Page last updated: 2024-10-06
noscapine biosynthesis
Proteins (6)
| Protein | Synonyms | Taxonomy |
|---|
| Reticuline oxidase | EC 1.21.3.3; Berberine bridge-forming enzyme; BBE; Tetrahydroprotoberberine synthase | Papaver somniferum (opium poppy) |
| Noscapine synthase SDR1 | EC 1.1.1.415; Short-chain dehydrogenase/reductase 1; PsSDR1 | Papaver somniferum (opium poppy) |
| Scoulerine-9-O-methyltransferase 2 | PsSOMT2; EC 2.1.1.117; 3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase OMT2; 2.1.1.352; O-methyltransferase 2 | Papaver somniferum (opium poppy) |
| Scoulerine-9-O-methyltransferase 1 | PsSOMT1; EC 2.1.1.117; Norreticuline 3-O-methyltransferase SOMT1; 2.1.1.-; O-methyltransferase 1; Reticuline 3-O-methyltransferase SOMT1; 2.1.1.-; Tetrahydrocolumbamine 2-O-methyltransferase SOMT1; 2.1.1.89 | Papaver somniferum (opium poppy) |
| (S)-1-hydroxy-N-methylcanadine 13-hydroxylase CYP82X2 | EC 1.14.14.163; Cytochrome P450 82X2 | Papaver somniferum (opium poppy) |
| 3-O-acetylpapaveroxine carboxylesterase CXE1 | EC 3.1.1.105; Carboxylesterase 1 | Papaver somniferum (opium poppy) |
Compounds (15)
| Compound | Description |
|---|
| hydronium ion | |
| acetic acid | Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed) |
| NADH | |
| noscapine | A naturally occurring opium alkaloid that is a centrally acting antitussive agent. |
| Hydrogen Peroxide | A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| discretamine | structure |
| nad | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| tetrahydrocolumbamine | a dopamine receptor ligand; from Polygala tenuifolia; structure given in first source |
| s-adenosylmethionine | Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) |
| Coenzyme A | |
| canadine | RN given refers to cpd without isomeric designation; structure |
| Acetyl Coenzyme A | Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent. |
| Flavin-Adenine Dinucleotide | A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972) |