fluorouracil has been researched along with Progressive Tapetochoroidal Dystrophy in 1 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Notably, REP1 is highly expressed in colon cancer tissues and cell lines, and silencing of REP1 sensitizes colon cancer cells to serum starvation- and 5-FU-induced apoptosis." | 1.46 | REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival. ( Bae, DJ; Bae, YK; Cho, H; Chung, JY; Hibi, M; Hong, SM; Hong, SO; Kim, MG; Kim, SY; Kim, TW; Kim, YN; Lee, HJ; Oh, SJ; Rho, SB; Shim, J; Song, KH; Woo, SR, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Song, KH | 1 |
| Woo, SR | 1 |
| Chung, JY | 1 |
| Lee, HJ | 1 |
| Oh, SJ | 1 |
| Hong, SO | 1 |
| Shim, J | 1 |
| Kim, YN | 1 |
| Rho, SB | 1 |
| Hong, SM | 1 |
| Cho, H | 1 |
| Hibi, M | 1 |
| Bae, DJ | 1 |
| Kim, SY | 1 |
| Kim, MG | 1 |
| Kim, TW | 1 |
| Bae, YK | 1 |
1 other study available for fluorouracil and Progressive Tapetochoroidal Dystrophy
| Article | Year |
|---|---|
REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Sur | 2017 |