leucyltyrosine profile

Leucyltyrosine, also known as Leu-Tyr, is a dipeptide composed of the amino acids leucine and tyrosine. It is a naturally occurring compound found in various proteins and has been studied for its potential biological effects.

Leu-Tyr has been investigated for its role in various biological processes, including:

* **Antioxidant activity:** Studies have shown that Leu-Tyr exhibits antioxidant properties, potentially protecting cells from damage caused by free radicals.
* **Neuroprotective effects:** Leu-Tyr has been suggested to have neuroprotective effects, potentially reducing neuronal damage in conditions like Alzheimer's disease.
* **Anti-inflammatory activity:** Research suggests that Leu-Tyr may possess anti-inflammatory properties, reducing inflammation in the body.

The synthesis of Leu-Tyr can be achieved through various methods, including:

* **Chemical synthesis:** Leu-Tyr can be synthesized chemically by coupling the amino acids leucine and tyrosine using specific reagents and conditions.
* **Enzymatic synthesis:** Enzymes like peptidases can be employed to synthesize Leu-Tyr from larger protein molecules.

Leu-Tyr is studied to understand its potential applications in:

* **Dietary supplements:** Due to its potential health benefits, Leu-Tyr is being explored as a potential ingredient in dietary supplements.
* **Therapeutic applications:** Research is underway to investigate the therapeutic potential of Leu-Tyr in treating conditions like neurodegenerative diseases and inflammatory disorders.

While research on Leu-Tyr is ongoing, further studies are required to fully elucidate its mechanisms of action, optimal dosage, and safety profile.'

leucyltyrosine: RN given refers to L-Tyr,L-Leu-isomer; RN for cpd without isomeric designation not avail 4/93 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	70410
CHEMBL ID	56099
CHEBI ID	73591
SCHEMBL ID	2474675
MeSH ID	M0214058

Synonym
leucyltyrosine
l-leucyl-l-tyrosine
968-21-8
chebi:73591 ,
CHEMBL56099 ,
L0040
h-leu-tyr-oh
bdbm50348865
AKOS010367110
n-l-leucyl-l-tyrosine
nsc 118372
einecs 213-527-8
l-y
l-leu-l-tyr
AKOS015853930
(2s)-2-[(2s)-2-amino-4-methylpentanamido]-3-(4-hydroxyphenyl)propanoic acid
SCHEMBL2474675
(s)-2-((s)-2-amino-4-methylpentanamido)-3-(4-hydroxyphenyl)propanoic acid
mfcd00020195
AS-73052
leucyl-tyrosine
Q27141905
AMY41886
T73104
A902475
DTXSID301317217

