Page last updated: 2024-11-12
pseudoberberine
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
pseudoberberine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 14707273 |
CHEMBL ID | 453368 |
MeSH ID | M0582190 |
Synonyms (4)
Synonym |
---|
pseudoberberine |
pseudoberberine chloride |
CHEMBL453368 |
17,18-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(21),2,4(8),9,13,15,17,19-octaene;chloride |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (41)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID439080 | Upregulation of InsR mRNA expression in human liver HepG2 at 10 ug/mL after 8 hrs by RT-PCR relative to control | 2009 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21 | Synthesis and biological evaluation of berberine analogues as novel up-regulators for both low-density-lipoprotein receptor and insulin receptor. |
AID346769 | Reduction of blood cholesterol level in hyperlipidemic Sprague-Dawley rat at 300 mg/kg, po daily twice for 17 days relative to control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346778 | Acute toxicity in Kunming mouse assessed as change in body weight at 1000 mg/kg, po | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID1654922 | Inhibition of cell proliferation of human KM12C cells incubated for 15 hrs by MTT assay | |||
AID694188 | Increase in AMPKalpha phosphorylation in human HepG2 cells at 10 uM after 4 hrs by Western blot analysis relative to untreated control | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22 | Synthesis and structure-activity relationship of berberine analogues in LDLR up-regulation and AMPK activation. |
AID346781 | Acute toxicity in Kunming mouse assessed as kidney damage upto 5000 mg/kg, po after 14 days by hematoxylin and eosin staining | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346771 | Induction of LDLR mRNA expression in hyperlipidemic Sprague-Dawley rat liver at 100 mg/kg, po daily twice for 17 days by RT-PCR relative to control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346780 | Acute toxicity in Kunming mouse assessed as liver damage upto 5000 mg/kg, po after 14 days by hematoxylin and eosin staining | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346766 | Toxicity in hyperlipidemic Sprague-Dawley rat assessed as liver and kidney function abnormalities at 100 mg/kg, po daily twice for 30 days | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346777 | Acute toxicity in Kunming mouse assessed as change in body weight at 250 mg/kg, po | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346775 | Induction of LDLR mRNA expression in hyperlipidemic C57BL/6J mouse liver at 100 mg/kg, po daily twice for 21 days by RT-PCR relative to control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346757 | Induction of LDLR protein expression in human HepG2 cells at 10 ug/mL after 12 hrs by flow cytometry | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346779 | Acute toxicity in Kunming mouse assessed as change in body weight at 5000 mg/kg, po after 2 to 3 days | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID694191 | Induction of AMPKalpha phosphorylation in human HepG2 cells at 10 uM by Western blot analysis relative to untreated control | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22 | Synthesis and structure-activity relationship of berberine analogues in LDLR up-regulation and AMPK activation. |
AID346783 | Acute toxicity in po dosed Kunming mouse assessed as lung damage upto 5000 mg/kg, po after 14 days by hematoxylin and eosin staining | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID694192 | Induction of AMPKalpha phosphorylation in human HepG2 cells after 4 hrs by Western blot analysis relative to untreated control | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22 | Synthesis and structure-activity relationship of berberine analogues in LDLR up-regulation and AMPK activation. |
AID346776 | Acute toxicity in po dosed Kunming mouse after 14 days | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346761 | Reduction of blood low density lipoprotein cholesterol level in hyperlipidemic Sprague-Dawley rat at 100 mg/kg, po daily twice | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346774 | Reduction of blood low density lipoprotein cholesterol level in hyperlipidemic C57BL/6J mouse at 100 mg/kg, po daily twice for 21 days relative to control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346770 | Reduction of blood low density lipoprotein cholesterol level in hyperlipidemic Sprague-Dawley rat at 300 mg/kg, po daily twice for 17 days relative to control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID694189 | Increase in total AMPKalpha level in human HepG2 cells at 10 uM after 4 hrs by Western blot analysis relative to untreated control | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22 | Synthesis and structure-activity relationship of berberine analogues in LDLR up-regulation and AMPK activation. |
