HBX 41,108: inhibits USP7 ubiquitin protease; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 16065773 |
| CHEMBL ID | 2398212 |
| SCHEMBL ID | 1512560 |
| MeSH ID | M0542779 |
| Synonym |
|---|
| 7-chloro-9-oxo-9h-indeno[1,2-b]pyrazine-2,3-dicarbonitrile |
| 924296-39-9 |
| FT-0664852 |
| AKOS016010870 |
| chembl2398212 , |
| bdbm50436151 |
| hbx 41108 |
| SCHEMBL1512560 |
| 9h-indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 7-chloro-9-oxo- |
| DTXSID00581703 |
| 7-chloro-9-oxo-9h-indeno[1,2-b]-pyrazine-2,3-dicarbonitrile |
| hbx41108 |
| hbx-41108 |
| BCP08394 |
| hbx41108; hbx-41108; hbx 41,108; hbx-41,108; hbx41,108 |
| BIGPXXAUSQLTQR-UHFFFAOYSA-N , |
| MS-23771 |
| unii-c7jh7ksp8z |
| 7-chloro-9-oxo-9h-indeno(1,2-b)pyrazine-2,3-dicarbonitrile |
| c7jh7ksp8z , |
| 9h-indeno(1,2-b)pyrazine-2,3-dicarbonitrile, 7-chloro-9-oxo- |
| HY-101666 |
| A903088 |
| 7-chloro-9-oxoindeno[1,2-b]pyrazine-2,3-dicarbonitrile |
| CS-0021776 |
| 7-chloro-9-oxo-9h-indeno[2,1-b]pyrazine-2,3-dicarbonitrile |
| hbx 41,108 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 8 | Homo sapiens (human) | IC50 (µMol) | 0.0960 | 0.0960 | 0.0960 | 0.0960 | AID1491533 |
| Ubiquitin carboxyl-terminal hydrolase 7 | Homo sapiens (human) | IC50 (µMol) | 0.4200 | 0.1300 | 4.0462 | 8.0000 | AID1491532; AID755344 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1491532 | Inhibition of full length wild-type human N-terminal His-tagged USP7 expressed in baculovirus infected Sf9 cells using Ub-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 2 hrs by fluorescence based assay | 2018 | Journal of medicinal chemistry, 01-25, Volume: 61, Issue:2 | Chemical Approaches to Intervening in Ubiquitin Specific Protease 7 (USP7) Function for Oncology and Immune Oncology Therapies. |
| AID1491533 | Inhibition of human full-length His-tagged USP8 expressed baculovirus infected insect cells using Ub-AMC as substrate by fluorescence spectroscopic analysis | 2018 | Journal of medicinal chemistry, 01-25, Volume: 61, Issue:2 | Chemical Approaches to Intervening in Ubiquitin Specific Protease 7 (USP7) Function for Oncology and Immune Oncology Therapies. |
| AID755344 | Inhibition of USP7 (unknown origin) using ubiquitin-EKL as substrate | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13 | Spongiacidin C, a pyrrole alkaloid from the marine sponge Stylissa massa, functions as a USP7 inhibitor. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 7 (87.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (18.79) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 2 (25.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (75.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||