| Assay ID | Title | Year | Journal | Article |
|---|
| AID1389532 | Inhibition of DAAO (unknown origin) at 20 uM | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8
| Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors. |
| AID1055716 | Antiproliferative activity against human MCF7 cells after 48 hrs by SRB assay | 2013 | European journal of medicinal chemistry, , Volume: 70 | Novel isatin-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents. |
| AID465619 | Anticancer activity against human U937 cells by MTS assay | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3
| QSAR study of isatin analogues as in vitro anti-cancer agents. |
| AID281478 | Inhibition of human liver CE1 expressed in sf21 cells | 2007 | Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8
| Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. |
| AID281481 | Inhibition of human BChE | 2007 | Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8
| Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. |
| AID1063516 | Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
| Design, synthesis and in vitro cytotoxicity evaluation of 5-(2-carboxyethenyl)isatin derivatives as anticancer agents. |
| AID1063518 | Cytotoxicity against human K562 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
| Design, synthesis and in vitro cytotoxicity evaluation of 5-(2-carboxyethenyl)isatin derivatives as anticancer agents. |
| AID281477 | Inhibition of human intestinal carboxylesterase expressed in sf21 cells | 2007 | Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8
| Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. |
| AID1406678 | Antiproliferative activity against human K562 cells after 48 hrs by MTT assay | | | |
| AID72522 | Inhibitory activity against Falcipain-2; no effect | 2003 | Bioorganic & medicinal chemistry letters, Oct-20, Volume: 13, Issue:20
| Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. |
| AID1055713 | Antiproliferative activity against human NCI-H460 cells after 48 hrs by SRB assay | 2013 | European journal of medicinal chemistry, , Volume: 70 | Novel isatin-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents. |
| AID1406679 | Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay | | | |
| AID281479 | Inhibition of rabbit liver carboxylesterase expressed in sf21 cells | 2007 | Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8
| Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. |
| AID1061202 | Inhibition of GST-tagged SARS coronavirus 3C-like protease at 1 mM by FRET assay | 2014 | Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1
| Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors. |
| AID213673 | Inhibitory activity against the Trypanosoma cruzi cysteine protease cruzain | 2003 | Bioorganic & medicinal chemistry letters, Oct-20, Volume: 13, Issue:20
| Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. |
| AID1063517 | Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2
| Design, synthesis and in vitro cytotoxicity evaluation of 5-(2-carboxyethenyl)isatin derivatives as anticancer agents. |
| AID1082383 | Inhibition of Brassica rapa subsp. oleifera root growth at 10 mg/L | 2011 | Journal of agricultural and food chemistry, Sep-28, Volume: 59, Issue:18
| Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives. |
| AID281480 | Inhibition of human AChE | 2007 | Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8
| Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. |
| AID1082385 | Inhibition of Arabidopsis thaliana AHAS at 100 mg/L colorimetric assay | 2011 | Journal of agricultural and food chemistry, Sep-28, Volume: 59, Issue:18
| Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives. |
| AID197811 | Inhibitory activity was tested against Rhodesain, a cysteine protease from Trypanosoma brucei rhodesiense; not determined | 2003 | Bioorganic & medicinal chemistry letters, Oct-20, Volume: 13, Issue:20
| Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. |
| AID1284106 | Anticancer activity against human Jurkat cells after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Apr-13, Volume: 112 | Synthesis and anti-cancer activity evaluation of 5-(2-carboxyethenyl)-isatin derivatives. |
| AID284490 | Cytotoxicity against human U937 cells | 2007 | Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2
| In vitro cytotoxicity evaluation of some substituted isatin derivatives. |
| AID1082384 | Inhibition of Brassica rapa subsp. oleifera at 100 mg/L | 2011 | Journal of agricultural and food chemistry, Sep-28, Volume: 59, Issue:18
| Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives. |
| AID1055715 | Antiproliferative activity against human AsPC1 cells after 48 hrs by SRB assay | 2013 | European journal of medicinal chemistry, , Volume: 70 | Novel isatin-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents. |
| AID1055714 | Antiproliferative activity against human PC3 cells after 48 hrs by SRB assay | 2013 | European journal of medicinal chemistry, , Volume: 70 | Novel isatin-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents. |
| AID1055717 | Antiproliferative activity against human SW620 cells after 48 hrs by SRB assay | 2013 | European journal of medicinal chemistry, , Volume: 70 | Novel isatin-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6
| A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | | | |
| AID1798240 | Enzyme Inhibition Assay from Article 10.1021/jm061471k: \\Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.\\ | 2007 | Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8
| Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |