cytokine induction and the discovery of non-linear phytosphingosine analogs. |
| AID1509403 | Binding affinity to CD1d in C57BL/6 mouse HMNC cells assessed as iNKT cells stimulation by measuring Th1-type cytokine, IFNgamma production at 25 nM incubated for 72 hrs by ELISA | 2019 | ACS medicinal chemistry letters, May-09, Volume: 10, Issue:5
| Development of α-GalCer Analogues with an α-Fluorocarbonyl Moiety as Th2-Selective Ligands of CD1d. |
| AID1593618 | Ratio of induction activity for IL-4 production in C57BL/6 mouse at 100 ug/kg, ip after 48 hrs by AUC method to induction activity for IFN-gamma production in C57BL/6 mouse at 100 ug/kg, ip after 48 hrs by AUC method | 2019 | Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11
| Design, synthesis, and evaluation of α-galactopyranosylceramide mimics promoting Th2 cytokines production. |
| AID1509402 | Binding affinity to CD1d in C57BL/6 mouse HMNC cells assessed as iNKT cells stimulation by measuring increase in Th2-type cytokine, IL-4 production at 25 nM incubated for 72 hrs by ELISA | 2019 | ACS medicinal chemistry letters, May-09, Volume: 10, Issue:5
| Development of α-GalCer Analogues with an α-Fluorocarbonyl Moiety as Th2-Selective Ligands of CD1d. |
| AID1509410 | Binding affinity to CD1d in C57BL/6 mouse HMNC cells assessed as iNKT cells stimulation by measuring increase in ratio of IL-4 to IFNgamma (IL-4/IFNgamma) level at 25 nM incubated for 72 hrs by ELISA | 2019 | ACS medicinal chemistry letters, May-09, Volume: 10, Issue:5
| Development of α-GalCer Analogues with an α-Fluorocarbonyl Moiety as Th2-Selective Ligands of CD1d. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2011 | Immunity, Mar-25, Volume: 34, Issue:3
| A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2010 | Journal of immunology (Baltimore, Md. : 1950), Jan-01, Volume: 184, Issue:1
| Mechanisms for glycolipid antigen-driven cytokine polarization by Valpha14i NKT cells. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |