5-Methoxyisatin profile

5-Methoxyisatin is a derivative of isatin, a heterocyclic compound with a wide range of biological activities. It has been investigated for its potential applications in various fields, including:

- **Antioxidant properties:** 5-Methoxyisatin exhibits antioxidant activity, which has been linked to its ability to scavenge free radicals.
- **Anti-cancer activity:** Studies have shown that 5-Methoxyisatin has anti-proliferative effects on certain cancer cell lines.
- **Anti-inflammatory activity:** It has been demonstrated that 5-Methoxyisatin possesses anti-inflammatory properties, potentially through modulation of inflammatory pathways.
- **Neuroprotective effects:** Some research suggests that 5-Methoxyisatin may provide neuroprotection against oxidative stress and neurotoxicity.

The synthesis of 5-Methoxyisatin involves various methods, including:

- **Fischer indole synthesis:** This classic method utilizes phenylhydrazine and a suitable ketone or aldehyde to generate the indole ring system.
- **Modified Fischer indole synthesis:** Variations of the Fischer indole synthesis have been developed to optimize the synthesis of 5-Methoxyisatin.

Due to its diverse biological activities and potential therapeutic applications, 5-Methoxyisatin is a subject of ongoing research in the fields of medicine, chemistry, and pharmacology.'

ID Source	ID
PubMed CID	38333
CHEMBL ID	222660
CHEBI ID	149863
SCHEMBL ID	21602

Synonym
39755-95-8
nsc-88052
nsc88052
BB 0254516
brn 0139520
1h-indole-2,3-dione, 5-methoxy-
indole-2,3-dione, 5-methoxy-
nsc 88052
5-methoxy-indole-2,3-dione
bdbm22811
isatin-based compound, 31
5-methoxy-2,3-dihydro-1h-indole-2,3-dione
MLS000561694
smr000177846
5-methoxy-1h-indole-2,3-dione
EC-000.1696
5-methoxyisatin
STK215331
AKOS000200895
CHEMBL222660
F0896-0193
5-methoxy-2,3-indolinedione ,
5-methoxyindole-2,3-dione
M1362
CHEBI:149863
A20428
NCGC00245347-01
HMS2557P21
5-methoxyindoline-2,3-dione
MLS002473346
c7ga9u9tn1 ,
5-21-13-00116 (beilstein handbook reference)
unii-c7ga9u9tn1
FT-0639576
FS-2332
CL3515
SCHEMBL21602
MB00814
mfcd00169023
SY021560
5-methoxy isatin
5-methoxyisatine
5-methoxy-1h-indole-2,3-dione #
AC-28109
J-517701
1h-indole-2,3-dione, 5-methoxy- (9ci)
DTXSID00192838
sr-01000390541
SR-01000390541-1
CS-W001176
isatin, 5-methoxy-
EN300-17177
AMY3503
Z56899037

