Target type: cellularcomponent
A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck. [ISBN:0198504888, NIF_Subcellular:sao1145756102]
The neuron spine is a small, mushroom-shaped protrusion that extends from the dendrite of a neuron. It is the site of most excitatory synapses in the brain, and it plays a critical role in learning and memory. The cellular component of a neuron spine is composed of several key structures:
* **Postsynaptic Density (PSD)**: A dense protein scaffold that is located on the membrane of the spine, directly opposite the presynaptic terminal. It contains a variety of receptors, signaling molecules, and structural proteins that are involved in synaptic transmission and plasticity.
* **Actin Cytoskeleton:** A network of actin filaments that provides structural support for the spine and allows it to change shape and size. This dynamic cytoskeleton is essential for spine development, plasticity, and the formation of new synapses.
* **Endoplasmic Reticulum (ER)**: A network of interconnected membranes that extends throughout the neuron, including the spine. The ER plays a role in protein synthesis, calcium signaling, and lipid metabolism.
* **Mitochondria:** These organelles are responsible for producing energy (ATP) for the neuron, and they are found in high concentrations in the spine. Mitochondria are crucial for maintaining the activity and plasticity of the synapse.
* **Synaptic Vesicles**: These small, membrane-bound sacs contain neurotransmitters, which are released into the synaptic cleft when a neuron fires. Synaptic vesicles are essential for communication between neurons.
* **Signaling Molecules**: Various signaling molecules, including kinases, phosphatases, and second messengers, are found in the spine. These molecules play a critical role in regulating synaptic plasticity and signal transduction pathways.
* **Structural Proteins**: A variety of structural proteins, such as PSD-95, Shank, and GKAP, provide structural support for the PSD and scaffold other signaling molecules.
The cellular component of the neuron spine is a complex and highly dynamic structure that is essential for neuronal function and plasticity. It is a key player in learning and memory, and it is the target of many neurodegenerative diseases.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Sodium/hydrogen exchanger 5 | A sodium/hydrogen exchanger 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14940] | Homo sapiens (human) |
| Disks large homolog 4 | A disks large homolog 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P78352] | Homo sapiens (human) |
| Glutamate receptor 1 | A glutamate receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42261] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| aminolevulinic acid | 5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp. Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS. | 4-oxo monocarboxylic acid; amino acid zwitterion; delta-amino acid | antineoplastic agent; dermatologic drug; Escherichia coli metabolite; human metabolite; mouse metabolite; photosensitizing agent; plant metabolite; prodrug; Saccharomyces cerevisiae metabolite |
| 5-aminovaleric acid | 5-aminopentanoic acid : A delta-amino acid comprising pentanoic acid with an amino substituent at C-5; a methylene homologue of gamma-aminobutyric acid (GABA) that is a weak GABA agonist. 5-aminovaleric acid: from red fox anal secretion; RN given refers to parent cpd | amino acid zwitterion; delta-amino acid; omega-amino fatty acid | human metabolite |
| alanylalanine | alanylalanine: RN given refers to (DL)-isomer | dipeptide | |
| alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies. | non-proteinogenic alpha-amino acid | |
| 5-(n,n-hexamethylene)amiloride | 5-(N,N-hexamethylene)amiloride : A member of the class of pyrazines that is amiloride in which the two amino hydrogens at position N-5 are replaced by a hexamethylene moiety, resulting in the formation of an azepane ring. 5-(N,N-hexamethylene)amiloride: inhibitor of Na+-H+ exchange; has anti-HIV-1 activity | aromatic amine; azepanes; guanidines; monocarboxylic acid amide; organochlorine compound; pyrazines | antineoplastic agent; apoptosis inducer; odorant receptor antagonist; sodium channel blocker |
| ethylisopropylamiloride | ethylisopropylamiloride : A member of the class of pyrazines that is amiloride in which the amino substitutent of the pyrazine ring that is adjacent to the chloro substituent has been substituted by an ethyl group and by an isopropyl group. ethylisopropylamiloride: structure in first source | aromatic amine; guanidines; monocarboxylic acid amide; organochlorine compound; pyrazines; tertiary amino compound | anti-arrhythmia drug; neuroprotective agent; sodium channel blocker |
