Page last updated: 2024-10-06

noscapine biosynthesis

Proteins (6)

ProteinSynonymsTaxonomy
Reticuline oxidaseEC 1.21.3.3; Berberine bridge-forming enzyme; BBE; Tetrahydroprotoberberine synthasePapaver somniferum (opium poppy)
Noscapine synthase SDR1EC 1.1.1.415; Short-chain dehydrogenase/reductase 1; PsSDR1Papaver somniferum (opium poppy)
Scoulerine-9-O-methyltransferase 2PsSOMT2; EC 2.1.1.117; 3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase OMT2; 2.1.1.352; O-methyltransferase 2Papaver somniferum (opium poppy)
Scoulerine-9-O-methyltransferase 1PsSOMT1; EC 2.1.1.117; Norreticuline 3-O-methyltransferase SOMT1; 2.1.1.-; O-methyltransferase 1; Reticuline 3-O-methyltransferase SOMT1; 2.1.1.-; Tetrahydrocolumbamine 2-O-methyltransferase SOMT1; 2.1.1.89Papaver somniferum (opium poppy)
(S)-1-hydroxy-N-methylcanadine 13-hydroxylase CYP82X2EC 1.14.14.163; Cytochrome P450 82X2Papaver somniferum (opium poppy)
3-O-acetylpapaveroxine carboxylesterase CXE1EC 3.1.1.105; Carboxylesterase 1Papaver somniferum (opium poppy)

Compounds (15)

CompoundDescription
hydronium ion
acetic acidProduct of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
NADH
noscapineA naturally occurring opium alkaloid that is a centrally acting antitussive agent.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
discretaminestructure
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
tetrahydrocolumbaminea dopamine receptor ligand; from Polygala tenuifolia; structure given in first source
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Coenzyme A
canadineRN given refers to cpd without isomeric designation; structure
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)