AID346785 | Acute toxicity in Kunming mouse assessed as colon damage upto 5000 mg/kg, po after 14 days by hematoxylin and eosin staining | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID694190 | Increase in AMPKalpha phosphorylation in human HepG2 cells at 10 uM after 4 hrs by Western blot analysis relative to untreated control relative to total AMPKalpha level | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22 | Synthesis and structure-activity relationship of berberine analogues in LDLR up-regulation and AMPK activation. |
AID346763 | Induction of HMG-CoA reductase mRNA expression in hyperlipidemic Sprague-Dawley rat liver at 100 mg/kg, po daily twice for 30 days by RT-PCR | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346765 | Toxicity in hyperlipidemic Sprague-Dawley rat assessed as food intake reduction at 100 mg/kg, po daily twice for 30 days | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID439079 | Upregulation of LDLR mRNA expression in human liver HepG2 at 10 ug/mL after 8 hrs by RT-PCR relative to control | 2009 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21 | Synthesis and biological evaluation of berberine analogues as novel up-regulators for both low-density-lipoprotein receptor and insulin receptor. |
AID346755 | Induction of LDLR mRNA expression in human HepG2 cells after 12 hrs by RT-PCR assay relative to untreated control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID694187 | Up regulation of LDLR expression in human HepG2 cells at 10 uM after 12 hrs by RT-PCR relative to untreated control | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22 | Synthesis and structure-activity relationship of berberine analogues in LDLR up-regulation and AMPK activation. |
AID694193 | Induction of AMPKalpha phosphorylation in rat L6 cells | 2012 | Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22 | Synthesis and structure-activity relationship of berberine analogues in LDLR up-regulation and AMPK activation. |
AID346772 | Induction of LDLR mRNA expression in hyperlipidemic Sprague-Dawley rat liver at 300 mg/kg, po daily twice for 17 days by RT-PCR relative to control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346762 | Induction of LDLR mRNA expression in hyperlipidemic Sprague-Dawley rat liver at 100 mg/kg, po daily twice for 30 days by RT-PCR relative to control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346773 | Reduction of blood cholesterol level in hyperlipidemic C57BL/6J mouse at 100 mg/kg, po daily twice for 21 days relative to control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346760 | Reduction of blood cholesterol level in hyperlipidemic Sprague-Dawley rat at 100 mg/kg, po daily twice | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346782 | Acute toxicity in Kunming mouse assessed as heart damage upto 5000 mg/kg, po after 14 days by hematoxylin and eosin staining | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346759 | Reduction of blood low density lipoprotein cholesterol level in hyperlipidemic Sprague-Dawley rat at 100 mg/kg, po daily twice for 30 days relative to control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID361587 | Upregulation of LDLR mRNA expression in human HepG2 cells after 8 hrs by RT-PCR relative to control | 2008 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 18, Issue:16 | Synthesis and structure-activity relationships of berberine analogues as a novel class of low-density-lipoprotein receptor up-regulators. |
AID346767 | Reduction of blood cholesterol level in hyperlipidemic Sprague-Dawley rat at 100 mg/kg, po daily twice for 17 days relative to control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346784 | Acute toxicity in Kunming mouse assessed as brain damage upto 5000 mg/kg, po after 14 days by hematoxylin and eosin staining | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346758 | Reduction of blood cholesterol level in hyperlipidemic Sprague-Dawley rat at 100 mg/kg, po daily twice for 30 days relative to control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346768 | Reduction of blood low density lipoprotein cholesterol level in hyperlipidemic Sprague-Dawley rat at 100 mg/kg, po daily twice for 17 days relative to control | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
AID346764 | Toxicity in hyperlipidemic Sprague-Dawley rat assessed as weight loss at 100 mg/kg, po daily twice for 30 days | 2009 | Journal of medicinal chemistry, Jan-22, Volume: 52, Issue:2 | Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: synthesis, structure-activity relationships, and cholesterol-lowering efficacy. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (6)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 4 (66.67) | 29.6817 |
2010's | 1 (16.67) | 24.3611 |
2020's | 1 (16.67) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.35
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.35) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 6 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |