Target type: molecularfunction
Catalysis of the reaction: O-phosphoethanolamine + H2O = ethanolamine + phosphate. [EC:3.1.3.75]
Phosphoethanolamine phosphatase activity catalyzes the hydrolysis of phosphoethanolamine, a molecule containing both a phosphate group and an ethanolamine moiety. This reaction removes the phosphate group from phosphoethanolamine, generating inorganic phosphate and ethanolamine. This enzymatic activity plays a crucial role in various biological processes, including:
1. **Lipid metabolism:** Phosphoethanolamine is a precursor to phosphatidylethanolamine, a major component of cell membranes. Phosphoethanolamine phosphatase activity regulates the levels of phosphoethanolamine, thereby influencing the synthesis and turnover of phosphatidylethanolamine.
2. **Signal transduction:** Phosphoethanolamine can act as a signaling molecule in certain pathways. Its dephosphorylation by phosphoethanolamine phosphatase can regulate the activity of downstream signaling components.
3. **Neurotransmission:** Phosphoethanolamine is involved in neurotransmitter metabolism and can be a precursor to the neurotransmitter acetylcholine. Phosphoethanolamine phosphatase activity contributes to the regulation of neurotransmitter levels.
4. **Other cellular processes:** Phosphoethanolamine phosphatase activity has been implicated in other cellular processes such as cell growth, proliferation, and differentiation.
In summary, phosphoethanolamine phosphatase activity is a critical enzyme involved in diverse cellular functions related to lipid metabolism, signal transduction, neurotransmission, and other cellular processes.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Alkaline phosphatase, tissue-nonspecific isozyme | An alkaline phosphatase, tissue-nonspecific isozyme that is encoded in the genome of cow. [OMA:P09487, PRO:DNx] | Bos taurus (cattle) |
| Phosphoethanolamine/phosphocholine phosphatase | A phosphoethanolamine/phosphocholine phosphatase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCT1] | Homo sapiens (human) |
| Alkaline phosphatase, tissue-nonspecific isozyme | An alkaline phosphatase, tissue-nonspecific isozyme that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05186] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| theophylline | dimethylxanthine | adenosine receptor antagonist; anti-asthmatic drug; anti-inflammatory agent; bronchodilator agent; drug metabolite; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; fungal metabolite; human blood serum metabolite; immunomodulator; muscle relaxant; vasodilator agent | |
| adenosine monophosphate | Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. | adenosine 5'-phosphate; purine ribonucleoside 5'-monophosphate | adenosine A1 receptor agonist; cofactor; EC 3.1.3.1 (alkaline phosphatase) inhibitor; EC 3.1.3.11 (fructose-bisphosphatase) inhibitor; fundamental metabolite; micronutrient; nutraceutical |
| leucine | leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group. Leucine: An essential branched-chain amino acid important for hemoglobin formation. | amino acid zwitterion; L-alpha-amino acid; leucine; proteinogenic amino acid; pyruvate family amino acid | algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite |
| phenylalanine | L-phenylalanine : The L-enantiomer of phenylalanine. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group. Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE. | amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid | algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite |
| tryptophan | tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3. Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals. | erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; L-alpha-amino acid zwitterion; proteinogenic amino acid; tryptophan; tryptophan zwitterion | antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite |
| homoarginine | L-homoarginine : An L-lysine derivative that is the L-enantiomer of homoarginine. | homoarginine; L-lysine derivative; non-proteinogenic L-alpha-amino acid | biomarker; EC 3.1.3.1 (alkaline phosphatase) inhibitor; human metabolite; rat metabolite; xenobiotic metabolite |
| levamisole | levamisole : A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine. Levamisole: An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6) | 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole | antinematodal drug; antirheumatic drug; EC 3.1.3.1 (alkaline phosphatase) inhibitor; immunological adjuvant; immunomodulator |
| levamisole hydrochloride | organic molecular entity | ||
| 1-(3,4-dihydroxyphenyl)-2-(1-imidazolyl)ethanone | aromatic ketone | ||
| 2-phenyl-1,2-benzisothiazol-3-(2h)-one | 2-phenyl-1,2-benzisothiazol-3-(2H)-one: structure given in first source; sulfur analog of ebselen | ||
| 1-(3,4-dihydroxyphenyl)-2-[(4,6-dimethyl-2-pyrimidinyl)thio]ethanone | aromatic ketone | ||
| 6-fluoro-2-phenyl-1,2-benzothiazol-3-one | benzothiazoles | ||
| 2-[4-methyl-3-(1-piperidinylsulfonyl)phenyl]-1,2-benzothiazol-3-one | sulfonamide | ||
| 2,5-dimethoxy-n-(quinolin-3-yl)benzenesulfonamide | 2,5-dimethoxy-N-(quinolin-3-yl)benzenesulfonamide: a tissue-nonspecific alkaline phosphatase inhibitor; structure in first source | quinolines | |
| 2-[[3-(3-oxo-1,2-benzothiazol-2-yl)phenyl]sulfonylamino]benzoic acid | sulfonamide | ||
| N,N-dimethyl-3-(3-oxo-1,2-benzothiazol-2-yl)benzenesulfonamide | sulfonamide | ||
| 3-nitrobenzaldehyde isonicotinoylhydrazone | 3-nitrobenzaldehyde isonicotinoylhydrazone: structure in first source | ||
| 2-(3-chlorophenyl)-1,2-benzothiazol-3-one | benzothiazoles | ||
| 2-(4-fluorophenyl)-1,2-benzothiazol-3-one | benzothiazoles | ||
| salinazid | aromatic carboxylic acid; pyridinemonocarboxylic acid | ||
| phthivazide |