| Assay ID | Title | Year | Journal | Article |
|---|
| AID151210 | In vitro antimalarial activity against Plasmodium falciparum D6. | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Protoberberine alkaloids as antimalarials. |
| AID1537277 | Permeability of the compound after 2.45 hrs by PAMPA | 2019 | Journal of natural products, 02-22, Volume: 82, Issue:2
| Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease. |
| AID656690 | Antiparasitic activity against Toxoplasma gondii ATCC 50839 infected in human fibroblasts assessed as inhibition of replication of tachyzoites after 4 days by bacterial beta-galactosidase assay | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
| Structure-activity studies of some berberine analogs as inhibitors of Toxoplasma gondii. |
| AID1537274 | Inhibition of POP (unknown origin) using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by spectrophotometric method | 2019 | Journal of natural products, 02-22, Volume: 82, Issue:2
| Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease. |
| AID136556 | In vivo Mean survival time of Plasmodium berghei parasitized mice dosed at 640 mg/kg | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Protoberberine alkaloids as antimalarials. |
| AID1537269 | Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's method | 2019 | Journal of natural products, 02-22, Volume: 82, Issue:2
| Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease. |
| AID136551 | In vivo Mean survival time of Plasmodium berghei parasitized mice dosed at 160 mg/kg | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Protoberberine alkaloids as antimalarials. |
| AID151349 | In vitro antimalarial activity against Plasmodium falciparum W2 | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Protoberberine alkaloids as antimalarials. |
| AID1732648 | Inhibition of amyloid beta (1 to 42 ) (unknown origin) aggregation at 10 uM after 20 hrs by thioflavin-T fluorescence method relative to control | 2021 | European journal of medicinal chemistry, Apr-05, Volume: 215 | The total synthesis of berberine and selected analogues, and their evaluation as amyloid beta aggregation inhibitors. |
| AID1732651 | Cytotoxicity against rat PC12 cells assessed as reduction in cell viability incubated for 24 hrs by WST-8 assay | 2021 | European journal of medicinal chemistry, Apr-05, Volume: 215 | The total synthesis of berberine and selected analogues, and their evaluation as amyloid beta aggregation inhibitors. |
| AID656691 | Cytotoxicity against human fibroblasts assessed as cell viability by microplate reader | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
| Structure-activity studies of some berberine analogs as inhibitors of Toxoplasma gondii. |
| AID136554 | In vivo Mean survival time of Plasmodium berghei parasitized mice dosed at 40 mg/kg | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Protoberberine alkaloids as antimalarials. |
| AID656692 | Therapeutic index, ratio of TD50 for human fibroblast cell to ID 50 for Toxoplasma gondii ATCC 50839 | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
| Structure-activity studies of some berberine analogs as inhibitors of Toxoplasma gondii. |
| AID1537271 | Selectivity index, ratio of IC50 for human BuChE to IC50 for human AChE | 2019 | Journal of natural products, 02-22, Volume: 82, Issue:2
| Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease. |
| AID1537270 | Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's method | 2019 | Journal of natural products, 02-22, Volume: 82, Issue:2
| Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease. |
| AID1537276 | Inhibition of GSK3B (unknown origin) at 10 uM relative to control | 2019 | Journal of natural products, 02-22, Volume: 82, Issue:2
| Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |