Page last updated: 2024-09-27

Benign Clear Cell Adenofibroma

Benign or borderline malignant neoplasm of the ovary and surrounding tissues. It is characterized by tumor(s) with cystic glands which are lined by cuboidal EPITHELIAL CELLS with clear cytoplasm, resembling ENDOMETRIUM cells. The glands are separated by fibroblastic STROMAL CELLS.

Synonyms(6)

Synonym
Clear Cell Adenofibroma
Benign Cystadenofibroma
Borderline Cystadenofibroma
Cystadenofibroma
Borderline Clear Cell Adenofibroma
Benign Clear Cell Adenofibroma

Research

Studies (5)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's5 (100.00)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
caffeine0low10
fluorouracil0low10
meglumine0low10
camptothecin0low10
paclitaxel0low10
irinotecan0low10
carboplatin0low10
leuprolide0low10
methimazole0low10
levoleucovorin0low10
pemetrexed0low10

Protein Targets (333)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Chitinase0101
phosphopantetheinyl transferase4004
RAR-related orphan receptor gamma3003
GLS protein1001
GLI family zinc finger 33003
AR protein4004
nuclear receptor subfamily 1, group I, member 33003
glucocorticoid receptor [Homo sapiens]4004
retinoic acid nuclear receptor alpha variant 13003
retinoid X nuclear receptor alpha4004
estrogen-related nuclear receptor alpha4004
farnesoid X nuclear receptor3003
pregnane X nuclear receptor4004
estrogen nuclear receptor alpha5005
euchromatic histone-lysine N-methyltransferase 25005
thyroid stimulating hormone receptor1001
v-jun sarcoma virus 17 oncogene homolog (avian)3003
atrial natriuretic peptide receptor 1 precursor1001
chromobox protein homolog 13003
thyroid hormone receptor beta isoform a1001
thyroid hormone receptor beta isoform 23003
DNA polymerase beta1001
nuclear factor erythroid 2-related factor 2 isoform 14004
nuclear receptor ROR-gamma isoform 13003
geminin4004
DNA polymerase kappa isoform 12002
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)2002
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40505
Voltage-dependent calcium channel gamma-2 subunit2002
Potassium channel subfamily K member 20011
Bile salt export pump0505
Glycogen phosphorylase, muscle form0101
Renin0101
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Cholinesterase0101
Glycogen phosphorylase, liver form0101
Glycogen phosphorylase, muscle form0101
Replicase polyprotein 1ab0101
Adenosine receptor A30101
Replicase polyprotein 1ab0101
Glutamate receptor 22002
Amine oxidase [flavin-containing] A0101
Acetylcholinesterase0303
Adenosine receptor A10203
Amine oxidase [flavin-containing] B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Adenosine receptor A30101
Adenosine receptor A2a0214
Adenosine receptor A2b0102
Adenosine receptor A2b0203
Adenosine receptor A10114
Adenosine receptor A2a0204
Vasopressin V2 receptor0001
Serine/threonine-protein kinase mTOR0101
Adenosine receptor A2a0101
Adenosine receptor A10101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
DNA-dependent protein kinase catalytic subunit0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10001
Chitotriosidase-10101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Adenosine receptor A2b0102
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Palmitoleoyl-protein carboxylesterase NOTUM0123
Endochitinase B10101
Muscarinic acetylcholine receptor0001
Canalicular multispecific organic anion transporter 10505
Phosphodiesterase 0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Guanine deaminase0101
ATP-dependent phosphofructokinase3003
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, Ferritin light chain1001
Chain A, Cruzipain1001
DNA topoisomerase 0101
thioredoxin reductase3003
15-lipoxygenase, partial1001
ATAD5 protein, partial2002
Fumarate hydratase2002
NFKB1 protein, partial1001
PPM1D protein2002
TDP1 protein5005
Thrombopoietin2002
aldehyde dehydrogenase 1 family, member A13003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
thyroid stimulating hormone receptor2002
regulator of G-protein signaling 41001
EWS/FLI fusion protein4004
polyprotein2002
67.9K protein4004
glucocerebrosidase1001
putative alpha-glucosidase1001
alpha-galactosidase1001
Bloom syndrome protein isoform 11001
lysosomal alpha-glucosidase preproprotein1001
peripheral myelin protein 22 isoform 12002
hemoglobin subunit beta2002
cellular tumor antigen p53 isoform a1001
cytochrome P450 2C19 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
nuclear factor erythroid 2-related factor 2 isoform 22002
huntingtin isoform 22002
ras-related protein Rab-9A1001
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor0011
serine/threonine-protein kinase mTOR isoform 12002
DNA polymerase iota isoform a (long)1001
survival motor neuron protein isoform d3003
cytochrome P450 3A4 isoform 11001
M-phase phosphoprotein 81001
muscleblind-like protein 1 isoform 12002
histone acetyltransferase KAT2A isoform 12002
relaxin receptor 1 isoform 11001
lamin isoform A-delta104004
Gamma-aminobutyric acid receptor subunit pi1001
Telomerase reverse transcriptase0101
Serine/threonine-protein kinase Chk10011
Histone deacetylase 30101
Type-2 restriction enzyme ScaI0101
Deoxyribonuclease-2-alpha0101
Tyrosyl-DNA phosphodiesterase 20101
Deoxyribonuclease-10101
Type-2 restriction enzyme PstI0101
Type-2 restriction enzyme EcoRI0101
Prothrombin0001
DNA ligase0101
Interferon beta3003
Integrin beta-31102
Integrin alpha-IIb1001
Heterogeneous nuclear ribonucleoprotein A10011
DNA topoisomerase 10117
DNA topoisomerase 2-alpha0101
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Type-2 restriction enzyme BamHI0101