Role	Description
anticoronaviral agent	Any antiviral agent which inhibits the activity of coronaviruses.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
indoles	Any compound containing an indole skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	44.6684	0.0447	17.8581	100.0000	AID485294
ATAD5 protein, partial	Homo sapiens (human)	Potency	25.9290	0.0041	10.8903	31.5287	AID504467
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	22.3872	0.0112	12.4002	100.0000	AID1030
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	89.1251	0.7079	36.9043	89.1251	AID504333
DNA polymerase eta isoform 1	Homo sapiens (human)	Potency	17.7828	0.1000	28.9256	213.3130	AID588591
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	89.1251	0.0501	27.0736	89.1251	AID588590
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Coagulation factor XII	Homo sapiens (human)	Ki	85.3400	0.0025	1.8669	7.2500	AID1798240
Cholinesterase	Homo sapiens (human)	Ki	87.7833	0.0000	1.5173	9.7300	AID1798240; AID281481
Liver carboxylesterase 1	Oryctolagus cuniculus (rabbit)	Ki	85.3400	0.0136	1.7025	7.2500	AID1798240
Acetylcholinesterase	Homo sapiens (human)	Ki	87.7833	0.0000	1.2786	9.7300	AID1798240; AID281480
Liver carboxylesterase 1	Homo sapiens (human)	Ki	87.7833	0.0025	2.0136	8.4800	AID1798240; AID281478
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
glycogen synthase kinase-3 beta isoform 1	Homo sapiens (human)	EC50 (µMol)	300.0000	0.2125	22.1562	83.9400	AID434954
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
plasma kallikrein-kinin cascade	Coagulation factor XII	Homo sapiens (human)
Factor XII activation	Coagulation factor XII	Homo sapiens (human)
blood coagulation, intrinsic pathway	Coagulation factor XII	Homo sapiens (human)
positive regulation of plasminogen activation	Coagulation factor XII	Homo sapiens (human)
protein processing	Coagulation factor XII	Homo sapiens (human)
protein autoprocessing	Coagulation factor XII	Homo sapiens (human)
positive regulation of blood coagulation	Coagulation factor XII	Homo sapiens (human)
zymogen activation	Coagulation factor XII	Homo sapiens (human)
fibrinolysis	Coagulation factor XII	Homo sapiens (human)
innate immune response	Coagulation factor XII	Homo sapiens (human)
response to misfolded protein	Coagulation factor XII	Homo sapiens (human)
positive regulation of fibrinolysis	Coagulation factor XII	Homo sapiens (human)
blood coagulation	Coagulation factor XII	Homo sapiens (human)
xenobiotic metabolic process	Cholinesterase	Homo sapiens (human)
learning	Cholinesterase	Homo sapiens (human)
negative regulation of cell population proliferation	Cholinesterase	Homo sapiens (human)
neuroblast differentiation	Cholinesterase	Homo sapiens (human)
peptide hormone processing	Cholinesterase	Homo sapiens (human)
response to alkaloid	Cholinesterase	Homo sapiens (human)
cocaine metabolic process	Cholinesterase	Homo sapiens (human)
negative regulation of synaptic transmission	Cholinesterase	Homo sapiens (human)
response to glucocorticoid	Cholinesterase	Homo sapiens (human)
response to folic acid	Cholinesterase	Homo sapiens (human)
choline metabolic process	Cholinesterase	Homo sapiens (human)
acetylcholine catabolic process	Cholinesterase	Homo sapiens (human)
acetylcholine catabolic process in synaptic cleft	Acetylcholinesterase	Homo sapiens (human)
regulation of receptor recycling	Acetylcholinesterase	Homo sapiens (human)
osteoblast development	Acetylcholinesterase	Homo sapiens (human)
acetylcholine catabolic process	Acetylcholinesterase	Homo sapiens (human)
cell adhesion	Acetylcholinesterase	Homo sapiens (human)
nervous system development	Acetylcholinesterase	Homo sapiens (human)
synapse assembly	Acetylcholinesterase	Homo sapiens (human)
receptor internalization	Acetylcholinesterase	Homo sapiens (human)
negative regulation of synaptic transmission, cholinergic	Acetylcholinesterase	Homo sapiens (human)
amyloid precursor protein metabolic process	Acetylcholinesterase	Homo sapiens (human)
positive regulation of protein secretion	Acetylcholinesterase	Homo sapiens (human)
retina development in camera-type eye	Acetylcholinesterase	Homo sapiens (human)
acetylcholine receptor signaling pathway	Acetylcholinesterase	Homo sapiens (human)
positive regulation of cold-induced thermogenesis	Acetylcholinesterase	Homo sapiens (human)
cholesterol biosynthetic process	Liver carboxylesterase 1	Homo sapiens (human)
cholesterol metabolic process	Liver carboxylesterase 1	Homo sapiens (human)
response to toxic substance	Liver carboxylesterase 1	Homo sapiens (human)
positive regulation of cholesterol efflux	Liver carboxylesterase 1	Homo sapiens (human)
negative regulation of cholesterol storage	Liver carboxylesterase 1	Homo sapiens (human)
epithelial cell differentiation	Liver carboxylesterase 1	Homo sapiens (human)
cholesterol homeostasis	Liver carboxylesterase 1	Homo sapiens (human)
reverse cholesterol transport	Liver carboxylesterase 1	Homo sapiens (human)
medium-chain fatty acid metabolic process	Liver carboxylesterase 1	Homo sapiens (human)
regulation of bile acid biosynthetic process	Liver carboxylesterase 1	Homo sapiens (human)
cellular response to cholesterol	Liver carboxylesterase 1	Homo sapiens (human)
cellular response to low-density lipoprotein particle stimulus	Liver carboxylesterase 1	Homo sapiens (human)
cholesterol ester hydrolysis involved in cholesterol transport	Liver carboxylesterase 1	Homo sapiens (human)
positive regulation of cholesterol metabolic process	Liver carboxylesterase 1	Homo sapiens (human)
regulation of bile acid secretion	Liver carboxylesterase 1	Homo sapiens (human)
lipid catabolic process	Liver carboxylesterase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
serine-type endopeptidase activity	Coagulation factor XII	Homo sapiens (human)
calcium ion binding	Coagulation factor XII	Homo sapiens (human)
protein binding	Coagulation factor XII	Homo sapiens (human)
misfolded protein binding	Coagulation factor XII	Homo sapiens (human)
amyloid-beta binding	Cholinesterase	Homo sapiens (human)
catalytic activity	Cholinesterase	Homo sapiens (human)
acetylcholinesterase activity	Cholinesterase	Homo sapiens (human)
cholinesterase activity	Cholinesterase	Homo sapiens (human)
protein binding	Cholinesterase	Homo sapiens (human)
hydrolase activity, acting on ester bonds	Cholinesterase	Homo sapiens (human)
enzyme binding	Cholinesterase	Homo sapiens (human)
choline binding	Cholinesterase	Homo sapiens (human)
identical protein binding	Cholinesterase	Homo sapiens (human)
amyloid-beta binding	Acetylcholinesterase	Homo sapiens (human)
acetylcholinesterase activity	Acetylcholinesterase	Homo sapiens (human)
cholinesterase activity	Acetylcholinesterase	Homo sapiens (human)
protein binding	Acetylcholinesterase	Homo sapiens (human)
collagen binding	Acetylcholinesterase	Homo sapiens (human)
hydrolase activity	Acetylcholinesterase	Homo sapiens (human)
serine hydrolase activity	Acetylcholinesterase	Homo sapiens (human)
acetylcholine binding	Acetylcholinesterase	Homo sapiens (human)
protein homodimerization activity	Acetylcholinesterase	Homo sapiens (human)
laminin binding	Acetylcholinesterase	Homo sapiens (human)
sterol esterase activity	Liver carboxylesterase 1	Homo sapiens (human)
methylumbelliferyl-acetate deacetylase activity	Liver carboxylesterase 1	Homo sapiens (human)
carboxylesterase activity	Liver carboxylesterase 1	Homo sapiens (human)
carboxylic ester hydrolase activity	Liver carboxylesterase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
extracellular region	Coagulation factor XII	Homo sapiens (human)
extracellular space	Coagulation factor XII	Homo sapiens (human)
plasma membrane	Coagulation factor XII	Homo sapiens (human)
collagen-containing extracellular matrix	Coagulation factor XII	Homo sapiens (human)
extracellular exosome	Coagulation factor XII	Homo sapiens (human)
extracellular space	Coagulation factor XII	Homo sapiens (human)
rough endoplasmic reticulum	Coagulation factor XII	Homo sapiens (human)
extracellular region	Cholinesterase	Homo sapiens (human)
nuclear envelope lumen	Cholinesterase	Homo sapiens (human)
endoplasmic reticulum lumen	Cholinesterase	Homo sapiens (human)
blood microparticle	Cholinesterase	Homo sapiens (human)
plasma membrane	Cholinesterase	Homo sapiens (human)
extracellular space	Cholinesterase	Homo sapiens (human)
extracellular region	Acetylcholinesterase	Homo sapiens (human)
basement membrane	Acetylcholinesterase	Homo sapiens (human)
extracellular space	Acetylcholinesterase	Homo sapiens (human)
nucleus	Acetylcholinesterase	Homo sapiens (human)
Golgi apparatus	Acetylcholinesterase	Homo sapiens (human)
plasma membrane	Acetylcholinesterase	Homo sapiens (human)
cell surface	Acetylcholinesterase	Homo sapiens (human)
membrane	Acetylcholinesterase	Homo sapiens (human)
neuromuscular junction	Acetylcholinesterase	Homo sapiens (human)
synaptic cleft	Acetylcholinesterase	Homo sapiens (human)
synapse	Acetylcholinesterase	Homo sapiens (human)
perinuclear region of cytoplasm	Acetylcholinesterase	Homo sapiens (human)
side of membrane	Acetylcholinesterase	Homo sapiens (human)
cytoplasm	Liver carboxylesterase 1	Homo sapiens (human)
endoplasmic reticulum	Liver carboxylesterase 1	Homo sapiens (human)
endoplasmic reticulum lumen	Liver carboxylesterase 1	Homo sapiens (human)
lipid droplet	Liver carboxylesterase 1	Homo sapiens (human)
cytosol	Liver carboxylesterase 1	Homo sapiens (human)
lipid droplet	Liver carboxylesterase 1	Homo sapiens (human)
endoplasmic reticulum	Liver carboxylesterase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (31)

