Page last updated: 2024-10-06

chelerythrine biosynthesis

Proteins (9)

ProteinSynonymsTaxonomy
Protopine 6-monooxygenaseEC 1.14.14.98; Protopine 6-hydroxylase; P6HEschscholzia californica (California poppy)
Reticuline oxidaseEC 1.21.3.3; Berberine bridge-forming enzyme; BBE; Tetrahydroprotoberberine synthaseEschscholzia californica (California poppy)
Reticuline oxidaseEC 1.21.3.3; Berberine bridge-forming enzyme; BBE; Tetrahydroprotoberberine synthasePapaver somniferum (opium poppy)
Sanguinarine reductaseEC 1.3.1.107Eschscholzia californica (California poppy)
Scoulerine-9-O-methyltransferase 2PsSOMT2; EC 2.1.1.117; 3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase OMT2; 2.1.1.352; O-methyltransferase 2Papaver somniferum (opium poppy)
Scoulerine-9-O-methyltransferase 3PsSOMT3; EC 2.1.1.117; O-methyltransferase 3Papaver somniferum (opium poppy)
Scoulerine-9-O-methyltransferase 1PsSOMT1; EC 2.1.1.117; Norreticuline 3-O-methyltransferase SOMT1; 2.1.1.-; O-methyltransferase 1; Reticuline 3-O-methyltransferase SOMT1; 2.1.1.-; Tetrahydrocolumbamine 2-O-methyltransferase SOMT1; 2.1.1.89Papaver somniferum (opium poppy)
Methyltetrahydroprotoberberine 14-monooxygenaseEC 1.14.14.97; (S)-cis-N-methylstylopine 14-hydroxylase; (S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase; Methyltetrahydroprotoberberine 14-hydroxylase; N-methylstylopine hydroxylase; MSHPapaver somniferum (opium poppy)
Putative O-methyltransferaseEschscholzia californica (California poppy)

Compounds (19)

CompoundDescription
hydronium ion
NADH
metyraponeAn inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
KetoconazoleBroad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
discretaminestructure
mercaptoethanolA water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
chelerythrine
tetrahydrocolumbaminea dopamine receptor ligand; from Polygala tenuifolia; structure given in first source
allocryptopineinduces muscle contraction and relaxation in urinary bladder and ileum, respectively
s-adenosylmethioninePhysiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
ancymidol
DitiocarbA chelating agent that has been used to mobilize toxic metals from the tissues of humans and experimental animals. It is the main metabolite of DISULFIRAM.
canadineRN given refers to cpd without isomeric designation; structure
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
dihydrochelerythrinetrypanocidal and antileishmanial dihydrochelerythrine derivative from Garcinia lucida; structure in first source