Role	Description
metabolite	Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
dipeptide	Any molecule that contains two amino-acid residues connected by peptide linkages.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	IC50 (µMol)	44.0000	0.0000	1.6129	10.0000	AID608775
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Assay ID	Title	Year	Journal	Article
AID233318	Bitter threshold value	1987	Journal of medicinal chemistry, Oct, Volume: 30, Issue:10	Quantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives.
AID1183271	Inhibition of ACE (unknown origin)	2014	European journal of medicinal chemistry, Sep-12, Volume: 84	CoMFA and CoMSIA analysis of ACE-inhibitory, antimicrobial and bitter-tasting peptides.
AID500816	Inhibition of nitrogen-starved wild type sigma1278b yeast Gap1-mediated amino acid uptake at 5 mM after 60 secs relative to L-citrulline	2009	Nature chemical biology, Jan, Volume: 5, Issue:1	Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.
AID500815	Activation of nitrogen-starved wild type sigma1278b yeast Gap1-mediated amino acid uptake at 5 mM after 60 secs relative to L-citrulline	2009	Nature chemical biology, Jan, Volume: 5, Issue:1	Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.
AID228722	Bitter tasting threshold was expressed as log 1/T.	1995	Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14	Amino acid side chain descriptors for quantitative structure-activity relationship studies of peptide analogues.
AID26797	Partition coefficient (logP)	1987	Journal of medicinal chemistry, Oct, Volume: 30, Issue:10	Quantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives.
AID608775	Inhibition of rabbit lung ACE preincubated for 5 mins by spectrophotometric assay	2011	European journal of medicinal chemistry, Aug, Volume: 46, Issue:8	Angiotensin-I-converting enzyme inhibitory peptides: Chemical feature based pharmacophore generation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (18.18)	18.7374
1990's	3 (27.27)	18.2507
2000's	2 (18.18)	29.6817
2010's	4 (36.36)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
hippuric acid hippuric acid: RN given refers to parent cpd; structure in Merck Index, 9th ed, #4591. N-benzoylglycine : An N-acylglycine in which the acyl group is specified as benzoyl.	1.97	1	N-acylglycine	human blood serum metabolite; uremic toxin
alanylalanine alanylalanine: RN given refers to (DL)-isomer	1.97	1	dipeptide
alanine [no description available]	1.97	1	alpha-amino acid; amino acid zwitterion	fundamental metabolite
glycine [no description available]	1.97	1	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
glycerol Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.	2.06	1	alditol; triol	algal metabolite; detergent; Escherichia coli metabolite; geroprotector; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; solvent
pipecolic acid pipecolic acid: RN given refers to cpd without isomeric designation. pipecolic acid : A piperidinemonocarboxylic acid in which the carboxy group is located at position C-2.. pipecolate : A piperidinecarboxylate that is the conjugate base of pipecolic acid.	2.05	1	piperidinemonocarboxylic acid
taurine [no description available]	2.05	1	amino sulfonic acid; zwitterion	antioxidant; Escherichia coli metabolite; glycine receptor agonist; human metabolite; mouse metabolite; nutrient; radical scavenger; Saccharomyces cerevisiae metabolite
5,5-dimethyl-1-pyrroline-1-oxide 5,5-dimethyl-1-pyrroline-1-oxide: do not confuse with DMPO (4',5'-dihydroxy-7-methoxy-4-phenyl-5,2'-oxidocoumarin). 5,5-dimethyl-1-pyrroline N-oxide : A member of the class of 1-pyrroline nitrones (1-pyrroline N-oxides) resulting from the formal N-oxidation of 5,5-dimethyl-1-pyrroline. Used as a spin trap for the study of radicals formed by enzymatic acetaldehyde oxidation.	2.07	1	1-pyrroline nitrones	neuroprotective agent; spin trapping reagent
n-acetylphenylalanine N-acetylphenylalanine: RN given refers to (DL)-isomer. N-acetylphenylalanine : The N-acetyl derivative of phenylalanine.	1.97	1	N-acetyl-amino acid; phenylalanine derivative	antidepressant; metabolite
pentetic acid Pentetic Acid: An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.	1.98	1	pentacarboxylic acid	copper chelator
cysteine [no description available]	1.97	1	cysteine zwitterion; cysteine; L-alpha-amino acid; proteinogenic amino acid; serine family amino acid	EC 4.3.1.3 (histidine ammonia-lyase) inhibitor; flour treatment agent; human metabolite
