Page last updated: 2024-09-28

Progressive Tapetochoroidal Dystrophy

Synonyms(2)

Synonym
Tapetochoroidal Dystrophy, Progressive
Progressive Tapetochoroidal Dystrophy

Research

Studies (27)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (3.70)23.3326
1990's2 (7.41)12.5806
2000's5 (18.52)18.1394
2010's13 (48.15)28.8240
2020's6 (22.22)9.53
DrugIndicatedRelationship StrengthStudiesTrials
caffeine0low10
fenofibrate0low10
fluorouracil0low10
tyrosine0low10
ornithine0low10
tryptophan0low10
perflutren0low10
thiophenes0low10
sulfur hexafluoride0low10
fomesafen0low10
simvastatin0low10
inositol 3-phosphate0low20
retinaldehyde0low10
ovalbumin0low10
beta carotene0low10
11-cis-retinal0low20
zeaxanthin0low10
lutein0medium21
dorzolamide0low10
bafilomycin a0low10
oxadiazoles0low30
ptc 1240low30
indocyanine green0low10
guanosine diphosphate0low10
eye0low30
leptin0low10

Protein Targets (359)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Retinaldehyde-binding protein 10011
Chain A, Retinaldehyde-binding protein 10011
TDP1 protein6006
aldehyde dehydrogenase 1 family, member A14004
core protein, partial0101
geminin4004
peripheral myelin protein 222002
histone acetyltransferase KAT2A isoform 12002
lamin isoform A-delta104004
Bile salt export pump0505
Solute carrier organic anion transporter family member 1B30202
Solute carrier organic anion transporter family member 1B10303
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Chitinase0101
phosphopantetheinyl transferase3003
RAR-related orphan receptor gamma6006
GLS protein2002
GLI family zinc finger 37007
AR protein9009
nuclear receptor subfamily 1, group I, member 36006
glucocorticoid receptor [Homo sapiens]8008
retinoic acid nuclear receptor alpha variant 18008
retinoid X nuclear receptor alpha6006
estrogen-related nuclear receptor alpha8008
farnesoid X nuclear receptor5005
pregnane X nuclear receptor6006
estrogen nuclear receptor alpha110011
euchromatic histone-lysine N-methyltransferase 24004
thyroid stimulating hormone receptor4004
v-jun sarcoma virus 17 oncogene homolog (avian)4004
atrial natriuretic peptide receptor 1 precursor1001
chromobox protein homolog 13003
thyroid hormone receptor beta isoform a1001
thyroid hormone receptor beta isoform 28008
DNA polymerase beta1001
nuclear factor erythroid 2-related factor 2 isoform 17007
nuclear receptor ROR-gamma isoform 14004
DNA polymerase kappa isoform 11001
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)2002
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Voltage-dependent calcium channel gamma-2 subunit5005
Potassium channel subfamily K member 20011
Glycogen phosphorylase, muscle form0101
Renin0101
Carbonic anhydrase 10306
Carbonic anhydrase 20317
Cholinesterase0101
Glycogen phosphorylase, liver form0101
Glycogen phosphorylase, muscle form0101
Replicase polyprotein 1ab0101
Adenosine receptor A30303
Replicase polyprotein 1ab0101
Glutamate receptor 25005
Amine oxidase [flavin-containing] A0101
Acetylcholinesterase0202
Adenosine receptor A10204
Amine oxidase [flavin-containing] B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Adenosine receptor A30101
Adenosine receptor A2a0214
Adenosine receptor A2b0102
Adenosine receptor A2b0203
Adenosine receptor A10114
Adenosine receptor A2a0205
Vasopressin V2 receptor0001
Serine/threonine-protein kinase mTOR0101
Adenosine receptor A2a0101
Adenosine receptor A10101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
DNA-dependent protein kinase catalytic subunit0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10001
Chitotriosidase-10101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Adenosine receptor A2b0102
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Palmitoleoyl-protein carboxylesterase NOTUM0123
Endochitinase B10101
Muscarinic acetylcholine receptor0001
Canalicular multispecific organic anion transporter 10404
Phosphodiesterase 0101
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Guanine deaminase0101
ATP-dependent phosphofructokinase4004
Chain A, CARBONIC ANHYDRASE II0101
Chain A, CARBONIC ANHYDRASE II0101
Chain A, CARBONIC ANHYDRASE II0101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase0101
Carbonic anhydrase 120104
Carbonic anhydrase 30104
5-hydroxytryptamine receptor 2C0101
Androgen receptor0101
5-hydroxytryptamine receptor 2A0101
Androgen receptor0101
Carbonic anhydrase 40205
Carbonic anhydrase 60104
