Assay ID | Title | Year | Journal | Article |
AID1063517 | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
| Design, synthesis and in vitro cytotoxicity evaluation of 5-(2-carboxyethenyl)isatin derivatives as anticancer agents. |
AID1055714 | Antiproliferative activity against human PC3 cells after 48 hrs by SRB assay | 2013 | European journal of medicinal chemistry, , Volume: 70 | Novel isatin-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents. |
AID281477 | Inhibition of human intestinal carboxylesterase expressed in sf21 cells | 2007 | Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8
| Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. |
AID281478 | Inhibition of human liver CE1 expressed in sf21 cells | 2007 | Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8
| Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. |
AID1055715 | Antiproliferative activity against human AsPC1 cells after 48 hrs by SRB assay | 2013 | European journal of medicinal chemistry, , Volume: 70 | Novel isatin-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents. |
AID1063518 | Cytotoxicity against human K562 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
| Design, synthesis and in vitro cytotoxicity evaluation of 5-(2-carboxyethenyl)isatin derivatives as anticancer agents. |
AID1061202 | Inhibition of GST-tagged SARS coronavirus 3C-like protease at 1 mM by FRET assay | 2014 | Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1
| Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors. |
AID1406679 | Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay | | | |
AID197811 | Inhibitory activity was tested against Rhodesain, a cysteine protease from Trypanosoma brucei rhodesiense; not determined | 2003 | Bioorganic & medicinal chemistry letters, Oct-20, Volume: 13, Issue:20
| Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. |
AID1082384 | Inhibition of Brassica rapa subsp. oleifera at 100 mg/L | 2011 | Journal of agricultural and food chemistry, Sep-28, Volume: 59, Issue:18
| Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives. |
AID1389532 | Inhibition of DAAO (unknown origin) at 20 uM | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8
| Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors. |
AID1082383 | Inhibition of Brassica rapa subsp. oleifera root growth at 10 mg/L | 2011 | Journal of agricultural and food chemistry, Sep-28, Volume: 59, Issue:18
| Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives. |
AID1406678 | Antiproliferative activity against human K562 cells after 48 hrs by MTT assay | | | |
AID281479 | Inhibition of rabbit liver carboxylesterase expressed in sf21 cells | 2007 | Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8
| Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. |
AID1674207 | Inhibition of CDK2/Cyclin A (unknown origin) using histone H1 as substrate by scintillation counting method | 2020 | Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
| Fragment Linking Strategies for Structure-Based Drug Design. |
AID72522 | Inhibitory activity against Falcipain-2; no effect | 2003 | Bioorganic & medicinal chemistry letters, Oct-20, Volume: 13, Issue:20
| Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. |
AID1055716 | Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay | 2013 | European journal of medicinal chemistry, , Volume: 70 | Novel isatin-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents. |
AID213673 | Inhibitory activity against the Trypanosoma cruzi cysteine protease cruzain | 2003 | Bioorganic & medicinal chemistry letters, Oct-20, Volume: 13, Issue:20
| Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. |
AID594815 | Inhibition of human transglutaminase 2 using Cbz-Gln-Gly as a substrate by GDH-coupled assay | 2011 | Bioorganic & medicinal chemistry letters, May-01, Volume: 21, Issue:9
| Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2. |
AID281480 | Inhibition of human AChE | 2007 | Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8
| Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. |
AID1284106 | Anticancer activity against human Jurkat cells after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Apr-13, Volume: 112 | Synthesis and anti-cancer activity evaluation of 5-(2-carboxyethenyl)-isatin derivatives. |
AID1055717 | Antiproliferative activity against human SW620 cells after 48 hrs by SRB assay | 2013 | European journal of medicinal chemistry, , Volume: 70 | Novel isatin-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents. |
AID1055713 | Antiproliferative activity against human NCI-H460 cells after 48 hrs by SRB assay | 2013 | European journal of medicinal chemistry, , Volume: 70 | Novel isatin-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents. |
AID281481 | Inhibition of human BChE | 2007 | Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8
| Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. |
AID1129169 | Inhibition of Escherichia coli DNA polymerase 3 beta assessed as inhibition of 5-carboxyfluorescein-QLDLF binding at <1 mM by fluorescence polarization-based competition assay | 2014 | Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6
| Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach. |
AID1063516 | Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
| Design, synthesis and in vitro cytotoxicity evaluation of 5-(2-carboxyethenyl)isatin derivatives as anticancer agents. |
AID1082385 | Inhibition of Arabidopsis thaliana AHAS at 100 mg/L colorimetric assay | 2011 | Journal of agricultural and food chemistry, Sep-28, Volume: 59, Issue:18
| Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives. |
AID1798240 | Enzyme Inhibition Assay from Article 10.1021/jm061471k: \\Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.\\ | 2007 | Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8
| Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |