Page last updated: 2024-12-10

beta-proline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

beta-proline: RN given refers to cpd without isomeric designation; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID3034645
CHEMBL ID4586784
SCHEMBL ID444559
MeSH IDM0196169

Synonyms (47)

Synonym
BB 0241794
59378-87-9
3-pyrrolidine carboxylic acid
3-pyrrolidinecarboxylic acid
AKOS005146133
FT-0650096
pyrrolidine-3-carboxylic acid
A8355
3-pyrrolidinecarboxylicacid
beta-proline
unii-xq9918nb1d
xq9918nb1d ,
FT-0641414
FT-0648202
PB19915
PB16017
pyrrolidine-3-carboxylicacid
SCHEMBL444559
SY010178
SY010177
SY008997
mfcd01318699
JAEIBKXSIXOLOL-UHFFFAOYSA-N
pyrrolidine-3-carboxylic
dl-3-pyrrolidine carboxylic acid
(rs)-pyrrolidine-3-carboxylic acid
beta-dl-proline
(+/-)-3-pyrrolidinecarboxylic acid
j1.621.322e
.beta.-proline
dl-pyrrolidine-3-carboxylic acid
rac-(3r*)-3-pyrrolidinecarboxylic acid
W-203220
pyrrolidine-3-carboxylic acid, aldrichcpr
CS-W019683
F0001-1559
BCP04865
4-benzyloxy-3-amino-a-[-benzyl-n-(1-methyl-2p-methoxyphenylether)amino-methylbenzylalcohol
DS-11132
SB10225
Q27293960
DTXSID20900992
noname_39
CHEMBL4586784 ,
bdbm50510630
EN300-67262
r-pyrrolidine-3-carboxylic acid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Sodium- and chloride-dependent GABA transporter 1Mus musculus (house mouse)IC50 (µMol)67.60830.03712.19228.5114AID1544944
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1544944Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition and measured after 4 mins by liquid scintillation counting method2019Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13
Application of the concept of oxime library screening by mass spectrometry (MS) binding assays to pyrrolidine-3-carboxylic acid derivatives as potential inhibitors of γ-aminobutyric acid transporter 1 (GAT1).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (23)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (8.70)18.2507
2000's9 (39.13)29.6817
2010's12 (52.17)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.43 (24.57)
Research Supply Index3.18 (2.92)
Research Growth Index5.03 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.43)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other23 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]