Carbonic anhydrase 5A, mitochondrial0101
5-hydroxytryptamine receptor 2B0101
Delta-type opioid receptor0101
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Carbonic anhydrase 5A, mitochondrial0104
Carbonic anhydrase0103
Carbonic anhydrase 70104
Carbonic anhydrase0103
Carbonic anhydrase 0101
Mu-type opioid receptor0101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase 90205
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0103
Carbonic anhydrase0103
Carbonic anhydrase0103
Carbonic anhydrase 0101
Delta carbonic anhydrase0101
Carbonic anhydrase 0103
Carbonic anhydrase 130101
Carbonic anhydrase 40202
Carbonic anhydrase 150103
Carbonic anhydrase 130103
Carbonic anhydrase 140104
Carbonic anhydrase 5B, mitochondrial0104
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, Ferritin light chain2002
Luciferase5005
endonuclease IV2002
ATAD5 protein, partial2002
USP1 protein, partial1001
Microtubule-associated protein tau3003
thyroid stimulating hormone receptor3003
progesterone receptor4004
EWS/FLI fusion protein4004
nonstructural protein 12002
G3003
bromodomain adjacent to zinc finger domain 2B3003
peroxisome proliferator-activated receptor delta5005
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
arylsulfatase A3003
aryl hydrocarbon receptor4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a7007
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a4004
serine-protein kinase ATM isoform a1001
Bloom syndrome protein isoform 12002
peripheral myelin protein 22 isoform 13003
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
potassium voltage-gated channel subfamily H member 2 isoform d2002
heat shock protein beta-13003
mitogen-activated protein kinase 11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
serine/threonine-protein kinase mTOR isoform 12002
survival motor neuron protein isoform d3003
cytochrome P450 3A4 isoform 12002
M-phase phosphoprotein 82002
neuropeptide S receptor isoform A1001
Gamma-aminobutyric acid receptor subunit pi2103
5-hydroxytryptamine receptor 40213
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Fatty acid-binding protein, liver0112
Fatty acid-binding protein, liver0101
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M10011
Muscarinic acetylcholine receptor M30011
Muscarinic acetylcholine receptor M40011
Muscarinic acetylcholine receptor M50011
Muscarinic acetylcholine receptor M20011
Fatty acid-binding protein, intestinal0112
Beta-3 adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit beta-12103
Alpha-1B adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit delta2103
Gamma-aminobutyric acid receptor subunit gamma-22103
Gamma-aminobutyric acid receptor subunit alpha-52103
Gamma-aminobutyric acid receptor subunit alpha-32103
Peroxisome proliferator-activated receptor alpha0011
Gamma-aminobutyric acid receptor subunit gamma-12103
Gamma-aminobutyric acid receptor subunit alpha-22103
Sodium-dependent noradrenaline transporter 0202
Cruzipain0101
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit alpha-42103
Gamma-aminobutyric acid receptor subunit gamma-32103
Gamma-aminobutyric acid receptor subunit alpha-62103
D(3) dopamine receptor0202
Peroxisome proliferator-activated receptor alpha0011
Peroxisome proliferator-activated receptor gamma0112
Peroxisome proliferator-activated receptor gamma0011
Alpha-1A adrenergic receptor0202
Histamine H2 receptor1001
Gamma-aminobutyric acid receptor subunit alpha-12103
Gamma-aminobutyric acid receptor subunit beta-32103
Gamma-aminobutyric acid receptor subunit beta-22103
Disintegrin and metalloproteinase domain-containing protein 171102
Sodium-dependent dopamine transporter 0202
Peroxisome proliferator-activated receptor alpha0112
GABA theta subunit2103
Inositol hexakisphosphate kinase 13003
Gamma-aminobutyric acid receptor subunit epsilon2103
Sigma non-opioid intracellular receptor 10011
cytochrome P450 2C9, partial3003
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, Uracil Phosphoribosyltransferase0101
interleukin 82002
acetylcholinesterase2002
glp-1 receptor, partial1001
Skn7p0001
thioredoxin reductase2002
pregnane X receptor2002
hypoxia-inducible factor 1 alpha subunit4004
Thrombopoietin1001
estrogen receptor 2 (ER beta)4004
67.9K protein1001
peroxisome proliferator activated receptor gamma8008
IDH12002
Histone H2A.x4004
hemoglobin subunit beta1001
nuclear factor erythroid 2-related factor 2 isoform 23003
