globo-h profile

alpha-L-Fucp-(1->2)-beta-D-Galp-(1->3)-beta-D-GlcpNAc : An amino trisaccharide consisting of alpha-L-fucose, beta-D-galactose and N-acetyl-beta-D-glucosamine residues joined by sequential (1->2)- and (1->3)-linkages. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	5326971
CHEBI ID	59296
MeSH ID	M0447807

Synonym
fucalpha1-2galbeta1-3glcnacbeta
CHEBI:59296 ,
fuca1-2galb1-3glcnacb
6-deoxy-alpha-l-galactopyranosyl-(1->2)-beta-d-galactopyranosyl-(1->3)-2-acetamido-2-deoxy-beta-d-glucopyranose
alpha-l-fuc-(1->2)-beta-d-gal-(1->3)-beta-d-glcnac
alpha-l-fucopyranosyl-(1->2)-beta-d-galactopyranosyl-(1->3)-2-acetamido-2-deoxy-beta-d-glucopyranose
human blood group h type 1 trisaccharide
alpha-l-fucp-(1->2)-beta-d-galp-(1->3)-beta-d-glcpnac
h type i epitope
globo-h ,
alphalfuc(1-2)betadgal(1-3)betadglcnac
alpha-l-fuc-(1-->2)-beta-d-gal-(1-->3)-beta-d-glcnac
h type i
DB04679
EPITOPE ID:130652
MGSDFCKWGHNUSM-QVPNGJTFSA-N
Q27126605

Excerpt	Relevance	Reference
" We are now conducting a de-escalation dosing study with NP-polySA-KLH to better assess the immunogenicity, toxicities, and optimal dose of this vaccine."	( Vaccination of small cell lung cancer patients with polysialic acid or N-propionylated polysialic acid conjugated to keyhole limpet hemocyanin. Baez, V; Guo, Z; Hood, C; Jennings, HJ; Kris, MG; Krug, LM; Livingston, PO; Miller, V; Ng, KK; Pizzo, B; Ragupathi, G; Tyson, L, 2004)	0.32

Role	Description
epitope	The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
alpha-L-Fucp-(1->2)-beta-D-Galp-(1->3)-D-GlcpNAc	An amino trisaccharide consisting of alpha-L-fucose, beta-D-galactose and N-acetyl-D-glucosamine residues joined by sequential (1->2)- and (1->3)-linkages.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	15 (35.71)	29.6817
2010's	21 (50.00)	24.3611
2020's	6 (14.29)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (2.38%)	5.53%
Reviews	5 (11.90%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	36 (85.71%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
pentetic acid Pentetic Acid: An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.	2.11	1	0	pentacarboxylic acid	copper chelator
galactose galactopyranose : The pyranose form of galactose.	2.03	1	0	D-galactose; galactopyranose	Escherichia coli metabolite; mouse metabolite
lactose Lactose: A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.. lactose : A glycosylglucose disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form.. beta-lactose : The beta-anomer of lactose.	2.04	1	0	lactose
fucose Fucose: A six-member ring deoxysugar with the chemical formula C6H12O5. It lacks a hydroxyl group on the carbon at position 6 of the molecule.. L-fucopyranose : The pyranose form of L-fucose.. fucose : Any deoxygalactose that is deoxygenated at the 6-position.	2.54	2	0	fucopyranose; L-fucose	Escherichia coli metabolite; mouse metabolite
ytterbium Ytterbium: An element of the rare earth family of metals. It has the atomic symbol Yb, atomic number 70, and atomic weight 173. Ytterbium has been used in lasers and as a portable x-ray source.	2.02	1	0	f-block element atom; lanthanoid atom
acetylglucosamine Acetylglucosamine: The N-acetyl derivative of glucosamine.. N-acetyl-beta-D-glucosamine : An N-acetyl-D-glucosamine having beta-configuration at the anomeric centre.	2.02	1	0	N-acetyl-D-glucosamine	epitope
thomsen-friedenreich antigen Thomsen-Friedenreich antigen: do not confuse with T antigens, which are viral	4.39	3	0
ganglioside, gd2 [no description available]	3.16	1	0
beta-escin [no description available]	3.4	1	1
g(m2) ganglioside G(M2) Ganglioside: A glycosphingolipid that accumulates due to a deficiency of hexosaminidase A or B (BETA-N-ACETYLHEXOSAMINIDASES), or GM2 activator protein, resulting in GANGLIOSIDOSES, heredity metabolic disorders that include TAY-SACHS DISEASE and SANDHOFF DISEASE.. ganglioside GM2 (18:0) : A sialotriaosylceramide that is N-acetyl-beta-D-galactosaminyl-(1->4)-alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-N-acylsphingosine in which the acyl group on the sphingosine nitrogen is octadecanoyl. A constituent of natural ganglioside GM2.	3.81	2	1	N-acetyl-beta-D-galactosaminyl-(1->4)-alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-N-acylsphingosine; sialotriaosylceramide	antigen
g(m1) ganglioside G(M1) Ganglioside: A specific monosialoganglioside that accumulates abnormally within the nervous system due to a deficiency of GM1-b-galactosidase, resulting in GM1 gangliosidosis.. ganglioside GM1 : A sialotetraosylceramide consisting of a branched pentasaccharide made up from one sialyl residue, two galactose residues, one N-acetylgalactosamine residue and a glucose residue at the reducing end attached to N-stearoylsphingosine via a beta-linkage.	4.13	3	1	alpha-N-acetylneuraminosyl-(2->3)-[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphingosine; sialotetraosylceramide
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene [no description available]	2.1	1	0	BODIPY compound
qs 21 [no description available]	3.4	1	1
lewis x antigen Lewis X Antigen: A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, Lewis X antigen is a stage-specific embryonic antigen.	4.09	2	0
fucosyl gm1 ganglioside [no description available]	2.02	1	0