Assay ID	Title	Year	Journal	Article
AID1798240	Enzyme Inhibition Assay from Article 10.1021/jm061471k: \\Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.\\	2007	Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8	Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1063516	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	2014	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2	Design, synthesis and in vitro cytotoxicity evaluation of 5-(2-carboxyethenyl)isatin derivatives as anticancer agents.
AID281479	Inhibition of rabbit liver carboxylesterase expressed in sf21 cells	2007	Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8	Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
AID1082385	Inhibition of Arabidopsis thaliana AHAS at 100 mg/L colorimetric assay	2011	Journal of agricultural and food chemistry, Sep-28, Volume: 59, Issue:18	Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives.
AID1063518	Cytotoxicity against human K562 cells after 48 hrs by MTT assay	2014	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2	Design, synthesis and in vitro cytotoxicity evaluation of 5-(2-carboxyethenyl)isatin derivatives as anticancer agents.
AID284490	Cytotoxicity against human U937 cells	2007	Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2	In vitro cytotoxicity evaluation of some substituted isatin derivatives.
AID1063517	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	2014	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 24, Issue:2	Design, synthesis and in vitro cytotoxicity evaluation of 5-(2-carboxyethenyl)isatin derivatives as anticancer agents.
AID1061202	Inhibition of GST-tagged SARS coronavirus 3C-like protease at 1 mM by FRET assay	2014	Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1	Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors.
AID281477	Inhibition of human intestinal carboxylesterase expressed in sf21 cells	2007	Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8	Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
AID1082383	Inhibition of Brassica rapa subsp. oleifera root growth at 10 mg/L	2011	Journal of agricultural and food chemistry, Sep-28, Volume: 59, Issue:18	Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives.
AID1082384	Inhibition of Brassica rapa subsp. oleifera at 100 mg/L	2011	Journal of agricultural and food chemistry, Sep-28, Volume: 59, Issue:18	Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives.
AID1284106	Anticancer activity against human Jurkat cells after 48 hrs by MTT assay	2016	European journal of medicinal chemistry, Apr-13, Volume: 112	Synthesis and anti-cancer activity evaluation of 5-(2-carboxyethenyl)-isatin derivatives.
AID281480	Inhibition of human AChE	2007	Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8	Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
AID1406678	Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
AID465619	Anticancer activity against human U937 cells by MTS assay	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	QSAR study of isatin analogues as in vitro anti-cancer agents.
AID281478	Inhibition of human liver CE1 expressed in sf21 cells	2007	Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8	Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
AID1406679	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
AID281481	Inhibition of human BChE	2007	Journal of medicinal chemistry, Apr-19, Volume: 50, Issue:8	Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (23.08)	29.6817
2010's	9 (69.23)	24.3611
2020's	1 (7.69)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
indole [no description available]	2.03	1	indole; polycyclic heteroarene	Escherichia coli metabolite
phthalimide phthalimide: RN given refers to parent cpd. phthalimide : A dicarboximide that is 2,3-dihydro-1H-isoindole substituted by oxo groups at positions 1 and 3.	2.03	1	phthalimides