huntingtin isoform 21001
flap endonuclease 12002
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
Vpr1001
muscleblind-like protein 1 isoform 11001
Solute carrier family 22 member 80001
Epidermal growth factor receptor0101
Cellular tumor antigen p536006
Amyloid-beta precursor protein1102
Thymidylate synthase0101
Aromatase0101
ATPase family AAA domain-containing protein 55005
Ataxin-25005
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Chain A, ELONGATION FACTOR TU (EF-TU)0011
Chain A, Elongation Factor G0011
Chain A, ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 30011
Chain A, Eukaryotic peptide chain release factor GTP-binding subunit0011
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b0011
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b0011
Chain A, interferon-inducible GTPase0011
Chain A, interferon-inducible GTPase0011
Chain A, Elongation factor 20011
Chain A, Guanine nucleotide-binding protein G(i), alpha-1 subunit0011
regulator of G-protein signaling 42002
72 kDa type IV collagenase0101
Matrilysin0101
2-dehydropantoate 2-reductase0011
Ras-related protein Rab-7a0011
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT60101
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT50101
Alpha-(1,3)-fucosyltransferase 70101
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 10101
P2Y purinoceptor 60011
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 90202
retinoic acid receptor alpha isoform 10101
retinoic acid receptor RXR-alpha isoform a0101
Chain A, ARGINASE 10101
Chain A, Arginase 10101
Chain A, ARGINASE 10101
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain A, L-ARGININE\\:GLYCINE AMIDINOTRANSFERASE0101
SMAD family member 23003
SMAD family member 33003
cytochrome P450 family 3 subfamily A polypeptide 42002
cytochrome P450 2D62002
nuclear receptor subfamily 1, group I, member 23003
histone deacetylase 9 isoform 31001
Flavin reductase (NADPH)0011
Chain A, Cellular retinoic acid-binding protein 20011
Chain A, Cellular retinoic acid-binding protein 20011
15-lipoxygenase, partial1001
caspase 7, apoptosis-related cysteine protease1001
caspase-31001
activating transcription factor 61001
Caspase-71001
cellular tumor antigen p53 isoform a1001
caspase-31001
Aldo-keto reductase family 1 member B100002
Integrin beta-31001
Integrin alpha-IIb1001
Aldo-keto reductase family 1 member B10001
Alpha-synuclein0101
Nuclear receptor ROR-gamma1001
Chain A, Beta-lactamase1001
Smad31001
PINK11001
Parkin1001
photoreceptor-specific nuclear receptor0101
vitamin D3 receptor isoform VDRA1001
serine/threonine-protein kinase PLK11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
3-hydroxy-3-methylglutaryl-coenzyme A reductase0202
ATP-dependent translocase ABCB10101
Insulin receptor 0101
Prostaglandin G/H synthase 20101
Nuclear receptor subfamily 4 group A member 20011
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
Spike glycoprotein1001
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
TAR DNA-binding protein 431001
Sigma non-opioid intracellular receptor 10101
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Chain A, 2-oxoglutarate Oxygenase1001
thioredoxin glutathione reductase1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
DNA polymerase iota isoform a (long)1001
Dihydrofolate reductase0202
Plasma kallikrein0002
Myeloperoxidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Stromelysin-10101
Intestinal-type alkaline phosphatase0101
Indoleamine 2,3-dioxygenase 10102
Substance-P receptor0101
Glutamate receptor ionotropic, NMDA 1 0002
Tryptophan 2,3-dioxygenase0102
Glutamate receptor ionotropic, NMDA 2A 0002
Glutamate receptor ionotropic, NMDA 2B0002
Glutamate receptor ionotropic, NMDA 2C0002
Large neutral amino acids transporter small subunit 10202
SLC16A10 protein0002
Uracil nucleotide/cysteinyl leukotriene receptor0101
Carbonic anhydrase-like protein, putative0002
Tryprostatin B synthase0001
Glutamate receptor ionotropic, NMDA 2D0002
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Glutamate receptor ionotropic, NMDA 3B0002
Monocarboxylate transporter 100002
Glutamate receptor ionotropic, NMDA 3A0002
Phospholipase A-2-activating protein0101
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Polyphenol oxidase 20001
Tubulin--tyrosine ligase0101
Taste receptor type 2 member 140001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]