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Somatostatin receptor type 10101
Somatostatin receptor type 20101
Somatostatin receptor type 40101
Somatostatin receptor type 30101
Somatostatin receptor type 50101
5-hydroxytryptamine receptor 2B0202
Type-2 restriction enzyme HindIII0101
D(1A) dopamine receptor1001
Histone deacetylase 40101
Ribonuclease pancreatic0101
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Inositol monophosphatase 11001
DNA topoisomerase 2-beta0001
DNA topoisomerase 10102
Histone deacetylase 10101
DNA topoisomerase 10101
Integrase 0101
Histone deacetylase 70101
GABA theta subunit1001
Histone deacetylase 20101
DNA topoisomerase type IB small subunit 0011
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit epsilon1001
Tyrosyl-DNA phosphodiesterase 10101
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
acetylcholinesterase2002
estrogen receptor 2 (ER beta)3003
G1001
cytochrome P450 2D61001
vitamin D3 receptor isoform VDRA1001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
HLA class I histocompatibility antigen, B alpha chain 1001
Inositol hexakisphosphate kinase 11001
cytochrome P450 2C9, partial1001
Chain A, Uracil Phosphoribosyltransferase0101
Luciferase3003
interleukin 81001
endonuclease IV1001
glp-1 receptor, partial1001
Skn7p0001
pregnane X receptor2002
hypoxia-inducible factor 1 alpha subunit2002
Microtubule-associated protein tau1001
progesterone receptor2002
nonstructural protein 11001
peroxisome proliferator-activated receptor delta2002
peroxisome proliferator activated receptor gamma2002
arylsulfatase A1001
IDH12002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
Histone H2A.x2002
flap endonuclease 11001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Vpr1001
peripheral myelin protein 222002
Solute carrier family 22 member 80001
Epidermal growth factor receptor0202
Cellular tumor antigen p532002
Amyloid-beta precursor protein1001
Thymidylate synthase0202
Aromatase0101
ATPase family AAA domain-containing protein 51001
Ataxin-21001
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Chain A, Acetylcholinesterase0101
interferon gamma precursor0001
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0101
Solute carrier family 22 member 30101
Interstitial collagenase0101
Acetylcholinesterase0101
Muscarinic acetylcholine receptor M40202
Cytochrome P450 3A40101
Alpha-2C adrenergic receptor0202
Liver carboxylesterase 10001
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
Gonadotropin-releasing hormone receptor0101
Gonadotropin-releasing hormone receptor0202
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
activating transcription factor 61001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
heat shock protein beta-11001
Polyphenol oxidase 20203
Bile salt export pump0101
Dopamine beta-hydroxylase 0202
Lactoperoxidase0101
Lanosterol 14-alpha demethylase0101
Chain A, Beta-lactamase1001
Genome polyprotein 0101
cytochrome P450 family 3 subfamily A polypeptide 41001
nuclear receptor subfamily 1, group I, member 21001
NPC intracellular cholesterol transporter 1 precursor1001
Tyrosine-protein kinase ABL10101
Tubulin alpha-1A chain0012
Tubulin beta chain0011
Tubulin beta-4A chain0113
Receptor tyrosine-protein kinase erbB-20101
Tyrosine-protein kinase Fyn0101
Integrin alpha-V 0101
Tubulin beta chain0113
ATP-dependent translocase ABCB10103
60 kDa chaperonin0101
Tubulin alpha-3C chain0113
Botulinum neurotoxin type A 0101
Apoptosis regulator Bcl-20101
60 kDa heat shock protein, mitochondrial0101
Fibroblast growth factor receptor 10101
Proto-oncogene tyrosine-protein kinase Src0101
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1-60101
ATP-dependent translocase ABCB10101
Substance-K receptor0202
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40101
Serum paraoxonase/arylesterase 10101
Cholecystokinin receptor type A0202
Melanocortin receptor 50202
UDP-glucuronosyltransferase 2B10 0101
Delta-type opioid receptor0202
10 kDa heat shock protein, mitochondrial0101
Tubulin alpha-1B chain0113
Tubulin alpha-4A chain0113
Tubulin beta-4B chain0113
Bcl-2-like protein 10101
Tyrosine-protein kinase Mer0101
Tubulin beta-3 chain0214
Tubulin beta-2A chain0113
Thiosulfate sulfurtransferase0101
Beta-tubulin 0101
Tubulin beta-8 chain0113
60 kDa chaperonin 0101
Tubulin beta-2B chain0013
Tubulin alpha-3E chain0113
Tubulin alpha-1A chain0113
10 kDa chaperonin 0101
Similar to alpha-tubulin isoform 1 0013
Similar to alpha-tubulin isoform 1 0002
Tubulin alpha-1C chain0113
Tubulin beta-6 chain0113
Tubulin beta-2B chain0113
Tubulin beta-1 chain0113
Nucleotide-binding oligomerization domain-containing protein 20101
Solute carrier organic anion transporter family member 1B30202
Solute carrier organic anion transporter family member 1B10202
Chain A, Thymidylate Synthase0101
Chain A, Thymidylate Synthase0101
Chain A, Thymidylate Synthase0101
Thymidylate synthase 0101
Thymidylate synthase 0101
tyrosine-protein kinase Yes1001
Dihydrofolate reductase0202
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Thymidylate synthase0202
Thymidylate synthase0202
Dihydrofolate reductase0101
Folate receptor beta0101
Folate receptor alpha0101
Dihydrofolate reductase0101
Trifunctional purine biosynthetic protein adenosine-30202
Bifunctional purine biosynthesis protein ATIC0202
Serine hydroxymethyltransferase, cytosolic0112
Reduced folate transporter0101
Thymidylate synthase 0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Trifunctional purine biosynthetic protein adenosine-30101
Proton-coupled folate transporter0203
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]