serine Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.. serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.	2.4	2	L-alpha-amino acid; proteinogenic amino acid; serine family amino acid; serine zwitterion; serine	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
aspartic acid Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.. aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent. L-aspartic acid : The L-enantiomer of aspartic acid.	2.4	2	aspartate family amino acid; aspartic acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; mouse metabolite; neurotransmitter
glutamine Glutamine: A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.. L-glutamine : An optically active form of glutamine having L-configuration.. glutamine : An alpha-amino acid that consists of butyric acid bearing an amino substituent at position 2 and a carbamoyl substituent at position 4.	1.97	1	amino acid zwitterion; glutamine family amino acid; glutamine; L-alpha-amino acid; polar amino acid zwitterion; proteinogenic amino acid	EC 1.14.13.39 (nitric oxide synthase) inhibitor; Escherichia coli metabolite; human metabolite; metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	2.4	2	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
tyrosine Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.	2.4	2	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine	EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical
leucine Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.	1.97	1	amino acid zwitterion; L-alpha-amino acid; leucine; proteinogenic amino acid; pyruvate family amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
methionine Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.	1.97	1	aspartate family amino acid; L-alpha-amino acid; methionine zwitterion; methionine; proteinogenic amino acid	antidote to paracetamol poisoning; human metabolite; micronutrient; mouse metabolite; nutraceutical
phenylalanine Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	2.4	2	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
ornithine Ornithine: An amino acid produced in the urea cycle by the splitting off of urea from arginine.. ornithine : An alpha-amino acid that is pentanoic acid bearing two amino substituents at positions 2 and 5.	1.97	1	non-proteinogenic L-alpha-amino acid; ornithine	algal metabolite; hepatoprotective agent; mouse metabolite
asparagine Asparagine: A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed). asparagine : An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 2-amino-2-oxoethyl group.	1.97	1	amino acid zwitterion; asparagine; aspartate family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
histidine Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.	2.4	2	amino acid zwitterion; histidine; L-alpha-amino acid; polar amino acid zwitterion; proteinogenic amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
valine Valine: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.. valine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isopropyl group.. L-valine : The L-enantiomer of valine.	1.97	1	L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid; valine	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
threonine Threonine: An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.. threonine : An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 1-hydroxyethyl group.	2.4	2	amino acid zwitterion; aspartate family amino acid; L-alpha-amino acid; proteinogenic amino acid; threonine	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
tryptophan Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.	2.4	2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; tryptophan zwitterion; tryptophan	antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
arginine Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.	1.97	1	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical
citrulline citrulline : The parent compound of the citrulline class consisting of ornithine having a carbamoyl group at the N(5)-position.	2.05	1	amino acid zwitterion; citrulline	Daphnia magna metabolite; EC 1.14.13.39 (nitric oxide synthase) inhibitor; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; protective agent; Saccharomyces cerevisiae metabolite
glycyl-glycyl-glycine glycyl-glycyl-glycine : A tripeptide in which three glycine units are linked via peptide bonds in a linear sequence.	2.4	2	tripeptide zwitterion; tripeptide
glycylglycine [no description available]	2.9	4	dipeptide zwitterion; dipeptide	human metabolite
carbonates Carbonates: Salts or ions of the theoretical carbonic acid, containing the radical CO2(3-). Carbonates are readily decomposed by acids. The carbonates of the alkali metals are water-soluble; all others are insoluble. (From Grant & Hackh's Chemical Dictionary, 5th ed). carbonates : Organooxygen compounds that are salts or esters of carbonic acid, H2CO3.	2.06	1	carbon oxoanion
norleucine Norleucine: An unnatural amino acid that is used experimentally to study protein structure and function. It is structurally similar to METHIONINE, however it does not contain SULFUR.. L-norleucine : A non-proteinogenic L-alpha-amino acid comprising hexanoic acid carrying an amino group at C-2. It does not occur naturally.	1.97	1	2-aminohexanoic acid; L-alpha-amino acid zwitterion; non-proteinogenic L-alpha-amino acid
deuterium oxide Deuterium Oxide: The isotopic compound of hydrogen of mass 2 (deuterium) with oxygen. (From Grant & Hackh's Chemical Dictionary, 5th ed) It is used to study mechanisms and rates of chemical or nuclear reactions, as well as biological processes.	2.06	1	deuterated compound; water	NMR solvent
cephalexin Cephalexin: A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.. cephalexin : A semisynthetic first-generation cephalosporin antibiotic having methyl and beta-(2R)-2-amino-2-phenylacetamido groups at the 3- and 7- of the cephem skeleton, respectively. It is effective against both Gram-negative and Gram-positive organisms, and is used for treatment of infections of the skin, respiratory tract and urinary tract.	1.98	1	beta-lactam antibiotic allergen; cephalosporin; semisynthetic derivative	antibacterial drug
glutamic acid Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.	2.4	2	glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical
norvaline norvaline: differs from valine in being 1 carbon longer instead of branched; RN given refers to (L)-isomer; structure. L-2-aminopentanoic acid : A 2-aminopentanoic acid that has S-configuration.	1.97	1	2-aminopentanoic acid; L-alpha-amino acid zwitterion	bacterial metabolite; hypoglycemic agent; neuroprotective agent
ethyl tyrosine ester ethyl tyrosine ester: RN given refers to L-isomer. ethyl L-tyrosinate : An L-tyrosyl ester that is L-tyrosine in which the hydrogen of the carboxy group has been replaced by an ethyl group.	1.97	1	ethyl ester; L-tyrosyl ester
tyrosine methyl ester tyrosine methyl ester: RN given refers to (L)-isomer. methyl L-tyrosinate : An L-tyrosyl ester that is the methyl ester of L-tyrosine.	1.97	1	L-tyrosyl ester; methyl ester
leucyl-glycyl-glycine leucyl-glycyl-glycine: RN given refers to (L-Leu)-isomer. Leu-Gly-Gly : A tripeptide composed of one L-leucine and two glycine residues joined in sequence.	2.4	2	tripeptide	metabolite
acetylleucine [no description available]	1.97	1	L-leucine derivative; N-acetyl-L-amino acid	metabolite
leucylleucine Leu-Leu : A dipeptide formed from two L-leucine residues.	2.68	3	dipeptide; L-aminoacyl-L-amino acid zwitterion	human metabolite; Mycoplasma genitalium metabolite
phenylalanylleucine phenylalanylleucine: RN given refers to (L)-isomer	2.38	2	dipeptide zwitterion; dipeptide	plant metabolite
methyl tryptophan, (l-trp)-isomer [no description available]	1.97	1
leucyl-alanine Leu-Ala : A dipeptide composed of L-leucine and L-alanine joined by a peptide linkage.	2.68	3	dipeptide	metabolite
tryptophan ethyl ester tryptophan ethyl ester: RN given refers to (DL)-isomer	1.97	1
leucyl-leucyl-leucine leucyl-leucyl-leucine: RN given refers to (L-Leu-L-Leu-L-Leu)-isomer. Leu-Leu-Leu : A tripeptide formed from three L-leucine residues.	2.4	2	tripeptide	metabolite
alanylproline alanylproline: RN given refers to all (L)-isomer	2.48	2	dipeptide zwitterion; dipeptide	metabolite
tyrosylleucine [no description available]	2.92	4	dipeptide	metabolite
Trp-Trp tryptophyltryptophan: an antigelation agent. Trp-Trp : A dipeptide formed from two L-tryptophan residues.	2.38	2	dipeptide	Mycoplasma genitalium metabolite
glycyltryptophan glycyltryptophan: RN given refers to (L)-isomer. Gly-Trp : A dipeptide formed from glycine and L-tryptophan residues.	2.92	4	dipeptide	metabolite
glycyltyrosine Gly-Tyr : A dipeptide composed of glycine and L-tyrosine joined by a peptide linkage.	2.92	4	dipeptide	metabolite