| cyclothiazide | cyclothiazide : 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted at positions 3, 5 and 6 by a 2-norbornen-5-yl group, chlorine, and a sulfonamide group, respectively. A thiazide diuretic, it has been used in the management of hypertension and oedema. cyclothiazide: inhibits the desensitization of AMPA-type receptors; structure | benzothiadiazine | antihypertensive agent; diuretic |
| kainic acid | Kainic Acid: (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose. | dicarboxylic acid; L-proline derivative; non-proteinogenic L-alpha-amino acid; pyrrolidinecarboxylic acid | antinematodal drug; excitatory amino acid agonist |
| glycylglycine | dipeptide; dipeptide zwitterion | human metabolite | |
| amiloride | amiloride : A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid. Amiloride: A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705) | aromatic amine; guanidines; organochlorine compound; pyrazines | diuretic; sodium channel blocker |
| glutamic acid | glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2. Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM. | glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid | Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical |
| selfotel | selfotel: a N-methyl-D-aspartate (NMDA) antagonist; used to treat stroke-induced impairment | non-proteinogenic alpha-amino acid | |
| leucyl-alanine | Leu-Ala : A dipeptide composed of L-leucine and L-alanine joined by a peptide linkage. | dipeptide | metabolite |
| alanylproline | alanylproline: RN given refers to all (L)-isomer | dipeptide; dipeptide zwitterion | metabolite |
| glycylleucine | Gly-Leu : A dipeptide composed of glycine and L-leucine joined by a peptide linkage. | dipeptide; dipeptide zwitterion | metabolite |
| alanyltyrosine | Ala-Tyr : A dipeptide composed of L-alanine and L-tyrosine joined by a peptide linkage. alanyltyrosine: tyrosine source; RN given refers to (L)-isomer | dipeptide | metabolite |
| glycylsarcosine | glycylsarcosine : A dipeptide obtained by formal condensation of the carboxy group of glycine with the amino group of sarcosine. | dipeptide; dipeptide zwitterion | |
| glycylaspartic acid | glycylaspartic acid: RN given refers to (L)-isomer | dipeptide | metabolite |
| histidinoalanine | histidinoalanine: cross-linking amino acid in calcified tissue collagen; RN given refers to (L)-isomer | dipeptide; dipeptide zwitterion | metabolite |
| jstx-3 | JSTX-3: structure in first source | N-acyl-amino acid | |
| argiotoxin-636 | argiotoxin-636: from the venom of Argiope aurantia; blocks neuromuscular transmission in insects; structure in first source. | N-acyl-amino acid | |
| 2-amino-3-(3-(carboxymethoxy)-5-methylisoxazol-4-yl)propionic acid | 2-amino-3-(3-(carboxymethoxy)-5-methylisoxazol-4-yl)propionic acid: glutamate receptor antagonist; protects against kainic acid neurotoxicity in cultured cerebral cortex neurons | ||
| 5-fluorowillardiine | 3-(5-fluorouracil-1-yl)-L-alanine : An alanine derivative that is L-alanine bearing a 5-fluorouracil-1-yl substituent at position 3. A more potent and selective AMPA receptor agonist (at hGluR1 and hGluR2) than AMPA itself (Ki = 14.7, 25.1, and 1820 nM for hGluR1, hGluR2 and hGluR5 respectively). 5-fluorowillardiine: a glutamate agonist; RN given for (S)-isomer | L-alanine derivative; non-proteinogenic L-alpha-amino acid; organofluorine compound | AMPA receptor agonist |
| gyki 53655 | GYKI 53655: an AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate) receptor antagonist | ||
| ly 293558 | tezampanel: structure given in first source; an AMPA receptor antagonist | ||
| alanylglutamic acid | alanylglutamic acid: RN given refers to (L)-isomer L-alanyl-L-glutamic acid : A dipeptide consisting of L-glutamic acid having an L-alanyl attached to its alpha-amino group | dipeptide | |
| cariporide | cariporide: a selective sodium-hydrogen exchange subtype 1 inhibitor; structure in first source | ||
| prolyl-tyrosine | Pro-Tyr : A dipeptide formed from L-proline and L-tyrosine residues. prolyl-tyrosine: structure given in first source | dipeptide | metabolite |
| alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid | |||
| 5-bromowillardiine | 5-bromowillardiine: acts as a kainate-like agonist on chick EAA receptors expressed in Xenopus oocytes; RN given refers to (S)-isomer; RN for cpd without isomeric designation not avail 5/91 | ||
| prolylglutamic acid | Pro-Glu : A dipeptide formed from L-proline and L-glutamic acid residues. | dipeptide | metabolite |
