Page last updated: 2024-11-07

estrone-3-glucuronide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID115255
CHEMBL ID1232444
SCHEMBL ID2505282
MeSH IDM0065465

Synonyms (39)

Synonym
CHEMBL1232444
3-hydroxy-estra-1,3,5(10)-trien-17-one 3-d-glucuronide
LMST05010011
17-oxoestra-1,3,5(10)-trien-3-yl beta-d-glucopyranosiduronic acid
estrone beta-d-glucuronide
2479-90-5
estrone glucuronide
estrone 3-glucuronide
e3g ,
(2s,3s,4s,5r,6s)-3,4,5-trihydroxy-6-[[(8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-3-yl]oxy]oxane-2-carboxylic acid
unii-933q277to2
estrone-3-glucosiduronate
estrone-3-glucuronide
beta-d-glucopyranosiduronic acid, 17-oxoestra-1,3,5(10)-trien-3-yl
933q277to2 ,
estrone .beta.-glucuronide
.beta.-d-glucopyranosiduronic acid, 17-oxoestra-1,3,5(10)-trien-3-yl
estrone monoglucosiduronate
.beta.-d-glucosiduronic acid, 17-oxoestra-1,3,5(10)-trien-3-yl
glucopyranosiduronic acid, 17-oxoestra-1,3,5(10)-trien-3-yl, .beta.-d-
estrone .beta.-d-glucuronide
estra-1,3,5(10)-trien-17-one, 3-(.beta.-d-glucopyranuronosyloxy)-
SCHEMBL2505282
estrone b-d-glucuronide
W-202037
estrone-3-glucosiduronic acid
estrone beta-delta-glucuronide
b-d-glucopyranosiduronic acid,17-oxoestra-1,3,5(10)-trien-3-yl
estrone-3-(beta-d-glucuronide)
estrone-3-glucuronide (estrone beta-d-glucuronide)
1,3,5(10)-estratrien-3-ol-17-one glucosiduronate
(2s,3s,4s,5r,6s)-3,4,5-trihydroxy-6-((8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthren-3-yloxy)tetrahydro-2h-pyran-2-carboxylic acid
(14beta)-17-oxoestra-1,3,5(10)-trien-3-yl beta-d-glucopyranosiduronic acid
DTXSID20891497
HY-113157
CS-0062306
Q27271553
1,3,5(10)-estratrien-3-ol-17-one3(o->1beta)-d-glycopyranosiduronicacid
PD150771

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" A dose-response relationship exists for serum levels achieved after oral E2 administration."( Pharmacokinetics of oral 17 beta-estradiol.
Cassidenti, DL; Lobo, RA, 1992
)
0.28
" The dose-response curve of the latter did not parallel that of E1G and is a possible cause of the non-parallelism."( Statistical correction for non-parallelism in a urinary enzyme immunoassay.
Brindle, E; Campbell, KL; Handcock, MS; Klein, NA; Mar, C; Miller, RC; O'Connor, KA; Shofer, JB; Soules, MR, 2004
)
0.32
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
human metaboliteAny mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
mouse metaboliteAny mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
steroid glucosiduronic acid
17-oxo steroidAny oxo steroid carrying the oxo group at position 17.
beta-D-glucosiduronic acidA glucosiduronic acid resulting from the formal condensation of any substance with beta-D-glucuronic acid to form a glycosidic bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (2)

PathwayProteinsCompounds
Estrone Metabolism1622
Estrogen metabolism025

Bioassays (2)

Assay IDTitleYearJournalArticle
AID680752TP_TRANSPORTER: inhibition of E1S uptake (E1S: 0.04 uM, Estrone-3-glucuronide: 100 uM) in OATP-C-expressing HEK293 cells2001Pharmaceutical research, Sep, Volume: 18, Issue:9
Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C.
AID680439TP_TRANSPORTER: inhibition of Ouabain uptake (Ouabain: 100 uM, Estrone-3-glucuronide: 100 uM) in Xenopus laevis oocytes1996The Journal of pharmacology and experimental therapeutics, Mar, Volume: 276, Issue:3
Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (176)

TimeframeStudies, This Drug (%)All Drugs %
pre-199065 (36.93)18.7374
1990's49 (27.84)18.2507
2000's40 (22.73)29.6817
2010's18 (10.23)24.3611
2020's4 (2.27)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.32

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.32 (24.57)
Research Supply Index5.35 (2.92)
Research Growth Index4.34 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.32)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials18 (9.42%)5.53%
Reviews4 (2.09%)6.00%
Case Studies1 (0.52%)4.05%
Observational2 (1.05%)0.25%
Other166 (86.91%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]