ginsenoside-f1 and Leukemia

ginsenoside-f1 has been researched along with Leukemia* in 1 studies

Other Studies

1 other study(ies) available for ginsenoside-f1 and Leukemia

Article	Year
Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia cells. Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1 Six dammarane-type saponins, including three new compounds, floralginsenosides Ta-Tc (1-3), and three known, floralginsenoside Td (4), ginsenoside F(1) (5), and ginsenoside F(5) (6), were isolated from the flower buds of Panax ginseng. Floralginsenoside Td (4) was first isolated from natural plant sources. Their structures were elucidated on the basis of extensive chemical and spectroscopic methods. Compounds 1, 5, and 6 showed cytotoxic activities towards the HL-60 human leukemia cell line with respective IC(50) values of 36.3, 23.2, and 62.4microM. In addition, after the HL-60 cells were treated with these compounds, several apoptosis events, including chromatin condensation and increase in the population of sub-G1 hypodiploid cells, were observed. Topics: Antineoplastic Agents, Phytogenic; Dammaranes; Flowers; HL-60 Cells; Humans; Leukemia; Magnetic Resonance Spectroscopy; Molecular Conformation; Panax; Saponins; Triterpenes	2010

Article

Year

Dammarane-type saponins from the flower buds of Panax ginseng and their effects on human leukemia cells.

Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1

Six dammarane-type saponins, including three new compounds, floralginsenosides Ta-Tc (1-3), and three known, floralginsenoside Td (4), ginsenoside F(1) (5), and ginsenoside F(5) (6), were isolated from the flower buds of Panax ginseng. Floralginsenoside Td (4) was first isolated from natural plant sources. Their structures were elucidated on the basis of extensive chemical and spectroscopic methods. Compounds 1, 5, and 6 showed cytotoxic activities towards the HL-60 human leukemia cell line with respective IC(50) values of 36.3, 23.2, and 62.4microM. In addition, after the HL-60 cells were treated with these compounds, several apoptosis events, including chromatin condensation and increase in the population of sub-G1 hypodiploid cells, were observed.

Topics: Antineoplastic Agents, Phytogenic; Dammaranes; Flowers; HL-60 Cells; Humans; Leukemia; Magnetic Resonance Spectroscopy; Molecular Conformation; Panax; Saponins; Triterpenes

2010