| cysteinylglycine | cysteinylglycine: RN given refers to (L)-isomer; RN for cpd without isomeric designation not in Chemlne 7/13/83 L-cysteinylglycine : A dipeptide consisting of glycine having an L-cysteinyl attached to its alpha-amino group. It is an intermediate metabolite in glutathione metabolism. | dipeptide; dipeptide zwitterion | Escherichia coli metabolite; human metabolite; Saccharomyces cerevisiae metabolite |
| willardiine | 3-(uracil-1-yl)-L-alanine : The 3-(uracil-1-yl) derivative of L-alanine. willardiine: isolated from seeds of Acacia willariana; structure | amino acid zwitterion; L-alanine derivative; non-proteinogenic L-alpha-amino acid | |
| (S)-ATPA | (S)-ATPA : A non-proteinogenic L-alpha-amino acid that is L-alanine in which one of the methyl hydrogens is replaced by a 5-tert-butyl-3-hydroxy-isooxazol-4-yl group. | isoxazoles; non-proteinogenic L-alpha-amino acid | metabolite |
| aspartyl-aspartic acid | Asp-Asp : A dipeptide formed from two L-aspartic acid units. aspartyl-aspartic acid: do not confuse with cyclo(Asp-Asp) | dipeptide | Mycoplasma genitalium metabolite |
| 4-bromohomoibotenic acid, (rs)-isomer | |||
| glycylproline | Gly-Pro : A dipeptide consisting of L-proline having a glycyl residue attached to its alpha-amino group. | dipeptide; dipeptide zwitterion | metabolite |
| 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline | 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline: structure given in first source; neuroprotectant for cerebral ischemia; AMPA receptor antagonist | naphthalenes; sulfonic acid derivative | |
| 6-cyano-7-nitroquinoxaline-2,3-dione | 6-Cyano-7-nitroquinoxaline-2,3-dione: A potent excitatory amino acid antagonist with a preference for non-NMDA iontropic receptors. It is used primarily as a research tool. | quinoxaline derivative | |
| fg 9041 | FG 9041: structure given in first source | quinoxaline derivative | |
| seryl-proline | Ser-Pro : A dipeptide formed from L-serine and L-proline residues. | dipeptide | metabolite |
| lofepramine hydrochloride | |||
| phenylalanylalanine | Phe-Ala : A dipeptide formed from L-phenylalanine and L-alanine residues. phenylalanylalanine: RN given refers to (L)-isomer | dipeptide; dipeptide zwitterion | metabolite |
| acetylalanylalanine | acetylalanylalanine: RN given refers to (D)-isomer | ||
| alpha-aspartylalanine | alpha-aspartylalanine: found in pig brain Asp-Ala : A dipeptide formed from L-alpha-aspartyl and L-valine residues. | dipeptide | metabolite |
| alanyltyrosine | Tyr-Ala : A dipeptide formed from L-tyrosine and L-alanine residues. | dipeptide | metabolite |
| prolylglycine | L-prolylglycine : A dipeptide consisting of glycine having an L-prolyl group attached to its alpha-amino nitrogen. prolylglycine: RN given refers to (L)-isomer | dipeptide; dipeptide zwitterion | |
| eniporide | eniporide: inhibits NHE-1 isoform; structure in first source | ||
| cx 614 | 2H,3H,6aH-pyrrolidino(2'',1''-3',2')1,3-oxazino(6',5'-5,4)benzo(e)1, 4-dioxan-10-one: an ampakine (AMPA receptor modulator); structure in first source | ||
| glutamylalanine | Glu-Ala : A dipeptide formed from L-alpha-glutamyl and L-alanine residues. | dipeptide | metabolite |
| phenylalanylphenylalanine | Phe-Phe : A dipeptide formed from two L-phenylalanine residues. | dipeptide; L-aminoacyl-L-amino acid zwitterion | human blood serum metabolite; Mycoplasma genitalium metabolite |
| phenylalanyl-valine | Val-Phe : A dipeptide formed from L-valine and L-phenylalanine residues. | dipeptide | metabolite |
| alanylglycine | dipeptide; dipeptide zwitterion | metabolite | |
| valyltyrosine | Val-Tyr : A dipeptide formed from L-valine and L-tyrosine residues. valyltyrosine: from sardine muscle hydrolyzate | dipeptide | metabolite |
| phenylalanylproline | Phe-Pro : A dipeptide formed from L-phenylalanine and L-proline residues. | dipeptide | metabolite |
| glycylhistidine | Gly-His : A dipeptide composed of glycine and L-histidine joined by a peptide linkage. glycylhistidine: RN given refers to (L)-isomer | dipeptide; dipeptide zwitterion | metabolite |
| prolyl-serine | Pro-Ser : A dipeptide formed from L-proline and L-serine residues. | dipeptide | metabolite |
| prolylvaline | Val-Pro : A dipeptide formed from L-valine and L-proline residues. | dipeptide | metabolite |
| tqx 173 | |||
| perampanel | perampanel : A member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy. | bipyridines; nitrile; pyridone | AMPA receptor antagonist; anticonvulsant |
| ly 404187 | LY 404187: structure in first source | ||
| tat-nr2b9c | Tat-NR2B9c: a synthetic peptide consisting of the C-terminal 9 amino acids of the NR2B subunit of the NMDA receptor fused to the cell membrane protein transduction domain of the HIV-1-Tat protein |