dorrigocin-b has been researched along with Cell-Transformation--Neoplastic* in 3 studies
3 other study(ies) available for dorrigocin-b and Cell-Transformation--Neoplastic
| Article | Year |
|---|---|
Dorrigocins: novel antifungal antibiotics that change the morphology of ras-transformed NIH/3T3 cells to that of normal cells. I. Taxonomy of the producing organism, fermentation and biological activity.
The dorrigocins are new secondary metabolites produced by submerged fermentation of a streptomycete which was isolated from a soil sample collected in Australia. The dorrigocins show moderate antifungal activity and reverse the morphology of ras-transformed NIH/3T3 cells from a transformed phenotype to a normal one. The producing culture was identified as Streptomyces platensis subsp. rosaceus strain AB1981F-75. Topics: 3T3 Cells; Animals; Antibiotics, Antineoplastic; Antifungal Agents; Cell Transformation, Neoplastic; Fermentation; Genes, ras; Humans; Mice; Neoplasms, Experimental; Piperidones; Streptomyces | 1994 |
Dorrigocins: novel antifungal antibiotics that change the morphology of ras-transformed NIH/3T3 cells to that of normal cells. II. Isolation and elucidation of structures.
Two novel antifungal antibiotics, named dorrigocin A and B have been isolated from the fermentation broth and mycelium of Streptomyces platensis subsp. rosaceus. These closely related compounds were separated from one another by countercurrent chromatography on an Ito coil planet centrifuge. The structures of the dorrigocins were determined by NMR and IR spectroscopy and mass spectrometry. Each is a putative propionate-acetate derived straight chain fatty acid terminating in cycloheximide. The dorrigocins differ from one another only in their oxidation pattern. Topics: 3T3 Cells; Animals; Antifungal Agents; Cell Transformation, Neoplastic; Genes, ras; Magnetic Resonance Spectroscopy; Mice; Piperidones; Spectrometry, Mass, Fast Atom Bombardment; Streptomyces | 1994 |
Dorrigocins: novel antifungal antibiotics that change the morphology of ras-transformed NIH/3T3 cells to that of normal cells. III. Biological properties and mechanism of action.
The dorrigocins are unique glutarimide antibiotics which were found to reverse the morphology of ras-transformed NIH/3T3 cells from a transformed phenotype to a normal one. The compounds also inhibited the release of yeast mating pheromone, a-factor. The activity of these compounds was not dependent on inhibition of prenylation or protein synthesis. Dorrigocin A was instead found to inhibit the carboxyl methylation in K-ras transformed cells. Topics: 3T3 Cells; Alkyl and Aryl Transferases; Animals; Antifungal Agents; Cell Transformation, Neoplastic; Genes, ras; Mating Factor; Methylation; Mice; Oncogene Protein p21(ras); Peptides; Piperidones; Protein Biosynthesis; Protein O-Methyltransferase; Signal Transduction; Transferases | 1994 |