5-bromoisatin [no description available]	3.32	6	indoles	anticoronaviral agent
isatin tribulin: endogenous MONOAMINE OXIDASE inhibitory activity extractable into ethyl acetate found in brain and many mammalian tissues and fluids; ISATIN is a major component; produced in excess following alcohol withdrawal;	3.31	6	indoledione	EC 1.4.3.4 (monoamine oxidase) inhibitor; plant metabolite
indene indene: structure in first source. 1H-indene : An ortho-fused bicyclic arene comprising of benzene and cyclopentene rings.	2.03	1	indene; ortho-fused bicyclic arene
indan indan: structure in first source. indane : An ortho-fused bicyclic hydrocarbon consisting of a benzene ring fused to a cyclopentane ring; a high-boiling (176 (o)C) colourless liquid.	2.03	1	indanes; ortho-fused bicyclic hydrocarbon
indoline indoline: structure given in first source	2.03	1	indoles
1-acetylisatin 1-acetylisatin: structure in first source	2.03	1	indoledione
1,3-indandione 1,3-indandione : A member of the class of indanones that is indane in which the hydrogens at positions 2 and 4 have been replaced by oxo groups.	2.03	1	aromatic ketone; beta-diketone; indanones
5-methylisatin 5-methylisatin: structure in first source	2.99	4
n-methylisatin N-methylisatin: structure given in first source	2.96	4
camptothecin NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source	2.52	2	delta-lactone; pyranoindolizinoquinoline; quinoline alkaloid; tertiary alcohol	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; genotoxin; plant metabolite
staurosporine [no description available]	2.03	1	indolocarbazole alkaloid; organic heterooctacyclic compound	apoptosis inducer; bacterial metabolite; EC 2.7.11.13 (protein kinase C) inhibitor; geroprotector
n-phenylphthalimide N-phenylphthalimide: structure given in first source	2.03	1
2,3-dioxo-5-indolinesulfonic acid 2,3-dioxo-5-indolinesulfonic acid: reagent for modification of tryptophan residues in peptides & proteins	2.06	1
5-Chloro-1H-indole-2,3-dione [no description available]	3.17	5	indoles	anticoronaviral agent
5-iodoisatin 5-iodoisatin: structure in first source	3.15	5	indoles	anticoronaviral agent
6-bromoisatin 6-bromoisatin: anticancer compound from Dicathais orbita; structure in first source	2.45	2
5-Fluoroisatin [no description available]	3.45	7	indoles	anticoronaviral agent
1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione [no description available]	2.03	1	indoles
5-Nitroisatin [no description available]	3.15	5	indoles	anticoronaviral agent
monosulfuron monosulfuron: structure in first source	2.06	1

Condition	Relationship Strength	Studies
Innate Inflammatory Response [description not available]	2.05	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.05	1
Benign Neoplasms [description not available]	2.13	1
Leukemia, Lymphocytic, T Cell [description not available]	2.13	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.13	1
Leukemia, T-Cell A malignant disease of the T-LYMPHOCYTES in the bone marrow, thymus, and/or blood.	2.13	1

5-Methoxyisatin

Cross-References

Synonyms (54)

Roles (1)

Drug Classes (1)

Protein Targets (12)

Potency Measurements

Inhibition Measurements

Activation Measurements

Biological Processes (54)

Molecular Functions (22)

Ceullar Components (23)

Bioassays (31)

Research

Studies (13)

Market Indicators

Research Demand Index: 19.39

Study Types

5-Methoxyisatin

Cross-References

Synonyms (54)

Roles (1)

Drug Classes (1)

Protein Targets (12)

Potency Measurements

Inhibition Measurements

Activation Measurements

Biological Processes (54)

Molecular Functions (22)

Ceullar Components (23)

Bioassays (31)

Research

Studies (13)

Market Indicators

Research Demand Index: 19.39

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Related Conditions (6)