glycylleucine Gly-Leu : A dipeptide composed of glycine and L-leucine joined by a peptide linkage.	2.68	3	dipeptide zwitterion; dipeptide	metabolite
histidine methyl ester histidine methyl ester: RN given refers to (L)-isomer; structure given in first source. histidine methyl ester : An alpha-amino acid ester that is the methyl ester of histidine.	1.97	1	histidine derivative
alanyltyrosine alanyltyrosine: tyrosine source; RN given refers to (L)-isomer. Ala-Tyr : A dipeptide composed of L-alanine and L-tyrosine joined by a peptide linkage.	2.42	2	dipeptide	metabolite
glycyl-l-phenylalanine glycylphenylalanine: RN given refers to (DL)-isomer. Gly-Phe : A dipeptide formed from glycine and L-phenylalanine residues.	2.92	4	dipeptide zwitterion; dipeptide	human metabolite; metabolite
aspartyl-phenylalanine aspartyl-phenylalanine: metabolite of aspartame; may inhibit angiotensin converting enzyme; RN given refers to all (L)-isomer	2.47	2	dipeptide	human blood serum metabolite; human xenobiotic metabolite
glycylsarcosine glycylsarcosine : A dipeptide obtained by formal condensation of the carboxy group of glycine with the amino group of sarcosine.	2.05	1	dipeptide zwitterion; dipeptide
n-acetylphenylalanine ethyl ester N-acetylphenylalanine ethyl ester: RN given refers to (L)-isomer	1.97	1
leucylleucine leucylleucine: RN given refers to (DL-Leu-DL-Leu)-isomer	2.05	1	peptide
alanylphenylalanine alanylphenylalanine: RN given refers to (L-Ala-L-PheAla)-isomer	2.69	3	dipeptide	metabolite
glycyl-leucyl-tyrosine glycyl-leucyl-tyrosine: structure given in first source	2.4	2	oligopeptide
glycyl-glycyl-proline Gly-Gly-Pro : A tripeptide composed of glycine, glycine and L-proline amino acids joined in sequence by peptide linkages.	2.05	1	tripeptide zwitterion; tripeptide
tryptophylglycine Trp-Gly : A dipeptide formed from L-tryptophan and glycine residues.	1.98	1	dipeptide	metabolite
glycylaspartic acid glycylaspartic acid: RN given refers to (L)-isomer	2.71	3	dipeptide	metabolite
glycyl-histidyl-glycine [no description available]	2.05	1	oligopeptide
n-glycylglutamic acid N-glycylglutamic acid: RN given refers to (L)-isomer. Gly-Glu : A dipeptide formed from glycyl and L-glutamic acid residues.	2.71	3	dipeptide	metabolite
histidylglycine histidylglycine: RN given refers to all (L)-isomer. His-Gly : A dipeptide formed from L-histidine and glycine residues.	2.41	2	dipeptide	metabolite
cobalt Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.	6.93	1	cobalt group element atom; metal allergen	micronutrient
valylvaline valylvaline: RN given refers to (L)-isomer. Val-Val : A dipeptide formed from two L-valine residues.	2.68	3	dipeptide	Mycoplasma genitalium metabolite
alpha-methylphenylalanine alpha-methylphenylalanine: induces chronic hyperphenylalaninemia in suckling rats; models for the study of inborn errors of metabolism; RN given refers to parent cpd without isomeric designation	2.05	1	benzenes; monocarboxylic acid
prolinamide prolinamide: RN given refers to cpd without isomeric designation. L-prolinamide : The carboxamide derivative of L-proline.	2.05	1	amino acid amide; L-proline derivative; pyrrolidinecarboxamide
tyrosyl-glycyl-glycine tyrosyl-glycyl-glycine: RN given refers to L-isomer; this may not be the same as IMREG-1. Tyr-Gly-Gly : A tripeptide composed of one L-tyrosine and two glycine residues joined in sequence.	2.05	1	tripeptide zwitterion; tripeptide	metabolite
proctolin proctolin: neurotransmitter in arthropods or invertebrates	1.98	1
glycylglutamine glycylglutamine: inhibitory neuropeptide derived from beta-endorphin; RN given refers to (L)-isomer	1.98	1	dipeptide zwitterion; dipeptide	metabolite; protective agent
proline Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.	2.4	2	amino acid zwitterion; glutamine family amino acid; L-alpha-amino acid; proline; proteinogenic amino acid	algal metabolite; compatible osmolytes; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
phenylalanylarginine phenylalanylarginine: RN given refers to all (L)-isomer. Phe-Arg : A dipeptide composed of L-phenylalanine and L-arginine joined by a peptide linkage.	1.98	1	dipeptide	metabolite
arginylproline arginylproline: first & second amino acid in substance P sequence; RN given refers to (L)-isomer. Arg-Pro : A dipeptide obtained by formal condensation of the carboxy group of L-arginine with the amino group of L-proline.	2.1	1	dipeptide
aspartylglycine Asp-Gly : A dipeptide composed of L-aspartic acid and glycine joined by a peptide linkage.	1.98	1	dipeptide	metabolite
