Target type: cellularcomponent
Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell. [GOC:isa_complete]
Extracellular membrane-bounded organelles are compartments enclosed by a membrane that are located outside of the cell. These organelles are often involved in secretion, uptake of nutrients, and other processes that require interaction with the external environment. The specific components of these organelles vary depending on the type of cell and its function, but some common features include:
* **Membrane:** The outermost layer of the organelle, which provides structural support and regulates the passage of molecules into and out of the organelle. This membrane is often continuous with the plasma membrane of the cell.
* **Lumen:** The internal space enclosed by the membrane. The lumen may contain various molecules, such as proteins, enzymes, and substrates, depending on the function of the organelle.
* **Proteins:** Embedded within the membrane and/or present in the lumen, proteins play a crucial role in the function of the organelle. For example, they may act as receptors, transporters, or enzymes.
Examples of extracellular membrane-bounded organelles include:
* **Endosomes:** Involved in the sorting and trafficking of internalized materials, such as proteins and lipids.
* **Lysosomes:** Contain enzymes that break down cellular debris and foreign materials.
* **Secretory vesicles:** Store and transport molecules that are destined for secretion outside of the cell.
* **Exosomes:** Small vesicles that are released from cells and can carry various molecules to other cells, playing a role in cell-cell communication.
These organelles are dynamic structures that are constantly being remodeled and re-formed to meet the changing needs of the cell. They play essential roles in various cellular processes, and their proper function is essential for maintaining cell health.'
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Protein | Definition | Taxonomy |
---|---|---|
Alkaline phosphatase, tissue-nonspecific isozyme | An alkaline phosphatase, tissue-nonspecific isozyme that is encoded in the genome of cow. [OMA:P09487, PRO:DNx] | Bos taurus (cattle) |
Phosphoethanolamine/phosphocholine phosphatase | A phosphoethanolamine/phosphocholine phosphatase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCT1] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
phenylalanine | L-phenylalanine : The L-enantiomer of phenylalanine. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group. Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE. | amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid | algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite |
levamisole | levamisole : A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine. Levamisole: An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6) | 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole | antinematodal drug; antirheumatic drug; EC 3.1.3.1 (alkaline phosphatase) inhibitor; immunological adjuvant; immunomodulator |
2-phenyl-1,2-benzisothiazol-3-(2h)-one | 2-phenyl-1,2-benzisothiazol-3-(2H)-one: structure given in first source; sulfur analog of ebselen | ||
6-fluoro-2-phenyl-1,2-benzothiazol-3-one | benzothiazoles | ||
2-[4-methyl-3-(1-piperidinylsulfonyl)phenyl]-1,2-benzothiazol-3-one | sulfonamide | ||
2-[[3-(3-oxo-1,2-benzothiazol-2-yl)phenyl]sulfonylamino]benzoic acid | sulfonamide | ||
N,N-dimethyl-3-(3-oxo-1,2-benzothiazol-2-yl)benzenesulfonamide | sulfonamide | ||
3-nitrobenzaldehyde isonicotinoylhydrazone | 3-nitrobenzaldehyde isonicotinoylhydrazone: structure in first source | ||
2-(3-chlorophenyl)-1,2-benzothiazol-3-one | benzothiazoles | ||
2-(4-fluorophenyl)-1,2-benzothiazol-3-one | benzothiazoles | ||
salinazid | aromatic carboxylic acid; pyridinemonocarboxylic acid | ||
phthivazide |