Condition	Relationship Strength	Studies	Trials
Cholangiocellular Carcinoma [description not available]	2.41	1	0
Bile Duct Cancer [description not available]	2.41	1	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.41	1	0
Bile Duct Neoplasms Tumors or cancer of the BILE DUCTS.	2.41	1	0
Cholangiocarcinoma A malignant tumor arising from the epithelium of the BILE DUCTS.	2.41	1	0
Benign Neoplasms [description not available]	5.08	6	0
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	5.08	6	0
Basophilic Leukemia, Acute [description not available]	2.21	1	0
Leukemia, Basophilic, Acute A rare acute myeloid leukemia in which the primary differentiation is to BASOPHILS. It is characterized by an extreme increase of immature basophilic granulated cells in the bone marrow and blood. Mature basophils are usually sparse.	2.21	1	0
Neuroectodermal Tumors Malignant neoplasms arising in the neuroectoderm, the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems, including some glial cells.	3.17	1	0
Epithelial Neoplasms [description not available]	3.17	1	0
Breast Cancer [description not available]	4.6	9	0
Breast Neoplasms Tumors or cancer of the human BREAST.	4.6	9	0
Carcinoma, Non-Small Cell Lung [description not available]	2.15	1	0
Cancer of Lung [description not available]	4.12	3	1
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	2.15	1	0
Lung Neoplasms Tumors or cancer of the LUNG.	4.12	3	1
Disease Exacerbation [description not available]	2.21	1	0
Hepatocellular Carcinoma [description not available]	2.5	2	0
Cancer of Liver [description not available]	2.5	2	0
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.5	2	0
Liver Neoplasms Tumors or cancer of the LIVER.	2.5	2	0
Carcinoma, Lewis Lung A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.	2.08	1	0
Hepatitis B Virus Infection [description not available]	2.1	1	0
Hepatitis B INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.	2.1	1	0
Carcinogenesis The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.	2.1	1	0
Angiogenesis, Pathologic [description not available]	2.1	1	0
Experimental Mammary Neoplasms [description not available]	2.11	1	0
Follicular Thyroid Carcinoma [description not available]	2.13	1	0
Familial Nonmedullary Thyroid Cancer [description not available]	2.13	1	0
Adenoma, Basal Cell [description not available]	2.13	1	0
Carcinoma, Anaplastic [description not available]	2.13	1	0
Carcinoma, Papillary A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)	2.13	1	0
Cancer of the Thyroid [description not available]	2.13	1	0
Invasiveness, Neoplasm [description not available]	2.13	1	0
Adenoma A benign epithelial tumor with a glandular organization.	2.13	1	0
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	2.13	1	0
Thyroid Neoplasms Tumors or cancer of the THYROID GLAND.	2.13	1	0
Adenocarcinoma, Follicular An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)	2.13	1	0
Carcinoma, Neuroendocrine A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round blue cells, granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small (oat) cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)	2.13	1	0
Cancer of Ovary [description not available]	2.15	1	0
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	2.15	1	0
Cystadenocarcinoma, Serous A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)	2.15	1	0
Infectious Diseases [description not available]	2.05	1	0
Communicable Diseases An illness caused by an infectious agent or its toxins that occurs through the direct or indirect transmission of the infectious agent or its products from an infected individual or via an animal, vector or the inanimate environment to a susceptible animal or human host.	2.05	1	0
Carcinoma, Oat Cell [description not available]	3.81	2	1
Carcinoma, Small Cell An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)	3.81	2	1
Cancer of Prostate [description not available]	3.34	2	0
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	3.34	2	0

globo-h

Description

Cross-References

Synonyms (17)

Research Excerpts

Dosage Studied

Roles (1)

Drug Classes (1)

Research

Studies (42)

Market Indicators

Research Demand Index: 26.49

Study Types