arginylarginine 2-naphthylamide arginylarginine 2-naphthylamide: substrate for dipeptidyl peptidase III	2.05	1
histidylphenylalanine His-Phe : A dipeptide obtained by formal condensation of the carboxy group of L-histidine with the amino group of L-phenylalanine.	2.05	1	dipeptide
prolyl-tyrosine prolyl-tyrosine: structure given in first source. Pro-Tyr : A dipeptide formed from L-proline and L-tyrosine residues.	2.38	2	dipeptide	metabolite
n-valyltryptophan N-valyltryptophan: RN given refers to (L)-isomer	2.42	2	peptide
lysylproline lysylproline: third & fourth amino acid in substance P sequence. Lys-Pro : A dipeptide formed from L-lysine and L-proline residues.	2.1	1	dipeptide	metabolite
histidylleucine His-Leu : A dipeptide formed from L-histidine and L-leucine residues.	2.39	2	dipeptide zwitterion; dipeptide	metabolite
glycyl-glycyl-valine [no description available]	2.05	1	oligopeptide
glycyl-glycyl-sarcosine glycyl-glycyl-sarcosine: structure given in first source	2.05	1
cysteinylglycine cysteinylglycine: RN given refers to (L)-isomer; RN for cpd without isomeric designation not in Chemlne 7/13/83. L-cysteinylglycine : A dipeptide consisting of glycine having an L-cysteinyl attached to its alpha-amino group. It is an intermediate metabolite in glutathione metabolism.	2.05	1	dipeptide zwitterion; dipeptide	Escherichia coli metabolite; human metabolite; Saccharomyces cerevisiae metabolite
glutamyl-glutamic acid glutamyl-glutamic acid: RN given for (L,L)-isomer. Glu-Glu : A dipeptide composed of two L-glutamic acid units joined by a peptide linkage.	2.05	1	dipeptide	Mycoplasma genitalium metabolite
isoleucylvaline isoleucylvaline: RN given refers to all (L)-isomer. Ile-Val : A dipeptide formed from L-isoleucine and L-valine residues.	2.38	2	dipeptide	metabolite
Phe-Tyr Phe-Tyr : A dipeptide formed from L-phenylalanine and L-tyrosine residues.	2.69	3	dipeptide	metabolite
n-acetyltryptophan N-acetyl-L-tryptophan : A N-acetyl-L-amino acid that is the N-acetyl derivative of L-tryptophan.	2.4	2	L-tryptophan derivative; N-acetyl-L-amino acid	metabolite
n-benzoylalanine N-benzoylalanine: RN given refers to parent cpd (L-Ala)-isomer. N-benzoylalanine : An N-acylamino acid that is the N-benzoyl derivative of alanine.. N-benzoyl-L-alanine : An N-acyl-L-alanine resulting from the formal condensation of L-alanine with the carboxy group of benzoic acid.	1.97	1	N-acyl-L-alanine; N-benzoylalanine	metabolite
phenylalanine methyl ester phenylalanine methyl ester: RN given refers to (L)-isomer. methyl L-phenylalaninate : An alpha-amino acid ester that is the methyl ester of L-phenylalanine.	1.97	1	alpha-amino acid ester; L-phenylalanine derivative
n-glycylalanine Gly-Ala : A dipeptide formed from glycine and L-alanine residues.	2.41	2	dipeptide	metabolite
glycylvaline glycylvaline: RN given refers to (DL)-isomer	2.68	3	dipeptide	human metabolite
epsilon-tert-butyloxycarbonyl-lysine epsilon-tert-butyloxycarbonyl-lysine: RN given refers to (L)-isomer	2.05	1
glycylproline Gly-Pro : A dipeptide consisting of L-proline having a glycyl residue attached to its alpha-amino group.	2.92	4	dipeptide zwitterion; dipeptide	metabolite
glycyllysine glycyllysine: RN given refers to (L)-isomer. Gly-Lys : A dipeptide formed from glycine and L-lysine residues.	2.42	2	dipeptide	metabolite
methionyltryptophan Met-Trp : A dipeptide formed from L-methionine and L-tryptophan residues.	2.1	1	dipeptide	metabolite
alanylalanine L-alanyl-L-alanine : A dipeptide consisting of two L-alanine units joined by a peptide linkage.	1.98	1	dipeptide zwitterion; dipeptide	Mycoplasma genitalium metabolite
alpha-aspartylalanine alpha-aspartylalanine: found in pig brain. Asp-Ala : A dipeptide formed from L-alpha-aspartyl and L-valine residues.	1.98	1	dipeptide	metabolite
alanyltyrosine Tyr-Ala : A dipeptide formed from L-tyrosine and L-alanine residues.	1.98	1	dipeptide	metabolite
prolylglycine prolylglycine: RN given refers to (L)-isomer. L-prolylglycine : A dipeptide consisting of glycine having an L-prolyl group attached to its alpha-amino nitrogen.	2.38	2	dipeptide zwitterion; dipeptide
tryptophanol tryptophanol: RN given refers to cpd without isomeric designation	2.05	1
phenylalanylglycine phenylalanylglycine: RN given refers to (DL)-isomer. Phe-Gly : A dipeptide formed from L-phenylalanine and glycine residues.	2.68	3	dipeptide	metabolite
