Page last updated: 2024-10-15

dehydroandrographolide

Cross-References

ID SourceID
PubMed CID129316823
MeSH IDM0455108

Synonyms (2)

Synonym
dehydroandrographolide
134418-28-3

Research Excerpts

Overview

Dehydroandrographolide (DA) is a main contributor of Andrographis paniculata (Burm.f.) Nees (family: Acanthaceae) DA has been shown to inhibit type I hypersensitivity.

ExcerptReference
"Dehydroandrographolide (DA) is a main contributor of Andrographis paniculata (Burm.f.) Nees (family: Acanthaceae) have been shown to inhibit type I hypersensitivity."( Dehydroandrographolide targets CD300f and negatively regulated MRGPRX2-induced pseudo-allergic reaction.
Che, D; Du, X; Geng, S; Hou, Y; Li, T; Zheng, Y, 2022
)
"Dehydroandrographolide (DA) is a diterpene compound of biological interest that contains one α,β-unsaturated lactone group and two hydroxy groups. "( Tracking the deprotonation site of dehydroandrographolide with electrospray ionization mass spectrometry by deuteration.
Feng, X; He, Y; Huo, Z; Qiu, F; Wang, Y, 2021
)

Pharmacokinetics

ExcerptReference
"t(1/2) ka, t(1/2) alpha, t/(1/2) beta, Cmax, tmax and AUCO-t were (0."( [Pharmacokinetics of Chuanxinlian tablet in healthy Chinese volunteers].
Hong, X; Huang, TL; Mi, SQ; Ou, WP; Wang, NS; Ye, SM, 2007
)
" The developed method was successfully applied to the determination of DAS in human plasma in a pharmacokinetic study following intravenous infusion of potassium sodium DAS to nine healthy volunteers."( Determination of dehydroandrographolide succinate in human plasma by liquid chromatography tandem mass spectrometry (LC-MS/MS): Method development, validation and clinical pharmacokinetic study.
Li, R; Li, S; Liu, Y; Lu, C; Wang, Y; Yang, D; Yu, C; Zhang, M; Zhou, J, 2010
)

Compound-Compound Interactions

ExcerptReference
"Modulation of drug transporters via herbal medicines which have been widely used in combination with conventional prescription drugs may result in herb-drug interactions in clinical practice."( Inhibitory effects of herbal constituents on P-glycoprotein in vitro and in vivo: herb-drug interactions mediated via P-gp.
Hu, J; Li, X; Li, Y; Liu, Z; Sheng, L; Wang, B; Yang, S, 2014
)

Bioavailability

ExcerptReference
" This study aimed to investigate the oral bioavailability and intestinal disposition of DP to provide useful information for the development of DP as a new candidate anticancer drug."( [Oral bioavailability and intestinal disposition of dehydroandrographolide in rats].
Liang, F; Liu, W; Liu, Z; Shi, J; Wang, F; Yang, X; Ye, L; Zhao, J, 2012
)
"The oral bioavailability of DP was 11."( [Oral bioavailability and intestinal disposition of dehydroandrographolide in rats].
Liang, F; Liu, W; Liu, Z; Shi, J; Wang, F; Yang, X; Ye, L; Zhao, J, 2012
)
"The bioavailability of DP was 11."( [Oral bioavailability and intestinal disposition of dehydroandrographolide in rats].
Liang, F; Liu, W; Liu, Z; Shi, J; Wang, F; Yang, X; Ye, L; Zhao, J, 2012
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (55)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's11 (20.00)29.6817
2010's36 (65.45)24.3611
2020's8 (14.55)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (3.64%)5.53%
Reviews2 (3.64%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other51 (92.73%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]