leucyl-phenylalanine Leu-Phe : A dipeptide formed from L-leucine and L-phenylalanine residues.	2.38	2	dipeptide	metabolite
glycyl-alanyl-phenylalanine [no description available]	2.05	1	oligopeptide
glutamylalanine Glu-Ala : A dipeptide formed from L-alpha-glutamyl and L-alanine residues.	1.98	1	dipeptide	metabolite
glycyl-alanyl-leucine glycyl-alanyl-leucine: RN given refers to all (L)-isomer; RN for cpd without isomeric designation not avail 9/91	1.97	1	peptide
glutaminyl-glycine Gln-Gly : A dipeptide formed from L-glutamine and glycine residues.	1.98	1	dipeptide	metabolite
methionylglycine methionylglycine: RN given refers to (L)-isomer. Met-Gly : A dipeptide formed from L-methionine and glycine residues.	2.41	2	dipeptide	metabolite
phenylalanylphenylalanine Phe-Phe : A dipeptide formed from two L-phenylalanine residues.	2.38	2	dipeptide; L-aminoacyl-L-amino acid zwitterion	human blood serum metabolite; Mycoplasma genitalium metabolite
histidylhistidine histidylhistidine: RN given for L-,L-isomer	2.05	1	dipeptide	Mycoplasma genitalium metabolite
valylleucine valylleucine: RN given refers to all L-isomer. Val-Leu : A dipeptide formed from L-valine and L-leucine residues.	2.68	3	dipeptide	metabolite
phenylalanyl-valine Val-Phe : A dipeptide formed from L-valine and L-phenylalanine residues.	2.42	2	dipeptide	metabolite
alanylglycine [no description available]	2.92	4	dipeptide zwitterion; dipeptide	metabolite
valyltyrosine valyltyrosine: from sardine muscle hydrolyzate. Val-Tyr : A dipeptide formed from L-valine and L-tyrosine residues.	2.72	3	dipeptide	metabolite
alpha-glutamyltryptophan Trp-Glu : A dipeptide formed from L-tryptophan and L-glutamic acid residues.	2.68	3	dipeptide	metabolite
methionylglutamic acid Met-Glu : A dipeptide formed from L-methionine and L-glutamic acid residues.	2.05	1	dipeptide	metabolite
phenylalanylproline Phe-Pro : A dipeptide formed from L-phenylalanine and L-proline residues.	2.71	3	dipeptide	metabolite
lysylglycine lysylglycine: structure in first source. Lys-Gly : A dipeptide formed from L-lysine and glycine residues.	1.98	1	dipeptide	metabolite
glycylhistidine glycylhistidine: RN given refers to (L)-isomer. Gly-His : A dipeptide composed of glycine and L-histidine joined by a peptide linkage.	1.98	1	dipeptide zwitterion; dipeptide	metabolite
prolylisoleucine prolylisoleucine: RN refers to (L)-isomer. Pro-Ile : A dipeptide formed from L-proline and L-isoleucine residues.	1.97	1	dipeptide	metabolite
phenylalanyl-valine phenylalanyl-valine: structure in first source. Phe-Val : A dipeptide formed from L-phenylalanine and L-valine residues.	2.05	1	dipeptide	metabolite
isoleucyl-tyrosine isoleucyl-tyrosine: a dipeptide with antihypertensive effect. Ile-Tyr : A dipeptide formed from L-isoleucine and L-tyrosine residues.	2.72	3	dipeptide	metabolite
valyl-prolyl-proline Val-Pro-Pro : A tripeptide composed of L-valine and two L-proline units joined by peptide linkages.	2.06	1	tripeptide	metabolite
prolylvaline Val-Pro : A dipeptide formed from L-valine and L-proline residues.	2.72	3	dipeptide	metabolite
homocarnosine homocarnosine: RN given refers to parent cpd. homocarnosine : A histidine derivative that is histidine in which one of the hydrogens attached to the alpha-amino group has been replaced by a 4-aminobutanoyl group.	2.05	1	dipeptide zwitterion; dipeptide; homocarnosine; L-histidine derivative; N-acyl-L-alpha-amino acid anion; N-acyl-L-alpha-amino acid	human metabolite
clove Madagascar: One of the Indian Ocean Islands off the southeast coast of Africa. Its capital is Antananarivo. It was formerly called the Malagasy Republic. Discovered by the Portuguese in 1500, its history has been tied predominantly to the French, becoming a French protectorate in 1882, a French colony in 1896, and a territory within the French union in 1946. The Malagasy Republic was established in the French Community in 1958 but it achieved independence in 1960. Its name was changed to Madagascar in 1975. (From Webster's New Geographical Dictionary, 1988, p714)	2.05	1

Condition	Indicated	Relationship Strength	Studies	Trials
Blood Pressure, High [description not available]	0	2.06	1	0
Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	0	2.06	1	0

leucyltyrosine

Description

Cross-References

Synonyms (26)

Roles (1)

Drug Classes (1)

Protein Targets (1)

Inhibition Measurements

Bioassays (7)

Research

Studies (11)

Market Indicators

Research Demand Index: 12.27

Study Types